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How does the Immunological System Change during the SARS-COV-2 Attack? A Clue for the New Immunotherapy Discovery
Curr Med Chem. 2023 Sep 18. doi: 10.2174/0929867331666230918092749. Online ahead of print.ABSTRACTThe COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COV-2) is one of the biggest unsolved global problems of the 21st century for which there has been no definitive cure yet. Like other respiratory viruses, SARS-COV-2 triggers the host immunity dramatically, causing dysfunction in the immune system, both innate and adaptive, which is a common feature of COVID-19 patients. Evidence shows that in the early stages of COVID-19, the immune system is suppressed while it is overactive in severe p...
Source: Current Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Mohammad Mahdi Hajihasani Najmeh Kaffash Farkhad Ali Mahmoudi Amirhossein Sahebkar Source Type: research

Correlative CD4 and CD8 T-cell immunodominance in humans and mice: Implications for preclinical testing
In this study, we addressed this matter by analyzing experimentally identified epitopes based on published data curated in the Immune Epitopes DataBase (IEDB) database. We first analyzed SARS-CoV-2 spike (S) and nucleoprotein (N), which are two common targets of the immune response and well studied in both human and mouse systems. We observed a weak but statistically significant correlation between human and H-2b mouse T-cell responses (CD8 S specific (r = 0.206, p = 1.37 × 10-13); CD4 S specific (r = 0.118, p = 2.63 × 10-5) and N specific (r = 0.179, p = 2.55 × 10-4)). Due to intrinsic differences in MHC molecules acro...
Source: Cellular and Molecular Immunology - September 19, 2023 Category: Molecular Biology Authors: Tertuliano Alves Pereira Neto John Sidney Alba Grifoni Alessandro Sette Source Type: research

Clinical Utility of Sero-Immunological Responses Against SARS-CoV-2 Nucleocapsid Protein During Subsequent Prevalence of Wild-Type, Delta Variant, and Omicron Variant
In conclusion, nucleocapsid antibody provides instructive clues about the immunogenicity of nucleocapsid proteins by different seroconversion rates and titers according to the severity of infection, host immune status, and different variants of concern.PMID:37724496 | PMC:PMC10506902 | DOI:10.3346/jkms.2023.38.e292
Source: J Korean Med Sci - September 19, 2023 Category: General Medicine Authors: Beomki Lee Jae-Hoon Ko Jin Yang Baek Haein Kim Kyungmin Huh Sun Young Cho Cheol-In Kang Doo Ryeon Chung Kyong Ran Peck Eun-Suk Kang Source Type: research

Preclinical evaluation of a SARS-CoV-2 variant B.1.351-based candidate DNA vaccine
Vaccine. 2023 Sep 17:S0264-410X(23)01091-5. doi: 10.1016/j.vaccine.2023.09.021. Online ahead of print.ABSTRACTThe SARS-CoV-2 pandemic revealed the critical shortfalls of global vaccine availability for emergent pathogens and the need for exploring additional vaccine platforms with rapid update potential in response to new variants. Thus, it remains essential, for the present evolving SARS-CoV-2/Covid-19 and future pandemics, to continuously develop and characterize new and different vaccine platforms. Here, we describe an expression-optimized DNA vaccine candidate based on the SARS-CoV-2 spike protein of the Beta variant (...
Source: Vaccine - September 19, 2023 Category: Allergy & Immunology Authors: Ria Lassauni ère Charlotta Polacek Jeanette Linnea Tingstedt Anders Fomsgaard Source Type: research

Nonclinical safety assessment of an mRNA Covid ‐19 vaccine candidate following repeated administrations and biodistribution
AbstractMessenger RNA (mRNA) vaccines have demonstrated efficacy against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in humans. mRNA technology holds tremendous potential for rapid control and prevention of emergencies due to its flexibility with respect to production, application, and design for an efficacious and safe use in humans. We assessed the toxicity and biodistribution of MRT5500, an mRNA vaccine encoding for the full-length of the SARS-CoV-2 spike protein and delivered by lipid nanoparticles (LNPs) containing a novel ionizable lipid, Lipid-1 in preclinical animal models. In the repeated dose tox...
Source: Journal of Applied Toxicology - September 19, 2023 Category: Toxicology Authors: Karine Broudic, S ébastien Laurent, Vladimir Perkov, Charlene Simon, Marie Garinot, Nathalie Truchot, Julie Latour, Paul Désert Tags: RESEARCH ARTICLE Source Type: research

Transcriptome-based analysis of human peripheral blood reveals regulators of immune response in different viral infections
DiscussionThe identified relationships between some of them and virus-induced alteration of immune functions are new and have not been found earlier, e.g., receptors for autocrine motility factor, insulin, prolactin, angiotensin II, and immunoglobulin epsilon. Modulation of the identified receptors can be investigated as one of therapeutic strategies for the treatment of severe viral infections.
Source: Frontiers in Immunology - September 19, 2023 Category: Allergy & Immunology Source Type: research

Molecules, Vol. 28, Pages 6696: Antiviral Effect of 5 & prime;-Arylchalcogeno-3-aminothymidine Derivatives in SARS-CoV-2 Infection
Molecules, Vol. 28, Pages 6696: Antiviral Effect of 5′-Arylchalcogeno-3-aminothymidine Derivatives in SARS-CoV-2 Infection Molecules doi: 10.3390/molecules28186696 Authors: Amanda Resende Tucci Raquel Mello da Rosa Alice Santos Rosa Otávio Augusto Chaves Vivian Neuza Santos Ferreira Thamara Kelcya Fonseca Oliveira Daniel Dias Coutinho Souza Nathalia Roberto Resende Borba Luciano Dornelles Nayra Salazar Rocha João Candido Pilar Mayer João B. Teixeira da Rocha Oscar Endrigo D. Rodrigues Milene Dias Miranda The understanding that zidovudine (ZDV or azidothymidine, AZT) inhibits t...
Source: Molecules - September 19, 2023 Category: Chemistry Authors: Amanda Resende Tucci Raquel Mello da Rosa Alice Santos Rosa Ot ávio Augusto Chaves Vivian Neuza Santos Ferreira Thamara Kelcya Fonseca Oliveira Daniel Dias Coutinho Souza Nathalia Roberto Resende Borba Luciano Dornelles Nayra Salazar Rocha Jo ão Candido Tags: Article Source Type: research

NewsCAP: Comparing SARS-CoV-2 home testing with RT-PCR and viral culture
Am J Nurs. 2022 Oct 1;122(10):15. doi: 10.1097/01.NAJ.0000890192.41745.c3.NO ABSTRACTPMID:37718954 | DOI:10.1097/01.NAJ.0000890192.41745.c3
Source: The American Journal of Nursing - September 18, 2023 Category: Nursing Source Type: research

Myositis after SARS-CoV-2 vaccination occurs more frequently than assumed and is probably causally related
Reumatismo. 2023 Sep 18;75(3). doi: 10.4081/reumatismo.2023.1601.ABSTRACTWe read with interest the article by Camargo-Coronel et al. reporting on a systematic review of patients with idiopathic, inflammatory myopathy developing after anti-SARS-CoV-2 vaccinations.PMID:37721345 | DOI:10.4081/reumatismo.2023.1601
Source: Reumatismo - September 18, 2023 Category: Rheumatology Authors: J Finsterer A S MohanaSundaram F Scorza Source Type: research

Response to: myositis after SARS-CoV-2 vaccination occurs more frequently than assumed and is probably causally related
Reumatismo. 2023 Sep 18;75(3). doi: 10.4081/reumatismo.2023.1623.ABSTRACTWe thank Finsterer et al. for the attention paid to our publication; we recognize the validity of the points mentioned in their letter to the editor and will try to answer the observations made.PMID:37721344 | DOI:10.4081/reumatismo.2023.1623
Source: Reumatismo - September 18, 2023 Category: Rheumatology Authors: H Qui ñones-Moya A Camargo-Coronel M R Hern ández-Zavala Source Type: research

Monitoring strategy of COVID-19 vaccination in dialysis patients based on a multiplex immunodot method: The CovidDial study
CONCLUSION: Three doses of mRNA-1273 vaccine induce a robust but time-limited immunologic response in dialysis patients. Lower anti-spike antibodies titers after initial vaccination are associated with a higher risk to subsequently contract SARS-CoV-2, even beyond 6 months.PMID:37718617 | DOI:10.1111/sdi.13175
Source: Seminars in Dialysis - September 18, 2023 Category: Urology & Nephrology Authors: Fr édéric Debelle Vo Thanh Phuong Nguyen Laurence Boitquin Miguel-Ange Guillen-Anaya Fabrice Gankam Anne-Emilie Decl èves CoviDial study group Source Type: research

High incidence of SARS-CoV-2 severe pneumonia in urban metropolitan areas: a  suggestive pathogenetic hypothesis
Wien Klin Wochenschr. 2023 Sep 18. doi: 10.1007/s00508-023-02279-0. Online ahead of print.NO ABSTRACTPMID:37721587 | DOI:10.1007/s00508-023-02279-0
Source: Wiener Klinische Wochenschrift - September 18, 2023 Category: General Medicine Authors: Nicola Abrescia Adelaide Maddaloni Maurizio D'Abbraccio Mario De Marco Source Type: research

CHEDDAR score versus YEARS algorithm for suspected pulmonary embolism in SARS-CoV-2-infected patients: A comparison of two strategies
Eur J Intern Med. 2023 Sep 16:S0953-6205(23)00328-X. doi: 10.1016/j.ejim.2023.09.008. Online ahead of print.NO ABSTRACTPMID:37722931 | DOI:10.1016/j.ejim.2023.09.008
Source: European Journal of Internal Medicine - September 18, 2023 Category: Internal Medicine Authors: Anabel Franco-Moreno Aida Izquierdo-Mart ínez Idoia Pagai-Valc árcel Juan Torres-Macho Cristina Luc ía de Ancos-Aracil CHEDDAR Research Group Source Type: research

Outpatient Treatment of Confirmed COVID-19: A Living, Rapid Evidence Review for the American College of Physicians (Version 2)
CONCLUSION: Nirmatrelvir-ritonavir and molnupiravir probably improve outcomes for outpatients with mild to moderate COVID-19.PRIMARY FUNDING SOURCE: American College of Physicians. (PROSPERO: CRD42023406456).PMID:37722115 | DOI:10.7326/M23-1626
Source: Annals of Internal Medicine - September 18, 2023 Category: Internal Medicine Authors: Isolde Sommer Dominic Ledinger Kylie Thaler Andreea Dobrescu Emma Persad Martin Fangmeyer Irma Klerings Gerald Gartlehner Source Type: research

Outpatient Treatment of Confirmed COVID-19: Living, Rapid Practice Points From the American College of Physicians (Version 2)
Ann Intern Med. 2023 Sep 19. doi: 10.7326/M23-1636. Online ahead of print.ABSTRACTDESCRIPTION: Evidence for the use of outpatient treatments in adults with confirmed COVID-19 continues to evolve with new data. This is version 2 of the American College of Physicians (ACP) living, rapid practice points focusing on 22 outpatient treatments for COVID-19, specifically addressing the dominant SARS-CoV-2 Omicron variant.METHODS: The Population Health and Medical Science Committee (formerly the Scientific Medical Policy Committee) developed this version of the living, rapid practice points on the basis of a living, rapid review do...
Source: Annals of Internal Medicine - September 18, 2023 Category: Internal Medicine Authors: Amir Qaseem Jennifer Yost George M Abraham Rebecca Andrews Janet A Jokela Matthew C Miller Linda L Humphrey Population Health and Medical Science Committee of the American College of Physicians Source Type: research