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Total 81081 results found since Jan 2013.
New SARS-CoV-2 Omicron Variant with Spike Protein Mutation Y451H, Kilifi, Kenya, March-May 2023
We report a newly emerged SARS-CoV-2 Omicron subvariant FY.4 that has mutations Y451H in spike and P42L in open reading frame 3a proteins. FY.4 emergence coincided with increased SARS-CoV-2 cases in coastal Kenya during April-May 2023. Continued SARS-CoV-2 genomic surveillance is needed to identify new lineages to inform COVID-19 outbreak prevention.PMID:37708843 | DOI:10.3201/eid2911.230894
Source: Emerging Infectious Diseases - September 14, 2023 Category: Infectious Diseases Authors: Mike J Mwanga Arnold W Lambisia John Mwita Morobe Nickson Murunga Edidah Moraa Leonard Ndwiga Robinson Cheruiyot Jennifer Musyoki Martin Mutunga Laura M Guzman-Rincon Charles Sande Joseph Mwangangi Philip Bejon Lynette Isabella Ochola-Oyier D James Nokes Source Type: research
One-step selective layer assemble: A versatile approach for the development of a SARS-CoV-2 electrochemical immunosensor
Anal Chim Acta. 2023 Oct 16;1278:341726. doi: 10.1016/j.aca.2023.341726. Epub 2023 Aug 16.ABSTRACTThe appearance of new viruses and diseases has made the development of rapid and reliable diagnostic tests crucial. In light of it, we proposed a new method for assembling an electrochemical immunosensor, based on a one-step approach for selective layer formation. For this purpose, a mixture containing the immobilizing agent (polyxydroxybutyrate, PHB) and the recognition element (antibodies against SARS-CoV-2 nucleocapsid protein) was prepared and used to modify a screen-printed carbon electrode with electrodeposited graphene ...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Gustavo Martins Helena R Galeski Gabrielle A Andrade Marcia G P Valenga Maria K Ramos Aldo J G Zarbin Bruno C Janegitz Marcelo M üller-Santos Emanuel M de Souza Luiz Humberto Marcolino-Junior M árcio F Bergamini Source Type: research
Wastewater Surveillance Data as a Complement to Emergency Department Visit Data for Tracking Incidence of Influenza A and Respiratory Syncytial Virus - Wisconsin, August 2022-March 2023
MMWR Morb Mortal Wkly Rep. 2023 Sep 15;72(37):1005-1009. doi: 10.15585/mmwr.mm7237a2.ABSTRACTWastewater surveillance has been used to assist public health authorities in tracking local transmission of SARS-CoV-2. The usefulness of wastewater surveillance to track community spread of other respiratory pathogens, including influenza virus and respiratory syncytial virus (RSV), is less clear. During the 2022-23 respiratory diseases season, concentrations of influenza A virus and RSV in wastewater samples in three major Wisconsin cities were compared with emergency department (ED) visits associated with these pathogens. In all...
Source: MMWR Morb Mortal Wkl... - September 14, 2023 Category: Epidemiology Authors: Peter M DeJonge Carly Adams Ian Pray Melissa K Schussman Rebecca B Fahney Martin Shafer Dagmara S Antkiewicz Ad élaïde Roguet Source Type: research
Idiopathic pulmonary fibrosis (IPF): disease pathophysiology, targets, and potential therapeutic interventions
In this study, we focus on the IPF and COVID-19 pathogenesis and the potential role of Apigenin in addressing disease progression.PMID:37707699 | DOI:10.1007/s11010-023-04845-6
Source: Molecular and Cellular Biochemistry - September 14, 2023 Category: Biochemistry Authors: Pritha Saha Priti Talwar Source Type: research
Bibliometric analysis of the worldwide scientific production on COVID-19 infection and cerebrovascular disease
CONCLUSION: It was observed that the United States was the country with the highest scientific production on COVID-19 and cerebrovascular disease in the year 2020 in the different health areas; however, more research is still needed worldwide for a better analysis of the bibliometric indicators on the subject.PMID:37706386 | PMC:PMC10284493 | DOI:10.4103/aca.aca_70_22
Source: Annals of Cardiac Anaesthesia - September 14, 2023 Category: Anesthesiology Authors: Camila Palomino-Leyva Jhonny Rivera-Recuenco Alicia Fernandez-Giusti John Barja-Ore Yesenia Retamozo-Siancas Frank Mayta-Tovalino Source Type: research
Obtaining a high titer of polyclonal antibodies from rats to the SARS-CoV-2 nucleocapsid protein and its N- and C-terminal domains for diagnostic test development
J Immunol Methods. 2023 Sep 11:113558. doi: 10.1016/j.jim.2023.113558. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is an enveloped, plus-stranded RNA virus responsible for the Coronavirus Disease 2019 (COVID-19). Patients infected with COVID-19 may be asymptomatic or have symptoms ranging from mild manifestations to severe cases of the disease that could lead to death. The SARS-CoV-2 genome encodes 4 structural proteins, including the Spike protein (S), the Nucleocapsid protein (N), membrane protein (M) and, the envelope (E). The N protein forms a major component of the ribonu...
Source: Journal of Immunological Methods - September 13, 2023 Category: Allergy & Immunology Authors: Michelle Teixeira de Almeida Ana Paula Barbosa Camila Gasque Bomfim Aline Biazola Visnardi Tania Churasacari Vinces Alexandre Ceroni Edison Luiz Durigon Cristiane Rodrigues Guzzo Source Type: research
SARS-CoV-2 viral genes Nsp6, Nsp8, and M compromise cellular ATP levels to impair survival and function of human pluripotent stem cell-derived cardiomyocytes
CONCLUSION: Overall, our findings uncover the extensive damaging effects of Nsp6, Nsp8, and M on hPSC-CMs, underlining the crucial role of ATP homeostasis in CM death and functional abnormalities induced by these SARS-CoV-2 genes, and reveal the potential therapeutic strategies to alleviate these detrimental effects with FDA-approved drugs.PMID:37705046 | DOI:10.1186/s13287-023-03485-3
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Juli Liu Shiyong Wu Yucheng Zhang Cheng Wang Sheng Liu Jun Wan Lei Yang Source Type: research
Omicron sub-lineage BA.5 infection results in attenuated pathology in hACE2 transgenic mice
Commun Biol. 2023 Sep 13;6(1):935. doi: 10.1038/s42003-023-05263-6.ABSTRACTA recently emerged sub-lineage of Omicron, BA.5, together with BA.4, caused a fifth wave of coronavirus disease (COVID-19) in South Africa and subsequently emerged as a predominant strain globally due to its high transmissibility. The lethality of BA.5 infection has not been studied in an acute hACE2 transgenic (hACE2.Tg) mouse model. Here, we investigated tissue-tropism and immuno-pathology induced by BA.5 infection in hACE2.Tg mice. Our data show that intranasal infection of BA.5 in hACE2.Tg mice resulted in attenuated pulmonary infection and path...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Zaigham Abbas Rizvi Jyotsna Dandotiya Srikanth Sadhu Ritika Khatri Janmejay Singh Virendra Singh Neeta Adhikari Kritika Sharma Vinayake Das Amit Kumar Pandey Bhabatosh Das Guruprasad Medigeshi Shalendra Mani Shinjini Bhatnagar Sweety Samal Anil Kumar Pand Source Type: research
Suramin inhibits SARS-CoV-2 nucleocapsid phosphoprotein genome packaging function
Virus Res. 2023 Sep 11:199221. doi: 10.1016/j.virusres.2023.199221. Online ahead of print.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic is fading, however its etiologic agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues posing - despite the availability of licensed vaccines - a global health threat, due to the potential emergence of vaccine-resistant SARS-CoV-2 variants. This makes the development of new drugs against COVID-19 a persistent urgency and sets as research priority the validation of novel therapeutic targets within the SARS-CoV-2 proteome. Among these, a promising one is the...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Irene Boniardi Angela Corona Jerome Basquin Claire Basquin Jessica Milia Istv án Nagy Enzo Tramontano Luca Zinzula Source Type: research
Prevalence of SARS-CoV-2 infection and impact of vaccination in dialysis patients over two years of the pandemic
J Nephrol. 2023 Sep 13. doi: 10.1007/s40620-023-01754-1. Online ahead of print.NO ABSTRACTPMID:37702913 | DOI:10.1007/s40620-023-01754-1
Source: Journal of Nephrology - September 13, 2023 Category: Urology & Nephrology Authors: Paolo Hitz Alberto Pagnamenta Laura Pertusini Tatiana Terrot Yves Franzosi Jessica Bassi Chiara Silacci-Fregni Valeria Gaia Gladys Martinetti Franco Keller Lorenzo Berwert Valentina Forni Ogna Soraya Lavorato-Hadjeres Davide Giunzioni Andrea D'Ermo Alan V Source Type: research
Inflammasome activation by SARS-CoV-2 and its participation in COVID-19 exacerbation
Curr Opin Immunol. 2023 Sep 11;84:102387. doi: 10.1016/j.coi.2023.102387. Online ahead of print.ABSTRACTCOVID-19 is an infectious and inflammatory disease caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome-Coronavirus-2) that might progress to severe illness in humans, characterized by excessive pulmonary and systemic inflammation. Exacerbated production of inflammatory cytokines and cell death contributes to disease aggravation and the inflammasomes take a central stage in this process. Activation of the NLRP3 has been demonstrated in macrophages and monocytes infected in vitro, in mouse models of infection, and in c...
Source: Current Opinion in Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Tamara S Rodrigues Dario S Zamboni Source Type: research
Impact of the early months of the COVID-19 pandemic on the sleep patterns of a Brazilian population sample
Chronobiol Int. 2023 Sep 12:1-13. doi: 10.1080/07420528.2023.2255667. Online ahead of print.ABSTRACTHumanitarian and health crisis have drastic effects on the physical and mental well-being of people. The COVID-19 pandemic forced many countries to impose containment measures on its population to halt the spread of the new coronavirus (SARS-CoV-2). This aim of this study was to explore self-reported sleep quality and insomnia symptoms in a sample of the Brazilian population before and during the COVID-19 quarantine period. Our data was collected through online questionnaires, including the Pittsburgh Sleep Quality Index, th...
Source: Chronobiology International - September 13, 2023 Category: Biology Authors: Sergio Brasil Tufik Gabriel Natan Pires Allan Saj Porcacchia Andr éia Gomes Bezerra Monica Levy Andersen Sergio Tufik Source Type: research
Suramin inhibits SARS-CoV-2 nucleocapsid phosphoprotein genome packaging function
Virus Res. 2023 Sep 11:199221. doi: 10.1016/j.virusres.2023.199221. Online ahead of print.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic is fading, however its etiologic agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues posing - despite the availability of licensed vaccines - a global health threat, due to the potential emergence of vaccine-resistant SARS-CoV-2 variants. This makes the development of new drugs against COVID-19 a persistent urgency and sets as research priority the validation of novel therapeutic targets within the SARS-CoV-2 proteome. Among these, a promising one is the...
Source: Virus Research - September 13, 2023 Category: Virology Authors: Irene Boniardi Angela Corona Jerome Basquin Claire Basquin Jessica Milia Istv án Nagy Enzo Tramontano Luca Zinzula Source Type: research
COVID-19 vaccine booster doses provide increased protection against COVID-19 hospitalization compared with previously vaccinated individuals: Interim findings from the REFORCO-Brazil real-world effectiveness study during Delta and Omicron
CONCLUSIONS: Our results support the use of AZD1222 and other adenoviral/mRNA vaccine boosters to maintain protection against COVID-19 hospitalization from Omicron subvariants, including in elderly and immunocompromised individuals at increased risk of accelerated waning or severe outcomes.PMID:37704499 | DOI:10.1016/j.vaccine.2023.08.085
Source: Vaccine - September 13, 2023 Category: Allergy & Immunology Authors: Wilhelmine Meeraus Anke L Stuurman Ilgaz Durukal Eduardo Conde-Sousa Andrew Lee Andr é Santa Maria B árbara Emoingt Furtado Mario Ouwens Christen M Gray Douglas Andreas Valverde Hugo Gomes da Silva Sylvia Taylor Source Type: research
