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Total 3278 results found since Jan 2013.

Autoimmunity contributes to nociceptive sensitization in a mouse model of complex regional pain syndrome
Summary: B-cell-mediated autoimmunity contributes to nociceptive sensitization in a rat tibia fracture model of complex regional pain syndrome.Abstract: Complex regional pain syndrome (CRPS) is a painful, disabling, chronic condition whose etiology remains poorly understood. The recent suggestion that immunological mechanisms may underlie CRPS provides an entirely novel framework in which to study the condition and consider new approaches to treatment. Using a murine fracture/cast model of CRPS, we studied the effects of B-cell depletion using anti-CD20 antibodies or by performing experiments in genetically B-cell-deficien...
Source: Pain - September 11, 2014 Category: Anesthesiology Authors: Wen-Wu Li, Tian-Zhi Guo, Xiaoyou Shi, Eva Czirr, Trisha Stan, Peyman Sahbaie, Tony Wyss-Coray, Wade S. Kingery, J. David Clark Tags: Research papers Source Type: research

What outcome measures are commonly used for Complex Regional Pain Syndrome clinical trials? A systematic review of the literature
ConclusionsCurrently, CRPS clinical trials use a wide range of outcome measures making the potential to synthesize evidence problematic. There is no internationally agreed core measurement set. This diversity of outcome measures demonstrates a clear need for the development of a core measurement set to be used in CRPS clinical trials.
Source: European Journal of Pain - June 16, 2015 Category: Anesthesiology Authors: S. Grieve, L. Jones, N. Walsh, C. McCabe Tags: Systematic Review Source Type: research

Skin sympathetic function in complex regional pain syndrome type 1
Conclusions The reduced SSwRs and SkVRs in the affected limb of our CRPS-1 patients may reflect underlying damage to the sympathetic postganglionic fibres.
Source: Clinical Autonomic Research - September 15, 2015 Category: Research Source Type: research

Update on the effects of graded motor imagery and mirror therapy on complex regional pain syndrome type 1: A systematic review.
Authors: Méndez-Rebolledo G, Gatica-Rojas V, Torres-Cueco R, Albornoz-Verdugo M, Guzmán-Muñoz E Abstract Graded motor imagery (GMI) and mirror therapy (MT) is thought to improve pain in patients with complex regional pain syndrome (CRPS) types 1 and 2. However, the evidence is limited and analysis are not independent between types of CRPS. The purpose of this review was to analyze the effects of GMI and MT on pain in independent groups of patients with CRPS types 1 and 2. Searches for literature published between 1990 and 2016 were conducted in databases. Randomized controlled trials that compared GMI or MT with...
Source: Journal of Back and Musculoskeletal Rehabilitation - November 20, 2016 Category: Orthopaedics Tags: J Back Musculoskelet Rehabil Source Type: research

Pain reduction due to novel sensory-motor training in Complex Regional Pain Syndrome I – A pilot study
Conclusions This is a first proof of principle study of a novel sensory-motor self-training protocol to reduce pain in CRPS patients. The more consistent the patients trained the larger the pain reduction. Sensory-motor training, which can be performed on a regular basis at home might provide a novel interventional strategy to improve symptoms of CRPS. Implications Although a larger study needs to be conducted to confirm our findings, including long-term follow-up, the results show, that a sensory-motor home-based training is a strategy worth exploring further for the reduction of pain as well as high frequency training fo...
Source: Scandinavian Journal of Pain - December 8, 2016 Category: Anesthesiology Source Type: research

Multicenter study on the asymmetry of skin temperature in complex regional pain syndrome: An examination of temperature distribution and symptom duration
In conclusion, a considerable proportion of the patients that participated in this study did not meet the thermal criteria set forth by the IASP and AMA. Further, there was no correlation between symptom duration and skin temperature difference.
Source: Medicine - December 1, 2016 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

11C-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome: A pilot study
Abstract: Complex regional pain syndrome (CRPS) is characterized by severe and chronic pain, but the pathophysiology of this disease are not clearly understood. The primary aim of our case–control study was to explore neuroinflammation in patients with CRPS using positron emission tomography (PET), with an 18-kDa translocator protein specific radioligand [11C]-(R)-PK11195. [11C]-(R)-PK11195 PET scans were acquired for 11 patients with CRPS (30–55 years) and 12 control subjects (30–52 years). Parametric image of distribution volume ratio (DVR) for each participant was generated by applying a relative equilibrium-based...
Source: Medicine - January 1, 2017 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Analysis of gene expression profile microarray data in complex regional pain syndrome.
Authors: Tan W, Song Y, Mo C, Jiang S, Wang Z Abstract The aim of the present study was to predict key genes and proteins associated with complex regional pain syndrome (CRPS) using bioinformatics analysis. The gene expression profiling microarray data, GSE47603, which included peripheral blood samples from 4 patients with CRPS and 5 healthy controls, was obtained from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) in CRPS patients compared with healthy controls were identified using the GEO2R online tool. Functional enrichment analysis was then performed using The Database f...
Source: Molecular Medicine Reports - July 19, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

A prospective, multisite, international validation of the Complex Regional Pain Syndrome Severity Score
Abstract: Clinical diagnosis of complex regional pain syndrome (CRPS) is a dichotomous (yes/no) categorization, a format necessary for clinical decision making. Such dichotomous diagnostic categories do not convey an individual's subtle gradations in the severity of the condition over time and have poor statistical power when used as an outcome measure in research. This prospective, international, multicenter study slightly modified and further evaluated the validity of the CRPS Severity Score (CSS), a continuous index of CRPS severity. Using a prospective design, medical evaluations were conducted in 156 patients with CRP...
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

The Effect of Ketamine Infusion in the Treatment of Complex Regional Pain Syndrome: a Systemic Review and Meta-analysis
AbstractPurpose of ReviewComplex regional pain syndrome (CRPS) is a painful debilitating neurological condition that accounts for approximately 1.2% of adult chronic pain population. Ketamine, an NMDA receptor antagonist, is an anesthetic agent that has been used by some pain specialists for CRPS. There is a growing body of clinical evidence to support the use of ketamine in the treatment of neuropathic pain, especially CRPS. This meta-analysis study was aimed to examine the efficacy of ketamine in the treatment of CRPS.Recent FindingsA search of Embase, Pubmed, Web of Knowledge, Cochrane, ClinicalTrial.gov, andFDA.gov bet...
Source: Current Pain and Headache Reports - February 5, 2018 Category: Neurology Source Type: research

Mitochondrial dysfunction in muscle tissue of complex regional pain syndrome type I patients
AbstractReactive oxygen species (ROS) are known to be involved in the pathophysiology of complex regional pain syndrome type I (CRPS I). Since the mitochondrial respiratory chain is a major source of ROS, we hypothesized that mitochondria play a role in the pathophysiology of CRPS I. The hypothesis was tested by studying mitochondrial energy metabolism in muscle tissue from amputated limbs of CRPS I patients. We observed that mitochondria obtained from CRPS I muscle tissue displayed reduced mitochondrial ATP production and substrate oxidation rates in comparison to control muscle tissue. Moreover, we observed reactive oxyg...
Source: European Journal of Pain - January 13, 2012 Category: Anesthesiology Authors: Edward C.T. Tanl, Antoon J.M. Janssenl, Peggy Roestenbergl, Lambert P. Heuvell, R. Jan A. Gorisl, Richard J.T. Rodenburgl Source Type: research

The serum protease network—one key to understand complex regional pain syndrome pathophysiology
Complex regional pain syndrome (CRPS) develops after fracture. The acute CRPS phenotype resembles exaggerated inflammation, which is explained by local and systemic activation of a proinflammatory network including peptides and cytokines. Epidemiologic data suggest that inactivation of the peptidase angiotensin-converting enzyme in patients treated for hypertension increases the odds to develop CRPS. This hint leads us to investigate the serum protease network activity in patients with CRPS vs respective controls. For this purpose, we developed a dabsyl-bradykinin (DBK)-based assay and used it to investigate patients with ...
Source: Pain - May 23, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Autoantibodies produce pain in complex regional pain syndrome by sensitizing nociceptors
Complex regional pain syndrome (CRPS) is a posttraumatic pain condition with an incompletely understood pathophysiological basis. Here, we have examined the cellular basis of pain in CRPS using behavioral and electrophysiological methods in mice treated with IgG from CRPS patients, in combination with a paw incision. Mice were subjected to a hind paw skin–muscle incision alone, or in combination with administration of IgG purified from either healthy control subjects or patients with persistent CRPS. Nociceptive function was examined behaviorally in vivo, and electrophysiologically in vitro using skin–nerve preparation...
Source: Pain - November 19, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Diagnostic value of C-reactive protein in discrimination between complicated and uncomplicated parapneumonic effusion
Conclusion: CRPs, CRPpf, and CRPg but not CRPr are much effective in discrimination between UCPPE and CPPE.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Kogan, Y., Sabo, E., Odeh, M. Tags: Clinical Problems Source Type: research

Role of C-reactive protein in distinguishing between transudative and exudative pleural effusion
Conclusion: CRPs, CRPpf, and CRPg but not CRPr, are very much effective in distinguishing between TrPE and ExPE.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Kogan, Y., Sabo, E., Odeh, M. Tags: Clinical Problems Source Type: research