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Total 3278 results found since Jan 2013.
Unimpaired endogenous pain inhibition in the early phase of complex regional pain syndrome
ConclusionAn impairment of endogenous pain inhibition does not explain the extent of pain in the early stage of CRPS or in neuralgia. The unexpectedly high CPM in CRPS patients might result from activation of the intact descending pathways in response to central sensitization, as cold hyperalgesia correlated with the CPM‐effect.
SignificanceConditioned pain modulation (CPM) is not impaired in the early phase of complex regional pain syndrome (CRPS) and neuralgia. Only in CRPS higher CPM was associated with lower cold pain thresholds.
Source: European Journal of Pain - January 31, 2017 Category: Anesthesiology Authors: N. Kumowski, T. Hegelmaier, J. Kolbenschlag, C. Maier, T. Mainka, J. Vollert, E. Enax ‐Krumova Tags: Original Article Source Type: research
Complex Regional Pain Syndrome After Distal Radius Fracture Is Uncommon and Is Often Associated With Fibromyalgia.
CONCLUSIONS: We found that a coded diagnosis of CPRS is uncommonly applied to patients on the higher range of pain, stiffness, and limitations after fracture of the distal radius-most commonly in women and in association with another nonspecific, objectively unverifiable diagnosis (fibromyalgia)-and that this label may lead to more testing and invasive treatment. Future research should address the utility and value of diagnoses that create subjective categories for aspects of human illness that occur on a continuum.
LEVEL OF EVIDENCE: Level III, prognostic study.
PMID: 29419627 [PubMed - as supplied by publisher]
Source: Clinical Orthopaedics and Related Research - February 5, 2018 Category: Orthopaedics Authors: Crijns TJ, van der Gronde BATD, Ring D, Leung N Tags: Clin Orthop Relat Res Source Type: research
Clinical Features of Pediatric Complex Regional Pain Syndrome: A 5-Year Retrospective Chart Review
Discussion:
In this cohort, pediatric CRPS was most common in girls around the age of 12, usually in the lower extremity, and most experienced a favorable outcome. Further research is needed to better understand the prognosis and relapse rate of pediatric CRPS.
Source: The Clinical Journal of Pain - November 8, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research
Complex regional pain syndrome patient immunoglobulin M has pronociceptive effects in the skin and spinal cord of tibia fracture mice
It has been proposed that complex regional pain syndrome (CRPS) is a post-traumatic autoimmune disease. Previously, we observed that B cells are required for the full expression of CRPS-like changes in a mouse tibia fracture model and that serum immunoglobulin M (IgM) antibodies from fracture mice have pronociceptive effects in muMT fracture mice lacking B cells. The current study evaluated the pronociceptive effects of injecting CRPS patient serum or antibodies into muMT fracture mice by measuring hind paw allodynia and unweighting changes. Complex regional pain syndrome serum binding was measured against autoantigens pre...
Source: Pain - March 26, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research
Muscle Hyperalgesia Correlates With Motor Function in Complex Regional Pain Syndrome Type 1
This study aims to investigate the relation between sensory and motor functioning in CRPS patients with and without dystonia. Patients with CRPS of the arm and controls underwent comprehensive quantitative sensory testing and kinematic analysis of repetitive finger movements. Both CRPS groups showed thermal hypoesthesia to cold and warm stimuli and hyperalgesia to cold stimuli. A decreased pressure pain threshold reflecting muscle hyperalgesia emerged as the most prominent sensory abnormality in both patient groups and was most pronounced in CRPS patients with dystonia. Moreover, the decreased pressure pain threshold was ...
Source: The Journal of Pain - March 29, 2013 Category: Materials Science Authors: Diana E. van Rooijen, Johan Marinus, Alfred C. Schouten, Lucas P.J.J. Noldus, Jacobus J. van Hilten Tags: Original Reports Source Type: research
Absent median somatosensory evoked potential is a predictor of type I complex regional pain syndrome after stroke.
Conclusions: In conclusion, GHS and the absent median SEP at sub-acute phase of stroke were primary predictors of the onset of post-stoke CRPS. Implications for Rehabilitation Recent investigations have suggested that autonomic, motor and somatosensory abnormalities of CRPS are impairments involving the central nervous system (CNS) as well as the peripheral neurogenic inflammatory process. However, the understanding of the pathophysiology of CRPS is still far from complete. The absence of SEP at the sub-acute stage of stroke correlated with the onset of post-stroke CRPS type I. The SEP evaluation at the sub-acute period af...
Source: Disability and Rehabilitation - September 19, 2013 Category: Rehabilitation Authors: Han EY, Jung HY, Kim MO Tags: Disabil Rehabil Source Type: research
Intense Pain Soon After Wrist Fracture Strongly Predicts Who Will Develop Complex Regional Pain Syndrome: Prospective Cohort Study
This study shows that excessive baseline pain in the week after wrist fracture greatly elevates the risk of developing CRPS. Clinicians can consider a rating of greater than 5/10 to the question “What is your average pain over the last 2 days?” to be a “red flag” for CRPS.
Source: The Journal of Pain - November 21, 2013 Category: Materials Science Authors: G. Lorimer Moseley, Robert D. Herbert, Timothy Parsons, Samantha Lucas, Jacobus J. Van Hilten, Johan Marinus Tags: Original Reports Source Type: research
Allergy/Hypersensitivity reactions as a predisposing factor to complex regional pain syndrome I in orthopedic patients.
Abstract
Several predisposing conditions have been associated with complex regional pain syndrome I (CRPS I). The purpose of this study was to determine the relationship between a history of allergy/hypersensitivity reactions and CRPS I in orthopedic patients. Orthopedic patients with CRPS I (n=115) who experienced pain relief after a successful sympathetic nerve blockade were identified for study inclusion; a control group (n=115) matched to the CRPS I group by age, sex, and location of injury was also included. All patients in the study had an average age of 42 years. In the CRPS I group, all participants were C...
Source: Orthopedics - March 1, 2014 Category: Orthopaedics Authors: Li X, Kenter K, Newman A, O'Brien S Tags: Orthopedics Source Type: research
Perioperative factors affecting the occurrence of acute complex regional pain syndrome following limb bone fracture surgery: data from the Japanese Diagnosis Procedure Combination database
Conclusion. Although a limited number of CRPS patients were analysed in this study, reduced operative time might help to prevent the development of acute CRPS following limb fracture.
Source: Rheumatology - June 19, 2014 Category: Rheumatology Authors: Sumitani, M., Yasunaga, H., Uchida, K., Horiguchi, H., Nakamura, M., Ohe, K., Fushimi, K., Matsuda, S., Yamada, Y. Tags: Systemic Sclerosis CLINICAL SCIENCE Source Type: research
Antiallodynic effect through spinal endothelin-B receptor antagonism in rat models of complex regional pain syndrome
Publication date: 1 January 2015 Source:Neuroscience Letters, Volume 584 Author(s): Yeo Ok Kim , In Ji Kim , Myung Ha Yoon Complex regional pain syndrome (CRPS) is a very complicated chronic pain disorder that has been classified into two types (I and II). Endothelin (ET) receptors are involved in pain conditions at the spinal level. We investigated the role of spinal ET receptors in CRPS. Chronic post-ischemia pain (CPIP) was induced in male Sprague–Dawley rats as a model for CRPS-I by placing a tourniquet (O-ring) at the ankle joint for 3h, and removing it to allow reperfusion. Ligation of L5 and L6 spinal nerves to ...
Source: Neuroscience Letters - November 27, 2014 Category: Neuroscience Source Type: research
Extent of recovery in the first 12 months of complex regional pain syndrome type‐1: A prospective study
ConclusionsOverall the results were less optimistic than several previously conducted prospective studies and suggest that few cases of CRPS resolve completely within 12 months of onset. Improvements were generally greater in the first 6 months, and suggest that it may be worth exploring early interventions to prevent long‐term disability in CRPS.
Source: European Journal of Pain - November 1, 2015 Category: Anesthesiology Authors: D.J. Bean, M.H. Johnson, W. Heiss‐Dunlop, R.R. Kydd Tags: Original Article Source Type: research
Factors Associated With Disability and Sick Leave in Early Complex Regional Pain Syndrome Type-1
Discussion: Although the study was cross-sectional and so cannot differentiate cause from effect, results suggest that even in the early stages of CRPS, a cycle of pain, disability, depression, and work absence can emerge. Treatments aimed to prevent this cycle may help prevent adverse long-term outcomes.
Source: The Clinical Journal of Pain - January 12, 2016 Category: Anesthesiology Tags: Original Articles Source Type: research
Endocrine disorders in women with complex regional pain syndrome type I
ConclusionsIn patients with CRPS I endocrine status is characterized by hormonal imbalances of the hypothalamic‐pituitary‐adrenal and hypothalamic‐pituitary‐gonadal systems. The changes in reproductive and adaptation homeostasis characterize CRPS I as a form of the disease of disadaptation.
SignificanceThis study determined the role of hypothalamic‐pituitary‐adrenal and hypothalamic‐pituitary‐ovarian systems in pathogenesis of CRPS I.
Source: European Journal of Pain - August 9, 2016 Category: Anesthesiology Authors: A. Buryanov, A. Kostrub, V. Kotiuk Tags: Original Article Source Type: research
A Comprehensive Outcome ‐Specific Review of the Use of Spinal Cord Stimulation for Complex Regional Pain Syndrome
ConclusionsSpinal cord stimulation remains a favorable and effective modality for treating CRPS with high‐level evidence (1B+) supporting its role in improving CRPS patients' perceived pain relief, pain score, and quality of life. A paucity of evidence for functional improvements, resolution of CRPS signs, sleep hygiene, psychological impact, and analgesic sparing effects mandate further investigation before conclusions can be drawn for these specific outcomes.
Source: Pain Practice - October 13, 2016 Category: Anesthesiology Authors: Ognjen Visnjevac, Shrif Costandi, Bimal A. Patel, Girgis Azer, Priya Agarwal, Robert Bolash, Nagy A. Mekhail Tags: Review Article Source Type: research
Investigate the Effect of Psychological Factors in Development of Complex Regional Pain Syndrome Type I in Patients with Fracture of the Distal Radius: A Prospective Study.
CONCLUSIONS: After fracturing the distal radius, patients who have high pain intensity have a higher risk of developing CRPS I. To following these patients closely for the development of CRPS I may be advantageous for early preventative and therapeutic interventions.
PMID: 30428789 [PubMed - in process]
Source: Hand Surgery - November 17, 2018 Category: Surgery Authors: Farzad M, Layeghi F, Hosseini A, Dianat A, Ahrari N, Rassafiani M, Mirzaei H Tags: J Hand Surg Asian Pac Vol Source Type: research
