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Drug: Metformin

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Total 6535 results found since Jan 2013.

Extensive therapeutic effects, underlying molecular mechanisms and disease treatment prediction of Metformin: a systematic review
Transl Res. 2023 Aug 9:S1931-5244(23)00130-5. doi: 10.1016/j.trsl.2023.08.001. Online ahead of print.ABSTRACTMetformin, a first-line management for Type 2 Diabetes Mellitus, has been expansively employed and studied with results indicating its therapeutic potential extending beyond glycaemic control. Beyond its established role, this therapeutic drug demonstrates a broad spectrum of action encompassing over sixty disorders, encompassing metabolic conditions, inflammatory disorders, carcinomas, cardiovascular diseases, and cerebrovascular pathologies. There is clear evidence of metformin's action targeting specific nodes in...
Source: Translational Research : the journal of laboratory and clinical medicine - August 11, 2023 Category: Laboratory Medicine Authors: Yifei Geng Zhen Wang Xiaoyu Xu Xiao Sun Xi Dong Yun Luo Xiaobo Sun Source Type: research

Polycystic ovary syndrome and thyroid disorder: a comprehensive narrative review of the literature
ConclusionPCOS and thyroid disorders are closely related, and their coexistence may identify patients with a higher reproductive and metabolic risk. Regular screening for thyroid function and thyroid-specific autoantibodies in women with PCOS, particularly before and during pregnancy, is highly recommended.
Source: Frontiers in Endocrinology - August 11, 2023 Category: Endocrinology Source Type: research

Novel pharmacological approaches in abdominal aortic aneurysm
Clin Sci (Lond). 2023 Aug 14;137(15):1167-1194. doi: 10.1042/CS20220795.ABSTRACTAbdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health issue with an unmet medical need for therapy. This disease is featured by a progressive dilation of the abdominal aorta, boosted by atherosclerosis, ageing, and smoking as major risk factors. Aneurysm growth increases the risk of aortic rupture, a life-threatening emergency with high mortality rates. Despite the increasing progress in our knowledge about the etiopathology of AAA, an effective pharmacological treatment against this disorder remains elusive and...
Source: Atherosclerosis - August 10, 2023 Category: Cardiology Authors: L ídia Puertas-Umbert Rafael Almendra-Pegueros Francesc Jim énez-Altayó Marc Sirvent Mar ía Galán Jos é Martínez-González Cristina Rodr íguez Source Type: research

Elevated glucose metabolism driving pro-inflammatory response in B cells contributes to the progression of type 1 diabetes
Clin Immunol. 2023 Aug 8:109729. doi: 10.1016/j.clim.2023.109729. Online ahead of print.ABSTRACTType 1 diabetes (T1D) is an autoimmune disease characterized by the immune system's failure to maintain self-tolerance, resulting in the autoimmune destruction of pancreatic beta cells. Although T1D has conventionally been viewed as a T-cell-dominant disease, recent research has emphasized the contribution of B cells in the onset of the disease. However, the mechanism underlying aberrant B cell responses remains unknown. B cell metabolism is a crucial prerequisite for B cell function and the development of adaptive immune respon...
Source: Clinical Immunology - August 10, 2023 Category: Allergy & Immunology Authors: Zeying Li Mingjiu Zhao Jingyue Li Wenjun Luo Juan Huang Gan Huang Zhiguo Xie Yang Xiao Jiaqi Huang Xia Li Bin Zhao Zhiguang Zhou Source Type: research

Metformin and combined oral contraceptive pills in the management of polycystic ovary syndrome: a systematic review and meta-analysis
CONCLUSIONS: The choice of metformin or COCP treatment should be based on symptoms, noting that there are some biochemical benefits from combination treatment, targeting both major endocrine disturbances seen in PCOS; hyperinsulinemia and hyperandrogenism.PMID:37554096 | DOI:10.1210/clinem/dgad465
Source: The Journal of Clinical Endocrinology and Metabolism - August 9, 2023 Category: Endocrinology Authors: Johanna Melin Maria Forslund Simon Alesi Terhi Piltonen Daniela Romualdi Poli Mara Spritzer Chau Thien Tay Alexia Pena Selma Feldman Witchel Aya Mousa Helena Teede Source Type: research

Influence of Solute Carrier Family 22 Member 1 (SLC22A1) Gene Polymorphism on Metformin Pharmacokinetics and HbA1c Levels: A Systematic Review
CONCLUSION: Three studies found that rs12208357, rs34059508, and G465R had a considerable impact (p < 0.05) on metformin pharmacokinetics, resulting in increased metformin plasma (Cmax), a higher active amount of drug in the blood (AUC), and lower volume of distribution (Vd) (p<0.05). SLC22A1 polymorphisms with effects on HbA1c include rs628031 (four of seven studies), rs622342 (four of six studies), rs594709 (one study), rs2297374, and rs1867351 (one of two studies), rs34130495 (one study), and rs11212617 (one study) (p < 0.05).PMID:37550919 | DOI:10.2174/1573399820666230807145202
Source: Current Diabetes Reviews - August 8, 2023 Category: Endocrinology Authors: Dimas Adhi Pradana Erna Kristin Dwi Aris Agung Nugrahaningsih Akhmad Kharis Nugroho Rizaldi Taslim Pinzon Source Type: research

New Inspirations from Discovering the Molecular Target of Metformin
Curr Pharm Des. 2023 Aug 7. doi: 10.2174/1381612829666230807160956. Online ahead of print.NO ABSTRACTPMID:37550903 | DOI:10.2174/1381612829666230807160956
Source: Current Pharmaceutical Design - August 8, 2023 Category: Drugs & Pharmacology Authors: Chengfei Zhao Source Type: research

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