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Total 55074 results found since Jan 2013.
Transcriptional regulation of the Japanese flounder Cu,Zn-SOD (Jfsod1) gene in RAW264.7 cells during oxidative stress caused by causative bacteria of edwardsiellosis
In this study, NUF251 stimulated intracellular superoxide radical production in mouse macrophage RAW264.7 cells, which was reduced by N-acetylcysteine. This result suggests that NUF251 infection causes oxidative stress. To evaluate the regulatory mechanism of Jfsod1 at transcriptional levels under oxidative stress induced by NUF251 infection, we cloned and determined the nucleotide sequence (1124 bp) of the 5'-flanking region of the Jfsod1 gene. The sequence analysis demonstrated that the binding sites for the transcription factors C/EBPα and NF-IL6 involved in the transcriptional regulation of the mammalian sod1 gene exi...
Source: Biochimie - September 4, 2023 Category: Biochemistry Authors: Xiao-Mi Sun Asami Yoshida Takuya Ishii Yan-Rong Jiang Yi-Li Gao Mikinori Ueno Katsuya Hirasaka Kiyoshi Osatomi Source Type: research
Assessment of Diagnosis Timing of Attention-Deficit/Hyperactivity Disorder in Working-Age Workers with Psychiatric Diseases Using Large Claims Data
This study aims to clarify the timing of diagnosis of ADHD in working-age workers with psychiatric comorbidities using large claims data in Japan. Based on a literature survey, we identified 10 typical comorbidities of ADHD. Among 3064162 participants with social insurance, 215060 working-age workers who were diagnosed with the 10 typical comorbidities of ADHD were included. Cohort 1 consisted of 96994 patients with the index date set as the earliest date of diagnosis of a comorbidity within the 12-month screening and 12-month observation periods. In cohort 2, 107436 patients were included, and the first date of diagnosis ...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Mutsumi Ando Kenji Momo Noriko Hida Taigi Yamazaki Iori Taki Tsutomu Nagai Takashi Yoshio Masahiro Kurosawa Source Type: research
Analysis of research trends on hydrogen explosion by bibliometric approach
In this study, the collected literature information was visually analyzed using VOSviewer and CiteSpace. The results show that China, USA, Germany, and Japan are major contributors to hydrogen explosion research; the International Journal of Hydrogen Energy has the highest publications among all source journals. The research theme of hydrogen explosion has developed into two main directions: hydrogen mixture explosion characteristics and suppression methods, hydrogen explosion characteristics and suppression methods. Compared to traditional suppression methods, fine water mist is more efficient and environmentally friendly...
Source: Environmental Science and Pollution Research International - September 4, 2023 Category: Environmental Health Authors: Haofeng Gong Wenling Guan Chengjie Dong Changxing Ren Source Type: research
Outcomes of Pain Management Training for the Fourth- and Fifth-Year Medical Students
In this study, we assessed students' understanding of pain management based on the results of pretests and posttests performed before and after their practicum. These tests were administered from November 2019 to April 2022 to 263 fourth- and fifth-year medical students who took the clinical pain study class. The test results were compared in terms of the percentage of correct answers and the total score for each question using McNemar's chi-square test and paired t-tests, respectively. The results showed a significant improvement in the mean of the total score, confirming the improvement in medical students' knowledge (6....
Source: Pain Research and Management - September 4, 2023 Category: Anesthesiology Authors: Ayano Saeki Yumiko Takao Keiichiro Suzuki Munetaka Hirose Source Type: research
Investigating the seasonal variation of heart failure hospitalizations and in-hospital mortality risks in Japan using a nationwide database
CONCLUSIONS: There was a significant seasonal variation in HF hospitalizations in Japan. Peak admission rates occurred in January. However, the risk of death during hospitalization was higher in August, September, and October than that in January.PMID:37666321 | DOI:10.1016/j.jjcc.2023.08.014
Source: Journal of Cardiology - September 4, 2023 Category: Cardiology Authors: Hideyuki Matsuda Takashi Kuragaichi Yukihito Sato Source Type: research
Effect of a Family Pharmacist System on Medication Adherence of Patients with Dyslipidemia during a COVID-19 Epidemic
In this study, using anonymously processed receipt data from 700 insurance pharmacies in our group, we evaluated medication adherence in patients taking statin drugs before, during the first and second years of coronavirus disease 2019 (COVID-19) epidemic in terms of medication persistence and medication possession, and compared the results between the family pharmacist group (FP group) and non-family pharmacist group (NoFP group). The odds ratios of good medication adherence (medication persistence and medication possession) rates for the FP group relative to the NoFP group were 1.446 [95% confidence interval (CI): 1.210-...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 4, 2023 Category: Drugs & Pharmacology Authors: Mamoru Maeda Yoshitaka Hasegawa Ryota Tsukioka Miya Oishi Source Type: research
Reduction in Patient Waiting Times in Pharmacies by a Protocol to Minimize Inquiries to Doctors under an Agreement between a Hospital and Community Pharmacies
In conclusion, introduction of a protocol aimed at minimizing inquiries about prescriptions to doctors from a community pharmacy was useful in reducing the waiting time of patients, and also likely in decreasing the working times of medical doctors and pharmacists.PMID:37661441 | DOI:10.1248/yakushi.23-00021
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 4, 2023 Category: Drugs & Pharmacology Authors: Hideaki Hiramatsu Ryo Kobayashi Hironori Fujii Mika Uno Chiho Masuda Syoko Mabuchi Tomoyuki Hirashita Takako Hayashi Kazuhiro Iguchi Hitomi Teramachi Hirokazu Ibuka Tetsuya Ohashi Akio Suzuki Kimio Yasuda Source Type: research
Descriptive Study on a Nationwide Exploratory Questionnaire Survey of Emergency Contraceptive Pills and Their Sexual History and Knowledge in Japan
This study showed that approximately half of participants may not have correct knowledge of emergency contraceptives. In addition, approximately half of sexually active participants are facing unintended pregnancies due to a lack of sexual and reproductive awareness. Hence, comprehensive sex education is necessary to achieve social and regulatory changes centered on emergency contraceptives.PMID:37661409 | DOI:10.1248/bpb.b23-00268
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Kenji Momo Erika Maeda Haruka Hattori Haruka Isozaki Hiroko Takita Hokuto Morohoshi Kakei Ryu Noriko Hida Takehiko Sambe Nahoko Shirato Source Type: research
Solubilization of Poorly Water-soluble Drugs with Amphiphilic Phospholipid Polymers
Yakugaku Zasshi. 2023;143(9):745-756. doi: 10.1248/yakushi.23-00023.ABSTRACTMost drug candidates developed in recent years are poorly water-soluble, which is a key challenge in pharmaceutical science. Various solubilization methods have been investigated thus far, most of which require solubilizers that provide a local hydrophobic environment wherein a drug can dissolve or induce interactions with drug molecules. We have focused on amphiphilic 2-methacryloyloxyethyl phosphoryl choline (MPC) polymers. In addition to the ease of molecular design of amphiphilic MPC polymers owing to their chemical structures, they have been r...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 4, 2023 Category: Drugs & Pharmacology Authors: Kensuke Yoshie Kazuhiko Ishihara Source Type: research
Comparison of the Speed of Enrollment for Clinical Trials Conducted by Japanese and Global Pharmaceutical Companies
In this study, we examined the speed of enrollment period in clinical trials. We surveyed clinical trials from January 1, 2010, to December 31, 2019, covering the top 10 pharmaceutical companies in each global sales ranking (Global 10) and the Japanese sales ranking (Japan 10). Clinical trial data were obtained from ClinicalTrials.gov, a clinical trial registration information database, and the speed of participant enrollment (cases/month) was compared for each phase of the trials. The number of clinical trials conducted during the 10 years was 8938 trials for Global 10 and 1439 trials for Japan 10. Comparing the speed of ...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Hideki Maeda Moeka Yamanoi Yuka Fukuda Yuina Inaba Source Type: research
Cultured Cells in the Aging Research, Exhibiting Cell Surface Component Functions, Intracellular Signaling, a Novel Adaptor Molecule, Aging Phenotype Expression and Various Aspects of the Cellular Physiology
Yakugaku Zasshi. 2023;143(9):729-744. doi: 10.1248/yakushi.23-00017.ABSTRACTCellular aging is one of the most extraordinary phenomena that mammalian cells undergo in vivo and in vitro. We have been observing their behavior for approximately 4 decades and here would like to summarize some of our salient findings. Normal cells such as human diploid cells exhibit finite growth potential in vitro as well as a set of senescent cell phenotypes. Those changes appear probabilistic and irreversible. In the search of the factor(s) to evoke the features we have observed that cellular glycosaminoglycan molecules plays significant role...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 4, 2023 Category: Drugs & Pharmacology Authors: Koozi Matuoka Source Type: research
Elucidation and Prediction of Absorption Behavior After Oral Administration of Poorly Water-Soluble Drugs as Different Lipid-Based Formulations
Yakugaku Zasshi. 2023;143(9):721-727. doi: 10.1248/yakushi.23-00092.ABSTRACTLipid-based formulations (LBFs) are isotropic mixtures typically comprising lipids, surfactants, and/or co-solvents, in which drugs are pre-solubilized. After oral administration, LBFs are piggybacked into endogenous lipid digestion pathways. This triggers drug super-saturation and improves absorption. However, super-saturation poses a risk of drug precipitation, which generally leads to poor drug absorption. Furthermore, a series of aqueous colloidal species including digestion products (typically fatty acids and monoglycerides) and endogenous mol...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 4, 2023 Category: Drugs & Pharmacology Authors: Yusuke Tanaka Source Type: research
Elucidation of the Mechanisms Underlying the Rapid Antidepressant Actions of Ketamine and Search for Possible Candidates for Novel Rapid-acting Antidepressants
Yakugaku Zasshi. 2023;143(9):713-720. doi: 10.1248/yakushi.23-00111.ABSTRACTKetamine, an N-methyl-D-aspartate receptor antagonist, elicits swift antidepressant effects even in subjects with treatment-resistant depression. Nonetheless, owing to the serious adverse effects associated with ketamine, including psychotomimetic effects, the development of safer rapid-acting antidepressants is imperative. The elucidation of the mechanisms underlying the antidepressant effects of ketamine will facilitate the advancement of these alternative treatments. Previous preclinical studies have indicated that the antidepressant properties ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 4, 2023 Category: Drugs & Pharmacology Authors: Satoshi Deyama Source Type: research
Geographical origin traceability of mulberry leaves using stable hydrogen, oxygen, and carbon isotope ratios
Anal Sci. 2023 Sep 4. doi: 10.1007/s44211-023-00414-5. Online ahead of print.ABSTRACTGeographical discrimination of mulberry leaves is very important for their efficacy and quality as a traditional Chinese medicine. Stable hydrogen, oxygen, and carbon isotope ratios were measured in 292 mulberry leaves collected at 2 growth stages in 2 seasons from 8 regions of China. A stepwise linear discriminant analysis (LDA) approach were proposed to combine with stable isotope technology to tracing the origin of mulberry leaves. The results showed that leaves sampled in autumn were extremely depleted in 2H and 18O and slightly enrich...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - September 4, 2023 Category: Chemistry Authors: Dan Yang Liling Jia Yang Zhou Jingzhong Lu Yujie He Jinpeng Jiao Ju Huang Runtao Xia Yuxing Li Lihua Han Zhiqin Peng Source Type: research
The Functional Roles and the Potential as Drug Targets of Glycoproteins Regulating Complement and Coagulation Pathways
Yakugaku Zasshi. 2023;143(9):707-712. doi: 10.1248/yakushi.23-00112.ABSTRACTComplement (C) activation occurs via three pathways, namely the classical, lectin, and alternative pathways. Intercommunication occurs between the complement and coagulation systems, which can trigger tissue injury and inflammation. Disseminated intravascular coagulation (DIC) is a life-threatening disease characterized by disordered coagulation and systemic inflammation; here, the intercommunication between the complement and coagulation systems contributes to the development of DIC. Extracellular histones, which are contributors to the damage-ass...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 4, 2023 Category: Drugs & Pharmacology Authors: Tomohiro Mizuno Source Type: research
