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Infectious Disease: Pandemics
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Total 138118 results found since Jan 2013.
Prostaglandin E < sub > 2 < /sub > and myocarditis; friend or foe?
Biochem Pharmacol. 2023 Sep 16:115813. doi: 10.1016/j.bcp.2023.115813. Online ahead of print.ABSTRACTThis review article summarizes the role of prostaglandin E2 (PGE2) and its receptors (EP1-EP4) as it relates to the inflammatory cardiomyopathy, myocarditis. During the COVID-19 pandemic, the onset of myocarditis in a subset of patients prompted a debate on the use of nonsteroidal anti-inflammatory drugs (NSAIDs), like ibuprofen, which act to inhibit the actions of prostaglandins. This review aims to further understanding of the role of PGE2 in the pathogenesis or protection of the myocardium in myocarditis. Inflammatory ca...
Source: Biochemical Pharmacology - September 18, 2023 Category: Drugs & Pharmacology Authors: Timothy D Bryson Pamela Harding Source Type: research
Trends in consultations and prescribing for rheumatic and musculoskeletal diseases: an electronic primary care records study
CONCLUSION: Pandemic-associated restrictions led to fewer primary care consultations and relative increases in analgesic prescribing, including strong opioids, for RMDs in the UK. Policymakers must consider the impact of these changes in future healthcare resource planning.PMID:37722859 | DOI:10.3399/BJGP.2022.0648
Source: The British Journal of General Practice - September 18, 2023 Category: Primary Care Authors: Victoria K Welsh Kayleigh J Mason James Bailey Ram Bajpai Kelvin P Jordan Christian D Mallen Claire Burton Source Type: research
General practice as a place to receive help for domestic abuse during the COVID-19 pandemic: a qualitative interview study in England and Wales
CONCLUSION: Perspectives of patients and their families affected by DVA should be prioritised in general practice service planning, including during periods of transition and change.PMID:37722856 | DOI:10.3399/BJGP.2022.0528
Source: The British Journal of General Practice - September 18, 2023 Category: Primary Care Authors: Elizabeth Emsley Caroline Coope Emma Williamson Estela Capelas Barbosa Gene Feder Eszter Szilassy Source Type: research
Impact of COVID-19 on the self-esteem, psychological and dental esthetics of dental students
CONCLUSION: The pandemic, aside from affecting the health of individuals worldwide, also badly affected the well-being, mental health, and self-esteem of the dental students. Dental aesthetics plays a crucial role in the mental wellbeing and self-esteem of the students.PMID:37718829 | DOI:10.3233/WOR-220627
Source: Work - September 18, 2023 Category: Occupational Health Authors: Firas K Alqarawi Beenish Fatima Alam Talha Nayab Sami Alshehry Badr Al-Jandan Faisal Fahim Saqib Ali Source Type: research
Prostaglandin E < sub > 2 < /sub > and myocarditis; friend or foe?
Biochem Pharmacol. 2023 Sep 16:115813. doi: 10.1016/j.bcp.2023.115813. Online ahead of print.ABSTRACTThis review article summarizes the role of prostaglandin E2 (PGE2) and its receptors (EP1-EP4) as it relates to the inflammatory cardiomyopathy, myocarditis. During the COVID-19 pandemic, the onset of myocarditis in a subset of patients prompted a debate on the use of nonsteroidal anti-inflammatory drugs (NSAIDs), like ibuprofen, which act to inhibit the actions of prostaglandins. This review aims to further understanding of the role of PGE2 in the pathogenesis or protection of the myocardium in myocarditis. Inflammatory ca...
Source: Biochemical Pharmacology - September 18, 2023 Category: Drugs & Pharmacology Authors: Timothy D Bryson Pamela Harding Source Type: research
Treatments for COVID-19
Annu Rev Med. 2023 Sep 18. doi: 10.1146/annurev-med-052422-020316. Online ahead of print.ABSTRACTThe treatment for COVID-19 has evolved rapidly since the start of the pandemic and now consists mainly of antiviral and immunomodulatory agents. Antivirals, such as remdesivir and nirmatrelvir-ritonavir, have proved to be most useful earlier in illness (e.g., as outpatient therapy) and for less severe disease. Immunomodulatory therapy, such as dexamethasone and interleukin-6 or Janus kinase inhibitors, are most useful in severe disease or critical illness. The role of anti-SARS-CoV-2 monoclonal antibodies has diminished because...
Source: Annual Review of Medicine - September 18, 2023 Category: General Medicine Authors: Hayden S Andrews Jonathan D Herman Rajesh T Gandhi Source Type: research
Trends in consultations and prescribing for rheumatic and musculoskeletal diseases: an electronic primary care records study
CONCLUSION: Pandemic-associated restrictions led to fewer primary care consultations and relative increases in analgesic prescribing, including strong opioids, for RMDs in the UK. Policymakers must consider the impact of these changes in future healthcare resource planning.PMID:37722859 | DOI:10.3399/BJGP.2022.0648
Source: The British Journal of General Practice - September 18, 2023 Category: Primary Care Authors: Victoria K Welsh Kayleigh J Mason James Bailey Ram Bajpai Kelvin P Jordan Christian D Mallen Claire Burton Source Type: research
Emergency department visits and hospital admissions for suicidal ideation, self-poisoning and self-harm among adolescents in Canada during the COVID-19 pandemic
CMAJ. 2023 Sep 18;195(36):E1221-E1230. doi: 10.1503/cmaj.220507.ABSTRACTBACKGROUND: The COVID-19 pandemic had profound effects on the mental wellbeing of adolescents. We sought to evaluate pandemic-related changes in health care use for suicidal ideation, self-poisoning and self-harm.METHODS: We obtained data from the Canadian Institute for Health Information on emergency department visits and hospital admissions from April 2015 to March 2022 among adolescents aged 10-18 years in Canada. We calculated the quarterly percentage of emergency department visits and hospital admissions for a composite outcome comprising suicidal...
Source: cmaj - September 18, 2023 Category: General Medicine Authors: Naveen Poonai Stephen B Freedman Amanda S Newton Scott Sawyer Nathalie Gaucher Samina Ali Bruce Wright Michael R Miller Ahmed Mater Eleanor Fitzpatrick Mona Jabbour Roger Zemek Mohamed Eltorki Quynh Doan Pediatric Emergency Research Canada (PERC) Network Source Type: research
Self-harm among youth during the first 28 months of the COVID-19 pandemic in Ontario, Canada: a population-based study
We reported relative differences between observed and expected monthly rates overall and by age group (10-13 yr and 14-17 yr), sex and mental health service use (new and continuing).RESULTS: In this population of about 1.3 million children and adolescents, rates of acute care visits for self-harm during the pandemic were higher than expected for emergency department visits (0.27/1000 population v. 0.21/1000 population; adjusted rate ratio [RR] 1.29, 95% confidence interval [CI] 1.19-1.39) and hospital admissions (0.74/10 000 population v. 0.43/10 000 population, adjusted RR 1.72, 95% CI 1.46-2.03). This increase was primar...
Source: cmaj - September 18, 2023 Category: General Medicine Authors: Rachel H B Mitchell Alene Toulany Hannah Chung Eyal Cohen Longdi Fu Rachel Strauss Simone N Vigod Therese A Stukel Kimberly Moran Astrid Guttmann Paul Kurdyak Azmina Artani Monica Kopec Natasha R Saunders Source Type: research
General practice as a place to receive help for domestic abuse during the COVID-19 pandemic: a qualitative interview study in England and Wales
CONCLUSION: Perspectives of patients and their families affected by DVA should be prioritised in general practice service planning, including during periods of transition and change.PMID:37722856 | DOI:10.3399/BJGP.2022.0528
Source: The British Journal of General Practice - September 18, 2023 Category: Primary Care Authors: Elizabeth Emsley Caroline Coope Emma Williamson Estela Capelas Barbosa Gene Feder Eszter Szilassy Source Type: research
Prone Positioning for Patients With COVID-19-Induced Acute Hypoxemic Respiratory Failure: Flipping the Script
Respir Care. 2023 Oct;68(10):1449-1464. doi: 10.4187/respcare.11227.ABSTRACTDuring the COVID-19 pandemic, prone positioning (PP) emerged as a widely used supportive therapy for patients with acute hypoxemic respiratory failure caused by COVID-19 infection. In particular, awake PP (APP)-the placement of non-intubated patients in the prone position-has gained popularity and hence is detailed first herein. This review discusses recent publications on the use of PP for non-intubated and intubated subjects with COVID-19, highlighting the physiological responses, clinical outcomes, influential factors affecting treatment success...
Source: Respiratory Care - September 18, 2023 Category: Respiratory Medicine Authors: Jie Li Miguel Ibarra-Estrada Claude Gu érin Source Type: research
Treatments for COVID-19
Annu Rev Med. 2023 Sep 18. doi: 10.1146/annurev-med-052422-020316. Online ahead of print.ABSTRACTThe treatment for COVID-19 has evolved rapidly since the start of the pandemic and now consists mainly of antiviral and immunomodulatory agents. Antivirals, such as remdesivir and nirmatrelvir-ritonavir, have proved to be most useful earlier in illness (e.g., as outpatient therapy) and for less severe disease. Immunomodulatory therapy, such as dexamethasone and interleukin-6 or Janus kinase inhibitors, are most useful in severe disease or critical illness. The role of anti-SARS-CoV-2 monoclonal antibodies has diminished because...
Source: Annual Review of Medicine - September 18, 2023 Category: General Medicine Authors: Hayden S Andrews Jonathan D Herman Rajesh T Gandhi Source Type: research
Impact of COVID-19 on the self-esteem, psychological and dental esthetics of dental students
CONCLUSION: The pandemic, aside from affecting the health of individuals worldwide, also badly affected the well-being, mental health, and self-esteem of the dental students. Dental aesthetics plays a crucial role in the mental wellbeing and self-esteem of the students.PMID:37718829 | DOI:10.3233/WOR-220627
Source: Work - September 18, 2023 Category: Occupational Health Authors: Firas K Alqarawi Beenish Fatima Alam Talha Nayab Sami Alshehry Badr Al-Jandan Faisal Fahim Saqib Ali Source Type: research
"It's already stressful being a foster parent": A qualitative inquiry into foster parenting stress during COVID-19
CONCLUSIONS: Findings from this study demonstrated foster parents experienced both shared and unique parenting challenges during COVID-19. Three areas for further consideration and development in practice included improving online service delivery, strengthening guidance for online parent-child visitation, and enhancing support for foster parents of children with special needs. Developing social support and self-care practices should continue to be ongoing priorities for foster parents and foster parent-serving agencies.PMID:37717544 | DOI:10.1016/j.chiabu.2023.106455
Source: Child Abuse and Neglect - September 17, 2023 Category: Child Development Authors: Erin Findley Source Type: research
Regulation of SARS-CoV-2 infection and antiviral innate immunity by ubiquitination and ubiquitin-like conjugation
Biochim Biophys Acta Gene Regul Mech. 2023 Sep 15:194984. doi: 10.1016/j.bbagrm.2023.194984. Online ahead of print.ABSTRACTA global pandemic COVID-19 resulting from SARS-CoV-2 has affected a significant portion of the human population. Antiviral innate immunity is critical for controlling and eliminating the viral infection. Ubiquitination is extensively involved in antiviral signaling, and recent studies suggest that ubiquitin-like proteins (Ubls) modifications also participate in innate antiviral pathways such as RLR and cGAS-STING pathways. Notably, virus infection harnesses ubiquitination and Ubls modifications to faci...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Yi Zheng Huiyu Yang Xuejing Zhang Chengjiang Gao Source Type: research
