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“The Greatest Scientist of All Time” says Scientific American. Who is it?
BY MIKE MAGEE When it comes to our earthly survival as a human species, words are often under-powered and off-the-mark. Clearer concepts, definitions and terms are required for clarity. Here are five terms that are useful and worth remembering: Planetary Boundaries Earth Systems Human Perturbations Planetary Scale Destabilization Holocene Epoch vs. Anthropogenic Epoch  These terms all tie back to a single source – a child of World War II, only seven when his home in Amsterdam was overrun by Nazis. His father was a waiter, his mother a cook in a local hospital. He’d later recall with a sh...
Source: The Health Care Blog - September 11, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Non-Health Chemistry Mike Magee Ozone Paul Crutzen Scientific American Source Type: blogs

Nanozyme colorimetric sensing of L-cysteine and copper ions based on PtCo nanoparticles@multi-walled carbon nanotubes
Anal Sci. 2023 Sep 12. doi: 10.1007/s44211-023-00411-8. Online ahead of print.ABSTRACTIn this work, PtCo bimetallic nanoparticles supported on multi-walled carbon nanotubes (PtCo@MWCNTs) nanohybrid was prepared simply and used for the first time as a novel nanozyme in the colorimetric sensing of L-cysteine (L-Cys) and Cu2+. Due to its strong enzyme-like catalytic activity, the prepared PtCo@MWCNTs nanohybrid can catalyze the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) to form ox-TMB without H2O2. Interestingly, the oxidase-like active of PtCo@MWCNTs was effectively suppressed by L-Cys, which could reduce ox-TMB to co...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - September 11, 2023 Category: Chemistry Authors: Xiaorong Lin Changting Wang Liuxia You Fanrui Fu Qiaoling Liu Source Type: research

Model-based assessment of the reference values of CAVI in healthy Russian population and benchmarking with CAVI0
CONCLUSIONS: We have evaluated the quantitative association between various population characteristics, CAVI and CAVI0 values and established a method for estimating the subject-level reference CAVI and CAVI0 measurements.PMID:37696678 | DOI:10.1093/ajh/hpad082
Source: American Journal of Hypertension - September 11, 2023 Category: Cardiology Authors: Tatiana Safronova Anna Kravtsova Sergei Vavilov Cristina Leon Anna Bragina Victor Milyagin Ruslan Makiev Alexei Sumin Kirill Peskov Victor Sokolov Valery Podzolkov Source Type: research

Endoscopic Surgical Skill Qualification System: propensity-score matched cohort analysis of accredited supervisors in laparoscopic rectal cancer surgery
CONCLUSION: This study demonstrated the educational benefits of ESSQS-certified supervisors, including assistants and advisors, evidenced by their superior short-term outcomes.PMID:37695301 | DOI:10.1093/bjs/znad282
Source: The British Journal of Surgery - September 11, 2023 Category: Surgery Authors: Yuki Kiyozumi Tomohiro Yamaguchi Nobuki Ichikawa Shigenori Homma Koji Ikeda Ryo Inada Koki Otsuka Akinobu Furutani Hiroaki Iijima Masahiko Watanabe Akinobu Taketomi Takeshi Naitoh EnSSURE study group collaborators in the Japan Society of Laparoscopic Colo Source Type: research

Model-based assessment of the reference values of CAVI in healthy Russian population and benchmarking with CAVI0
CONCLUSIONS: We have evaluated the quantitative association between various population characteristics, CAVI and CAVI0 values and established a method for estimating the subject-level reference CAVI and CAVI0 measurements.PMID:37696678 | DOI:10.1093/ajh/hpad082
Source: American Journal of Hypertension - September 11, 2023 Category: Cardiology Authors: Tatiana Safronova Anna Kravtsova Sergei Vavilov Cristina Leon Anna Bragina Victor Milyagin Ruslan Makiev Alexei Sumin Kirill Peskov Victor Sokolov Valery Podzolkov Source Type: research

Lymphopenia is a risk factor for severe infections in older patients with microscopic polyangiitis: a retrospective cohort study in Japan
CONCLUSION: Lymphopenia is a predictor of subsequent severe infections in patients with MPA who receive immunosuppressive therapy. These results suggest the importance of sustained infection surveillance, particularly in older patients who develop lymphopenia during strong immunosuppressive therapy.PMID:37692053 | PMC:PMC10483030 | DOI:10.1093/rap/rkad073
Source: Adv Data - September 11, 2023 Category: Epidemiology Authors: Makoto Yamaguchi Hirokazu Sugiyama Hironobu Nobata Hiroshi Kinashi Akimasa Asai Fumiya Kitamura Takayuki Katsuno Masahiko Ando Yoko Kubo Shogo Banno Yasuhiko Ito Takuji Ishimoto Source Type: research

Efficacy and Safety of Upacicalcet in Hemodialysis Patients with Secondary Hyperparathyroidism: A Randomized Placebo-Controlled Trial
CONCLUSIONS: Upacicalcet, a novel injectable calcimimetic, is effective and safe for secondary hyperparathyroidism patients receiving HD.CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: Phase 3 Study of SK-1403, NCT03801980.PMID:37696667 | DOI:10.2215/CJN.0000000000000253
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 11, 2023 Category: Urology & Nephrology Authors: Takashi Shigematsu Fumihiko Koiwa Yoshitaka Isaka Masafumi Fukagawa Keiko Hagita Yukihisa S Watanabe Daisuke Honda Tadao Akizawa Source Type: research

Nanozyme colorimetric sensing of L-cysteine and copper ions based on PtCo nanoparticles@multi-walled carbon nanotubes
Anal Sci. 2023 Sep 12. doi: 10.1007/s44211-023-00411-8. Online ahead of print.ABSTRACTIn this work, PtCo bimetallic nanoparticles supported on multi-walled carbon nanotubes (PtCo@MWCNTs) nanohybrid was prepared simply and used for the first time as a novel nanozyme in the colorimetric sensing of L-cysteine (L-Cys) and Cu2+. Due to its strong enzyme-like catalytic activity, the prepared PtCo@MWCNTs nanohybrid can catalyze the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) to form ox-TMB without H2O2. Interestingly, the oxidase-like active of PtCo@MWCNTs was effectively suppressed by L-Cys, which could reduce ox-TMB to co...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - September 11, 2023 Category: Chemistry Authors: Xiaorong Lin Changting Wang Liuxia You Fanrui Fu Qiaoling Liu Source Type: research

Lymphopenia is a risk factor for severe infections in older patients with microscopic polyangiitis: a retrospective cohort study in Japan
CONCLUSION: Lymphopenia is a predictor of subsequent severe infections in patients with MPA who receive immunosuppressive therapy. These results suggest the importance of sustained infection surveillance, particularly in older patients who develop lymphopenia during strong immunosuppressive therapy.PMID:37692053 | PMC:PMC10483030 | DOI:10.1093/rap/rkad073
Source: Adv Data - September 11, 2023 Category: Epidemiology Authors: Makoto Yamaguchi Hirokazu Sugiyama Hironobu Nobata Hiroshi Kinashi Akimasa Asai Fumiya Kitamura Takayuki Katsuno Masahiko Ando Yoko Kubo Shogo Banno Yasuhiko Ito Takuji Ishimoto Source Type: research

Efficacy and Safety of Upacicalcet in Hemodialysis Patients with Secondary Hyperparathyroidism: A Randomized Placebo-Controlled Trial
CONCLUSIONS: Upacicalcet, a novel injectable calcimimetic, is effective and safe for secondary hyperparathyroidism patients receiving HD.CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: Phase 3 Study of SK-1403, NCT03801980.PMID:37696667 | DOI:10.2215/CJN.0000000000000253
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 11, 2023 Category: Urology & Nephrology Authors: Takashi Shigematsu Fumihiko Koiwa Yoshitaka Isaka Masafumi Fukagawa Keiko Hagita Yukihisa S Watanabe Daisuke Honda Tadao Akizawa Source Type: research

Hyoro-zeme in the Battle for Tottori Castle: The first description of refeeding syndrome in Japan
Am J Med Sci. 2023 Sep 8:S0002-9629(23)01327-7. doi: 10.1016/j.amjms.2023.08.015. Online ahead of print.ABSTRACTEating after a period of starvation can cause refeeding syndrome, a fatal condition caused by a shift in fluids and electrolytes that can result in sudden death. The Battle for Tottori Castle (1581) during the Warring States Period of Japan, which witnessed the use of hyoro-zeme, the tactic of intentionally starving a besieged enemy, was followed by a dramatic episode of mass death among starving soldiers not from fighting but from eating; accounts from the period relate that many of the besieged soldiers survive...
Source: The American Journal of the Medical Sciences - September 10, 2023 Category: General Medicine Authors: Yasuhiro Kano Sayaka Aoyama Ryuichiro Yamamoto Source Type: research

Current Status of Robotic Gastrointestinal Surgery
This article reviews current trends and potential developments in robotic surgery.PMID:37690822 | DOI:10.1272/jnms.JNMS.2023_90-404
Source: Journal of Nippon Medical School - September 10, 2023 Category: Universities & Medical Training Authors: Keisuke Minamimura Keisuke Hara Satoshi Matsumoto Tomohiko Yasuda Hiroki Arai Daisuke Kakinuma Yukio Ohshiro Youichi Kawano Masanori Watanabe Hideyuki Suzuki Hiroshi Yoshida Source Type: research