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Cancer: Colorectal Cancer
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Total 41065 results found since Jan 2013.
Prevalence of mutations in common tumour types in Northern England and comparable utility of national and international Trial Finders
CONCLUSIONS: Regional differences in mutations may exist with advanced stage accounting for prevalence of specific mutations. A national Trial Finder shows utility in finding targeted trials whilst commercial sequencing reports may over-report 'actionable' mutations. Understanding local prevalence and trial availability could increase enrolment onto matched early phase trials.PMID:37702806 | DOI:10.1007/s00432-023-05365-y
Source: Clinical Breast Cancer - September 13, 2023 Category: Cancer & Oncology Authors: S Rae E Plummer L Fitzgerald L Hogarth A Bridgewood L Brown-Schofield J Graham S Haigh C McAnulty Y Drew N Haris S Bashir R Plummer A Greystoke Source Type: research
Battling colorectal cancer via s-triazine-based MMP-10/13 inhibitors armed with electrophilic warheads for concomitant ferroptosis induction; the first-in-class dual-acting agents
Bioorg Chem. 2023 Sep 7;141:106839. doi: 10.1016/j.bioorg.2023.106839. Online ahead of print.ABSTRACTThere is an increasing interest in halting CRC by combining ferroptosis with other forms of tumor cell death. However, ferroptosis induction is seldom studied in tandem with inhibiting MMPs. A combination that is expected to enhance the therapeutic outcome based on mechanistic ferroptosis studies highlighting the interplay with MMPs, especially MMP-13 associated with CRC metastasis and poor prognosis. Herein, we report new hybrid triazines capable of simultaneous MMP-10/13 inhibition and ferroptosis induction bridging the g...
Source: Bioorganic Chemistry - September 13, 2023 Category: Chemistry Authors: Christine A Morcos Sherine N Khattab Nesreen S Haiba Rafik W Bassily Marwa M Abu-Serie Mohamed Teleb Source Type: research
Metabolomics analysis of amino acid and fatty acids in colorectal cancer patients based on tandem mass spectrometry
In conclusion, we assessed the difference between CRC patients and NI, which supports guidelines for an early diagnosis and effective treatment.PMID:37700848 | PMC:PMC10493213 | DOI:10.3164/jcbn.22-110
Source: Clinical Biochemistry - September 13, 2023 Category: Biochemistry Authors: Zhuo Zhao Jing Bai Chang Liu Yansong Wang Shuang Wang Furong Zhao Qiufang Gu Source Type: research
Activation of vascular endothelial cells by synovial fibrosis promotes Netrin-1-induced sensory nerve sprouting and exacerbates pain sensitivity
J Cell Mol Med. 2023 Sep 13. doi: 10.1111/jcmm.17950. Online ahead of print.ABSTRACTSynovial fibrosis is one of the most dominant histopathological changes in osteoarthritis of the knee (KOA), and activation of vascular endothelial cells in synovial fibrosis is both an important factor in mediating pain in KOA and a major contributor to the generation of pain signals. At the same time, angiogenesis and nerve fibres are more likely to underlie the pathology of pain induced by synovial fibrosis. In the present study, we established a co-culture model of human umbilical vein endothelial cells (HUVECs) with dorsal root ganglio...
Source: J Cell Mol Med - September 13, 2023 Category: Molecular Biology Authors: Zhenyuan Ma Yibao Wei Taiyang Liao Lishi Jie Nan Yang Likai Yu Peimin Wang Source Type: research
pH-responsive resveratrol-loaded ZIF-8 nanoparticles modified with tannic acid for promoting colon cancer cell apoptosis
In conclusion, the Res@ZIF-8/TA NPs pH-responsive drug delivery systems we developed may offer a promising avenue for cancer therapy. By addressing some of the challenges associated with Res-based treatments, this system could contribute to advancements in cancer therapeutics.PMID:37702969 | DOI:10.1002/jbm.b.35320
Source: Biomed Res - September 13, 2023 Category: Research Authors: Xueqiang Sun Fuxin Li Lingyan Yuan Zhitong Bing Xun Li Kehu Yang Source Type: research
Different oncological features of colorectal cancer codon-specific < em > KRAS < /em > mutations: Not codon 13 but codon 12 have prognostic value
CONCLUSION: This study provides evidence that KRAS codon 13 mutation is less likely to serve as a prognostic biomarker than codon 12 mutation for CRC in a large-scale cohort.PMID:37701134 | PMC:PMC10494767 | DOI:10.3748/wjg.v29.i32.4883
Source: World Journal of Gastroenterology - September 13, 2023 Category: Gastroenterology Authors: Hong-Min Ahn Duck-Woo Kim Hyeon Jeong Oh Hyung Kyung Kim Hye Seung Lee Tae Gyun Lee Hye-Rim Shin In Jun Yang Jeehye Lee Jung Wook Suh Heung-Kwon Oh Sung-Bum Kang Source Type: research
Activation of vascular endothelial cells by synovial fibrosis promotes Netrin-1-induced sensory nerve sprouting and exacerbates pain sensitivity
J Cell Mol Med. 2023 Sep 13. doi: 10.1111/jcmm.17950. Online ahead of print.ABSTRACTSynovial fibrosis is one of the most dominant histopathological changes in osteoarthritis of the knee (KOA), and activation of vascular endothelial cells in synovial fibrosis is both an important factor in mediating pain in KOA and a major contributor to the generation of pain signals. At the same time, angiogenesis and nerve fibres are more likely to underlie the pathology of pain induced by synovial fibrosis. In the present study, we established a co-culture model of human umbilical vein endothelial cells (HUVECs) with dorsal root ganglio...
Source: Molecular Medicine - September 13, 2023 Category: Molecular Biology Authors: Zhenyuan Ma Yibao Wei Taiyang Liao Lishi Jie Nan Yang Likai Yu Peimin Wang Source Type: research
Different oncological features of colorectal cancer codon-specific < em > KRAS < /em > mutations: Not codon 13 but codon 12 have prognostic value
CONCLUSION: This study provides evidence that KRAS codon 13 mutation is less likely to serve as a prognostic biomarker than codon 12 mutation for CRC in a large-scale cohort.PMID:37701134 | PMC:PMC10494767 | DOI:10.3748/wjg.v29.i32.4883
Source: World Journal of Gastroenterology : WJG - September 13, 2023 Category: Gastroenterology Authors: Hong-Min Ahn Duck-Woo Kim Hyeon Jeong Oh Hyung Kyung Kim Hye Seung Lee Tae Gyun Lee Hye-Rim Shin In Jun Yang Jeehye Lee Jung Wook Suh Heung-Kwon Oh Sung-Bum Kang Source Type: research
Prevalence of mutations in common tumour types in Northern England and comparable utility of national and international Trial Finders
CONCLUSIONS: Regional differences in mutations may exist with advanced stage accounting for prevalence of specific mutations. A national Trial Finder shows utility in finding targeted trials whilst commercial sequencing reports may over-report 'actionable' mutations. Understanding local prevalence and trial availability could increase enrolment onto matched early phase trials.PMID:37702806 | DOI:10.1007/s00432-023-05365-y
Source: Clinical Prostate Cancer - September 13, 2023 Category: Cancer & Oncology Authors: S Rae E Plummer L Fitzgerald L Hogarth A Bridgewood L Brown-Schofield J Graham S Haigh C McAnulty Y Drew N Haris S Bashir R Plummer A Greystoke Source Type: research
MicroRNAs Regulate Tumorigenesis by Downregulating SOCS3 Expression: An < em > In silico < /em > Approach
This study identifies the interactions of known (miR-203a-5p) and novel (miR-6756-5p, miR-6732-5p, miR-1203, miR-6887-5p) microRNAs with SOCS3 regions due to their maximum interactions. Identifying the interactions of these microRNAs with SOCS3 will significantly advance the understanding of oncomiRs (miRNAs that are associated with cancer development) in tumor development due to their influence on SOCS3 expression. These insights will assist in future studies to understand the significance of miRNA-SOCS3-associated tumor development and progression.PMID:37701630 | PMC:PMC10493049 | DOI:10.1177/11779322231193535
Source: Bioinformatics and Biology Insights - September 13, 2023 Category: Bioinformatics Authors: Sura Al-Asadi Hiba Mansour Ahmed Jwaid Ataimish Rusul Al-Kahachi Jamila Rampurawala Source Type: research
Plasma Cetuximab Concentrations Correlate With Survival in Patients With Advanced KRAS Wild Type Colorectal Cancer
CONCLUSION: The standard cetuximab dosing regimen may not be optimal for all patients. Further pharmacokinetic studies are needed to optimize cetuximab dosing given the potential improvement in OS.PMID:37704538 | DOI:10.1016/j.clcc.2023.08.006
Source: Clinical Colorectal Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Di Maria Jiang Shruti Parshad Luna Zhan Hao-Wen Sim Lillian L Siu Geoffrey Liu Jeremy D Shapiro Timothy J Price Derek J Jonker Christos S Karapetis Andrew H Strickland Wenjiang Zhang Mark Jeffery Dongsheng Tu Siobhan Ng Sabe Sabesan Jenny Shannon Amanda T Source Type: research
Generalizability of Self-Supervised Training Models for Digital Pathology: A Multicountry Comparison in Colorectal Cancer
CONCLUSION: We find that using unlabeled image data for SSL pretraining in CRC related tasks is more effective than using ImageNet pretraining. Furthermore, SSL pretraining using data from multiple countries achieve more stable performance and better generalization than single-country pretraining.PMID:37703507 | DOI:10.1200/CCI.22.00178
Source: Clinical Colorectal Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Zhuchen Shao Liuxi Dai Jitendra Jonnagaddala Yang Chen Yifeng Wang Zijie Fang Yongbing Zhang Source Type: research
Prevalence of mutations in common tumour types in Northern England and comparable utility of national and international Trial Finders
CONCLUSIONS: Regional differences in mutations may exist with advanced stage accounting for prevalence of specific mutations. A national Trial Finder shows utility in finding targeted trials whilst commercial sequencing reports may over-report 'actionable' mutations. Understanding local prevalence and trial availability could increase enrolment onto matched early phase trials.PMID:37702806 | DOI:10.1007/s00432-023-05365-y
Source: Clinical Colorectal Cancer - September 13, 2023 Category: Cancer & Oncology Authors: S Rae E Plummer L Fitzgerald L Hogarth A Bridgewood L Brown-Schofield J Graham S Haigh C McAnulty Y Drew N Haris S Bashir R Plummer A Greystoke Source Type: research
Metabolomics analysis of amino acid and fatty acids in colorectal cancer patients based on tandem mass spectrometry
In conclusion, we assessed the difference between CRC patients and NI, which supports guidelines for an early diagnosis and effective treatment.PMID:37700848 | PMC:PMC10493213 | DOI:10.3164/jcbn.22-110
Source: Clinical Colorectal Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Zhuo Zhao Jing Bai Chang Liu Yansong Wang Shuang Wang Furong Zhao Qiufang Gu Source Type: research
FHIP1A-DT is a potential novel diagnostic, prognostic, and therapeutic biomarker of colorectal cancer: A pan-cancer analysis
CONCLUSION: FHIP1A-DT was a novel CRC-related lncRNA related to CRC diagnosis, prognosis, and treatment sensitivity. It could be used as a significant CRC biomarker in the future.PMID:37703762 | DOI:10.1016/j.bbrc.2023.08.059
Source: Biochemical and Biophysical Research communications - September 13, 2023 Category: Biochemistry Authors: Yongjun Yang Zuming Xiong Wenxin Li Yirong Lin Wei Huang Sen Zhang Source Type: research
