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Drug: Metformin
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Total 6535 results found since Jan 2013.
A hospital-based assessment of glycemic control and medication adherence in type 2 diabetes mellitus in Eastern Nepal
CONCLUSION: The majority of the diabetic patients had good glycemic control and medium MA. Patients taking regular fruit, being involved in daily jogging, having a shorter duration of drug therapy, and having good diabetic knowledge were identified as factors that affect both glycemic control and MA.PMID:37636174 | PMC:PMC10451609 | DOI:10.4103/jfmpc.jfmpc_90_23
Source: Primary Care - August 28, 2023 Category: Primary Care Authors: Deependra Prasad Sarraf Pramendra Prasad Gupta Source Type: research
The correlation between vitamin B12 and folate levels and bone mineral density among the Saudi population in a primary care setting
CONCLUSION: Vitamin B12 is associated with fracture risk; however, vitamin B12 and folate levels are not correlated to BMD (femoral neck and lumbar spine).PMID:37636170 | PMC:PMC10451589 | DOI:10.4103/jfmpc.jfmpc_1209_22
Source: Primary Care - August 28, 2023 Category: Primary Care Authors: Sarah I Bin Hussain Abdullah AlKhenizan Ahmed Mahmoud Hussain Qashlaq Source Type: research
The benefit of metformin in the treatment of pediatric non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomized controlled trials
Conclusion: According to the data of this meta-analysis, treatment with metformin failed to statistically improve liver enzymes but may be beneficial in the improvement of lipid parameters and insulin metabolism regulation in pediatric patients with NAFLD. As there are not enough available studies in the literature, the influence of metformin on liver ultrasonography or histology in pediatric NAFLD should be further analyzed in future studies.What is Known:• Lifestyle modification with weight loss through physical activity and dietary modification is the recommended treatment option for pediatric NAFLD.• Metformin may ...
Source: European Journal of Pediatrics - August 28, 2023 Category: Pediatrics Source Type: research
The Effect of Metformin on Triple-Negative Breast Cancer Cells and Nude Mice
This study delves deeper into the impact of metformin on TNBC by examining changes in proliferation, apoptosis, invasion, migration, and adhesion of TNBC cells, specifically MDA-MB-231, post-metformin exposure. The treatment of MDA-MB-231 with metformin in immunodeficient nude mice led to discernible changes in tumor metrics such as size, weight, lymph node engagement, and angiogenesis. Post-treatment, MDA-MB-231 cells exhibited a marked decline in proliferation, invasion, migration, and adhesion, alongside a significant rise in apoptosis. In the in vivo model with nude mice, tumors displayed notable reductions in size and...
Source: Alternative Therapies in Health and Medicine - August 26, 2023 Category: Complementary Medicine Authors: Jin Song Junfeng Du Lili Han Xue Lin Cibo Fan Gang Chen Source Type: research
Metformin Impedes Oxidation of LDL In Vitro
Pharmaceutics. 2023 Aug 9;15(8):2111. doi: 10.3390/pharmaceutics15082111.ABSTRACTMetformin is the most commonly prescribed glucose-lowering drug for the treatment of type 2 diabetes. The aim of this study was to investigate whether metformin is capable of impeding the oxidation of LDL, a crucial step in the development of endothelial dysfunction and atherosclerosis. LDL was oxidized by addition of CuCl2 in the presence of increasing concentrations of metformin. The extent of LDL oxidation was assessed by measuring lipid hydroperoxide and malondialdehyde concentrations, relative electrophoretic mobilities, and oxidation-spe...
Source: Atherosclerosis - August 26, 2023 Category: Cardiology Authors: Christine Rossmann Cornelia Ranz Gerd Kager Gerhard Ledinski Martin Koestenberger Willibald Wonisch Thomas Wagner Sebastian P Schwaminger Bruno Di Geronimo Andelko Hrzenjak Seth Hallst öm Gilbert Reibnegger Gerhard Cvirn Margret Paar Source Type: research
The Effect of Metformin on Triple-Negative Breast Cancer Cells and Nude Mice
This study delves deeper into the impact of metformin on TNBC by examining changes in proliferation, apoptosis, invasion, migration, and adhesion of TNBC cells, specifically MDA-MB-231, post-metformin exposure. The treatment of MDA-MB-231 with metformin in immunodeficient nude mice led to discernible changes in tumor metrics such as size, weight, lymph node engagement, and angiogenesis. Post-treatment, MDA-MB-231 cells exhibited a marked decline in proliferation, invasion, migration, and adhesion, alongside a significant rise in apoptosis. In the in vivo model with nude mice, tumors displayed notable reductions in size and...
Source: Alternative Therapies in Health and Medicine - August 26, 2023 Category: Complementary Medicine Authors: Jin Song Junfeng Du Lili Han Xue Lin Cibo Fan Gang Chen Source Type: research
Reevaluating First-Line Therapies in Youth-onset Type 2 Diabetes
J Clin Endocrinol Metab. 2023 Aug 25:dgad508. doi: 10.1210/clinem/dgad508. Online ahead of print.ABSTRACTThe prevalence of youth-onset type 2 diabetes is growing worldwide and current first-line treatment with metformin and intensive behavior and lifestyle changes are suboptimal in over 50% of youth within two years of diagnosis. This perspective article is a call-to-action for reevaluation of existing strategies and critical appraisal of metformin as first-line therapy in youth-onset type 2 diabetes. Increased attention should be given to novel therapeutics approved in youth, including glucagon-like 1 receptor agonists, s...
Source: The Journal of Clinical Endocrinology and Metabolism - August 25, 2023 Category: Endocrinology Authors: Stephanie T Chung Faith Davis Tejal Patel Lilian Mabundo Doris E Estrada Source Type: research
Non-coding RNA genes modulate PI3K/AKT signaling pathway in polycystic ovary syndrome
CONCLUSIONS: miRNA486 and miRNA483 downregulation may contribute to the etiology of PCOS, influence glucose metabolism, and result in IR in PCOS. Metformin's upregulation of those miRNAs affects glucose metabolism by controlling the expression of GLUT4, ameliorates PCOS-related insulin resistance, and improves PCOS-related hormonal imbalance by controlling the PI3K/AKT signaling pathway.PMID:37620736 | DOI:10.1007/s11033-023-08604-0
Source: Molecular Biology Reports - August 24, 2023 Category: Molecular Biology Authors: Heba S Omar Osama Ahmed Ibrahim Maha Gomaa Sayed Eman Mohammed Faruk Hanan Fouad Miriam Safwat Source Type: research
Strategy of targeting the tumor microenvironment via inhibition of fibroblast/fibrosis remodeling new era to cancer chemo-immunotherapy resistance
Eur J Pharmacol. 2023 Aug 22:175991. doi: 10.1016/j.ejphar.2023.175991. Online ahead of print.ABSTRACTThe use of repurposing drugs that may have neoplastic and anticancer effects increases the efficiency and decrease resistance to chemotherapy drugs through a biochemical and mechanical transduction mechanisms through modulation of fibroblast/fibrosis remodeling in tumor microenvironment (TME). Interestingly, fibroblast/fibrosis remodeling plays a vital role in mediating cancer metastasis and drug resistance after immune chemotherapy. The most essential hypothesis for induction of chemo-immunotherapy resistance is via activ...
Source: European Journal of Pharmacology - August 24, 2023 Category: Drugs & Pharmacology Authors: Mahboubeh Tajaldini Amirhoushang Poorkhani Taghi Amiriani Amirhossein Amiriani Hossein Javid Parham Aref Farahnazsadat Ahmadi Somayeh Sadani Vahid Khori Source Type: research
