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One-step selective layer assemble: A versatile approach for the development of a SARS-CoV-2 electrochemical immunosensor
Anal Chim Acta. 2023 Oct 16;1278:341726. doi: 10.1016/j.aca.2023.341726. Epub 2023 Aug 16.ABSTRACTThe appearance of new viruses and diseases has made the development of rapid and reliable diagnostic tests crucial. In light of it, we proposed a new method for assembling an electrochemical immunosensor, based on a one-step approach for selective layer formation. For this purpose, a mixture containing the immobilizing agent (polyxydroxybutyrate, PHB) and the recognition element (antibodies against SARS-CoV-2 nucleocapsid protein) was prepared and used to modify a screen-printed carbon electrode with electrodeposited graphene ...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Gustavo Martins Helena R Galeski Gabrielle A Andrade Marcia G P Valenga Maria K Ramos Aldo J G Zarbin Bruno C Janegitz Marcelo M üller-Santos Emanuel M de Souza Luiz Humberto Marcolino-Junior M árcio F Bergamini Source Type: research

Idiopathic pulmonary fibrosis (IPF): disease pathophysiology, targets, and potential therapeutic interventions
In this study, we focus on the IPF and COVID-19 pathogenesis and the potential role of Apigenin in addressing disease progression.PMID:37707699 | DOI:10.1007/s11010-023-04845-6
Source: Molecular and Cellular Biochemistry - September 14, 2023 Category: Biochemistry Authors: Pritha Saha Priti Talwar Source Type: research

Integrated Immunopeptidomics and Proteomics Study of SARS-CoV-2 Infected Calu-3 Cells Reveals Dynamic Changes in Allele-specific HLA Abundance and Antigen Presentation
We present an integrated immunopeptidomics and proteomics study of SARS-CoV-2 infection to comprehensively decipher the changes in host cells in response to viral infection. Immunopeptidomics analysis identified viral antigens presented by host cells through both Class I and Class II MHC system for recognition by the adaptive immune system. The host proteome changes were characterized by quantitative proteomics and glycoproteomics and from these data, the activation of TLR3-interferon pathway was identified. Glycosylation analysis of HLA proteins from the elution and flow-through of immunoprecipitation revealed that SARS-C...
Source: Molecular and Cellular Proteomics : MCP - September 14, 2023 Category: Molecular Biology Authors: Rui Chen Kelly M Fulton Anh Tran Diana Duque Kevin Kovalchik Etienne Caron Susan M Twine Jianjun Li Source Type: research

Wastewater Surveillance Data as a Complement to Emergency Department Visit Data for Tracking Incidence of Influenza A and Respiratory Syncytial Virus - Wisconsin, August 2022-March 2023
MMWR Morb Mortal Wkly Rep. 2023 Sep 15;72(37):1005-1009. doi: 10.15585/mmwr.mm7237a2.ABSTRACTWastewater surveillance has been used to assist public health authorities in tracking local transmission of SARS-CoV-2. The usefulness of wastewater surveillance to track community spread of other respiratory pathogens, including influenza virus and respiratory syncytial virus (RSV), is less clear. During the 2022-23 respiratory diseases season, concentrations of influenza A virus and RSV in wastewater samples in three major Wisconsin cities were compared with emergency department (ED) visits associated with these pathogens. In all...
Source: MMWR Morb Mortal Wkl... - September 14, 2023 Category: Epidemiology Authors: Peter M DeJonge Carly Adams Ian Pray Melissa K Schussman Rebecca B Fahney Martin Shafer Dagmara S Antkiewicz Ad élaïde Roguet Source Type: research

Idiopathic pulmonary fibrosis (IPF): disease pathophysiology, targets, and potential therapeutic interventions
In this study, we focus on the IPF and COVID-19 pathogenesis and the potential role of Apigenin in addressing disease progression.PMID:37707699 | DOI:10.1007/s11010-023-04845-6
Source: Molecular and Cellular Biochemistry - September 14, 2023 Category: Biochemistry Authors: Pritha Saha Priti Talwar Source Type: research

One-step selective layer assemble: A versatile approach for the development of a SARS-CoV-2 electrochemical immunosensor
Anal Chim Acta. 2023 Oct 16;1278:341726. doi: 10.1016/j.aca.2023.341726. Epub 2023 Aug 16.ABSTRACTThe appearance of new viruses and diseases has made the development of rapid and reliable diagnostic tests crucial. In light of it, we proposed a new method for assembling an electrochemical immunosensor, based on a one-step approach for selective layer formation. For this purpose, a mixture containing the immobilizing agent (polyxydroxybutyrate, PHB) and the recognition element (antibodies against SARS-CoV-2 nucleocapsid protein) was prepared and used to modify a screen-printed carbon electrode with electrodeposited graphene ...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Gustavo Martins Helena R Galeski Gabrielle A Andrade Marcia G P Valenga Maria K Ramos Aldo J G Zarbin Bruno C Janegitz Marcelo M üller-Santos Emanuel M de Souza Luiz Humberto Marcolino-Junior M árcio F Bergamini Source Type: research

New SARS-CoV-2 Omicron Variant with Spike Protein Mutation Y451H, Kilifi, Kenya, March-May 2023
We report a newly emerged SARS-CoV-2 Omicron subvariant FY.4 that has mutations Y451H in spike and P42L in open reading frame 3a proteins. FY.4 emergence coincided with increased SARS-CoV-2 cases in coastal Kenya during April-May 2023. Continued SARS-CoV-2 genomic surveillance is needed to identify new lineages to inform COVID-19 outbreak prevention.PMID:37708843 | DOI:10.3201/eid2911.230894
Source: Emerging Infectious Diseases - September 14, 2023 Category: Infectious Diseases Authors: Mike J Mwanga Arnold W Lambisia John Mwita Morobe Nickson Murunga Edidah Moraa Leonard Ndwiga Robinson Cheruiyot Jennifer Musyoki Martin Mutunga Laura M Guzman-Rincon Charles Sande Joseph Mwangangi Philip Bejon Lynette Isabella Ochola-Oyier D James Nokes Source Type: research

One-step selective layer assemble: A versatile approach for the development of a SARS-CoV-2 electrochemical immunosensor
Anal Chim Acta. 2023 Oct 16;1278:341726. doi: 10.1016/j.aca.2023.341726. Epub 2023 Aug 16.ABSTRACTThe appearance of new viruses and diseases has made the development of rapid and reliable diagnostic tests crucial. In light of it, we proposed a new method for assembling an electrochemical immunosensor, based on a one-step approach for selective layer formation. For this purpose, a mixture containing the immobilizing agent (polyxydroxybutyrate, PHB) and the recognition element (antibodies against SARS-CoV-2 nucleocapsid protein) was prepared and used to modify a screen-printed carbon electrode with electrodeposited graphene ...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Gustavo Martins Helena R Galeski Gabrielle A Andrade Marcia G P Valenga Maria K Ramos Aldo J G Zarbin Bruno C Janegitz Marcelo M üller-Santos Emanuel M de Souza Luiz Humberto Marcolino-Junior M árcio F Bergamini Source Type: research

Bibliometric analysis of the worldwide scientific production on COVID-19 infection and cerebrovascular disease
CONCLUSION: It was observed that the United States was the country with the highest scientific production on COVID-19 and cerebrovascular disease in the year 2020 in the different health areas; however, more research is still needed worldwide for a better analysis of the bibliometric indicators on the subject.PMID:37706386 | PMC:PMC10284493 | DOI:10.4103/aca.aca_70_22
Source: Annals of Cardiac Anaesthesia - September 14, 2023 Category: Anesthesiology Authors: Camila Palomino-Leyva Jhonny Rivera-Recuenco Alicia Fernandez-Giusti John Barja-Ore Yesenia Retamozo-Siancas Frank Mayta-Tovalino Source Type: research

Wastewater Surveillance Data as a Complement to Emergency Department Visit Data for Tracking Incidence of Influenza A and Respiratory Syncytial Virus - Wisconsin, August 2022-March 2023
MMWR Morb Mortal Wkly Rep. 2023 Sep 15;72(37):1005-1009. doi: 10.15585/mmwr.mm7237a2.ABSTRACTWastewater surveillance has been used to assist public health authorities in tracking local transmission of SARS-CoV-2. The usefulness of wastewater surveillance to track community spread of other respiratory pathogens, including influenza virus and respiratory syncytial virus (RSV), is less clear. During the 2022-23 respiratory diseases season, concentrations of influenza A virus and RSV in wastewater samples in three major Wisconsin cities were compared with emergency department (ED) visits associated with these pathogens. In all...
Source: MMWR Morb Mortal Wkl... - September 14, 2023 Category: Epidemiology Authors: Peter M DeJonge Carly Adams Ian Pray Melissa K Schussman Rebecca B Fahney Martin Shafer Dagmara S Antkiewicz Ad élaïde Roguet Source Type: research

Risk factors of Omicron variant associated acute encephalitis/encephalopathy in children
CONCLUSIONS: Most cases of COVID-19-associated acute encephalitis/encephalopathy showed no evidence of direct viral invasion but associations with older age, increased peripheral neutrophil, and serum procalcitonin. These findings may imply the neutrophil-mediated systemic inflammatory response plays an important role on central nerve system, leading to cerebral dysfunction.PMID:37709632 | DOI:10.1016/j.jmii.2023.08.010
Source: Journal of Microbiology, Immunology, and Infection - September 14, 2023 Category: Microbiology Authors: Chong-Wei Huang Jainn-Jim Lin Chen-Yen Kuo Kuang-Lin Lin Yhu-Chering Huang Cheng-Hsun Chiu Yi-Ching Chen Chih-Ho Chen Yu-Chia Hsieh Source Type: research