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Cancer: Gastric (Stomach) Cancer
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Total 20369 results found since Jan 2013.
The potential of trastuzumab deruxtecan as a tissue agnostic drug
Oncology. 2023 Aug 31. doi: 10.1159/000533866. Online ahead of print.ABSTRACTBACKGROUND: Many modern anticancer drugs are designed to target specific molecular alterations harbored by the cancer. If a specific drug is able to target these alterations, regardless of the organ or tissue in which the cancer originates, it will often be characterized as a tissue- or tumor agnostic drug. According to the Food and Drug Administration (FDA), a tissue agnostic drug refers to a drug that targets a specific molecular alteration across multiple cancer types, as defined by organ, tissue, or tumor type.SUMMARY: Over the last six years,...
Source: Oncology - August 31, 2023 Category: Cancer & Oncology Authors: Jan Tr øst Jørgensen Source Type: research
Aflatoxins posing threat to food safety and security in Pakistan: Call for a one health approach
Food Chem Toxicol. 2023 Aug 29:114006. doi: 10.1016/j.fct.2023.114006. Online ahead of print.ABSTRACTAflatoxins are among the most important mycotoxins due to their widespread occurrence and adverse impacts on humans and animals. These toxins and/or their metabolites cannot be destroyed with cooking or boiling methods. Therefore, consumption of aflatoxin-contaminated food may lead to impaired growth, compromised immunity, stomach and liver cancer, and acute toxicity. These adverse effects along with food wastage might have detrimental consequences on a country's economy. Several studies from Pakistan reported a high preval...
Source: Food and Chemical Toxicology - August 31, 2023 Category: Food Science Authors: Waseela Ashraf Abdul Rehman Masood Rabbani Waseem Shaukat Jia-Sheng Wang Source Type: research
Mechanism of Quercetin as a Multidrug-resistant Reversing Compound in Oxaliplatin-resistant Gastric-cancer Cell Lines
CONCLUSIONS: Qur induced a dramatic reduction in the survival rate of KATOIII/OxR cells and may reverse OxR resistance through a decrease in P-gp expression and activity. These data imply that exposure of KATOIII/OxR cells in the dose-dependent manner to Qur can circumvent MDR by improving the intracellular accumulation of OxR. Qur might provide a new treatment strategy and improve patients' survival after chemotherapy for gastric cancer.PMID:37652429
Source: Alternative Therapies in Health and Medicine - August 31, 2023 Category: Complementary Medicine Authors: Guodong Zhao Siwei Xue Source Type: research
The potential of trastuzumab deruxtecan as a tissue agnostic drug
Oncology. 2023 Aug 31. doi: 10.1159/000533866. Online ahead of print.ABSTRACTBACKGROUND: Many modern anticancer drugs are designed to target specific molecular alterations harbored by the cancer. If a specific drug is able to target these alterations, regardless of the organ or tissue in which the cancer originates, it will often be characterized as a tissue- or tumor agnostic drug. According to the Food and Drug Administration (FDA), a tissue agnostic drug refers to a drug that targets a specific molecular alteration across multiple cancer types, as defined by organ, tissue, or tumor type.SUMMARY: Over the last six years,...
Source: Oncology - August 31, 2023 Category: Cancer & Oncology Authors: Jan Tr øst Jørgensen Source Type: research
GLIS3, a novel prognostic indicator of gastric adenocarcinoma, contributes to the malignant biological behaviors of tumor cells via modulating TGF- β1/TGFβR1/Smad1/5 signaling pathway
Cytokine. 2023 Aug 29;170:156342. doi: 10.1016/j.cyto.2023.156342. Online ahead of print.ABSTRACTGLIS3 is highly expressed in multiple cancers, but it has not been studied in gastric adenocarcinoma (GAC). Based on bioinformatics analysis, the prognostic significance of GLIS3 in GAC was analyzed. GAC cells were transfected with small interfering (si)-GLIS3 and GLIS3 overexpression plasmid as well as treated with SB505124 [an inhibitor for transforming growth factor beta receptor 1 (TGFβR1)] and dorsomorphin [an inhibitor for bone morphogenetic protein receptor 1 (BMPR1)]. The GLIS3 expression was detected using qRT-PCR. Th...
Source: Cytokine - August 31, 2023 Category: Molecular Biology Authors: Yue Zhang Bo Wang Hui Song Min Han Source Type: research
Mechanism of Quercetin as a Multidrug-resistant Reversing Compound in Oxaliplatin-resistant Gastric-cancer Cell Lines
CONCLUSIONS: Qur induced a dramatic reduction in the survival rate of KATOIII/OxR cells and may reverse OxR resistance through a decrease in P-gp expression and activity. These data imply that exposure of KATOIII/OxR cells in the dose-dependent manner to Qur can circumvent MDR by improving the intracellular accumulation of OxR. Qur might provide a new treatment strategy and improve patients' survival after chemotherapy for gastric cancer.PMID:37652429
Source: Alternative Therapies in Health and Medicine - August 31, 2023 Category: Complementary Medicine Authors: Guodong Zhao Siwei Xue Source Type: research
Aflatoxins posing threat to food safety and security in Pakistan: Call for a one health approach
Food Chem Toxicol. 2023 Aug 29:114006. doi: 10.1016/j.fct.2023.114006. Online ahead of print.ABSTRACTAflatoxins are among the most important mycotoxins due to their widespread occurrence and adverse impacts on humans and animals. These toxins and/or their metabolites cannot be destroyed with cooking or boiling methods. Therefore, consumption of aflatoxin-contaminated food may lead to impaired growth, compromised immunity, stomach and liver cancer, and acute toxicity. These adverse effects along with food wastage might have detrimental consequences on a country's economy. Several studies from Pakistan reported a high preval...
Source: Food and Chemical Toxicology - August 31, 2023 Category: Food Science Authors: Waseela Ashraf Abdul Rehman Masood Rabbani Waseem Shaukat Jia-Sheng Wang Source Type: research
The potential of trastuzumab deruxtecan as a tissue agnostic drug
Oncology. 2023 Aug 31. doi: 10.1159/000533866. Online ahead of print.ABSTRACTBACKGROUND: Many modern anticancer drugs are designed to target specific molecular alterations harbored by the cancer. If a specific drug is able to target these alterations, regardless of the organ or tissue in which the cancer originates, it will often be characterized as a tissue- or tumor agnostic drug. According to the Food and Drug Administration (FDA), a tissue agnostic drug refers to a drug that targets a specific molecular alteration across multiple cancer types, as defined by organ, tissue, or tumor type.SUMMARY: Over the last six years,...
Source: Oncology - August 31, 2023 Category: Cancer & Oncology Authors: Jan Tr øst Jørgensen Source Type: research
Tusamitamab Ravtansine in Patients with Advanced Solid Tumors: Phase I Study of Safety, Pharmacokinetics, and Antitumor Activity Using Alternative Dosing Regimens
CONCLUSIONS: Tusamitamab ravtansine had a favorable safety profile with both alternative administration schedules; MTDs were 170 mg/m2 (LD) followed by 100 mg/m2 Q2W, and 170 mg/m2 Q3W as a fixed dose. (NCT02187848).SIGNIFICANCE: The collective results of this phase I dose-escalation study will inform further studies of tusamitamab ravtansine in patients with solid tumors with CEACAM5 expression, including patients with non-small cell lung cancer.PMID:37645622 | PMC:PMC10461573 | DOI:10.1158/2767-9764.CRC-23-0284
Source: Cell Research - August 30, 2023 Category: Cytology Authors: Josep Tabernero Philippe L Bedard Yung-Jue Bang Maria Vieito Min-Hee Ryu Nathalie Fagniez Mustapha Chadjaa Christine Soufflet Nina Masson Anas Gazzah Source Type: research
Synthesis, docking studies and evaluation of chalcones as anti-Helicobacter pylori and antitumoral agents
In this study, we synthesized and characterized a series of 14 chalcones and evaluated their anti-H. pylori, NO inhibition (in vitro and in silico), and AGS cells cytotoxic effects. The compounds 3b and 3h showed MIC of 8 µg/mL. We observed structure-activity relationships, mainly related to the influence of methoxyl substituent at C-2 (3b) and the nitro group at C-4 (3h) in chalcone scaffold. The fourteen chalcones inhibited the NO production in LPS-stimulated macrophages and showed potential for interaction on the active site of the iNOS enzyme. Finally, 3b and 3h showed the highest selectivity to the AGS cells line. Th...
Source: Chemistry and Biodiversity - August 30, 2023 Category: Biochemistry Authors: Jessica Rodrigues Pereira de Oliveira Borlot Luna Schlittler Dos Santos Guilherme Jos é Schwarzt Sampaio Augusto Santos Borges Ricardo Pereira Rodrigues Rita de C ássia Ribeiro Gonçalves Reginaldo Bezerra Dos Santos Rodrigo Rezende Kitagawa Source Type: research
Identification and bioactivity evaluation of miliusanes from Miliusa sinensis
Bioorg Chem. 2023 Aug 24;140:106797. doi: 10.1016/j.bioorg.2023.106797. Online ahead of print.ABSTRACTMiliusanes are a class of anticancer lead molecules belonging to meroterpenoids with an 18-carbon skeleton isolated from Miliusa plants. A phytochemical study of the plant M. sinensis was carried out to discover new miliusanes with diverse structural features in order to better understand their structure-activity relationship. As a result, 20 compounds including 12 new ones (7-14 and 17-20) belonging to two sub-classes of miliusanes were isolated and identified from the twigs and leaves of this plant. Their structures, inc...
Source: Bioorganic Chemistry - August 30, 2023 Category: Chemistry Authors: Wen-Jian Xie Xin-Ya Xu Yi-Xuan Xia Chu Shing Lam Tie Chen Yun-Shi Zhi Kuan Ming Lee Xun Song Stephen T Deyrup Zhen-Dan He Hong-Jie Zhang Source Type: research
Risk Factor of Sarcopenia After Gastrectomy in Elderly Patients With Gastric Cancer
CONCLUSION: Open gastrectomy is an independent risk factor for the progression of sarcopenia after gastrectomy in elderly patients with gastric cancer. Laparoscopic surgery is an eligible method for preserving skeletal muscle mass in elderly patients with gastric cancer.PMID:37648324 | DOI:10.21873/anticanres.16612
Source: Cancer Control - August 30, 2023 Category: Cancer & Oncology Authors: Hironori Iwasaki Erina Haraguchi Takafumi Ihashi Hiroshi Yokomizo Source Type: research
