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Total 41065 results found since Jan 2013.
Angiogenesis inhibitor or aggressiveness marker? The function of endostatin in cancer through electrochemical biosensing
Bioelectrochemistry. 2023 Sep 14;155:108571. doi: 10.1016/j.bioelechem.2023.108571. Online ahead of print.ABSTRACTThis work reports the first electrochemical bioplatform developed for the determination of human endostatin (HE), a biomarker with recognized antiangiogenic potential whose elevated circulating levels have also been associated with the development of aggressive cancers. The developed electroanalytical biotool combines the benefits of using magnetic microparticles for the implementation of sandwich immunoassays and amperometric transduction on disposable carbon electrodes. A limit of detection (LOD) of 34.1 pg m...
Source: Bioelectrochemistry - September 17, 2023 Category: Biochemistry Authors: Sandra Tejerina-Miranda Mar ía Pedrero Marina Bl ázquez-García Ver ónica Serafín Ana Montero-Calle Maria Garranzo-Asensio A Julio Reviejo Jos é M Pingarrón Rodrigo Barderas Susana Campuzano Source Type: research
Green synthesis of multifunctional zinc oxide nanoparticles from cordia myxa gum; and their catalytic reduction of nitrophenol, anticancer and antimicrobial activity
This study uses CMX gum as a bioreduction to produce multifunctional, environmentally friendly zinc-oxide nanocomposites (ZnO NPs). The process involves a low reaction time and temperature and utilizes CMX as a reducing and stabilizing agent. The structural, morphological, and optical properties of the CMX-ZnO nanocomposite were characterized. The biosynthetic CMX-ZnO NPs exhibited robust catalytic activity and recycling capacity for rapidly oxidizing hazardous p-NPs. The complete reduction of 4-NP to CMX-ZnO NPs in excess NaBH4 was achieved within 15 min, with recyclability and pseudo-first-order kinetics with a rate cons...
Source: International Journal of Biological Macromolecules - September 17, 2023 Category: Biochemistry Authors: Kasula Nagaraja O H Tae Hwan Source Type: research
Angiogenesis inhibitor or aggressiveness marker? The function of endostatin in cancer through electrochemical biosensing
Bioelectrochemistry. 2023 Sep 14;155:108571. doi: 10.1016/j.bioelechem.2023.108571. Online ahead of print.ABSTRACTThis work reports the first electrochemical bioplatform developed for the determination of human endostatin (HE), a biomarker with recognized antiangiogenic potential whose elevated circulating levels have also been associated with the development of aggressive cancers. The developed electroanalytical biotool combines the benefits of using magnetic microparticles for the implementation of sandwich immunoassays and amperometric transduction on disposable carbon electrodes. A limit of detection (LOD) of 34.1 pg m...
Source: Bioelectrochemistry - September 17, 2023 Category: Biochemistry Authors: Sandra Tejerina-Miranda Mar ía Pedrero Marina Bl ázquez-García Ver ónica Serafín Ana Montero-Calle Maria Garranzo-Asensio A Julio Reviejo Jos é M Pingarrón Rodrigo Barderas Susana Campuzano Source Type: research
Luteolin exhibits synergistic therapeutic efficacy with erastin to induce ferroptosis in colon cancer cells through the HIC1-mediated inhibition of GPX4 expression
This study aimed to examine the synergistic therapeutic impact of combining erastin with a bioactive flavonoid compound luteolin on the ferroptosis-mediated suppression of colon cancer. Human colon cancer HCT116 and SW480 cells were used for the in vitro studies and a xenograft of colon cancer model in BALB/c nude mice was established for the in vivo experiments. The results showed that combinative treatment of luteolin and erastin effectively inhibited the viability and proliferation of colon cancer cells. Luteolin and erastin cotreatment synergistically induced ferroptosis, concomitant with a reduction in glutathione and...
Source: Free Radical Biology and Medicine - September 17, 2023 Category: Biology Authors: Yinli Zheng Leyan Li Haipeng Chen Yuting Zheng Xuanjing Tan Guiyu Zhang Ruidi Jiang Hong Yu Senyi Lin Yijie Wei Ying Wang Rong Zhang Zhongqiu Liu Jinjun Wu Source Type: research
The siRNA-mediated knockdown of SNHG4 efficiently induced pro-apoptotic signaling and suppressed metastasis in SW1116 colorectal cancer cell line
CONCLUSIONS: In conclusion, SNHG4 promotes CRC by dysregulating apoptosis and cell migration, and shows significant prognostic potential for CRC.PMID:37715875 | DOI:10.1007/s11033-023-08742-5
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Mina Khajehdehi Mohammad Khalaj-Kondori Behzad Baradaran Source Type: research
Three cases of colon cancer in four generations of the Saudi family, caused by endogamous germline mutations
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):163-171. doi: 10.14715/cmb/2023.69.8.25.ABSTRACTVarious research pieces of evidence have been published in recent years, establishing the increasing prevalence of early colon cancer among young people. In this background, the current study aimed to analyze the reasons behind colon cancer recurrence among endogamous consanguineous cases in four generations of a single Saud family. For this study, the authors conducted the whole-exome sequencing analysis to screen for germline mutations in DNA samples from consanguineous cases within the family. After collecting the colon sam...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Dalal S Alshaya Tahani Mohamed Ibrahim Al-Hazani Mashael Alhumaidi Alotaibi Dalia Mostafa Domiaty Eman Alshehri Maha Abdulla Alwaili Amani Mohammed Alotaibi Areej Saud Jalal Alaa Ali AlQahtani Fatima Abdullah AlQassim Gadah Albasher Wedad Saeed Al-Qahtani Source Type: research
Circular RNA METTL15/miR-374a-5p/ESCO2 axis induces colorectal cancer development
In conclusion, the results of this study reveal the role of circMETTL15 in CRC and the underlying molecular mechanism, which provides potential data support for the development of future CRC drugs.PMID:37715994 | DOI:10.18388/abp.2020_6470
Source: Acta Biochim Pol - September 16, 2023 Category: Biochemistry Authors: Feng Guo Yang Luo GuangYao Ye WeiJun Tang Source Type: research
The siRNA-mediated knockdown of SNHG4 efficiently induced pro-apoptotic signaling and suppressed metastasis in SW1116 colorectal cancer cell line
CONCLUSIONS: In conclusion, SNHG4 promotes CRC by dysregulating apoptosis and cell migration, and shows significant prognostic potential for CRC.PMID:37715875 | DOI:10.1007/s11033-023-08742-5
Source: Molecular Biology Reports - September 16, 2023 Category: Molecular Biology Authors: Mina Khajehdehi Mohammad Khalaj-Kondori Behzad Baradaran Source Type: research
Label-free drug response evaluation of human derived tumor spheroids using three-dimensional dynamic optical coherence tomography
This study aims at demonstrating label-free drug-response-patterns assessment of different tumor spheroids and drug types by dynamic optical coherence tomography (D-OCT). The study involved human breast cancer (MCF-7) and colon cancer (HT-29) spheroids. The MCF-7 and HT-29 spheroids were treated with paclitaxel (Taxol; PTX) and the active metabolite of irinotecan SN-38, respectively. The drugs were applied with 0 (control), 0.1, 1, and 10 μM concentrations and the treatment durations were 1, 3, and 6 days. A swept-source OCT microscope equipped with a repeated raster scanning protocol was used to scan the spheroids. Logar...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Ibrahim Abd El-Sadek Larina Tzu-Wei Shen Tomoko Mori Shuichi Makita Pradipta Mukherjee Antonia Lichtenegger Satoshi Matsusaka Yoshiaki Yasuno Source Type: research
A metabolomic investigation of serum perfluorooctane sulfonate and perfluorooctanoate
CONCLUSIONS: In this large metabolomic study, we observed robust positive associations with PFOS for several molecules. Further investigation of these metabolites may offer insight into PFOS-related biologic effects.PMID:37716341 | DOI:10.1016/j.envint.2023.108198
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Jongeun Rhee Erikka Loftfield Demetrius Albanes Tracy M Layne Rachael Stolzenberg-Solomon Linda M Liao Mary C Playdon Sonja I Berndt Joshua N Sampson Neal D Freedman Steven C Moore Mark P Purdue Source Type: research
Cancer cell-intrinsic PD-1: Its role in malignant progression and immunotherapy
Biomed Pharmacother. 2023 Sep 14;167:115514. doi: 10.1016/j.biopha.2023.115514. Online ahead of print.ABSTRACTProgrammed cell death protein-1 (PD-1), also called CD279, is coded by the PDCD1 gene and is constitutively expressed on the surface of immune cells. As a receptor and immune checkpoint, PD-1 can bind to programmed death ligand-1/programmed death ligand-2 (PD-L1/PD-L2) in tumor cells, leading to tumor immune evasion. Anti-PD-1 and anti-PD-L1 are important components in tumor immune therapy. PD-1 is also expressed as an intrinsic variant (iPD-1) in cancer cells where it plays important roles in malignant progression...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Muhua Chen Lei Bie Jieer Ying Source Type: research
A metabolomic investigation of serum perfluorooctane sulfonate and perfluorooctanoate
CONCLUSIONS: In this large metabolomic study, we observed robust positive associations with PFOS for several molecules. Further investigation of these metabolites may offer insight into PFOS-related biologic effects.PMID:37716341 | DOI:10.1016/j.envint.2023.108198
Source: Environment International - September 16, 2023 Category: Environmental Health Authors: Jongeun Rhee Erikka Loftfield Demetrius Albanes Tracy M Layne Rachael Stolzenberg-Solomon Linda M Liao Mary C Playdon Sonja I Berndt Joshua N Sampson Neal D Freedman Steven C Moore Mark P Purdue Source Type: research
Colonoscopy Combined with Me-Nbi to Observe the Canceration Characteristics of Colon Polyps and the Correlation of RHOC Protein Expression
In conclusion, NICE classification under colonoscopy combined with magnifying colonoscopy has a good effect on colorectal lesions. Differential diagnostic value, RhoC protein is highly expressed in colon cancer and is closely related to the occurrence of colon cancer and the depth of lesion invasion. With the progression of colorectal adenomas, the expression of RhoC protein in the lesions gradually increased.PMID:37715435 | DOI:10.14715/cmb/2023.69.7.7
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: None Shuqi Xu None Weimin Chen None Yiming Chen None Xuanfu Xu None Ying Dai None Jianqing Chen None Wenhui Mo None Meng Ji None Yueyue Li None Wenjing Liu Source Type: research
Prognosis of carcinoembryonic antigen (CEA) in stage I colorectal adenocarcinoma and development of a prediction model: a retrospective study based on the SEER database
CONCLUSION: Elevated CEA is a risk factor for stage I CCA, but not for MUC. And the nomogram is accurate enough to predict the risk and prognostic factors of CCA.PMID:37715832 | DOI:10.1007/s00432-023-05410-w
Source: Clinical Colorectal Cancer - September 16, 2023 Category: Cancer & Oncology Authors: Zhongbiao Chen Zhimin Lin Source Type: research
