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Cancer: Gastric (Stomach) Cancer
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Homeobox-D 1 and FTO form a transcriptional-epigenetic feedback loop to promote head and neck cancer proliferation
In this study, we demonstrate that the TF homeobox-D1 (HOXD1) and the m6A demethylase fat mass and obesity-associated protein (FTO) form a positive feedback loop to promote cell proliferation and survival in HNSC. Clinically, HOXD1 expression is dysregulated in multiple cancer types and is associated with worse prognosis in patients with HNSC, stomach adenocarcinoma, uterine corpus endometrial carcinoma, and pheochromocytoma and paraganglioma. Mechanistically, FTO is overexpressed in HNSC tumor samples and positively regulates HOXD1 expression in an m6A-dependent manner. Functionally, deficiency of HOXD1 relieved the resis...
Source: Cell Biology International - September 1, 2023 Category: Cytology Authors: Chunyan Zhang Linsen Xie Zhen Lin Source Type: research
Expression of p53 as a biomarker in determining response to apatinib for advanced gastric cancer
CONCLUSIONS: Apatinib showed promising efficiency and was well tolerated as a second-line treatment for AGC patients. AGC patients with p53-negative were likely to benefit from apatinib treatment; however, the expression of Ki67 proteins has no significant impact on the outcome of AGC patients.PMID:37655112 | PMC:PMC10466417 | DOI:10.3389/fonc.2023.1203980
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Zhiyuan Qiu Rong Qin Ziyi Zhang Ting Zhang Zhao Zhang Chunyue Qiao Yan Xi Guangyu Tian Yan Wang Source Type: research
Weidiao-3 Mixture Improves the Clinical Efficacy of Immunotherapy for Advanced Gastric Cancer by Regulating Intestinal Flora
Conclusion WD-3 Mixture may increase the relative abundance of Bifidobacteria and Coprococcus and the content of isobutyric acid and isovaleric acid to alter the intestinal microecology,thereby improving the efficacy of immunotherapy for gastric cancer.PMID:37654138 | DOI:10.3881/j.issn.1000-503X.15496
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Xiao-Na Huang Chen-Yang Zhu Yu-Zhen Li Chun-Hui Jin Source Type: research
Herbal melanin modulates PGE2 and IL-6 gastroprotective markers through COX-2 and TLR4 signaling in the gastric cancer cell line AGS
In conclusion, our results showed that HM enhances TLR4/COX-2-mediated secretion of gastroprotective markers PGE2 and IL-6, and upregulates mucin 4 gene expression in the human gastric epithelial cell line AGS, which may contribute to the promising beneficial gastroprotective effect of HM for human gastric prevention and treatment.PMID:37658354 | DOI:10.1186/s12906-023-04124-3
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Adila El-Obeid Yahya Maashi Rehab AlRoshody Ghada Alatar Modhi Aljudayi Hamad Al-Eidi Nouf AlGaith Altaf Husain Khan Adil Hassib Sabine Matou-Nasri Source Type: research
Comparing effectiveness and safety of paclitaxel plus raltitrexed vs. paclitaxel alone in second-line palliative chemotherapy for metastatic gastric adenocarcinoma: A randomized phase II clinical trial
CONCLUSIONS: Second-line palliative chemotherapy with RP was shown to prolong the PFS and OS, especially among patients with ascites or peritoneal involvement, which warrants confirmation using larger sample studies.PMID:37653589 | DOI:10.20892/j.issn.2095-3941.2023.0112
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Xiaoying Zhao Zhiyu Chen Xiaowei Zhang Xiaodong Zhu Wen Zhang Lixin Qiu Chenchen Wang Mingzhu Huang Zhe Zhang Wenhua Li Lei Yang Weijian Guo Source Type: research
Homeobox-D 1 and FTO form a transcriptional-epigenetic feedback loop to promote head and neck cancer proliferation
In this study, we demonstrate that the TF homeobox-D1 (HOXD1) and the m6A demethylase fat mass and obesity-associated protein (FTO) form a positive feedback loop to promote cell proliferation and survival in HNSC. Clinically, HOXD1 expression is dysregulated in multiple cancer types and is associated with worse prognosis in patients with HNSC, stomach adenocarcinoma, uterine corpus endometrial carcinoma, and pheochromocytoma and paraganglioma. Mechanistically, FTO is overexpressed in HNSC tumor samples and positively regulates HOXD1 expression in an m6A-dependent manner. Functionally, deficiency of HOXD1 relieved the resis...
Source: Cell Biology International - September 1, 2023 Category: Cytology Authors: Chunyan Zhang Linsen Xie Zhen Lin Source Type: research
Prognostic significance of lactate dehydrogenase and its impact on the outcomes of gastric cancer: a systematic review and meta-analysis
ConclusionIn patients with GC, elevated LDH levels may correlate with worse OS and DFS, but the association is not significant. LDH is a significant predictor of OS but not of DFS. Further studies with larger sample sizes and more standardized criteria for defining elevated LDH levels are needed to confirm our findings.Systematic review registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42023412449.
Source: Frontiers in Oncology - September 1, 2023 Category: Cancer & Oncology Source Type: research
Micafungin: A promising inhibitor of UBE2M in cancer cell growth suppression
Eur J Med Chem. 2023 Aug 19;260:115732. doi: 10.1016/j.ejmech.2023.115732. Online ahead of print.ABSTRACTNeddylation is a protein modification process similar to ubiquitination, carried out through a series of activating (E1), conjugating (E2), and ligating (E3) enzymes. This process has been found to be overactive in various cancers, leading to increased oncogenic activities. Ubiquitin-conjugating enzyme 2 M (UBE2M) is one of two neddylation enzymes that play a vital role in this pathway. Studies have shown that targeting UBE2M in cancer treatment is crucial, as it regulates many molecular mechanisms like DNA damage, apop...
Source: European Journal of Medicinal Chemistry - August 31, 2023 Category: Chemistry Authors: M A A Mamun Shuan Liu Lijie Zhao Lijuan Zhao Zhong-Rui Li Dandan Shen Yu Zheng Yi-Chao Zheng Hong-Min Liu Source Type: research
Efficacy and safety of patient-controlled thoracic epidural analgesia alone versus patient-controlled intravenous analgesia with acetaminophen after laparoscopic distal gastrectomy for gastric cancer: a propensity score-matched analysis
CONCLUSIONS: PCIA + Ace can be safely applied without an increase in complications or deterioration in gastrointestinal function; moreover, PCIA + Ace use may provide better pain control than PCEA use in patients following LDG.PMID:37653160 | DOI:10.1007/s00464-023-10370-w
Source: Cancer Control - August 31, 2023 Category: Cancer & Oncology Authors: Gen Ebara Shinichi Sakuramoto Kazuaki Matsui Keiji Nishibeppu Shouhei Fujita Shiro Fujihata Shuichiro Oya Seigi Lee Yutaka Miyawaki Hirofumi Sugita Hiroshi Sato Keishi Yamashita Source Type: research
Aflatoxins posing threat to food safety and security in Pakistan: Call for a one health approach
Food Chem Toxicol. 2023 Aug 29:114006. doi: 10.1016/j.fct.2023.114006. Online ahead of print.ABSTRACTAflatoxins are among the most important mycotoxins due to their widespread occurrence and adverse impacts on humans and animals. These toxins and/or their metabolites cannot be destroyed with cooking or boiling methods. Therefore, consumption of aflatoxin-contaminated food may lead to impaired growth, compromised immunity, stomach and liver cancer, and acute toxicity. These adverse effects along with food wastage might have detrimental consequences on a country's economy. Several studies from Pakistan reported a high preval...
Source: Food and Chemical Toxicology - August 31, 2023 Category: Food Science Authors: Waseela Ashraf Abdul Rehman Masood Rabbani Waseem Shaukat Jia-Sheng Wang Source Type: research
The potential of trastuzumab deruxtecan as a tissue agnostic drug
Oncology. 2023 Aug 31. doi: 10.1159/000533866. Online ahead of print.ABSTRACTBACKGROUND: Many modern anticancer drugs are designed to target specific molecular alterations harbored by the cancer. If a specific drug is able to target these alterations, regardless of the organ or tissue in which the cancer originates, it will often be characterized as a tissue- or tumor agnostic drug. According to the Food and Drug Administration (FDA), a tissue agnostic drug refers to a drug that targets a specific molecular alteration across multiple cancer types, as defined by organ, tissue, or tumor type.SUMMARY: Over the last six years,...
Source: Oncology - August 31, 2023 Category: Cancer & Oncology Authors: Jan Tr øst Jørgensen Source Type: research
GLIS3, a novel prognostic indicator of gastric adenocarcinoma, contributes to the malignant biological behaviors of tumor cells via modulating TGF- β1/TGFβR1/Smad1/5 signaling pathway
Cytokine. 2023 Aug 29;170:156342. doi: 10.1016/j.cyto.2023.156342. Online ahead of print.ABSTRACTGLIS3 is highly expressed in multiple cancers, but it has not been studied in gastric adenocarcinoma (GAC). Based on bioinformatics analysis, the prognostic significance of GLIS3 in GAC was analyzed. GAC cells were transfected with small interfering (si)-GLIS3 and GLIS3 overexpression plasmid as well as treated with SB505124 [an inhibitor for transforming growth factor beta receptor 1 (TGFβR1)] and dorsomorphin [an inhibitor for bone morphogenetic protein receptor 1 (BMPR1)]. The GLIS3 expression was detected using qRT-PCR. Th...
Source: Cytokine - August 31, 2023 Category: Molecular Biology Authors: Yue Zhang Bo Wang Hui Song Min Han Source Type: research
Mechanism of Quercetin as a Multidrug-resistant Reversing Compound in Oxaliplatin-resistant Gastric-cancer Cell Lines
CONCLUSIONS: Qur induced a dramatic reduction in the survival rate of KATOIII/OxR cells and may reverse OxR resistance through a decrease in P-gp expression and activity. These data imply that exposure of KATOIII/OxR cells in the dose-dependent manner to Qur can circumvent MDR by improving the intracellular accumulation of OxR. Qur might provide a new treatment strategy and improve patients' survival after chemotherapy for gastric cancer.PMID:37652429
Source: Alternative Therapies in Health and Medicine - August 31, 2023 Category: Complementary Medicine Authors: Guodong Zhao Siwei Xue Source Type: research
