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Research Progress of Metformin in the Treatment of Oral Squamous Cell Carcinoma
Endocrinology. 2023 Sep 20:bqad139. doi: 10.1210/endocr/bqad139. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is one of the most common malignancies with high mortality, posing a great threat to both human physical and mental health. With the advancement of scientific research, a variety of cancer therapies have been used for OSCC treatment. However, the prognosis of OSCC shows no significant improvement. Metformin has been recognized as the first-line drug for the treatment of diabetes, and recent studies have shown that metformin has a remarkable suppressive effect on tumor progression. Metformin can...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Jiayi Liu Jing Zhao Xue Qiao Source Type: research
A Survey of the Status of Methadone Switching in Japan Using a Hospital-Based Administrative Claims Database
In conclusion, more than 30% of the patients underwent high-dose methadone switching and required long completion periods, suggesting that methadone switching remains challenging in Japan. This article is protected by copyright. All rights reserved.PMID:37737471 | DOI:10.1002/jcph.2351
Source: The Journal of Clinical Pharmacology - September 22, 2023 Category: Drugs & Pharmacology Authors: Shungo Imai Natsumi Aoki Keisuke Ikegami Hayato Kizaki Satoko Hori Source Type: research
Mass Spectrometry-Based Proteogenomics: New Therapeutic Opportunities for Precision Medicine
Annu Rev Pharmacol Toxicol. 2023 Sep 22. doi: 10.1146/annurev-pharmtox-022723-113921. Online ahead of print.ABSTRACTProteogenomics refers to the integration of comprehensive genomic, transcriptomic, and proteomic measurements from the same samples with the goal of fully understanding the regulatory processes converting genotypes to phenotypes, often with an emphasis on gaining a deeper understanding of disease processes. Although specific genetic mutations have long been known to drive the development of multiple cancers, gene mutations alone do not always predict prognosis or response to targeted therapy. The benefit of p...
Source: Annual Review of Pharmacology and Toxicology - September 22, 2023 Category: Drugs & Pharmacology Authors: Sunil K Joshi Paul Piehowski Tao Liu Sara J C Gosline Jason E McDermott Brian J Druker Elie Traer Jeffrey W Tyner Anupriya Agarwal Cristina E Tognon Karin D Rodland Source Type: research
Cancers, Vol. 15, Pages 4686: The Role of the Dysregulation of Long Non-Coding and Circular RNA Expression in Medulloblastoma: A Systematic Review
ldaiturriaga
Medulloblastoma (MB) is the most common malignant brain tumor in childhood. Although recent multi-omic studies have led to advances in MB classification, there is still room for improvement with regard to treatment response and survival. Therefore, identification of new and less invasive biomarkers is needed to refine the diagnostic process and to develop more personalized treatment strategies. In this context, non-coding RNAs (ncRNAs) could be useful biomarkers for MB. In this article, we reviewed the role of two types of ncRNAs, long non-coding (lncRNAs) and circular RNAs (circRNAs), as biomarkers for th...
Source: Cancers - September 22, 2023 Category: Cancer & Oncology Authors: Ivan Martinez de Estibariz Anastasija Jakjimovska Unai Illarregi Idoia Martin-Guerrero Angela Guti érrez-Camino Elixabet Lopez-Lopez Nerea Bilbao-Aldaiturriaga Tags: Systematic Review Source Type: research
Role of Mediterranean diet in the development and recurrence of meningiomas: a narrative review
This study aims to provide an overview about the relationship between meningiomas and food assumption in the Mediterranean diet and whether it can be useful in meningioma prevention or it, somehow, can prevent their recurrence. The authors performed a wide literature search in PubMed and Scopus databases investigating the presence of a correlation between Mediterranean diet and meningiomas. The following MeSH and free text terms were used: “Meningiomas” AND “Diet” and “Brain tumors” AND “diet.” Databases’ search yielded a total of 749 articles. After duplicate removal, an abstract screening according to t...
Source: Neurosurgical Review - September 22, 2023 Category: Neurosurgery Source Type: research
Cancers, Vol. 15, Pages 4680: Health-Related Quality of Life Outcomes in Meningioma Patients Based upon Tumor Location and Treatment Modality: A Systematic Review and Meta-Analysis
S. D’Amico
Patients with meningiomas may have reduced health-related quality of life (HRQoL) due to postoperative neurological deficits, cognitive dysfunction, and psychosocial burden. Although advances in surgery and radiotherapy have improved progression-free survival rates, there is limited evidence regarding treatment outcomes on HRQoL. This review examines HRQoL outcomes based on tumor location and treatment modality. A systematic search in PubMed yielded 28 studies with 3167 patients. The mean age was 54.27 years and most patients were female (70.8%). Approximately 78% of meningiomas were located in the skull ...
Source: Cancers - September 22, 2023 Category: Cancer & Oncology Authors: Ali San Raphia K. Rahman Praveen Sanmugananthan Michael D. Dub é Nicholas Panico Ogechukwu Ariwodo Vidur Shah Randy S. D ’Amico Tags: Systematic Review Source Type: research
Vascular Supply Identification, Lesion Extension and Search for Tumor Similarity at a Distance by VTM in Breast Cancer
Condition: Breast Cancer Female Intervention: Device: VTM examination and breast biopsy Sponsors: Galzu Institute of Research, Teaching, Science and Applied Technology; Hospital Santa Casa de Misericordia de Campos; Hospital Escola Alvaro Alvim; Universidade Estadual do Norte Fluminense (UENF) Not yet recruiting
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials
10-Patient Trial: Remarkable Responses in Pediatric Cancers
Clin Cancer Res. 2023 Sep 21. doi: 10.1158/1078-0432.CCR-23-2232. Online ahead of print.ABSTRACTA clinical trial of Nivolumab in 10 pediatric cancer patients with high tumor mutational burden demonstrated complete responses in 50% of patients. This result recapitulates multiple clinical trial results in high mutation burden adult cancers and may redefine best practice in the setting of germline DNA mismatch repair-based susceptibility.PMID:37733329 | DOI:10.1158/1078-0432.CCR-23-2232
Source: Clinical Cancer Research - September 21, 2023 Category: Cancer & Oncology Authors: Elaine R Mardis Source Type: research
AACR Cancer Centers Alliance: Fostering Collaboration and Innovation to Advance Lifesaving Scientific Discoveries for Patients
Clin Cancer Res. 2023 Sep 13:OF1-OF3. doi: 10.1158/1078-0432.CCR-23-2625. Online ahead of print.ABSTRACTBasic and clinical cancer research discoveries stemming from the nation's cancer centers have markedly improved outcomes for many cancer patients. Despite this forward momentum in our progress against this complex disease, cancer in all its forms remains a major public health challenge that touches the lives of nearly every American, either directly or indirectly. The newly formed AACR Cancer Centers Alliance will accelerate the pace of discovery by providing an ongoing mechanism for transferring new knowledge, sharing r...
Source: Clinical Cancer Research - September 21, 2023 Category: Cancer & Oncology Authors: Carlos L Arteaga John L Cleveland Margaret Foti Ruben A Mesa Louis M Weiner Cheryl L Willman David A Tuveson Source Type: research
Deuterium Magnetic Resonance Imaging Using Deuterated Water-Induced 2H-Tissue Labeling Allows Monitoring Cancer Treatment at Clinical Field Strength
CONCLUSIONS: Deuterium MRI at 1.5T proved feasibility to track 2H distribution throughout mouse tissues during D2O administration and revealed a higher 2H accumulation in the tumor xenografts. This research demonstrated a promising successful method for preliminary assessment of radiotherapy and chemotherapy of cancer.PMID:37732903 | DOI:10.1158/1078-0432.CCR-23-1635
Source: Clinical Cancer Research - September 21, 2023 Category: Cancer & Oncology Authors: Hirofumi Asano Abdelazim Elsayed Elhelaly Fuminori Hyodo Ryota Iwasaki Yoshifumi Noda Hiroki Kato Koki Ichihashi Hiroyuki Tomita Masaharu Murata Takashi Mori Masayuki Matsuo Source Type: research
Unveiling the anti-cancer mechanisms of calotropin: Insights into cell growth inhibition, cell cycle arrest, and metabolic regulation in human oral squamous carcinoma cells (HSC-3)
CONCLUSION: Overall, our findings shed an experimental evidence on how calotropin inhibits the HSC-3 oral squamous cancer cell growth, highlighting the drug's potential as a treatment for oral cancer. Further, investigation on in-vivo experiment is warranted to explore its potential mechanism of action and to develop a novel drug towards clinical trial.PMID:37731845 | PMC:PMC10507650 | DOI:10.1016/j.jobcr.2023.09.002
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Selvaraj Jayaraman Sathan Raj Natarajan Vishnu Priya Veeraraghavan Sharmila Jasmine Source Type: research
Kinesin Superfamily Member 18B (KIF18B) Promotes Cell Proliferation in Colon Adenocarcinoma Retraction
Cancer Manag Res. 2023 Sep 15;15:1011-1012. doi: 10.2147/CMAR.S440061. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.2147/CMAR.S261894.].PMID:37731840 | PMC:PMC10508229 | DOI:10.2147/CMAR.S440061
Source: Cell Research - September 21, 2023 Category: Cytology Source Type: research
Novel green synthesis of silver nanoparticles mediated by < em > Curcumae kwangsiensis < /em > for anti-lung cancer activities: a preclinical trial study
CONCLUSIONS: After confirming the above results in the clinical trial research, this formulation can be administered to treat human lung cancers in humans.PMID:37732031 | PMC:PMC10507782 | DOI:10.5114/aoms/134059
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Zhihong Liu Zhuohong Zhang Xiaomei Du Ying Liu Abdullah Alarfaj Abdurahman Hirad Siddique Akber Ansari Zhiguo Zhang Source Type: research
