Filtered By:
Condition: SARS
This page shows you your search results in order of date. This is page number 20.
Order by Relevance | Date
Total 81081 results found since Jan 2013.
The Power of Molecular Dynamics Simulations and Their Applications to Discover Cysteine Protease Inhibitors
Mini Rev Med Chem. 2023 Sep 1. doi: 10.2174/1389557523666230901152257. Online ahead of print.ABSTRACTA large family of enzymes with the function of hydrolyzing peptide bonds, called peptidases or cysteine proteases (CPs), are divided into three categories according to the peptide chain involved. CPs catalyze the hydrolysis of amide, ester, thiol ester, and thioester peptide bonds. They can be divided into several groups, such as papain-like (CA), viral chymotrypsin-like CPs (CB), papain-like endopeptidases of RNA viruses (CC), legumain-type caspases (CD), and showing active residues of His, Glu/Asp, Gln, Cys (CE). The cata...
Source: Mini Reviews in Medicinal Chemistry - September 8, 2023 Category: Chemistry Authors: Igor Jos é Dos Santos Nascimento Joilly Nilce Santana Gomes J éssika de Oliveira Viana Yvnni Maria Sales de Medeiros E Silva Euz ébio Guimarães Barbosa Ricardo Olimpio de Moura Source Type: research
A fully integrated duplex RT-LAMP device for the detection of viral infections
In this study, we showed and evaluated a prototype of a microfluidic system, and showed that duplex RT-LAMP can detect and distinguish between the two viruses, with LoDs of 2,000 copies/ml for bovine coronavirus and 200 copies/ml for influenza A/X-31 virus.PMID:37682413 | PMC:PMC10491696 | DOI:10.1007/s10544-023-00676-w
Source: Biomedical Microdevices - September 8, 2023 Category: Biomedical Engineering Authors: Nicolas Mytzka Skaiste Arbaciauskaite Natalia Sandetskaya Kai Mattern Dirk Kuhlmeier Source Type: research
USE OF RECOMBINANT S1 PROTEIN WITH hFc FOR ANALYSIS OF SARS-COV-2 ADSORPTION AND EVALUATION OF DRUGS THAT INHIBIT ENTRY INTO VERO E6 CELLS
Immunol Lett. 2023 Sep 6:S0165-2478(23)00145-1. doi: 10.1016/j.imlet.2023.09.002. Online ahead of print.ABSTRACTThe significant number of deaths and cases of infection by the new coronavirus SARS-CoV-2 requires an urgent demand for effective and available drugs for the treatment of COVID-19.However, the need for biosafety level 3 (NB-3) laboratories for experiments with the virus has made it very difficult for such research to meet this demand. It is known that angiotensin-converting enzyme 2 (ACE2), located on the surface of host cells, is the viral receptor for the spike (S) protein of SARS-CoV-2. This protein is a tetra...
Source: Immunology Letters - September 8, 2023 Category: Allergy & Immunology Authors: J éssica Carla Martins Couto Ta ís Vidal Eduardo Reichert Decker Janio M Santurio Carlos Fernando de Mello Micheli Mainardi Pillat Source Type: research
A fully integrated duplex RT-LAMP device for the detection of viral infections
In this study, we showed and evaluated a prototype of a microfluidic system, and showed that duplex RT-LAMP can detect and distinguish between the two viruses, with LoDs of 2,000 copies/ml for bovine coronavirus and 200 copies/ml for influenza A/X-31 virus.PMID:37682413 | PMC:PMC10491696 | DOI:10.1007/s10544-023-00676-w
Source: Biomedical Microdevices - September 8, 2023 Category: Biomedical Engineering Authors: Nicolas Mytzka Skaiste Arbaciauskaite Natalia Sandetskaya Kai Mattern Dirk Kuhlmeier Source Type: research
Nanotechnology-based theranostic and prophylactic approaches against SARS-CoV-2
AbstractSARS-CoV-2 (COVID-19) pandemic has been an unpredicted burden on global healthcare system by infecting over 700 million individuals, with approximately 6 million deaths worldwide. COVID-19 significantly impacted all sectors, but it very adversely affected the healthcare system. These effects were much more evident in the resource limited part of the world. Individuals with acute conditions were also severely impacted. Although classical COVID-19 diagnostics such as RT-PCR and rapid antibody testing have played a crucial role in reducing the spread of infection, these diagnostic techniques are associated with certai...
Source: Immunologic Research - September 8, 2023 Category: Allergy & Immunology Source Type: research
First cases of SARS-CoV-2 BA.2.86 in Denmark, 2023
We describe 10 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant BA.2.86 detected in Denmark, including molecular characteristics and results from wastewater surveillance that indicate that the variant is circulating in the country at a low level. This new variant with many spike gene mutations was classified as a variant under monitoring by the World Health Organization on 17 August 2023. Further global monitoring of COVID-19, BA.2.86 and other SARS-CoV-2 variants is highly warranted.PMID:37676147 | DOI:10.2807/1560-7917.ES.2023.28.36.2300460
Source: Euro Surveill - September 7, 2023 Category: Infectious Diseases Authors: Morten Rasmussen Frederik Trier M øller Vithiagaran Gunalan Sharmin Baig Marc Bennedb æk Lasse Engbo Christiansen Arieh Sierra Cohen Kirsten Ellegaard Anders Fomsgaard Kristina Tr æholt Franck Nicolai Balle Larsen Tine Graakj ær Larsen Ria Lassauni è Source Type: research
A standardised protocol for relative SARS-CoV-2 variant severity assessment, applied to Omicron BA.1 and Delta in six European countries, October 2021 to February 2022
In conclusion, this study demonstrates the feasibility of conducting variant severity analyses in a multinational collaborative framework and adds evidence for the reduced severity of the Omicron BA.1 variant.PMID:37676146 | DOI:10.2807/1560-7917.ES.2023.28.36.2300048
Source: Euro Surveill - September 7, 2023 Category: Infectious Diseases Authors: Tommy Nyberg Peter Bager Ingrid Bech Svalgaard Dritan Bejko Nick Bundle Josie Evans Tyra Grove Krause Jim McMenamin Jo ël Mossong Heather Mutch Ajibola Omokanye Andr é Peralta-Santos Pedro Pinto-Leite Jostein Starrfelt Simon Thelwall Lamprini Veneti Rob Source Type: research
