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Cancer: Colorectal Cancer
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Total 41065 results found since Jan 2013.
High-throughput sequencing reveals Jatrorrhizine inhibits colorectal cancer growth by ferroptosis-related genes
CONCLUSIONS: JAT can inhibit COAD growth by ferroptosis-related genes. And it is a potential natural substance for the treatment of COAD.PMID:37710311 | PMC:PMC10500743 | DOI:10.1186/s12920-023-01619-3
Source: Cancer Control - September 14, 2023 Category: Cancer & Oncology Authors: Lingyu Huang Yu Sha Wenken Liang Chune Mo Chunhong Li Yecheng Deng Weiwei Gong Xianliang Hou Minglin Ou Source Type: research
Efficacy of a 1 day Rifaximin and Metronidazole Regimen and Mechanical Bowel Preparation for Preventing Surgical Site Infection in Minimally Invasive Colorectal Cancer Surgery: A Prospective Observational Study
DISCUSSION: A 1 day rifaximin and metronidazole regimen with mechanical bowel preparation for elective minimally invasive surgery for colorectal cancer was associated with a favorable SSI rate of 2.9%, safety, and high compliance. This approach is appropriate for inclusion in the current guidelines for perioperative management of patients scheduled to undergo minimally invasive surgery for colorectal cancer.PMID:37707885 | DOI:10.1177/00031348231200667
Source: The American Surgeon - September 14, 2023 Category: Surgery Authors: Seung-Hwan Yoon In Jun Yang Ji Yeon Kim Kyung-Ha Lee Source Type: research
Correction: MKRN1 promotes colorectal cancer metastasis by activating the TGF- β signalling pathway through SNIP1 protein degradation
J Exp Clin Cancer Res. 2023 Sep 15;42(1):240. doi: 10.1186/s13046-023-02825-8.NO ABSTRACTPMID:37710340 | DOI:10.1186/s13046-023-02825-8
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Yi Zhang Qinshan Li Honglin Liu Hongting Tang Hanlin Yang Daoqiu Wu Yuying Huang Licheng Li Lihong Liu Mengxing Li Source Type: research
Evaluation of commercial kits for isolation and bisulfite conversion of circulating cell-free tumor DNA from blood
CONCLUSIONS: Based on a thorough evaluation of five bisulfite conversion kits and three cfDNA isolation kits, both individually and in combination, the CNA kit and the EpiTect kit were identified as the best-performing kit combination, with highest DNA yield and recovery across a range of DNA input amounts. The combination was successfully used for detection of clinically relevant DNA methylation biomarkers in plasma from cancer patients.PMID:37710283 | DOI:10.1186/s13148-023-01563-0
Source: Clinical Colorectal Cancer - September 14, 2023 Category: Cancer & Oncology Authors: Stine H Kresse Sara Brandt-Winge Heidi Pharo Bj ørnar T B Flatin Marine Jeanmougin Hege Marie Vedeld Guro E Lind Source Type: research
Zinc intake, SLC30A8 rs3802177 polymorphism, and colorectal cancer risk in a Korean population: a case-control study
CONCLUSIONS: In summary, our findings suggest an inverse association between dietary zinc intake and CRC risk, and this relationship may be modified by SLC30A8 rs3802177 polymorphism.PMID:37707576 | DOI:10.1007/s00432-023-05381-y
Source: Clinical Colorectal Cancer - September 14, 2023 Category: Cancer & Oncology Authors: Linh Thi Dieu Nguyen Madhawa Gunathilake Jeonghee Lee Jae Hwan Oh Hee Jin Chang Dae Kyung Sohn Aesun Shin Jeongseon Kim Source Type: research
A novel 4-(1,3,4-thiadiazole-2-ylthio)pyrimidine derivative inhibits cell proliferation by suppressing the MEK/ERK signaling pathway in colorectal cancer
Acta Pharm. 2023 Sep 14;73(3):489-502. doi: 10.2478/acph-2023-0025. Print 2023 Sep 1.ABSTRACTColorectal cancer (CRC) is one of the most common types of malignant cancers worldwide. Although molecularly targeted therapies have significantly improved treatment outcomes, most of these target inhibitors are resistant. Novel inhibitors as potential anticancer drug candidates are still needed to be discovered. Therefore, in the present study, we synthesized a novel 4-(1,3,4-thiadiazole-2-ylthio)pyrimidine derivative (compound 4) using fragment- and structure-based techniques and then investigated the anticancer effect and underl...
Source: Acta Pharmaceutica - September 14, 2023 Category: Drugs & Pharmacology Authors: Weiwei Li Zhifu Yang Likun Ding Ying Wang Xian Zhao Jian Jie Chu Qing Ji Minna Yao Jingwen Wang Source Type: research
Attenuated Salmonella-delivered PD-1 siRNA enhances the antitumor effects of EZH2 inhibitors in colorectal cancer
This study suggests an emerging strategy based on a combination of EZH2 inhibitor and immunotherapy based on PD-1 inhibition.PMID:37708707 | DOI:10.1016/j.intimp.2023.110918
Source: International Immunopharmacology - September 14, 2023 Category: Allergy & Immunology Authors: Mengmeng Lv Sheng Guo Xinyu Zhang Yan Zou Qiang Chen Chongyi Zang Shuo Huang Yuhan Hu Yanling Wang Qianqing Wang Jiateng Zhong Source Type: research
< em > KIF18A < /em > improves migration and invasion colorectal cancer (CRC) cells through inhibiting < em > PTEN < /em > signaling
CONCLUSION: In conclusion, KIF18A can further the activation of PI3K/Akt signaling pathway by means of inhibiting PTEN transcription. Therefore, it is inferred that that KIF18A is a therapeutic target for CRC.PMID:37708299 | DOI:10.18632/aging.205027
Source: Aging - September 14, 2023 Category: Biomedical Science Authors: Yuan Liu Ming Sun Bin Zhang Wenyan Zhao Source Type: research
Seseli bocconei Guss. and S. tortuosum subsp. maritimum Guss. essential oils inhibit colon cancer cell viability
In this study, the chemical compositions of two essential oils (EOs) obtained from different parts (flowers, leaves, stems, and roots) of Seseli bocconei Guss. and of Seseli tortuosum subsp. maritimum Guss., wild endemic species of Sicily, were investigated. The main classes of metabolites for the essential oils of S. bocconei were, respectively, monoterpenes hydrocarbons for flowers, sesquiterpenes hydrocarbons for leaves, and a breakdown between the two previously mentioned classes for stems. In the case of S. tortuosum subsp. maritimum, on the other hand, the main metabolite class for all the vegetative parts analyzed (...
Source: Fitoterapia - September 14, 2023 Category: Biochemistry Authors: Alessandro Vaglica Antonella Maggio Natale Badalamenti Maurizio Bruno Marianna Lauricella Antonella D'Anneo Source Type: research
"To be myself again": Perceived benefits of group-based exercise for colorectal cancer patients
CONCLUSIONS: This study shows that exercise is a coping strategy that benefitted CRC patients in several ways related to their physical and psychosocial quality of life.PMID:37708625 | DOI:10.1016/j.ejon.2023.102405
Source: European Journal of Oncology Nursing - September 14, 2023 Category: Nursing Authors: Juan Tortosa-Mart ínez Vicente J Beltr án-Carrillo Mar ía Romero-Elías Ana Ruiz-Casado Alejandro Jim énez-Loaisa David Gonz ález-Cutre Source Type: research
Pain-related stigma in patients with breast, colon, prostate or lung cancer : Results of a bicentric register-based cross-sectional study
CONCLUSIONS: Our findings support the assumption that the experience of pain can have an impact on the perceived stigmatization of cancer patients. Depression might influence the perceived stigmatization. Therefore, this group of patients should receive special attention and psycho-oncological care in clinical practice. Further research on the course and mechanisms of action of pain-related perceived stigmatization is also required.PMID:37710022 | DOI:10.1007/s00482-023-00752-3
Source: Schmerz - September 14, 2023 Category: Anesthesiology Authors: A Roicke P Esser B Hornemann J Ernst Source Type: research
A study on metabolic characteristics and metabolic markers of gastrointestinal tumors
In conclusion, we identified differences among subtypes in clinical characteristics such as prognosis and revealed the potential function of metabolic subtype in response to chemotherapeutic agents and oncogene mutations. This work highlighted the potential clinical meaning of metabolic subtype and characteristics in drug therapy and prognosis assessment of malignant tumors.PMID:37705174 | DOI:10.1080/15384047.2023.2255369
Source: Cancer Biology and Therapy - September 14, 2023 Category: Cancer & Oncology Authors: Shan Cong Shanshan Bai Minghao Zhang Yanfang Bi Yu Wang Shi Jin Hui He Source Type: research
Metabolic signatures and potential biomarkers for the diagnosis and treatment of colon cancer cachexia
In this study, we establish a mouse model of colon CAC and categorize the mice into three groups: CAC, NCAC and normal control (NOR). By performing nuclear magnetic resonance (NMR)-based metabolomic profiling on mouse sera, we elucidate the metabolic properties of these groups. Our findings unveil significant differences in the metabolic profiles among the CAC, NCAC and NOR groups, highlighting significant impairments in energy metabolism and amino acid metabolism during cachexia progression. Additionally, we observe the elevated serum levels of lysine and acetate during the transition from the NCAC to CAC stages. Using mu...
Source: Acta Biochimica et Biophysica Sinica - September 14, 2023 Category: Biochemistry Authors: Xu Qiu Ruohan Lu Qiqing He Shu Chen Caihua Huang Donghai Lin Source Type: research
