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Abemaciclib as adjuvant treatment for high-risk early breast cancer
CONCLUSIONS: The results of the pivotal trial are sufficient to consider abemaciclib as adjuvant treatment for high-risk early breast cancer in highly selected patients. However, in order to the efficacy results present less uncertainty, we must wait for a evaluation later, in which we can have a mature determination at 3 years (with more patients at risk).PMID:37735004 | DOI:10.1016/j.farma.2023.08.006
Source: Farmacia Hospitalaria - September 21, 2023 Category: Drugs & Pharmacology Authors: Ganfornina Andrades Ana F énix Caballero Silvia Salguero Olid Alba Alegre Del-Rey Emilio Jes ús Source Type: research
Development and evaluation of the MiCheck ® Prostate test for clinically significant prostate cancer
CONCLUSIONS: The MiCheck® Prostate test identifies clinically significant prostate cancer with high sensitivity and negative predictive value (NPV). It can be performed in a clinical laboratory using a Roche Cobas clinical chemistry analyzer. The MiCheck® Prostate test could assist in reducing unnecessary prostate biopsies with a marginal number of patients experiencing a delayed diagnosis.PMID:37734979 | DOI:10.1016/j.urolonc.2023.08.005
Source: Ann Oncol - September 21, 2023 Category: Cancer & Oncology Authors: Neal D Shore Dmitry M Polikarpov Christopher M Pieczonka R Jonathan Henderson James L Bailen Daniel R Saltzstein Raoul S Concepcion Jennifer L Beebe-Dimmer Julie J Ruterbusch Rachel A Levin Sandra Wissmueller Thao Ho Le David A Gillatt Daniel W Chan Niant Source Type: research
Standard vs. prolonged intervals to surgery in resectable oesophageal cancer: does timing matter?
Ann Oncol. 2023 Sep 19:S0923-7534(23)03943-1. doi: 10.1016/j.annonc.2023.09.3105. Online ahead of print.NO ABSTRACTPMID:37734663 | DOI:10.1016/j.annonc.2023.09.3105
Source: Ann Oncol - September 21, 2023 Category: Cancer & Oncology Authors: Sarah Derks Hanneke W M van Laarhoven Source Type: research
ASO Author Reflections: Can Nodal Features Improve Treatment Response Prediction in Esophageal Cancer?
Ann Surg Oncol. 2023 Sep 20. doi: 10.1245/s10434-023-14299-1. Online ahead of print.NO ABSTRACTPMID:37731144 | DOI:10.1245/s10434-023-14299-1
Source: Ann Oncol - September 21, 2023 Category: Cancer & Oncology Authors: Kunwei Li Shuaitong Zhang Hong Shan Source Type: research
Cardiovascular Imaging in Contemporary Cardio-Oncology: A Scientific Statement From the American Heart Association
Circulation. 2023 Sep 21. doi: 10.1161/CIR.0000000000001174. Online ahead of print.ABSTRACTAdvances in cancer therapeutics have led to dramatic improvements in survival, now inclusive of nearly 20 million patients and rising. However, cardiovascular toxicities associated with specific cancer therapeutics adversely affect the outcomes of patients with cancer. Advances in cardiovascular imaging have solidified the critical role for robust methods for detecting, monitoring, and prognosticating cardiac risk among patients with cancer. However, decentralized evaluations have led to a lack of consensus on the optimal uses of ima...
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Daniel Addison Tomas G Neilan Ana Barac Marielle Scherrer-Crosbie Tochi M Okwuosa Juan C Plana Kerryn W Reding Viviany R Taqueti Eric H Yang Vlad G Zaha American Heart Association Council on Cardiovascular Radiology and Intervention; Cardio-Oncology Commi Source Type: research
Research Progress and New Perspectives of Anticancer Effects of Emodin
In conclusion, emodin represents a promising natural compound with potent anticancer properties, and its potential as a therapeutic agent for cancer treatment warrants further investigation. This review provides a comprehensive overview of the current research progress and new perspectives on emodin's anticancer effects, which may facilitate the development of novel therapeutic strategies for cancer treatment.PMID:37732372 | DOI:10.1142/S0192415X23500787
Source: The American Journal of Chinese Medicine - September 21, 2023 Category: Complementary Medicine Authors: Wu Liu Eskandar Qaed Yuelin Zhu Wenzhang Tian Yizhen Wang Le Kang Xiaodong Ma Zeyao Tang Source Type: research
Near-infrared spectral tomography for predicting residual cancer burden during early stage neoadjuvant chemotherapy for breast cancer
CONCLUSION: NIRST holds promise as a potential clinical tool that can be seamlessly integrated into existing clinical workflow within the infusion suite. By providing early assessment of RCB, NIRST has potential to improve breast cancer patient management strategies.PMID:37733788 | DOI:10.1158/1078-0432.CCR-23-1593
Source: Clinical Genitourinary Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Xu Cao Kristen E Muller Mary D Chamberlin Jiang Gui Peter A Kaufman Gary N Schwartz Roberta M DiFlorio-Alexander Brian W Pogue Keith D Paulsen Shudong Jiang Source Type: research
Identification of a TRP channel-related risk model for predicting prognosis and therapeutic effects of patients with hepatocellular carcinoma
CONCLUSIONS: We successfully established a highly accurate prognostic model for predicting overall survival and therapeutic effects using TRP channel-related genes.PMID:37733242 | DOI:10.1007/s00432-023-05394-7
Source: Clinical Genitourinary Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Chong Pang Zhe Xu Jilong Han Fujun Li Hongyan Zhu Jiaqi Zhang Dong Wang Xundi Xu Source Type: research
Traumatic sigmoid colon rupture due to breast cancer metastasis: a case report
Clin J Gastroenterol. 2023 Sep 21. doi: 10.1007/s12328-023-01859-x. Online ahead of print.ABSTRACTThe metastasis of breast cancer to the gastrointestinal tract is rare. Herein, we presented the case of an 85-year-old woman who had a history of invasive lobular carcinoma and experienced complete colon rupture due to relatively low-energy trauma. The patient underwent bilateral total mastectomy and axillary dissection following preoperative chemotherapy 6 years ago. She had a local recurrence 2 years after the surgery and underwent chemotherapy. Subsequently, the cancer metastasized to the thoracolumbar area and retroperiton...
Source: Clinical Genitourinary Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Tomonori Yoshida Munenori Ide Kazuhisa Katayama Mitsuhiro Yanai Ryo Kurosaki Hisashi Shimizu Kazuhisa Arakawa Tatsuya Miyazaki Hiroshi Saeki Ken Shirabe Source Type: research
Development and Characterization of Proteomic Aging Clocks in the Atherosclerosis Risk in Communities (ARIC) Study
We examined their associations with mortality from all-cause, cardiovascular disease (CVD), cancer, and lower respiratory disease (LRD) using Cox proportional hazards regression in all remaining participants irrespective of health. The model was adjusted for chronological age, smoking, body mass index (BMI), and other confounders. The ARIC PACs had a slightly stronger correlation with chronological age than published PACs in healthy participants at each time point. Associations with mortality were similar for the ARIC and published PACs. For late-life and midlife age acceleration for the ARIC PACs, respectively, hazard rat...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Authors Shuo Wang Zexi Rao Rui Cao Anne H Blaes Josef Coresh Corinne E Joshu Benoit Lehallier Pamela L Lutsey James S Pankow Sanaz Sedaghat Weihong Tang Bharat Thyagarajan Keenan A Walker Peter Ganz Elizabeth A Platz Weihua Guan Anna Prizment Source Type: research
Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation
In this study, we investigated the roles of the polar protein Par3L in M1 macrophage polarization and atherosclerosis. To induce atherosclerosis, Apoe-/- mice were fed with an atherosclerotic Western diet for 8 or 16 weeks. We showed that Par3L expression was significantly increased in human and mouse atherosclerotic plaques. In primary mouse macrophages, oxidized low-density lipoprotein (oxLDL, 50 μg/mL) time-dependently increased Par3L expression. In Apoe-/- mice, adenovirus-mediated Par3L overexpression aggravated atherosclerotic plaque formation accompanied by increased M1 macrophages in atherosclerotic plaques and bo...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Yi-Min Huang Yu-Sen Wu Yuan-Ye Dang Yi-Ming Xu Kong-Yang Ma Xiao-Yan Dai Source Type: research
Deuterium Magnetic Resonance Imaging Using Deuterated Water-Induced 2H-Tissue Labeling Allows Monitoring Cancer Treatment at Clinical Field Strength
CONCLUSIONS: Deuterium MRI at 1.5T proved feasibility to track 2H distribution throughout mouse tissues during D2O administration and revealed a higher 2H accumulation in the tumor xenografts. This research demonstrated a promising successful method for preliminary assessment of radiotherapy and chemotherapy of cancer.PMID:37732903 | DOI:10.1158/1078-0432.CCR-23-1635
Source: Clinical Colorectal Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Hirofumi Asano Abdelazim Elsayed Elhelaly Fuminori Hyodo Ryota Iwasaki Yoshifumi Noda Hiroki Kato Koki Ichihashi Hiroyuki Tomita Masaharu Murata Takashi Mori Masayuki Matsuo Source Type: research
Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon diagnosed by molecular pathology: A case report and literature review
CONCLUSION: Based on pathological and genetic analysis, surgery combined with chemotherapy or chemoradiotherapy may have good therapeutic effects for collision tumor.PMID:37731579 | PMC:PMC10507543 | DOI:10.12998/wjcc.v11.i26.6289
Source: Clinical Colorectal Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Meng Jiang Xiao-Ping Yuan Source Type: research
Large colonic lipoma with a laterally spreading tumor treated by endoscopic submucosal dissection: A case report
CONCLUSION: ESD is effective and safe for treating a large colonic lipoma with an LST by minimizing electrical thermal injury.PMID:37731566 | PMC:PMC10507559 | DOI:10.12998/wjcc.v11.i26.6194
Source: Clinical Colorectal Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Jun Yong Bae Hun Kyu Kim Yee Jin Kim Se Woong Kim Youngeun Lee Chang Beom Ryu Moon Sung Lee Source Type: research
Research progress on the pathogenesis of the SDHB mutation and related diseases
Biomed Pharmacother. 2023 Sep 19;167:115500. doi: 10.1016/j.biopha.2023.115500. Online ahead of print.ABSTRACTWith the improvement of genetic testing technology in diseases in recent years, researchers have a more detailed and clear understanding of the source of cancers. Succinate dehydrogenase B (SDHB), a mitochondrial gene, is related to the metabolic activities of cells and tissues throughout the body. The mutations of SDHB have been found in pheochromocytoma, paraganglioma and other cancers, and is proved to affect the occurrence and progress of those cancers due to the important structural functions. The importance o...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 21, 2023 Category: Drugs & Pharmacology Authors: Chang Liu Dayang Zhou Kexin Yang Ning Xu Jibang Peng Zhu Zhu Source Type: research
