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Total 41065 results found since Jan 2013.
A novel 4-(1,3,4-thiadiazole-2-ylthio)pyrimidine derivative inhibits cell proliferation by suppressing the MEK/ERK signaling pathway in colorectal cancer
Acta Pharm. 2023 Sep 14;73(3):489-502. doi: 10.2478/acph-2023-0025. Print 2023 Sep 1.ABSTRACTColorectal cancer (CRC) is one of the most common types of malignant cancers worldwide. Although molecularly targeted therapies have significantly improved treatment outcomes, most of these target inhibitors are resistant. Novel inhibitors as potential anticancer drug candidates are still needed to be discovered. Therefore, in the present study, we synthesized a novel 4-(1,3,4-thiadiazole-2-ylthio)pyrimidine derivative (compound 4) using fragment- and structure-based techniques and then investigated the anticancer effect and underl...
Source: Acta Pharmaceutica - September 14, 2023 Category: Drugs & Pharmacology Authors: Weiwei Li Zhifu Yang Likun Ding Ying Wang Xian Zhao Jian Jie Chu Qing Ji Minna Yao Jingwen Wang Source Type: research
Seseli bocconei Guss. and S. tortuosum subsp. maritimum Guss. essential oils inhibit colon cancer cell viability
In this study, the chemical compositions of two essential oils (EOs) obtained from different parts (flowers, leaves, stems, and roots) of Seseli bocconei Guss. and of Seseli tortuosum subsp. maritimum Guss., wild endemic species of Sicily, were investigated. The main classes of metabolites for the essential oils of S. bocconei were, respectively, monoterpenes hydrocarbons for flowers, sesquiterpenes hydrocarbons for leaves, and a breakdown between the two previously mentioned classes for stems. In the case of S. tortuosum subsp. maritimum, on the other hand, the main metabolite class for all the vegetative parts analyzed (...
Source: Fitoterapia - September 14, 2023 Category: Biochemistry Authors: Alessandro Vaglica Antonella Maggio Natale Badalamenti Maurizio Bruno Marianna Lauricella Antonella D'Anneo Source Type: research
pH ‐responsive resveratrol‐loaded ZIF‐8 nanoparticles modified with tannic acid for promoting colon cancer cell apoptosis
In conclusion, the Res@ZIF-8/TA NPs pH-responsive drug delivery systems we developed may offer a promising avenue for cancer therapy . By addressing some of the challenges associated with Res-based treatments, this system could contribute to advancements in cancer therapeutics.
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 14, 2023 Category: Materials Science Authors: Xueqiang Sun,
Fuxin Li,
Lingyan Yuan,
Zhitong Bing,
Xun Li,
Kehu Yang Tags: RESEARCH ARTICLE Source Type: research
Prevalence of mutations in common tumour types in Northern England and comparable utility of national and international Trial Finders
CONCLUSIONS: Regional differences in mutations may exist with advanced stage accounting for prevalence of specific mutations. A national Trial Finder shows utility in finding targeted trials whilst commercial sequencing reports may over-report 'actionable' mutations. Understanding local prevalence and trial availability could increase enrolment onto matched early phase trials.PMID:37702806 | DOI:10.1007/s00432-023-05365-y
Source: Clinical Lung Cancer - September 13, 2023 Category: Cancer & Oncology Authors: S Rae E Plummer L Fitzgerald L Hogarth A Bridgewood L Brown-Schofield J Graham S Haigh C McAnulty Y Drew N Haris S Bashir R Plummer A Greystoke Source Type: research
Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells
Cancer Metab. 2023 Sep 13;11(1):15. doi: 10.1186/s40170-023-00315-1.ABSTRACTHypercholesterolemia is often correlated with obesity which is considered a risk factor for various cancers. With the growing population of hypercholesterolemic individuals, there is a need to understand the role of increased circulatory cholesterol or dietary cholesterol intake towards cancer etiology and pathology. Recently, abnormality in the blood cholesterol level of colon cancer patients has been reported. In the present study, we demonstrate that alteration in cholesterol levels (through a high-cholesterol or high-fat diet) increases the inc...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Shyamananda Singh Mayengbam Abhijeet Singh Himanshi Yaduvanshi Firoz Khan Bhati Bhavana Deshmukh Dipti Athavale Pranay L Ramteke Manoj Kumar Bhat Source Type: research
Activation of vascular endothelial cells by synovial fibrosis promotes Netrin-1-induced sensory nerve sprouting and exacerbates pain sensitivity
J Cell Mol Med. 2023 Sep 13. doi: 10.1111/jcmm.17950. Online ahead of print.ABSTRACTSynovial fibrosis is one of the most dominant histopathological changes in osteoarthritis of the knee (KOA), and activation of vascular endothelial cells in synovial fibrosis is both an important factor in mediating pain in KOA and a major contributor to the generation of pain signals. At the same time, angiogenesis and nerve fibres are more likely to underlie the pathology of pain induced by synovial fibrosis. In the present study, we established a co-culture model of human umbilical vein endothelial cells (HUVECs) with dorsal root ganglio...
Source: Molecular Medicine - September 13, 2023 Category: Molecular Biology Authors: Zhenyuan Ma Yibao Wei Taiyang Liao Lishi Jie Nan Yang Likai Yu Peimin Wang Source Type: research
FHIP1A-DT is a potential novel diagnostic, prognostic, and therapeutic biomarker of colorectal cancer: A pan-cancer analysis
CONCLUSION: FHIP1A-DT was a novel CRC-related lncRNA related to CRC diagnosis, prognosis, and treatment sensitivity. It could be used as a significant CRC biomarker in the future.PMID:37703762 | DOI:10.1016/j.bbrc.2023.08.059
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Yongjun Yang Zuming Xiong Wenxin Li Yirong Lin Wei Huang Sen Zhang Source Type: research
Bacterial endotoxin lipopolysaccharides regulate gene expression in human colon cancer cells
The objective of this study was to survey the effect of LPS on cell viability and gene expression of 55 molecular targets in human colon cancer cells.RESULTS: LPS did not affect the viability of COLO 225 cells under the culture conditions but affected the expression of a number of genes important in inflammatory responses and cancer development. LPS increased TTP family, GLUT family and DGAT1 mRNA levels but decreased DGAT2a and DGAT2b expression in the human colon cancer cells. LPS also increased COX2, CXCL1, ELK1, ICAM1, TNFSF10 and ZFAND5 but decreased BCL2L1, CYP19A1 and E2F1 mRNA levels in the colon cancer cells. Thes...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Heping Cao Source Type: research
Prevalence of mutations in common tumour types in Northern England and comparable utility of national and international Trial Finders
CONCLUSIONS: Regional differences in mutations may exist with advanced stage accounting for prevalence of specific mutations. A national Trial Finder shows utility in finding targeted trials whilst commercial sequencing reports may over-report 'actionable' mutations. Understanding local prevalence and trial availability could increase enrolment onto matched early phase trials.PMID:37702806 | DOI:10.1007/s00432-023-05365-y
Source: Clinical Prostate Cancer - September 13, 2023 Category: Cancer & Oncology Authors: S Rae E Plummer L Fitzgerald L Hogarth A Bridgewood L Brown-Schofield J Graham S Haigh C McAnulty Y Drew N Haris S Bashir R Plummer A Greystoke Source Type: research
pH-responsive resveratrol-loaded ZIF-8 nanoparticles modified with tannic acid for promoting colon cancer cell apoptosis
In conclusion, the Res@ZIF-8/TA NPs pH-responsive drug delivery systems we developed may offer a promising avenue for cancer therapy. By addressing some of the challenges associated with Res-based treatments, this system could contribute to advancements in cancer therapeutics.PMID:37702969 | DOI:10.1002/jbm.b.35320
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Xueqiang Sun Fuxin Li Lingyan Yuan Zhitong Bing Xun Li Kehu Yang Source Type: research
Metabolomics analysis of amino acid and fatty acids in colorectal cancer patients based on tandem mass spectrometry
In conclusion, we assessed the difference between CRC patients and NI, which supports guidelines for an early diagnosis and effective treatment.PMID:37700848 | PMC:PMC10493213 | DOI:10.3164/jcbn.22-110
Source: Clinical Biochemistry - September 13, 2023 Category: Biochemistry Authors: Zhuo Zhao Jing Bai Chang Liu Yansong Wang Shuang Wang Furong Zhao Qiufang Gu Source Type: research
MicroRNAs Regulate Tumorigenesis by Downregulating SOCS3 Expression: An < em > In silico < /em > Approach
This study identifies the interactions of known (miR-203a-5p) and novel (miR-6756-5p, miR-6732-5p, miR-1203, miR-6887-5p) microRNAs with SOCS3 regions due to their maximum interactions. Identifying the interactions of these microRNAs with SOCS3 will significantly advance the understanding of oncomiRs (miRNAs that are associated with cancer development) in tumor development due to their influence on SOCS3 expression. These insights will assist in future studies to understand the significance of miRNA-SOCS3-associated tumor development and progression.PMID:37701630 | PMC:PMC10493049 | DOI:10.1177/11779322231193535
Source: Bioinformatics and Biology Insights - September 13, 2023 Category: Bioinformatics Authors: Sura Al-Asadi Hiba Mansour Ahmed Jwaid Ataimish Rusul Al-Kahachi Jamila Rampurawala Source Type: research
Different oncological features of colorectal cancer codon-specific < em > KRAS < /em > mutations: Not codon 13 but codon 12 have prognostic value
CONCLUSION: This study provides evidence that KRAS codon 13 mutation is less likely to serve as a prognostic biomarker than codon 12 mutation for CRC in a large-scale cohort.PMID:37701134 | PMC:PMC10494767 | DOI:10.3748/wjg.v29.i32.4883
Source: World Journal of Gastroenterology - September 13, 2023 Category: Gastroenterology Authors: Hong-Min Ahn Duck-Woo Kim Hyeon Jeong Oh Hyung Kyung Kim Hye Seung Lee Tae Gyun Lee Hye-Rim Shin In Jun Yang Jeehye Lee Jung Wook Suh Heung-Kwon Oh Sung-Bum Kang Source Type: research
Activation of vascular endothelial cells by synovial fibrosis promotes Netrin-1-induced sensory nerve sprouting and exacerbates pain sensitivity
J Cell Mol Med. 2023 Sep 13. doi: 10.1111/jcmm.17950. Online ahead of print.ABSTRACTSynovial fibrosis is one of the most dominant histopathological changes in osteoarthritis of the knee (KOA), and activation of vascular endothelial cells in synovial fibrosis is both an important factor in mediating pain in KOA and a major contributor to the generation of pain signals. At the same time, angiogenesis and nerve fibres are more likely to underlie the pathology of pain induced by synovial fibrosis. In the present study, we established a co-culture model of human umbilical vein endothelial cells (HUVECs) with dorsal root ganglio...
Source: J Cell Mol Med - September 13, 2023 Category: Molecular Biology Authors: Zhenyuan Ma Yibao Wei Taiyang Liao Lishi Jie Nan Yang Likai Yu Peimin Wang Source Type: research
