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Association of ADME gene polymorphisms on toxicity to CDK4/6 inhibitors in patients with HR+ HER2- metastatic breast cancer
This study explored the impact of genetic polymorphisms in ADME genes (responsible for drug absorption, distribution, metabolism, and elimination) on CDKis safety profiles in 230 patients. Selected endpoints include grade 3/4 neutropenia at day 14 of the first treatment cycle, early dose-limiting toxicities (DLTs), and dose reductions within the initial three cycles. Our analysis revealed associations between these endpoints and polymorphisms in CYP3A4, CYP3A5, ABCB1, and ABCG2 genes. Their impact on CDKis plasma concentrations (Ctrough) was also examined. Specifically, ABCB1 c.1236C>T and c.2677C>T polymorphisms cor...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 21, 2023 Category: Drugs & Pharmacology Authors: Elena Peruzzi Lorenzo Gerratana Marcella Montico Bianca Posocco Serena Corsetti Michele Bartoletti Sara Gagno Marco Orleni Elena De Mattia Massimo Baraldo Erika Cecchin Fabio Puglisi Giuseppe Toffoli Rossana Roncato Source Type: research

Magnetic Nanoparticles: A Review on Synthesis, Characterization, Functionalization, and Biomedical Applications
This review outlines diverse magnetic nanoparticle (MNP) designs, materials, morphologies, and characterization methods. It assesses various MNP synthesis techniques, their pros and cons, and explores inorganic and organic surface coatings. Biomedical MNP applications are covered, spanning hyperthermia, MRI, drug delivery, biosensors, and magnetic particle imaging. Future MNP structure trends and novel biomedical prospects are also discussed. AbstractNowadays, magnetic nanoparticles (MNPs)  are applied in numerous fields, especially in biomedical applications. Since biofluidic samples and biological tissues are nonmagneti...
Source: Small - September 21, 2023 Category: Nanotechnology Authors: Bahareh Rezaei, Parsa Yari, Sean M. Sanders, Haotong Wang, Vinit Kumar Chugh, Shuang Liang, Shahriar Mostufa, Kanglin Xu, Jian ‐Ping Wang, Jenifer Gómez‐Pastora, Kai Wu Tags: Review Source Type: research

Functional roles of magnetic nanoparticles for the identification of metastatic lymph nodes in cancer patients
Staging lymph nodes (LN) is crucial in diagnosing and treating cancer metastasis. Biotechnologies for the specific localization of metastatic lymph nodes (MLNs) have attracted significant attention to efficien...
Source: Journal of Nanobiotechnology - September 21, 2023 Category: Nanotechnology Authors: Yuanliang Yan, Yuanhong Liu, Tongfei Li, Qiuju Liang, Abhimanyu Thakur, Kui Zhang, Wei Liu, Zhijie Xu and Yuzhen Xu Tags: Review Source Type: research

Patients experience of using colonoscopy as a diagnostic test after a positive FOBT/FIT: a systematic review of the quantitative literature
Conclusion This review highlighted that patient-reported experiences associated with colonoscopy were generally positive. To improve the colonoscopy experience, bowel screening centres should investigate means to: make bowel preparation more acceptable, make colonoscopy less painful and reduce post-colonoscopy symptoms.
Source: BMJ Open - September 21, 2023 Category: General Medicine Authors: Kayal, G., Kerrison, R., Hirst, Y., von Wagner, C. Tags: Open access, Public health Source Type: research

Potential targets and applications of nanodrug targeting myeloid cells in osteosarcoma for the enhancement of immunotherapy
Targeted immunotherapies have emerged as a transformative approach in cancer treatment, offering enhanced specificity to tumor cells, and minimizing damage to healthy tissues. The targeted treatment of the tumor immune system has become clinically applicable, demonstrating significant anti-tumor activity in both early and late-stage malignancies, subsequently enhancing long-term survival rates. The most frequent and significant targeted therapies for the tumor immune system are executed through the utilization of checkpoint inhibitor antibodies and chimeric antigen receptor T cell treatment. However, when using immunothera...
Source: Frontiers in Pharmacology - September 21, 2023 Category: Drugs & Pharmacology Source Type: research

Frailty and long-term survival of patients with gastric cancer: a meta-analysis
ConclusionFrailty is associated with poor long-term survival of patients with GC.
Source: Frontiers in Oncology - September 21, 2023 Category: Cancer & Oncology Source Type: research

Comparison of the efficacy and safety of third-line treatments for metastatic colorectal cancer: a systematic review and network meta-analysis
ConclusionTAS-102, fruquintinib, TAS-102 plus bevacizumab, the regorafenib standard dose regimen (regorafenib), and the regorafenib dose-escalation regimen (regorafenib 80+) all demonstrated improved OS and PFS compared to BSC in mCRC patients. However, TAS-102 plus bevacizumab may be the optimal choice for third-line treatment in mCRC patients.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php, CRD42023434929.
Source: Frontiers in Oncology - September 21, 2023 Category: Cancer & Oncology Source Type: research

Effect of artificial intelligence –based computer-aided diagnosis on the screening outcomes of digital mammography: a matched cohort study
ConclusionsAI-CAD increases the specificity for radiologists without decreasing sensitivity as a supportive tool in the single reading of DM for breast cancer screening.Clinical relevance statementThis study shows that AI-CAD could improve the specificity of radiologists ’ DM interpretation in the single reading system without decreasing sensitivity, suggesting that it can benefit patients by reducing false positive and recall rates.Key Points• In this retrospective-matched cohort study (DM without AI-CAD vs DM with AI-CAD), radiologists showed higher specificity and lower AIR when AI-CAD was used to support decision-m...
Source: European Radiology - September 20, 2023 Category: Radiology Source Type: research

Two curcumin analogs inhibited the function and protein expression of breast cancer resistance protein: < em > in vitro < /em > and < em > in vivo < /em > studies
Xenobiotica. 2023 Sep 20:1-32. doi: 10.1080/00498254.2023.2260886. Online ahead of print.ABSTRACT1. Two curcumin analogs, (1E,6E)-1,7-bis(3,5-diethyl-4-hydroxyphenyl)hepta-1,6-diene-3,5- dione (N17) and its prodrug ((1E,6E)-3,5-dioxohepta-1,6-diene-1,7-diyl)bis(2,6-diethyl-4,1- phenylene)bis(3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate) (N17'), were evaluated as breast cancer resistance protein (BCRP) inhibitors.2. MDCKII-BCRP and MDCKII-WT were used to evaluate the modulation effects of N17 and N17' on BCRP and to explore the relevant mechanism. Sprague-Dawley rats were orally administered rosuvastatin (ROS), a probe su...
Source: Xenobiotica - September 20, 2023 Category: Research Authors: Chung-Ping Yu Yi-Ru Wang Yu-Chi Hou Min-Tsang Hsieh Pei-Ying Li Sheng-Chu Kuo Shiuan-Pey Lin Source Type: research

Analysis of Prognoses according to Breast MRI Results in Patients with Axillary Lymph Node Metastases from an Unknown Primary Origin
CONCLUSION: The prognoses of MR-negative patients with ACUPax who received ALND and WBRT followed by chemotherapy were as good as those of patients with MRI-detected primary breast cancers.PMID:37727923 | DOI:10.3349/ymj.2023.0181
Source: Yonsei Medical Journal - September 20, 2023 Category: Universities & Medical Training Authors: E-Ryung Choi Ok Hee Woo Eun Young Ko Boo-Kyung Han Ji Soo Choi Eun Sook Ko Haejung Kim Myoung Kyoung Kim Jeong Eon Lee Source Type: research

Prevalence of women with breast implants in Sweden: a study based on the population-based mammography screening programme
CONCLUSION: The prevalence of breast implants in Swedish women is estimated to be around 4%. The population-based mammography screening programme in countries with a publicly funded welfare-type healthcare system and a clear documentation of mammography screening attendance, seems to be a feasible way to establish the prevalence of breast implants in the population. The large number of women with breast implants warrants further studies regarding the best diagnostic and treatment alternatives for this group. Pre-registration: ClinicalTrials.Gov identifier NCT05222100.PMID:37728392 | DOI:10.2340/jphs.v58.15298
Source: Hand Surgery - September 20, 2023 Category: Surgery Authors: Emma Hansson Sarah Zaya Susanne Meyer Alexa Freiin von Wrangel Fredrik W ärnberg Sophia Zackrisson Source Type: research

Submandibular suction lipectomy and single-hole inflator-free endoscopic thyroidectomy with a submental approach: a new surgical technique
Gland Surg. 2023 Jul 31;12(7):974-981. doi: 10.21037/gs-22-624. Epub 2023 Jun 30.ABSTRACTWe have successfully carried out single-hole inflator-free endoscopic thyroidectomy through a submental approach, which has the advantages of less trauma, fewer complications, and hidden incisions. However, for patients with submandibular fat accumulation, submental incisions are not easy to hide, which directly affects the cosmetic effect. We developed a new surgical strategy "submandibular suction lipectomy and single-hole inflator-free endoscopic thyroidectomy with a submental approach" for these patients. We initially used submandi...
Source: Hand Surgery - September 20, 2023 Category: Surgery Authors: Zhongliang Lang Jing Lv Deling Wu Chunlei Sun Zhiwei Xing Gaoyuan Yu Gongshuai Tao Liping Zhao Xiaopeng Ma Source Type: research

Paracetamol and the decreased risk of ovarian cancer in a dose-response manner
BJOG. 2023 Sep 19. doi: 10.1111/1471-0528.17671. Online ahead of print.NO ABSTRACTPMID:37726966 | DOI:10.1111/1471-0528.17671
Source: BJOG : An International Journal of Obstetrics and Gynaecology - September 20, 2023 Category: OBGYN Authors: Christos Iavazzo Alexandros Fotiou Nikolaos Vrachnis Source Type: research

Chronic Obstructive Pulmonary Disease Mortality in Bladder Cancer Patients: A SEER-Based Competing Risk Analysis
CONCLUSIONS: In comparison to the general population, the risk of COPD mortality is significantly higher in patients with BC. Pre-identification of high-risk groups and respiratory care provisions are important measures to effectively improve survival in this group of patients.PMID:37727915 | DOI:10.22037/uj.v20i.7644
Source: Urology Journal - September 20, 2023 Category: Urology & Nephrology Authors: Shunde Wang Chengguo Ge Source Type: research

Comparison of Health-Related Quality of Life Changes in Prostate Cancer Patients Undergoing Laparoscopic versus Robotic-Assisted Laparoscopic Radical Prostatectomy: A Systematic review
CONCLUSION: Both robotic-assisted and laparoscopic radical prostatectomy are valid treatment options to achieve a good quality of life following surgery. The intermediate and long-term results in regard to QoL are comparable between the two procedures. RALRP might be superior to LRP in terms of immediate health-related quality of life, which might contribute to early recovery of urinary function.PMID:37727913 | DOI:10.22037/uj.v20i.7707
Source: Urology Journal - September 20, 2023 Category: Urology & Nephrology Authors: Sertac Yazici Senol Tonyali Source Type: research