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Impact of the lipase inhibitor orlistat on the human gut microbiota
This study aimed to explore the effects of orlistat on the gut microbiota and fatty acid metabolism of Japanese individuals with obesity. Fourteen subjects with visceral fat obesity (waist circumference ≥85 cm) took orlistat orally at a dose of 60 mg, 3 times a day for 8 weeks. Body weight; waist circumference; visceral fat area; levels of short-chain fatty acids, gut microbiota, fatty acid metabolites in the feces, and gastrointestinal hormones; and adverse events were evaluated. Body weight, waist circumference, and blood leptin concentrations were significantly lower after orlistat treatment (mean ± standard deviatio...
Source: Clin Med Res - September 7, 2023 Category: Research Authors: Yudai Uehira Hiroaki Ueno Junki Miyamoto Ikuo Kimura Yohei Ishizawa Hiroshi Iijima Shota Muroga Toru Fujita Soichi Sakai Yoshishige Samukawa Yuri Tanaka Shinya Murayama Hideyuki Sakoda Masamitsu Nakazato Source Type: research
The evaluation of photochemical behavior of antihistaminic drug triprolidine in an aqueous media
In this study, we sought to examine the photochemical behavior of triprolidine (TRP), which is a member of the first-generation antihistamine and utilized for a relief of an allergic conditions, in an aqueous media. There are no reports focused on its potential photoproducts and photodegradation pathways in detail to the best of our knowledge. TRP photodegradation induced by ultraviolet light (UV) irradiation was monitored utilizing high-performance liquid chromatography (HPLC), and structural elucidation of the TRP photoproduct was performed by electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) and nuclear ma...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - September 7, 2023 Category: Chemistry Authors: Kohei Kawabata Misaki Masumoto Masanori Inagaki Hiroyuki Nishi Source Type: research
Isolation and Characterization of Single-Domain Antibodies from Immune Phage Display Libraries
We present and discuss comprehensive, step-by-step methods for isolating and characterization of antigen-specific VHHs. This includes protocols for expression, biotinylation, purification, and characterization of the isolated VHHs. To demonstrate the feasibility of the entire strategy, we present examples of VHHs previously isolated and characterized in our laboratory.PMID:37679618 | DOI:10.1007/978-1-0716-3381-6_7
Source: Mol Biol Cell - September 7, 2023 Category: Molecular Biology Authors: Martin A Rossotti Frederic Trempe Henk van Faassen Greg Hussack Mehdi Arbabi-Ghahroudi Source Type: research
Clinical Study of Percutaneous Endoscopic Large-channel Fusion and Transforaminal Lumbar Interbody Fusion in the Treatment of Degenerative Lumbar Spinal Stenosis
CONCLUSIONS: Both percutaneous, endoscopic, large-channel fusion and TLIF had good therapeutic effects in the treatment of degenerative lumbar spinal stenosis. However, compared with the latter, the former was more effective, with better comprehensive efficacy and more obvious benefits for patients, so it's worthy of clinical promotion and use.PMID:37678853
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Xianguo Bao Haitao Lu Zengxin Gao Qinghua Cheng Chen Cheng Yingjun Chen Source Type: research
Morphology of the Radial Attachment of the Radioulnar Ligament and Surrounding Landmarks
CONCLUSIONS: The anatomical center on the RUL attachment of the radius can be determined from osseous landmarks.CLINICAL RELEVANCE: The findings of this study contribute to the understanding of RUL attachment to the distal radius and may assist surgeons in performing anatomical reconstruction of TFCC.PMID:37676190 | DOI:10.1016/j.jhsa.2023.08.001
Source: Hand Surgery - September 7, 2023 Category: Surgery Authors: Masanori Matsuura Kotaro Sato Kenya Murakami Gaku Takahashi Hasegawa Hiroshi Minoru Doita Source Type: research
The evaluation of photochemical behavior of antihistaminic drug triprolidine in an aqueous media
In this study, we sought to examine the photochemical behavior of triprolidine (TRP), which is a member of the first-generation antihistamine and utilized for a relief of an allergic conditions, in an aqueous media. There are no reports focused on its potential photoproducts and photodegradation pathways in detail to the best of our knowledge. TRP photodegradation induced by ultraviolet light (UV) irradiation was monitored utilizing high-performance liquid chromatography (HPLC), and structural elucidation of the TRP photoproduct was performed by electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) and nuclear ma...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - September 7, 2023 Category: Chemistry Authors: Kohei Kawabata Misaki Masumoto Masanori Inagaki Hiroyuki Nishi Source Type: research
Clinical Study of Percutaneous Endoscopic Large-channel Fusion and Transforaminal Lumbar Interbody Fusion in the Treatment of Degenerative Lumbar Spinal Stenosis
CONCLUSIONS: Both percutaneous, endoscopic, large-channel fusion and TLIF had good therapeutic effects in the treatment of degenerative lumbar spinal stenosis. However, compared with the latter, the former was more effective, with better comprehensive efficacy and more obvious benefits for patients, so it's worthy of clinical promotion and use.PMID:37678853
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Xianguo Bao Haitao Lu Zengxin Gao Qinghua Cheng Chen Cheng Yingjun Chen Source Type: research
< em > Mesoterricola silvestris < /em > gen. nov., sp. nov., < em > Mesoterricola sediminis < /em > sp. nov., < em > Geothrix oryzae < /em > sp. nov., < em > Geothrix edaphica < /em > sp. nov., < em > Geothrix rubra < /em > sp. nov., and < em > Geothrix limicola < /em > sp. nov., six novel members of < em > Acidobacteriota < /em > isolated from soils
Int J Syst Evol Microbiol. 2023 Sep;73(9). doi: 10.1099/ijsem.0.006073.ABSTRACTForty-eight Acidobacteriota strains were isolated from soils and sediments in Japan. Among them, six representative strains, designated W79T, W786T, Red222T, Red802T, Red803T, and Red804T, were subjected to the taxonomic classification. These six strains are Gram-stain-negative, non-spore-forming, rod-shaped, and facultative anaerobic bacterium that can reduce ferric iron. Phylogenetic and phylogenomic trees based on 16S rRNA genes and multiple single-copy gene sequences showed that strains Red222T, Red802T, Red803T, and Red804T formed a cluster...
Source: International Journal of Systematic and Evolutionary Microbiology - September 7, 2023 Category: Microbiology Authors: Hideomi Itoh Yumi Sugisawa Kazumori Mise Zhenxing Xu Miyu Kuniyasu Natsumi Ushijima Keisuke Kawano Emiko Kobayashi Yutaka Shiratori Yoko Masuda Keishi Senoo Source Type: research
Clinical Study of Percutaneous Endoscopic Large-channel Fusion and Transforaminal Lumbar Interbody Fusion in the Treatment of Degenerative Lumbar Spinal Stenosis
CONCLUSIONS: Both percutaneous, endoscopic, large-channel fusion and TLIF had good therapeutic effects in the treatment of degenerative lumbar spinal stenosis. However, compared with the latter, the former was more effective, with better comprehensive efficacy and more obvious benefits for patients, so it's worthy of clinical promotion and use.PMID:37678853
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Xianguo Bao Haitao Lu Zengxin Gao Qinghua Cheng Chen Cheng Yingjun Chen Source Type: research
The evaluation of photochemical behavior of antihistaminic drug triprolidine in an aqueous media
In this study, we sought to examine the photochemical behavior of triprolidine (TRP), which is a member of the first-generation antihistamine and utilized for a relief of an allergic conditions, in an aqueous media. There are no reports focused on its potential photoproducts and photodegradation pathways in detail to the best of our knowledge. TRP photodegradation induced by ultraviolet light (UV) irradiation was monitored utilizing high-performance liquid chromatography (HPLC), and structural elucidation of the TRP photoproduct was performed by electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) and nuclear ma...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - September 7, 2023 Category: Chemistry Authors: Kohei Kawabata Misaki Masumoto Masanori Inagaki Hiroyuki Nishi Source Type: research
Impact of the lipase inhibitor orlistat on the human gut microbiota
This study aimed to explore the effects of orlistat on the gut microbiota and fatty acid metabolism of Japanese individuals with obesity. Fourteen subjects with visceral fat obesity (waist circumference ≥85 cm) took orlistat orally at a dose of 60 mg, 3 times a day for 8 weeks. Body weight; waist circumference; visceral fat area; levels of short-chain fatty acids, gut microbiota, fatty acid metabolites in the feces, and gastrointestinal hormones; and adverse events were evaluated. Body weight, waist circumference, and blood leptin concentrations were significantly lower after orlistat treatment (mean ± standard deviatio...
Source: Clin Med Res - September 7, 2023 Category: Research Authors: Yudai Uehira Hiroaki Ueno Junki Miyamoto Ikuo Kimura Yohei Ishizawa Hiroshi Iijima Shota Muroga Toru Fujita Soichi Sakai Yoshishige Samukawa Yuri Tanaka Shinya Murayama Hideyuki Sakoda Masamitsu Nakazato Source Type: research
A Japan-Poland Collaboration for Coupling Molecular Nanomagnetism and Luminescent Thermometry
Angew Chem Int Ed Engl. 2023 Sep 6:e202312126. doi: 10.1002/anie.202312126. Online ahead of print.ABSTRACTThis invited Team Profile was created by the Laboratory of Advanced Functional Materials (Tokoro Lab), Division of Materials Science, Faculty of Pure and Applied Sciences, University of Tsukuba (Japan); the Multifunctional Luminescent Materials Group (Szymon Group, MLMG), Faculty of Chemistry, Jagiellonian University, Kraków (Poland); and the Solid State Physical Chemistry Group (Ohkoshi Lab), Department of Chemistry, School of Science, The University of Tokyo (Japan). They recently published an article on a bimetalli...
Source: Angewandte Chemie - September 6, 2023 Category: Chemistry Source Type: research
Mixed-mode chromatographic performance using nicotinic acid-functionalized chito-oligosaccharide-bonded Ti/Si hybrid monolithic capillary columns
This article describes the fabrication of porous nicotinic acid-functionalized chito-oligosaccharide-bonded titania/silica hybrid monoliths (TiO2/SiO2@ChO-N) through a co-gelation sol-gel process. A capillary monolith with a well-defined and homogeneous structure was obtained by controlling the hydrolysis speed of titanium alkoxides in a sol mixture by using glycerol and acetylacetone. As a result of the functionalization with chito-oligosaccharides (ChO)-modified nicotinic acid, the obtained stationary phase provides superior physiochemical properties, such as a cationic hydrophilic surface, porosity, and mechanical stren...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - September 6, 2023 Category: Chemistry Authors: Mahmoud A M El-Nouby Lee Wah Lim Source Type: research
