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A novel 4-(1,3,4-thiadiazole-2-ylthio)pyrimidine derivative inhibits cell proliferation by suppressing the MEK/ERK signaling pathway in colorectal cancer
Acta Pharm. 2023 Sep 14;73(3):489-502. doi: 10.2478/acph-2023-0025. Print 2023 Sep 1.ABSTRACTColorectal cancer (CRC) is one of the most common types of malignant cancers worldwide. Although molecularly targeted therapies have significantly improved treatment outcomes, most of these target inhibitors are resistant. Novel inhibitors as potential anticancer drug candidates are still needed to be discovered. Therefore, in the present study, we synthesized a novel 4-(1,3,4-thiadiazole-2-ylthio)pyrimidine derivative (compound 4) using fragment- and structure-based techniques and then investigated the anticancer effect and underl...
Source: Acta Pharmaceutica - September 14, 2023 Category: Drugs & Pharmacology Authors: Weiwei Li Zhifu Yang Likun Ding Ying Wang Xian Zhao Jian Jie Chu Qing Ji Minna Yao Jingwen Wang Source Type: research
Efficacy of a 1 day Rifaximin and Metronidazole Regimen and Mechanical Bowel Preparation for Preventing Surgical Site Infection in Minimally Invasive Colorectal Cancer Surgery: A Prospective Observational Study
DISCUSSION: A 1 day rifaximin and metronidazole regimen with mechanical bowel preparation for elective minimally invasive surgery for colorectal cancer was associated with a favorable SSI rate of 2.9%, safety, and high compliance. This approach is appropriate for inclusion in the current guidelines for perioperative management of patients scheduled to undergo minimally invasive surgery for colorectal cancer.PMID:37707885 | DOI:10.1177/00031348231200667
Source: The American Surgeon - September 14, 2023 Category: Surgery Authors: Seung-Hwan Yoon In Jun Yang Ji Yeon Kim Kyung-Ha Lee Source Type: research
Seseli bocconei Guss. and S. tortuosum subsp. maritimum Guss. essential oils inhibit colon cancer cell viability
In this study, the chemical compositions of two essential oils (EOs) obtained from different parts (flowers, leaves, stems, and roots) of Seseli bocconei Guss. and of Seseli tortuosum subsp. maritimum Guss., wild endemic species of Sicily, were investigated. The main classes of metabolites for the essential oils of S. bocconei were, respectively, monoterpenes hydrocarbons for flowers, sesquiterpenes hydrocarbons for leaves, and a breakdown between the two previously mentioned classes for stems. In the case of S. tortuosum subsp. maritimum, on the other hand, the main metabolite class for all the vegetative parts analyzed (...
Source: Fitoterapia - September 14, 2023 Category: Biochemistry Authors: Alessandro Vaglica Antonella Maggio Natale Badalamenti Maurizio Bruno Marianna Lauricella Antonella D'Anneo Source Type: research
Efficacy of a 1 day Rifaximin and Metronidazole Regimen and Mechanical Bowel Preparation for Preventing Surgical Site Infection in Minimally Invasive Colorectal Cancer Surgery: A Prospective Observational Study
DISCUSSION: A 1 day rifaximin and metronidazole regimen with mechanical bowel preparation for elective minimally invasive surgery for colorectal cancer was associated with a favorable SSI rate of 2.9%, safety, and high compliance. This approach is appropriate for inclusion in the current guidelines for perioperative management of patients scheduled to undergo minimally invasive surgery for colorectal cancer.PMID:37707885 | DOI:10.1177/00031348231200667
Source: The American Surgeon - September 14, 2023 Category: Surgery Authors: Seung-Hwan Yoon In Jun Yang Ji Yeon Kim Kyung-Ha Lee Source Type: research
Seseli bocconei Guss. and S. tortuosum subsp. maritimum Guss. essential oils inhibit colon cancer cell viability
In this study, the chemical compositions of two essential oils (EOs) obtained from different parts (flowers, leaves, stems, and roots) of Seseli bocconei Guss. and of Seseli tortuosum subsp. maritimum Guss., wild endemic species of Sicily, were investigated. The main classes of metabolites for the essential oils of S. bocconei were, respectively, monoterpenes hydrocarbons for flowers, sesquiterpenes hydrocarbons for leaves, and a breakdown between the two previously mentioned classes for stems. In the case of S. tortuosum subsp. maritimum, on the other hand, the main metabolite class for all the vegetative parts analyzed (...
Source: Fitoterapia - September 14, 2023 Category: Biochemistry Authors: Alessandro Vaglica Antonella Maggio Natale Badalamenti Maurizio Bruno Marianna Lauricella Antonella D'Anneo Source Type: research
< em > KIF18A < /em > improves migration and invasion colorectal cancer (CRC) cells through inhibiting < em > PTEN < /em > signaling
CONCLUSION: In conclusion, KIF18A can further the activation of PI3K/Akt signaling pathway by means of inhibiting PTEN transcription. Therefore, it is inferred that that KIF18A is a therapeutic target for CRC.PMID:37708299 | DOI:10.18632/aging.205027
Source: Aging - September 14, 2023 Category: Biomedical Science Authors: Yuan Liu Ming Sun Bin Zhang Wenyan Zhao Source Type: research
Seseli bocconei Guss. and S. tortuosum subsp. maritimum Guss. essential oils inhibit colon cancer cell viability
In this study, the chemical compositions of two essential oils (EOs) obtained from different parts (flowers, leaves, stems, and roots) of Seseli bocconei Guss. and of Seseli tortuosum subsp. maritimum Guss., wild endemic species of Sicily, were investigated. The main classes of metabolites for the essential oils of S. bocconei were, respectively, monoterpenes hydrocarbons for flowers, sesquiterpenes hydrocarbons for leaves, and a breakdown between the two previously mentioned classes for stems. In the case of S. tortuosum subsp. maritimum, on the other hand, the main metabolite class for all the vegetative parts analyzed (...
Source: Fitoterapia - September 14, 2023 Category: Biochemistry Authors: Alessandro Vaglica Antonella Maggio Natale Badalamenti Maurizio Bruno Marianna Lauricella Antonella D'Anneo Source Type: research
Attenuated Salmonella-delivered PD-1 siRNA enhances the antitumor effects of EZH2 inhibitors in colorectal cancer
This study suggests an emerging strategy based on a combination of EZH2 inhibitor and immunotherapy based on PD-1 inhibition.PMID:37708707 | DOI:10.1016/j.intimp.2023.110918
Source: International Immunopharmacology - September 14, 2023 Category: Allergy & Immunology Authors: Mengmeng Lv Sheng Guo Xinyu Zhang Yan Zou Qiang Chen Chongyi Zang Shuo Huang Yuhan Hu Yanling Wang Qianqing Wang Jiateng Zhong Source Type: research
Pain-related stigma in patients with breast, colon, prostate or lung cancer : Results of a bicentric register-based cross-sectional study
CONCLUSIONS: Our findings support the assumption that the experience of pain can have an impact on the perceived stigmatization of cancer patients. Depression might influence the perceived stigmatization. Therefore, this group of patients should receive special attention and psycho-oncological care in clinical practice. Further research on the course and mechanisms of action of pain-related perceived stigmatization is also required.PMID:37710022 | DOI:10.1007/s00482-023-00752-3
Source: Schmerz - September 14, 2023 Category: Anesthesiology Authors: A Roicke P Esser B Hornemann J Ernst Source Type: research
A novel 4-(1,3,4-thiadiazole-2-ylthio)pyrimidine derivative inhibits cell proliferation by suppressing the MEK/ERK signaling pathway in colorectal cancer
Acta Pharm. 2023 Sep 14;73(3):489-502. doi: 10.2478/acph-2023-0025. Print 2023 Sep 1.ABSTRACTColorectal cancer (CRC) is one of the most common types of malignant cancers worldwide. Although molecularly targeted therapies have significantly improved treatment outcomes, most of these target inhibitors are resistant. Novel inhibitors as potential anticancer drug candidates are still needed to be discovered. Therefore, in the present study, we synthesized a novel 4-(1,3,4-thiadiazole-2-ylthio)pyrimidine derivative (compound 4) using fragment- and structure-based techniques and then investigated the anticancer effect and underl...
Source: Acta Pharmaceutica - September 14, 2023 Category: Drugs & Pharmacology Authors: Weiwei Li Zhifu Yang Likun Ding Ying Wang Xian Zhao Jian Jie Chu Qing Ji Minna Yao Jingwen Wang Source Type: research
< em > KIF18A < /em > improves migration and invasion colorectal cancer (CRC) cells through inhibiting < em > PTEN < /em > signaling
CONCLUSION: In conclusion, KIF18A can further the activation of PI3K/Akt signaling pathway by means of inhibiting PTEN transcription. Therefore, it is inferred that that KIF18A is a therapeutic target for CRC.PMID:37708299 | DOI:10.18632/aging.205027
Source: Aging - September 14, 2023 Category: Biomedical Science Authors: Yuan Liu Ming Sun Bin Zhang Wenyan Zhao Source Type: research
Pain-related stigma in patients with breast, colon, prostate or lung cancer : Results of a bicentric register-based cross-sectional study
CONCLUSIONS: Our findings support the assumption that the experience of pain can have an impact on the perceived stigmatization of cancer patients. Depression might influence the perceived stigmatization. Therefore, this group of patients should receive special attention and psycho-oncological care in clinical practice. Further research on the course and mechanisms of action of pain-related perceived stigmatization is also required.PMID:37710022 | DOI:10.1007/s00482-023-00752-3
Source: Schmerz - September 14, 2023 Category: Anesthesiology Authors: A Roicke P Esser B Hornemann J Ernst Source Type: research
< em > KIF18A < /em > improves migration and invasion colorectal cancer (CRC) cells through inhibiting < em > PTEN < /em > signaling
CONCLUSION: In conclusion, KIF18A can further the activation of PI3K/Akt signaling pathway by means of inhibiting PTEN transcription. Therefore, it is inferred that that KIF18A is a therapeutic target for CRC.PMID:37708299 | DOI:10.18632/aging.205027
Source: Aging - September 14, 2023 Category: Biomedical Science Authors: Yuan Liu Ming Sun Bin Zhang Wenyan Zhao Source Type: research
Efficacy of a 1 day Rifaximin and Metronidazole Regimen and Mechanical Bowel Preparation for Preventing Surgical Site Infection in Minimally Invasive Colorectal Cancer Surgery: A Prospective Observational Study
DISCUSSION: A 1 day rifaximin and metronidazole regimen with mechanical bowel preparation for elective minimally invasive surgery for colorectal cancer was associated with a favorable SSI rate of 2.9%, safety, and high compliance. This approach is appropriate for inclusion in the current guidelines for perioperative management of patients scheduled to undergo minimally invasive surgery for colorectal cancer.PMID:37707885 | DOI:10.1177/00031348231200667
Source: The American Surgeon - September 14, 2023 Category: Surgery Authors: Seung-Hwan Yoon In Jun Yang Ji Yeon Kim Kyung-Ha Lee Source Type: research
