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Condition: SARS
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Total 81081 results found since Jan 2013.
Farnesoid X receptor enhances epithelial ACE2 expression and inhibits viral-induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2
CONCLUSION: By virtue of its ability to modulate epithelial ACE2 expression and inhibit virus-mediated pro-inflammatory cytokine release, FXR represents a promising target for development of new approaches to prevent intestinal manifestations of SARS-CoV-2.PMID:37697930 | DOI:10.1152/ajpgi.00099.2023
Source: Am J Physiol Gastroi... - September 12, 2023 Category: Gastroenterology Authors: Jessica S Smyth Jennifer K Truong Anuradha Rao Jennifer Foulke-Abel Luciano Adorini Mark Donowitz Paul A Dawson Stephen J Keely Source Type: research
Airway Basal Stem Cells in COVID-19 Exhibit a Proinflammatory Signature and Impaired Mucocililary Differentiation
This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).PMID:37699145 | DOI:10.1165/rcmb.2023-0104OC
Source: Am J Respir Cell Mol... - September 12, 2023 Category: Respiratory Medicine Authors: Kamakshi Bankoti Wei Wang Gaurang M Amonkar Linjie Xiong Jessica E Shui Caiqi Zhao Eric Van Chimwemwe Mwase Jin-Ah Park Hongmei Mou Yinshan Fang Jianwen Que Yan Bai Paul H Lerou Xingbin Ai Source Type: research
Farnesoid X receptor enhances epithelial ACE2 expression and inhibits viral-induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2
CONCLUSION: By virtue of its ability to modulate epithelial ACE2 expression and inhibit virus-mediated pro-inflammatory cytokine release, FXR represents a promising target for development of new approaches to prevent intestinal manifestations of SARS-CoV-2.PMID:37697930 | DOI:10.1152/ajpgi.00099.2023
Source: Am J Physiol Gastroi... - September 12, 2023 Category: Gastroenterology Authors: Jessica S Smyth Jennifer K Truong Anuradha Rao Jennifer Foulke-Abel Luciano Adorini Mark Donowitz Paul A Dawson Stephen J Keely Source Type: research
Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19
Life Sci Alliance. 2023 Sep 12;6(11):e202302106. doi: 10.26508/lsa.202302106. Print 2023 Nov.ABSTRACTPreviously, we and others have shown that SARS-CoV-2 spike-specific IgG antibodies play a major role in disease severity in COVID-19 by triggering macrophage hyperactivation, disrupting endothelial barrier integrity, and inducing thrombus formation. This hyperinflammation is dependent on high levels of anti-spike IgG with aberrant Fc tail glycosylation, leading to Fcγ receptor hyperactivation. For development of immune-regulatory therapeutics, drug specificity is crucial to counteract excessive inflammation whereas simulta...
Source: Atherosclerosis - September 12, 2023 Category: Cardiology Authors: Chiara E Geyer Hung-Jen Chen Alexander P Bye Xue D Manz Denise Guerra Tom G Caniels Tom Pl Bijl Guillermo R Griffith Willianne Hoepel Steven W de Taeye Jennifer Veth Alexander Pj Vlaar Amsterdam UMC COVID-19 Biobank Gestur Vidarsson Harm Jan Bogaard Jurja Source Type: research
Farnesoid X receptor enhances epithelial ACE2 expression and inhibits viral-induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2
CONCLUSION: By virtue of its ability to modulate epithelial ACE2 expression and inhibit virus-mediated pro-inflammatory cytokine release, FXR represents a promising target for development of new approaches to prevent intestinal manifestations of SARS-CoV-2.PMID:37697930 | DOI:10.1152/ajpgi.00099.2023
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - September 12, 2023 Category: Physiology Authors: Jessica S Smyth Jennifer K Truong Anuradha Rao Jennifer Foulke-Abel Luciano Adorini Mark Donowitz Paul A Dawson Stephen J Keely Source Type: research
Comparative effectiveness of mRNA-1273 and BNT162b2 COVID-19 vaccines in immunocompromised individuals: a systematic review and meta-analysis using the GRADE framework
ConclusionThis GRADE meta-analysis based on a large number of consistent observational studies showed that the mRNA-1273 COVID-19 vaccine is associated with improved clinical effectiveness in IC populations compared with BNT162b2.
Source: Frontiers in Immunology - September 12, 2023 Category: Allergy & Immunology Source Type: research
Metformin and Covid-19: a systematic review of systematic reviews with meta-analysis
Conclusions More in-depth studies on the use of metformin, compared to other molecules, may be required to understand the real protective potential of the drug against negative outcomes caused by COVID-19 infection in DM2 patients.PMID:37695186 | DOI:10.23750/abm.v94iS3.14405
Source: Acta Bio-Medica : Atenei Parmensis - September 11, 2023 Category: General Medicine Authors: Fabio Petrelli Iolanda Grappasonni Cuc Thi Thu Nguyen Marina Tesauro Paola Pantanetti Sonila Xhafa Giovanni Cangelosi Source Type: research
Herpes zoster in a patient with first onset of childhood nephrotic syndrome following the second SARS-CoV-2 vaccination
CEN Case Rep. 2023 Sep 11. doi: 10.1007/s13730-023-00818-2. Online ahead of print.NO ABSTRACTPMID:37695475 | DOI:10.1007/s13730-023-00818-2
Source: Herpes - September 11, 2023 Category: Infectious Diseases Authors: Kaoru Nakashima Tomoko Horinouchi Yu Tanaka Yuta Ichikawa Kandai Nozu Source Type: research
