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Total 3278 results found since Jan 2013.

Delayed diagnosis and worsening of pain following orthopedic surgery in patients with complex regional pain syndrome (CRPS)
Conclusions and implications A mean time delay of 3.9 years before diagnosis of CRPS is unacceptable. A lack of attention to more subtle signs of autonomic dysfunction may be an important contributing factor for the missing CRPS diagnosis, in particular serious in patients reporting worsening of pain following subsequent orthopedic surgery. It is strongly recommended to consider the diagnosis of CRPS in all patients with a long-lasting pain condition. We emphasize that the present report is not meant as criticism to orthopedic surgical practice, but as a discussion for a hopefully increased awareness and understanding of t...
Source: Scandinavian Journal of Pain - December 3, 2015 Category: Anesthesiology Source Type: research

Increased prevalence of posttraumatic stress disorder in CRPS
Conclusionsposttraumatic stress disorder (PTSD) is more frequent in patients with CRPS than it is in the general population. SignificanceResearch has not yet provided support for specific psychological predictors for CRPS.
Source: European Journal of Pain - September 21, 2016 Category: Anesthesiology Authors: V. Speck, T. Schlereth, F. Birklein, C. Maih öfner Tags: Original Article Source Type: research

Prevalence and Cost Analysis of Complex Regional Pain Syndrome (CRPS): A Role for Neuromodulation
ConclusionsOur study demonstrates that there is a significant increase in cost and healthcare resource utilization one‐year prior to and around the time of CRPS diagnosis. Furthermore, there is an increased annual cost post‐diagnosis compared to baseline costs prior to CRPS diagnosis.
Source: Neuromodulation: Technology at the Neural Interface - September 29, 2017 Category: Biotechnology Authors: Aladine A. Elsamadicy, Siyun Yang, Amanda R. Sergesketter, Bilal Ashraf, Lefko Charalambous, Hanna Kemeny, Tiffany Ejikeme, Xinru Ren, Promila Pagadala, Beth Parente, Jichun Xie, Shivanand P. Lad Tags: Clinical Research Source Type: research

Physiotherapy for pain and disability in adults with complex regional pain syndrome (CRPS) types I and II
CONCLUSIONS: The evidence is very uncertain about the effects of physiotherapy interventions on pain and disability in CRPS. This conclusion is similar to our 2016 review. Large-scale, high-quality RCTs with longer-term follow-up are required to test the effectiveness of physiotherapy-based interventions for treating pain and disability in adults with CRPS I and II.PMID:35579382 | DOI:10.1002/14651858.CD010853.pub3
Source: Cochrane Database of Systematic Reviews - May 17, 2022 Category: General Medicine Authors: Keith M Smart Michael C Ferraro Benedict M Wand Neil E O'Connell Source Type: research

Skin Hyperpigmentation in Complex Regional Pain Syndrome (CRPS) (P3.315)
CONCLUSIONS: There are hyperpigmentary skin manifestations of CRPS resembling Schamberg’s purpura. However, mirror-image skin of unaffected limbs can become affected in CRPS and lesions can disappear with improvement of CRPS suggesting a neurogenic/humoral mechanism. Study Support: None.Disclosure: Dr. Knobler has received personal compensation for activities with Teva Neurosciences and Questcor Pharmaceuticals as a speaker.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Knobler, R. Tags: Pain and Palliative Care Source Type: research

The Severity Spectrum in Persistent Complex Regional Pain Syndrome (CRPS), Palliation with Ongoing Hyperbaric Oxygen Therapy (HBOT), and the Role of Serial Photo-Documentation (P6.271)
CONCLUSIONS: Persistent CRPS severity is defined on a spectrum reflecting degree of tissue changes, not by duration alone. Limb threatening skin ulceration, weeping wounds and cellulitis responded to HBOT, avoiding amputation. Serial photo-documentation facilitated management by chronicling therapeutic-effectiveness.Disclosure: Dr. Knobler has received personal compensation for activities with Teva Neurosciences and Mallinckrodt Pharmaceuticals as a speaker.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Knobler, R. Tags: Pain and Palliative Care Source Type: research

Local cytokine changes in complex regional pain syndrome type I (CRPS I) resolve after 6months
Summary: Local cytokine changes were analyzed in CRPS I patients. TNF-α, MIP-1β, and IL-1RA were changed bilaterally but returned to the level of non-CRPS patients after 6months.Abstract: There is evidence that inflammatory processes are involved in at least the early phase of complex regional pain syndrome (CRPS). We compared a panel of pro- and antiinflammatory cytokines in skin blister fluids and serum from patients with CRPS and patients with upper-limb pain of other origin (non-CRPS) in the early stage (
Source: Pain - July 1, 2013 Category: Anesthesiology Authors: Melanie Lenz, Nurcan Üçeyler, Jule Frettlöh, Oliver Höffken, Elena K. Krumova, Silke Lissek, Annika Reinersmann, Claudia Sommer, Philipp Stude, Ana M. Waaga-Gasser, Martin Tegenthoff, Christoph Maier Tags: Research papers Source Type: research

Prevalence and Co-prevalence of Complex Regional Pain Syndrome (CRPS) and Carpal Tunnel Syndrome (CTS) in Hand Rehabilitation.
Conclusion: CRPS and CTS are often associated. Rehabilitative therapy was effective for CRPS- and CRPS+CTS patients. PMID: 27272240 [PubMed - as supplied by publisher]
Source: Handchirurgie Mikrochirurgie Plastische Chirurgie - June 10, 2016 Category: Cosmetic Surgery Tags: Handchir Mikrochir Plast Chir Source Type: research

National Trends in the Diagnosis of CRPS after Open and Endoscopic Carpal Tunnel Release
Jnl Wrist Surg DOI: 10.1055/s-0039-1678674 Background Complex regional pain syndrome (CRPS) occurs in 2 to 8% of patients that receive open or endoscopic carpal tunnel release (CTR). Because CRPS is difficult to treat after onset, identifying risk factors can inform prevention. We determined the incidence of CRPS following open and endoscopic CTR using a national claims database. We also examined whether psychosocial conditions were associated with CRPS after CTR. Methods We accessed insurance claims using diagnostic and procedural codes. We calculated the incidence of CRPS following open carpal tunnel release an...
Source: Journal of Wrist Surgery - February 27, 2019 Category: Orthopaedics Authors: Mertz, Kevin Trunzter, Jeremy Wu, Edward Barnes, James Eppler, Sara L. Kamal, Robin N. Tags: Scientific Article Source Type: research

A CRPS-IgG-transfer-trauma model reproducing inflammatory and positive sensory signs associated with complex regional pain syndrome
Summary: The transfer of serum IgG from patients with long-standing complex regional pain syndrome (CRPS) to mice, followed by mild hind paw trauma, causes typical signs of CRPS.Abstract: The aetiology of complex regional pain syndrome (CRPS), a highly painful, usually post-traumatic condition affecting the limbs, is unknown, but recent results have suggested an autoimmune contribution. To confirm a role for pathogenic autoantibodies, we established a passive-transfer trauma model. Prior to undergoing incision of hind limb plantar skin and muscle, mice were injected either with serum IgG obtained from chronic CRPS patients...
Source: Pain - October 21, 2013 Category: Anesthesiology Authors: Valéria Tékus, Zsófia Hajna, Éva Borbély, Adrienn Markovics, Teréz Bagoly, János Szolcsányi, Victoria Thompson, Ágnes Kemény, Zsuzsanna Helyes, Andreas Goebel Tags: Research papers Source Type: research

Influence of vitamin C on the incidence of CRPS-I after subacromial shoulder surgery
ConclusionsThe present study found that VC administered prophylactically for 50  days postoperatively is effective in preventing CRPS-I development after SaSS. CRPS-I is a common complication following SaSS, especially in the setting of an open approach. The authors recommend preventive management with VC and arthroscopic approaches when possible for SaSS.Level of evidence IIIRetrospective comparative study.
Source: European Journal of Orthopaedic Surgery and Traumatology - September 19, 2019 Category: Orthopaedics Source Type: research

Bone microstructure is significantly altered in CRPS-affected distal tibiae as detected by HR-pQCT: a retrospective cross-sectional study
AbstractIn the course of complex regional pain syndrome (CRPS), local osteopenia in the subchondral/subcortical areas of the affected limb represents a central manifestation. Mechanistic aspects of CRPS-associated pathologies remain unclear, and knowledge about bone morphology in CRPS-affected areas is rare. The aim of this study was to assess trabecular and cortical bone microstructure in patients with CRPS of the distal tibiae. We retrospectively analysed 14 women diagnosed with unilateral CRPS type I of the lower limb whose affected and unaffected distal tibiae were examined by high-resolution peripheral quantitative co...
Source: Journal of Bone and Mineral Metabolism - November 21, 2018 Category: Orthopaedics Source Type: research

Inflammation in CRPS: Role of the sympathetic supply.
Abstract Acute Complex Regional Pain Syndrome (CRPS) is associated with signs of inflammation such as increased skin temperature, oedema, skin colour changes and pain. Pro-inflammatory cytokines (tumour necrosis factor-α (TNF-α), interleukin-2 (IL-2), IL-1beta, IL-6) are up-regulated, whereas anti-inflammatory cytokines (IL-4, IL-10) are diminished. Adaptive immunity seems to be involved in CRPS pathophysiology as many patients have autoantibodies directed against β2 adrenergic and muscarinic-2 receptors. In an animal tibial fracture model changes in the innate immune response such as up-regulation of keratinoc...
Source: Autonomic Neuroscience - December 22, 2013 Category: Neuroscience Authors: Schlereth T, Drummond PD, Birklein F Tags: Auton Neurosci Source Type: research

Neuropsychological Changes in Complex Regional Pain Syndrome (CRPS).
Abstract Complex Regional Pain Syndrome (CRPS) is a poorly understood chronic pain condition of multifactorial origin. CRPS involves sensory, motor, and autonomic symptoms primarily affecting one extremity. Patients can also present with neuropsychological changes such as reduced attention to the CRPS-affected extremity, reminiscent of hemispatial neglect, yet in the absence of any brain lesions. However, this "neglect-like" framework is not sufficient to characterise the range of higher cognitive functions that can be altered in CRPS. This comprehensive literature review synthesises evidence of neuropsychological...
Source: Behavioural Neurology - May 14, 2020 Category: Neurology Authors: Halicka M, Vittersø AD, Proulx MJ, Bultitude JH Tags: Behav Neurol Source Type: research

Complex regional pain syndrome what is the outcome? ‐ a systematic review of the course and impact of CRPS at 12 months from symptom onset and beyond
ConclusionsResults provide first time quantitative data specific evidence about losses to motor function and long-term compromises to work status. Results demonstrate the ongoing impact of CRPS on hand function and work status is relatively high.
Source: European Journal of Pain - April 18, 2022 Category: Anesthesiology Authors: Selina Johnson, Fiona Cowell, Sharon Gillespie, Andreas Goebel Tags: REVIEW ARTICLE Source Type: research