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Cancer: Gastric (Stomach) Cancer
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Big Data and Artificial Intelligence in Drug Discovery for Gastric Cancer: Current Applications and Future Perspectives
Curr Med Chem. 2023 Sep 13. doi: 10.2174/0929867331666230913105829. Online ahead of print.ABSTRACTGastric cancer (GC) represents a significant global health burden, ranking as the fifth most common malignancy and the fourth leading cause of cancer-related death worldwide. Despite recent advancements in GC treatment, the five-year survival rate for advanced-stage GC patients remains low. Consequently, there is an urgent need to identify novel drug targets and develop effective therapies. However, traditional drug discovery approaches are associated with high costs, time-consuming processes, and a high failure rate, posing c...
Source: Current Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Mai Hanh Nguyen Ngoc Dung Tran Nguyen Quoc Khanh Le Source Type: research
Synthesis and evaluation of biological effects of modified graphene oxide nanoparticles containing Lawson (Henna extract) on gastric cancer cells
CONCLUSION: This study showed the efficacy of nanoparticles in inhibiting gastric cancer cells by relying on inhibiting angiogenesis.PMID:37715021 | DOI:10.1007/s11033-023-08797-4
Source: Molecular Biology Reports - September 15, 2023 Category: Molecular Biology Authors: Mohammed Abdullah Hamdan Alkwedhim Vahid Pouresmaeil Fatemeh Davoodi-Dehaghani Mobina Mahavar Masoud Homayouni Tabrizi Source Type: research
Fabrication of Nickel/Zinc Oxide Nanocomposites from Citrus sinensis Extract Prompts Apoptosis Through Impeding JAK/STAT3 Signaling in Gastric Cancer
In this study, we sought to fabricate nickel/zinc oxide nanocomposites utilizing Citrus sinensis (C. sinensis) peel extract (CS-Ni/ZnO NCs) and investigate their ability to impede the JAK/STAT3 signaling pathway in gastric cancer AGS cells. Different methods, including UV-Vis spectral analysis, FT-IR, XRD, FE-SEM, EDAX, DLS, and zeta potential, were used to characterize the fabricated CS-Ni/ZnO NCs. By measuring ROS, MMP, and apoptotic cell death using the appropriate fluorescence describing procedures, the anticancer potential of CS-Ni/ZnO NCs was examined against AGS cells. The synthesized CS-Ni/ZnO NCs displayed a rod s...
Source: Applied Biochemistry and Biotechnology - September 15, 2023 Category: Biochemistry Authors: Zhifei Li Zhongwei Sun Source Type: research
Manganese-based nanoparticles for chemodynamic therapy of gastrointestinal cancer
CONCLUSION: MSN@Mn-GOx nanoparticles have good chemodynamic properties and a strong anti-tumor effect and provide a potential therapeutic option for gastric cancer.PMID:37712282 | DOI:10.12122/j.issn.1673-4254.2023.08.22
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: X Lin M Huang J Chen X Zhou Z Zhong W Lu X Huang T Liu Source Type: research
Synthesis and evaluation of biological effects of modified graphene oxide nanoparticles containing Lawson (Henna extract) on gastric cancer cells
CONCLUSION: This study showed the efficacy of nanoparticles in inhibiting gastric cancer cells by relying on inhibiting angiogenesis.PMID:37715021 | DOI:10.1007/s11033-023-08797-4
Source: Molecular Biology Reports - September 15, 2023 Category: Molecular Biology Authors: Mohammed Abdullah Hamdan Alkwedhim Vahid Pouresmaeil Fatemeh Davoodi-Dehaghani Mobina Mahavar Masoud Homayouni Tabrizi Source Type: research
Value of Echocardiography and Cardiac Magnetic resonance in assessing left ventricular function in breast and gastric cancer patients after Anthracycline Chemotherapy
CONCLUSION: Breast and gastric cancer patients exhibited elevated levels of hs-cTnT after 6 cycles of chemotherapy, indicating potential cardiotoxicity. Additionally, cardiac MRI and 2-dimensional ECHO showed good agreement in assessing left ventricular function, with ECHO tending to underestimate volume measurements compared to MRI.PMID:37715125 | PMC:PMC10504696 | DOI:10.1186/s12872-023-03495-2
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Chao-Long Jin Xue-Gong Shi Ting-Ting Wang Hong-Wen Li Ding-Xin Zhang Zhe Sheng Jie Xiao Yong-Qiang Yu Source Type: research
Synthesis and evaluation of biological effects of modified graphene oxide nanoparticles containing Lawson (Henna extract) on gastric cancer cells
CONCLUSION: This study showed the efficacy of nanoparticles in inhibiting gastric cancer cells by relying on inhibiting angiogenesis.PMID:37715021 | DOI:10.1007/s11033-023-08797-4
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Mohammed Abdullah Hamdan Alkwedhim Vahid Pouresmaeil Fatemeh Davoodi-Dehaghani Mobina Mahavar Masoud Homayouni Tabrizi Source Type: research
Prognostic Analysis of Prophylactic Hyperthermic Intraperitoneal Chemotherapy for Advanced Gastric Cancer: a Propensity Score-Matched Analysis
CONCLUSION: Our study showed that prophylactic HIPEC could prevent postoperative PM in patients with AGC and did not increase the incidence of postoperative complications. However, it was not found to be effective in the prevention of other metastases, such as hepatic metastases.PMID:37715013 | DOI:10.1007/s11605-023-05823-5
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Lei Liu Longbo Zheng Shanglong Liu Maoshen Zhang Simeng Zhang Zinian Jiang Chen Qin Dongsheng Wang Source Type: research
Manganese-based nanoparticles for chemodynamic therapy of gastrointestinal cancer
CONCLUSION: MSN@Mn-GOx nanoparticles have good chemodynamic properties and a strong anti-tumor effect and provide a potential therapeutic option for gastric cancer.PMID:37712282 | PMC:PMC10505582 | DOI:10.12122/j.issn.1673-4254.2023.08.22
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: X Lin M Huang J Chen X Zhou Z Zhong W Lu X Huang T Liu Source Type: research
A web-based prediction model for long-term cancer-specific survival of middle-aged patients with early-stage gastric cancer: a multi-institutional retrospective study
CONCLUSION: This study developed and validated a new nomogram to predict CSS in middle-aged patients with EGC. The prediction model has unique and practical value and can help doctors carry out individualized treatment and judge prognosis.PMID:37712958 | DOI:10.1007/s00432-023-05405-7
Source: Pain Physician - September 15, 2023 Category: Anesthesiology Authors: Simeng Zhang Longbo Zheng Yuxia Zhang Yuan Gao Lei Liu Zinian Jiang Liang Wang Zheng Ma Jinhui Wu Jiansheng Chen Yun Lu Dongsheng Wang Source Type: research
Big Data and Artificial Intelligence in Drug Discovery for Gastric Cancer: Current Applications and Future Perspectives
Curr Med Chem. 2023 Sep 13. doi: 10.2174/0929867331666230913105829. Online ahead of print.ABSTRACTGastric cancer (GC) represents a significant global health burden, ranking as the fifth most common malignancy and the fourth leading cause of cancer-related death worldwide. Despite recent advancements in GC treatment, the five-year survival rate for advanced-stage GC patients remains low. Consequently, there is an urgent need to identify novel drug targets and develop effective therapies. However, traditional drug discovery approaches are associated with high costs, time-consuming processes, and a high failure rate, posing c...
Source: Current Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Mai Hanh Nguyen Ngoc Dung Tran Nguyen Quoc Khanh Le Source Type: research
Manganese-based nanoparticles for chemodynamic therapy of gastrointestinal cancer
CONCLUSION: MSN@Mn-GOx nanoparticles have good chemodynamic properties and a strong anti-tumor effect and provide a potential therapeutic option for gastric cancer.PMID:37712282 | DOI:10.12122/j.issn.1673-4254.2023.08.22
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: X Lin M Huang J Chen X Zhou Z Zhong W Lu X Huang T Liu Source Type: research
Big Data and Artificial Intelligence in Drug Discovery for Gastric Cancer: Current Applications and Future Perspectives
Curr Med Chem. 2023 Sep 13. doi: 10.2174/0929867331666230913105829. Online ahead of print.ABSTRACTGastric cancer (GC) represents a significant global health burden, ranking as the fifth most common malignancy and the fourth leading cause of cancer-related death worldwide. Despite recent advancements in GC treatment, the five-year survival rate for advanced-stage GC patients remains low. Consequently, there is an urgent need to identify novel drug targets and develop effective therapies. However, traditional drug discovery approaches are associated with high costs, time-consuming processes, and a high failure rate, posing c...
Source: Current Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Mai Hanh Nguyen Ngoc Dung Tran Nguyen Quoc Khanh Le Source Type: research
