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Flower-like porous BCN assembled by nanosheets for paclitaxel delivery
This study presents a novel template method for preparing porous BCN nanomaterials, offering a promising platform for high-performance anticancer drug delivery.PMID:37727129 | DOI:10.1039/d3cc03320a
Source: Chemical Communications - September 20, 2023 Category: Chemistry Authors: Haiyan Wang Congling Wang Yuxian Deng Yuxin Han Shuo Xiang Hanning Xiao Qunhong Weng Source Type: research
TRPM8 as a Potential Biomarker and Therapeutic Target for Gastric Cancer Identified by a Combination of Text Mining and RNA Sequencing
CONCLUSION: This study provides insights into the underlying role of TRPM8 in cell proliferation. In addition, TRPM8 may be used as a potential therapeutic target for patients with gastric cancer.PMID:37728085 | DOI:10.2174/1566523223666230529142423
Source: Current Gene Therapy - September 20, 2023 Category: Genetics & Stem Cells Authors: Na Kong Wendong Li Jun Zhang Xin Wang Lin Hu Qiqi Xu Source Type: research
Exosomal miRNAs as Next-generation Therapy Vehicles in Breast Cancer
Curr Gene Ther. 2023;23(5):330-342. doi: 10.2174/1566523223666230215103524.ABSTRACTThe second most pervasive cancer affecting the survival of women across the world is breast cancer. One of the biggest challenges in breast cancer treatment is the chemoresistance of cancer cells to various medications after some time. Therefore, highly specific blood-based biomarkers are required for early breast cancer diagnosis to overcome chemoresistance and improve patient survival. These days, exosomal miRNAs have attracted much attention as early diagnostic blood-based biomarkers because of their high stability, secretion from maligna...
Source: Current Gene Therapy - September 20, 2023 Category: Genetics & Stem Cells Authors: Priyanka Thakur Harshita Dahiya Ankur Kaushal Vijai Kumar Gupta Adesh K Saini Reena V Saini Source Type: research
MicroRNA Theranostics in Cancer
Curr Gene Ther. 2023;23(5):329. doi: 10.2174/156652322305230808102847.NO ABSTRACTPMID:37728083 | DOI:10.2174/156652322305230808102847
Source: Current Gene Therapy - September 20, 2023 Category: Genetics & Stem Cells Authors: Sujay Paul Source Type: research
Improving the Enantioselectivity of CHMO Brevi1 for Asymmetric Synthesis of Podophyllotoxin Precursor
In this study, we use a strategy called "focused rational iterative site-specific mutagenesis" (FRISM) at residues ranging of 6 Å from substrate. The mutations by using a restricted set of rationally chosen amino acids allows the formation of a small mutant library. By generating and screening less than 60 variants, we achieved high ee of 96.8%. Coupled with the cofactor regeneration system, 9.3 mM substrate was converted completely in a 100-mL scale reaction. Therefore, our work reveals a promising synthetic method for (R)-β-piperonyl-γ-butyrolactone with the highest enantioselectivity, and provides a new opportunity f...
Source: Chembiochem - September 20, 2023 Category: Biochemistry Authors: Shou-Cheng Huang Yi-Ke Zhang Qiang Geng Qi-Kang Huang Jian-He Xu Yi-Feng Chen Hui-Lei Yu Source Type: research
Synthesis, cytotoxic activity evaluation and mechanistic investigation of novel 3,7-diarylsubstituted 6-azaindoles
Eur J Med Chem. 2023 Sep 13;261:115804. doi: 10.1016/j.ejmech.2023.115804. Online ahead of print.ABSTRACTA number of new disubstituted 6-azaindoles have been designed and synthesized bearing a crucial structural modification in respect to an analogous antiproliferative hit compound. The synthesis was performed using 2-amino-3-nitro-4-picoline, that was suitably modified and converted to 7-chloro-3-iodo-6-azaindole and this central scaffold was used for successive Suzuki-type couplings, to result in the target compounds. The evaluation of the cytotoxic activity was performed against four human cancer cell lines, as well as ...
Source: European Journal of Medicinal Chemistry - September 20, 2023 Category: Chemistry Authors: Nikolaos Lougiakis Nikolaos Sakalis Maria Georgiou Panagiotis Marakos Nicole Pouli Alexios-Leandros Skaltsounis Eleni Mavrogonatou Harris Pratsinis Dimitris Kletsas Source Type: research
Single-cell genotypic and phenotypic analysis of measurable residual disease in acute myeloid leukemia
Sci Adv. 2023 Sep 22;9(38):eadg0488. doi: 10.1126/sciadv.adg0488. Epub 2023 Sep 20.ABSTRACTMeasurable residual disease (MRD), defined as the population of cancer cells that persist following therapy, serves as the critical reservoir for disease relapse in acute myeloid leukemia and other malignancies. Understanding the biology enabling MRD clones to resist therapy is necessary to guide the development of more effective curative treatments. Discriminating between residual leukemic clones, preleukemic clones, and normal precursors remains a challenge with current MRD tools. Here, we developed a single-cell MRD (scMRD) assay ...
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Troy M Robinson Robert L Bowman Sonali Persaud Ying Liu Rosemary Neigenfind Qi Gao Jingping Zhang Xiaotian Sun Linde A Miles Sheng F Cai Adam Sciambi Aaron Llanso Christopher Famulare Aaron Goldberg Ahmet Dogan Mikhail Roshal Ross L Levine Wenbin Xiao Source Type: research
Shuttle between arginine and lysine: influence on cancer immunonutrition
Amino Acids. 2023 Sep 20. doi: 10.1007/s00726-023-03327-9. Online ahead of print.ABSTRACTAmino acids which are essential nutrients for all cell types' survival are also recognised to serve as opportunistic/alternative fuels in cancers auxotrophic for specific amino acids. Accordingly, restriction of amino acids has been utilised as a therapeutic strategy in these cancers. Contrastingly, amino acid deficiencies in cancer are found to greatly impair immune functions, increasing mortality and morbidity rates. Dietary and supplemental amino acids in such conditions have revealed their importance as 'immunonutrients' by modulat...
Source: Amino Acids - September 20, 2023 Category: Biochemistry Authors: R Sindhu M Supreeth Shashanka K Prasad M Thanmaya Source Type: research
Rechallenge with Anti-PD-1 Inhibitors in Patients with Recurrent Gynecologic Malignancies
CONCLUSION: These results suggest that responses to ICI rechallenge are not as intolerable as responses to previous ICI. Clinicians should carefully consider rechallenge with PD-1 inhibitors outside of clinical trials until there are sufficient data to routinely support this practice.PMID:37727917 | DOI:10.3349/ymj.2023.0063
Source: Yonsei Medical Journal - September 20, 2023 Category: Universities & Medical Training Authors: Migang Kim Chi-Son Chang Min Chul Choi Jeong-Won Lee Hyun Park Won Duk Joo Source Type: research
Medicinal Chemistry-driven Approach to Novel 2-Substituted Benzoxazole - Estradiol Chimeras: Synthesis, Anticancer Activity and Early ADME Profile
ChemMedChem. 2023 Sep 20:e202300352. doi: 10.1002/cmdc.202300352. Online ahead of print.ABSTRACTThe efficient synthesis of novel estradiol-based A-ring-fused oxazole derivatives, which can be considered as benzoxazole-steroid domain-integrated hybrids containing a common benzene structural motif, is described. The target compounds were prepared from steroidal 2-aminophenol precursors by heterocycle formation or functional group interconversion (FGI) strategies. According to 2D projection-based t-distributed stochastic neighbor embedding (t-SNE), the novel molecules were proved to represent a new chemical space among steroi...
Source: ChemMedChem - September 20, 2023 Category: Chemistry Authors: Ferenc Kov ács Ildik ó Huliák H édi Árva M ónika Kiricsi D óra Erdős Marianna Kocsis Gergely Tak ács Gy örgy T Balogh Éva Frank Source Type: research
Upregulation of FAM134B inhibits endoplasmic reticulum stress-related degradation protein expression and promotes hepatocellular carcinogenesis
J Cell Mol Med. 2023 Sep 20. doi: 10.1111/jcmm.17964. Online ahead of print.ABSTRACTEndoplasmic reticulum (ER) stress can stimulate the proliferation and metastasis of hepatocellular carcinoma (HCC) cells while hindering apoptosis and immune system function, but the molecular mechanism of ER stress in HCC has yet to be fully studied. We aim to investigate the molecular mechanism by which FAM134B inhibits autophagy of HCC cells by reducing the expression of ER stress-related degradation proteins. Clinical samples were collected for this study. Normal liver cell lines HL7702 and Hep3B and Huh7 HCC cell lines were cultured. C...
Source: J Cell Mol Med - September 20, 2023 Category: Molecular Biology Authors: Houhong Wang Lu Liu Huihui Gong Heng Li Source Type: research
Implications of ubiquitination and the maintenance of replication fork stability in cancer therapy
Biosci Rep. 2023 Sep 20:BSR20222591. doi: 10.1042/BSR20222591. Online ahead of print.ABSTRACTDNA replication forks are subject to intricate surveillance and strict regulation by sophisticated cellular machinery. Such close regulation is necessary to ensure the accurate duplication of genetic information and to tackle the diverse endogenous and exogenous stresses that impede this process. Stalled replication forks are vulnerable to collapse, which is a major cause of genomic instability and carcinogenesis. Replication stress responses, which are organized via a series of coordinated molecular events, stabilize stalled repli...
Source: Bioscience Reports - September 20, 2023 Category: Biomedical Science Authors: Donghui Xia Xuefei Zhu Ying Wang Peng Gong Hong-Shu Su Xingzhi Xu Source Type: research
Immune evasion of G-CSF and GM-CSF in lung cancer
Tuberc Respir Dis (Seoul). 2023 Sep 20. doi: 10.4046/trd.2023.0037. Online ahead of print.ABSTRACTTumor immune evasion is a complex process that involves various mechanisms, such as antigen recognition restriction, immune system suppression, and T cell exhaustion. The tumor microenvironment contains various immune cells involved in immune evasion. Recent studies have demonstrated that granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) induce immune evasion in lung cancer by modulating neutrophils and myeloid-derived suppressor cells. Here we describe the origin and f...
Source: Respiratory Care - September 20, 2023 Category: Respiratory Medicine Authors: Yeonhee Park Chauek Chung Source Type: research
CRISPR-mediated reversion of oncogenic KRAS mutation results in increased proliferation and reveals independent roles of Ras and mTORC2 in the migration of A549 lung cancer cells
Mol Biol Cell. 2023 Sep 20:mbcE23050152. doi: 10.1091/mbc.E23-05-0152. Online ahead of print.ABSTRACTAlthough the RAS oncogene has been extensively studied, new aspects concerning its role and regulation in normal biology and cancer continue to be discovered. Recently, others and we have shown that the mechanistic Target of Rapamycin Complex 2 (mTORC2) is a Ras effector in Dictyostelium and mammalian cells. mTORC2 plays evolutionarily conserved roles in cell survival and migration and has been linked to tumorigenesis. Since RAS is often mutated in lung cancer, we investigated whether a Ras-mTORC2 pathway contributes to enh...
Source: Mol Biol Cell - September 20, 2023 Category: Molecular Biology Authors: Alyssa N Werner Avani I Kumar Pascale G Charest Source Type: research
Asymmetric aza-BODIPY photosensitizer for photoacoustic/photothermal imaging-guided synergistic photodynamic/photothermal therapy
Colloids Surf B Biointerfaces. 2023 Sep 16;231:113547. doi: 10.1016/j.colsurfb.2023.113547. Online ahead of print.ABSTRACTCancer synergistic therapy usually shows improved therapeutic efficacy with low side effects. In this contribution, an aza-BODIPY-derived photosensitizer NBDP with asymmetric structure and the periphery phenyl ring modified with bromine atom was designed and synthesized for synergistic photothermal therapy (PTT) and photodynamic therapy (PDT). Photosensitizer NBDP exhibited good singlet oxygen (1O2) generation capacity (1.43 times higher than that of ICG), and NBDP NPs showed an outstanding photothermal...
Source: Colloids and Surfaces - September 20, 2023 Category: Biotechnology Authors: Xiaohong Ruan Min Wei Xiaoyu He Leichen Wang Dongliang Yang Yu Cai Jinjun Shao Xiaochen Dong Source Type: research
