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Drug: Metformin
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Long-term oral tribasic copper chloride exposure impedes cognitive function and disrupts mitochondrial metabolism by inhibiting mitophagy in rats
Environ Pollut. 2023 Aug 29:122474. doi: 10.1016/j.envpol.2023.122474. Online ahead of print.ABSTRACTCopper (Cu) is an essential micronutrient element that commonly acted as a feed additive and antimicrobial in agricultural production. Tribasic copper chloride (TBCC) is a relatively new dietary Cu source, and its exposure directly or indirectly affects the safety of animals and ecological environment, thus posing a potential risk to human health. Cu overexposure would produce toxic reactive oxygen species (ROS) that may have toxic effects on the host, but the mechanism of neurotoxicity remains unclear. Herein, to explore t...
Source: Environmental Pollution - August 31, 2023 Category: Environmental Health Authors: Wenlan Yu Xiaoyue Chang Jianzhao Liao Jinwen Quan Siying Liu Ting He Gaolong Zhong Jilei Huang Zhonghua Liu Zhaoxin Tang Source Type: research
Metformin HCl-loaded transethosomal gel; development, characterization, and antidiabetic potential evaluation in the diabetes-induced rat model
Drug Deliv. 2023 Dec;30(1):2251720. doi: 10.1080/10717544.2023.2251720.ABSTRACTHerein we designed, optimized, and characterized the Metformin Hydrochloride Transethosomes (MTF-TES) and incorporate them into Chitosan gel to develop Metformin Hydrochloride loaded Transethosomal gel (MTF-TES gel) that provides a sustained release, improved transdermal flux and improved antidiabetic response of MTF. Design Expert® software (Ver. 12, Stat-Ease, USA) was applied for the statistical optimization of MTF-TES. The formulation with Mean Particle Size Distribution (MPSD) of 165.4 ± 2.3 nm, Zeta Potential (ZP) of -21.2 ± 1.9 mV, Pol...
Source: Drug Delivery - August 31, 2023 Category: Drugs & Pharmacology Authors: Kainat Nousheen Fakhar Ud Din Humzah Jamshaid Rabia Afza Saif Ullah Khan Maimoona Malik Zakir Ali Sibgha Batool Alam Zeb Abid Mehmood Yousaf Ali H Almari Saud Alqahtani Salman Khan Gul Majid Khan Source Type: research
Mitophagy-promoting agents and their ability to promote healthy-aging
In conclusion, this article provides an up-to-date source of information about natural and synthetic substances that activate mitophagy and, hopefully, stimulates new hypotheses and studies that promote healthy human aging worldwide.PMID:37650304 | DOI:10.1042/BST20221363
Source: Biochemical Society Transactions - August 31, 2023 Category: Biochemistry Authors: Vijigisha Srivastava Einav Gross Source Type: research
Metformin HCl-loaded transethosomal gel; development, characterization, and antidiabetic potential evaluation in the diabetes-induced rat model
Drug Deliv. 2023 Dec;30(1):2251720. doi: 10.1080/10717544.2023.2251720.ABSTRACTHerein we designed, optimized, and characterized the Metformin Hydrochloride Transethosomes (MTF-TES) and incorporate them into Chitosan gel to develop Metformin Hydrochloride loaded Transethosomal gel (MTF-TES gel) that provides a sustained release, improved transdermal flux and improved antidiabetic response of MTF. Design Expert® software (Ver. 12, Stat-Ease, USA) was applied for the statistical optimization of MTF-TES. The formulation with Mean Particle Size Distribution (MPSD) of 165.4 ± 2.3 nm, Zeta Potential (ZP) of -21.2 ± 1.9 mV, Pol...
Source: Drug Delivery - August 31, 2023 Category: Drugs & Pharmacology Authors: Kainat Nousheen Fakhar Ud Din Humzah Jamshaid Rabia Afza Saif Ullah Khan Maimoona Malik Zakir Ali Sibgha Batool Alam Zeb Abid Mehmood Yousaf Ali H Almari Saud Alqahtani Salman Khan Gul Majid Khan Source Type: research
Metformin and SGLT2i as First-line Combination Therapy in Type 2 Diabetes: A Real-world Study With a Focus on Ethnicity
Clin Ther. 2023 Aug 28:S0149-2918(23)00302-8. doi: 10.1016/j.clinthera.2023.07.026. Online ahead of print.ABSTRACTPURPOSE: Suboptimal glucose control early in the diagnosis of type 2 diabetes (T2D) is strongly associated with subsequent morbidity and mortality, termed the 'glycaemic legacy'. Additionally, it is known that Asian and Black individuals are at increased risk of T2D, and its associated complications compared to their White counterparts. However, ethnicity does not currently feature in the treatment algorithm of T2D, unlike in other cardiovascular disease states such as hypertension. We therefore sought to evalu...
Source: Clinical Therapeutics - August 30, 2023 Category: Drugs & Pharmacology Authors: Matthew Anson Sizheng Steven Zhao Hani Essa Philip Austin Gema Hern ández Ibarburu Gregory Y H Lip Uazman Alam Source Type: research
Metformin has anti-inflammatory effects and induces immunometabolic reprogramming in hidradenitis suppurativa via multiple mechanisms
CONCLUSIONS: Our study provides insight into the mechanisms of action of metformin in HS. The anti-inflammatory effects of metformin support its use as a therapeutic agent in HS, while its effects on immunometabolism suggest that targeting metabolism is a promising therapeutic option in inflammatory diseases, including HS.PMID:37648653 | DOI:10.1093/bjd/ljad305
Source: The British Journal of Dermatology - August 30, 2023 Category: Dermatology Authors: Andreea Petrasca Roisin Hambly Niamh Kearney Conor M Smith Emily K Pender Julie Mac Mahon Aoife M O'Rourke Mohamed Ismaiel Patrick A Boland Jose P Almeida Czara Kennedy Alexandra Zaborowski Siun Murphy Desmond Winter Brian Kirby Jean M Fletcher Source Type: research
Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19
CONCLUSION: In this trial, metformin consumption had no effect on mortality and ICU admission rates in non-diabetic patients. However, metformin improved COVID-19 complications in diabetic patients who had been receiving metformin prior to COVID-19 infection, and it significantly lowered the intubation rates.PMID:37646067 | PMC:PMC10460805 | DOI:10.34172/apb.2023.066
Source: Adv Data - August 30, 2023 Category: Epidemiology Authors: Elnaz Shaseb Saba Ghaffary Alireza Garjani Elnaz Zoghi Nasrin Maleki Dizaji Somaieh Soltani Parvin Sarbakhsh Mohammad Hossein Somi Parya Valizadeh Ali Taghizadieh Masood Faghihdinevari Mojtaba Varshochi Behrooz Naghily Zhinous Bayatmakoo Parviz Saleh Sepe Source Type: research
Metformin and SGLT2i as First-line Combination Therapy in Type 2 Diabetes: A Real-world Study With a Focus on Ethnicity
Clin Ther. 2023 Aug 28:S0149-2918(23)00302-8. doi: 10.1016/j.clinthera.2023.07.026. Online ahead of print.ABSTRACTPURPOSE: Suboptimal glucose control early in the diagnosis of type 2 diabetes (T2D) is strongly associated with subsequent morbidity and mortality, termed the 'glycaemic legacy'. Additionally, it is known that Asian and Black individuals are at increased risk of T2D, and its associated complications compared to their White counterparts. However, ethnicity does not currently feature in the treatment algorithm of T2D, unlike in other cardiovascular disease states such as hypertension. We therefore sought to evalu...
Source: Clinical Therapeutics - August 30, 2023 Category: Drugs & Pharmacology Authors: Matthew Anson Sizheng Steven Zhao Hani Essa Philip Austin Gema Hern ández Ibarburu Gregory Y H Lip Uazman Alam Source Type: research
Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19
CONCLUSION: In this trial, metformin consumption had no effect on mortality and ICU admission rates in non-diabetic patients. However, metformin improved COVID-19 complications in diabetic patients who had been receiving metformin prior to COVID-19 infection, and it significantly lowered the intubation rates.PMID:37646067 | PMC:PMC10460805 | DOI:10.34172/apb.2023.066
Source: Adv Data - August 30, 2023 Category: Epidemiology Authors: Elnaz Shaseb Saba Ghaffary Alireza Garjani Elnaz Zoghi Nasrin Maleki Dizaji Somaieh Soltani Parvin Sarbakhsh Mohammad Hossein Somi Parya Valizadeh Ali Taghizadieh Masood Faghihdinevari Mojtaba Varshochi Behrooz Naghily Zhinous Bayatmakoo Parviz Saleh Sepe Source Type: research
Metformin has anti-inflammatory effects and induces immunometabolic reprogramming in hidradenitis suppurativa via multiple mechanisms
CONCLUSIONS: Our study provides insight into the mechanisms of action of metformin in HS. The anti-inflammatory effects of metformin support its use as a therapeutic agent in HS, while its effects on immunometabolism suggest that targeting metabolism is a promising therapeutic option in inflammatory diseases, including HS.PMID:37648653 | DOI:10.1093/bjd/ljad305
Source: The British Journal of Dermatology - August 30, 2023 Category: Dermatology Authors: Andreea Petrasca Roisin Hambly Niamh Kearney Conor M Smith Emily K Pender Julie Mac Mahon Aoife M O'Rourke Mohamed Ismaiel Patrick A Boland Jose P Almeida Czara Kennedy Alexandra Zaborowski Siun Murphy Desmond Winter Brian Kirby Jean M Fletcher Source Type: research
Metformin and SGLT2i as First-line Combination Therapy in Type 2 Diabetes: A Real-world Study With a Focus on Ethnicity
Clin Ther. 2023 Aug 28:S0149-2918(23)00302-8. doi: 10.1016/j.clinthera.2023.07.026. Online ahead of print.ABSTRACTPURPOSE: Suboptimal glucose control early in the diagnosis of type 2 diabetes (T2D) is strongly associated with subsequent morbidity and mortality, termed the 'glycaemic legacy'. Additionally, it is known that Asian and Black individuals are at increased risk of T2D, and its associated complications compared to their White counterparts. However, ethnicity does not currently feature in the treatment algorithm of T2D, unlike in other cardiovascular disease states such as hypertension. We therefore sought to evalu...
Source: Clinical Therapeutics - August 30, 2023 Category: Drugs & Pharmacology Authors: Matthew Anson Sizheng Steven Zhao Hani Essa Philip Austin Gema Hern ández Ibarburu Gregory Y H Lip Uazman Alam Source Type: research
A hospital-based assessment of glycemic control and medication adherence in type 2 diabetes mellitus in Eastern Nepal
CONCLUSION: The majority of the diabetic patients had good glycemic control and medium MA. Patients taking regular fruit, being involved in daily jogging, having a shorter duration of drug therapy, and having good diabetic knowledge were identified as factors that affect both glycemic control and MA.PMID:37636174 | PMC:PMC10451609 | DOI:10.4103/jfmpc.jfmpc_90_23
Source: Primary Care - August 28, 2023 Category: Primary Care Authors: Deependra Prasad Sarraf Pramendra Prasad Gupta Source Type: research
