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Infectious Disease: Influenza
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Interspecies Transmission of Swine Influenza A Viruses and Human Seasonal Vaccine-Mediated Protection Investigated in Ferret Model
Emerg Infect Dis. 2023 Sep;29(9):1798-1807. doi: 10.3201/eid2909.230066.ABSTRACTWe investigated the infection dynamics of 2 influenza A(H1N1) virus isolates from the swine 1A.3.3.2 (pandemic 2009) and 1C (Eurasian, avian-like) lineages. The 1C-lineage virus, A/Pavia/65/2016, although phylogenetically related to swine-origin viruses, was isolated from a human clinical case. This strain infected ferrets, a human influenza model species, and could be transmitted by direct contact and, less efficiently, by airborne exposure. Infecting ferrets and pigs (the natural host) resulted in mild or inapparent clinical signs comparable ...
Source: Emerging Infectious Diseases - August 23, 2023 Category: Infectious Diseases Authors: Pauline M van Diemen Alexander M P Byrne Andrew M Ramsay Samantha Watson Alejandro Nunez Ana V Moreno Chiara Chiapponi Emanuela Foni Ian H Brown Sharon M Brookes Helen E Everett Source Type: research
Shifting Patterns of Influenza Circulation during the COVID-19 Pandemic, Senegal
Emerg Infect Dis. 2023 Sep;29(9):1808-1817. doi: 10.3201/eid2909.230307.ABSTRACTHistorically low levels of seasonal influenza circulation were reported during the first years of the COVID-19 pandemic and were mainly attributed to implementation of nonpharmaceutical interventions. In tropical regions, influenza's seasonality differs largely, and data on this topic are scarce. We analyzed data from Senegal's sentinel syndromic surveillance network before and after the start of the COVID-19 pandemic to assess changes in influenza circulation. We found that influenza shows year-round circulation in Senegal and has 2 distinct e...
Source: Emerging Infectious Diseases - August 23, 2023 Category: Infectious Diseases Authors: Alexandre Lampros Cheikh Talla Maryam Diarra Billo Tall Samba Sagne Mamadou Korka Diallo Boly Diop Ibrahim Oumar Ndongo Dia Amadou Alpha Sall Mamadou Aliou Barry Cheikh Loucoubar Source Type: research
Cell-Cell Fusion Assays to Study Henipavirus Entry and Evaluate Therapeutics
Methods Mol Biol. 2023;2682:59-69. doi: 10.1007/978-1-0716-3283-3_4.ABSTRACTHenipaviruses include the deadly zoonotic Nipah (NiV) and Hendra (HeV) paramyxoviruses, which have caused recurring outbreaks in human populations. A hallmark of henipavirus infection is the induction of cell-cell fusion (syncytia), caused by the expression of the attachment (G) and fusion (F) glycoproteins on the surface of infected cells. The interactions of G and F with each other and with receptors on cellular plasma membranes drive both viral entry and syncytia formation and are thus of great interest. While F shares structural and functional ...
Source: Mol Biol Cell - August 23, 2023 Category: Molecular Biology Authors: I Abrrey Monreal Hector C Aguilar Source Type: research
Chicken miR-26a-5p modulates MDA5 during highly pathogenic avian influenza virus infection
In this study, we aimed to investigate the systemic biological function of gga-miR-26a-5p, a chicken miRNA, in the immune responses to HPAIV H5N1 infection in the Vietnamese Ri chicken line. Our results showed a significant downregulation in gga-miR-26a expression in the lung tissue of Ri chickens during HPAIV H5N1 infection. Overexpression of gga-miR-26a and the reporter construct, either containing the wildtype or mutant melanoma differentiation-associated protein 5 (MDA5) 3' untranslated region (3' UTR)-luciferase, into a chicken fibroblast cell line, revealed that gga-miR-26a can act as a direct translational repressor...
Source: Developmental and Comparative Immunology - August 23, 2023 Category: Allergy & Immunology Authors: Thi Hao Vu Jubi Heo Suyeon Kang Chaeeun Kim Hyun S Lillehoj Yeong Ho Hong Source Type: research
Interspecies Transmission of Swine Influenza A Viruses and Human Seasonal Vaccine-Mediated Protection Investigated in Ferret Model
Emerg Infect Dis. 2023 Sep;29(9):1798-1807. doi: 10.3201/eid2909.230066.ABSTRACTWe investigated the infection dynamics of 2 influenza A(H1N1) virus isolates from the swine 1A.3.3.2 (pandemic 2009) and 1C (Eurasian, avian-like) lineages. The 1C-lineage virus, A/Pavia/65/2016, although phylogenetically related to swine-origin viruses, was isolated from a human clinical case. This strain infected ferrets, a human influenza model species, and could be transmitted by direct contact and, less efficiently, by airborne exposure. Infecting ferrets and pigs (the natural host) resulted in mild or inapparent clinical signs comparable ...
Source: Emerging Infectious Diseases - August 23, 2023 Category: Infectious Diseases Authors: Pauline M van Diemen Alexander M P Byrne Andrew M Ramsay Samantha Watson Alejandro Nunez Ana V Moreno Chiara Chiapponi Emanuela Foni Ian H Brown Sharon M Brookes Helen E Everett Source Type: research
Shifting Patterns of Influenza Circulation during the COVID-19 Pandemic, Senegal
Emerg Infect Dis. 2023 Sep;29(9):1808-1817. doi: 10.3201/eid2909.230307.ABSTRACTHistorically low levels of seasonal influenza circulation were reported during the first years of the COVID-19 pandemic and were mainly attributed to implementation of nonpharmaceutical interventions. In tropical regions, influenza's seasonality differs largely, and data on this topic are scarce. We analyzed data from Senegal's sentinel syndromic surveillance network before and after the start of the COVID-19 pandemic to assess changes in influenza circulation. We found that influenza shows year-round circulation in Senegal and has 2 distinct e...
Source: Emerging Infectious Diseases - August 23, 2023 Category: Infectious Diseases Authors: Alexandre Lampros Cheikh Talla Maryam Diarra Billo Tall Samba Sagne Mamadou Korka Diallo Boly Diop Ibrahim Oumar Ndongo Dia Amadou Alpha Sall Mamadou Aliou Barry Cheikh Loucoubar Source Type: research
Immune checkpoint inhibitor-induced neurotoxicity is not associated with seroprevalence of neurotropic infections
CONCLUSION: Previous viral, bacterial and protozoal neurotropic infections appear not to be associated with the development of neurological irAEs in melanoma patients who underwent therapy with ICI across 3 countries. Further efforts are needed to unravel the factors underlying neurological irAEs in order to identify risk factors for these toxicities, especially with the increasing use of ICI in earlier stage disease.PMID:37606856 | DOI:10.1007/s00262-023-03498-0
Source: Herpes - August 22, 2023 Category: Infectious Diseases Authors: C Schmitt E P Hoefsmit T Fangmeier N Kramer C Kabakci J Vera Gonz ález J M Versluis A Compter T Harrer H Mijo čević S Schubert T Hundsberger A M Menzies R A Scolyer G V Long L E French C U Blank L M Heinzerling Source Type: research
The Possible Mechanisms of Cu and Zn in the Treatment and Prevention of HIV and COVID-19 Viral Infection
Biol Trace Elem Res. 2023 Aug 23. doi: 10.1007/s12011-023-03788-9. Online ahead of print.ABSTRACTDue to their unique properties and their potential therapeutic and prophylactic applications, heavy metals have attracted the interest of many researchers, especially during the outbreak of COVID-19. Indeed, zinc (Zn) and copper (Cu) have been widely used during viral infections. Zn has been reported to prevent excessive inflammatory response and cytokine storm, improve the response of the virus to Type I interferon (IFN-1), and enhance the production of IFN-a to counteract the antagonistic effect of SARS-CoV-2 virus protein on...
Source: Biological Trace Element Research - August 22, 2023 Category: Biology Authors: Shatha A Albalawi Raneem A Albalawi Amaal A Albalawi Raghad F Alanazi Raghad M Almahlawi Basma S Alhwity Bashayer D Alatawi Nehal Elsherbiny Saleh F Alqifari Mohamed S Abdel-Maksoud Source Type: research
Increasing Influenza vaccination uptake rates in the 65-year-old population
Ir Med J. 2023 Aug 17;116(7):805.NO ABSTRACTPMID:37606210
Source: Ir Med J - August 22, 2023 Category: General Medicine Source Type: research
The Possible Mechanisms of Cu and Zn in the Treatment and Prevention of HIV and COVID-19 Viral Infection
Biol Trace Elem Res. 2023 Aug 23. doi: 10.1007/s12011-023-03788-9. Online ahead of print.ABSTRACTDue to their unique properties and their potential therapeutic and prophylactic applications, heavy metals have attracted the interest of many researchers, especially during the outbreak of COVID-19. Indeed, zinc (Zn) and copper (Cu) have been widely used during viral infections. Zn has been reported to prevent excessive inflammatory response and cytokine storm, improve the response of the virus to Type I interferon (IFN-1), and enhance the production of IFN-a to counteract the antagonistic effect of SARS-CoV-2 virus protein on...
Source: Biological Trace Element Research - August 22, 2023 Category: Biology Authors: Shatha A Albalawi Raneem A Albalawi Amaal A Albalawi Raghad F Alanazi Raghad M Almahlawi Basma S Alhwity Bashayer D Alatawi Nehal Elsherbiny Saleh F Alqifari Mohamed S Abdel-Maksoud Source Type: research
Immune checkpoint inhibitor-induced neurotoxicity is not associated with seroprevalence of neurotropic infections
CONCLUSION: Previous viral, bacterial and protozoal neurotropic infections appear not to be associated with the development of neurological irAEs in melanoma patients who underwent therapy with ICI across 3 countries. Further efforts are needed to unravel the factors underlying neurological irAEs in order to identify risk factors for these toxicities, especially with the increasing use of ICI in earlier stage disease.PMID:37606856 | DOI:10.1007/s00262-023-03498-0
Source: Herpes - August 22, 2023 Category: Infectious Diseases Authors: C Schmitt E P Hoefsmit T Fangmeier N Kramer C Kabakci J Vera Gonz ález J M Versluis A Compter T Harrer H Mijo čević S Schubert T Hundsberger A M Menzies R A Scolyer G V Long L E French C U Blank L M Heinzerling Source Type: research
Increasing Influenza vaccination uptake rates in the 65-year-old population
Ir Med J. 2023 Aug 17;116(7):805.NO ABSTRACTPMID:37606210
Source: Ir Med J - August 22, 2023 Category: General Medicine Source Type: research
Immune checkpoint inhibitor-induced neurotoxicity is not associated with seroprevalence of neurotropic infections
CONCLUSION: Previous viral, bacterial and protozoal neurotropic infections appear not to be associated with the development of neurological irAEs in melanoma patients who underwent therapy with ICI across 3 countries. Further efforts are needed to unravel the factors underlying neurological irAEs in order to identify risk factors for these toxicities, especially with the increasing use of ICI in earlier stage disease.PMID:37606856 | DOI:10.1007/s00262-023-03498-0
Source: Cancer Control - August 22, 2023 Category: Cancer & Oncology Authors: C Schmitt E P Hoefsmit T Fangmeier N Kramer C Kabakci J Vera Gonz ález J M Versluis A Compter T Harrer H Mijo čević S Schubert T Hundsberger A M Menzies R A Scolyer G V Long L E French C U Blank L M Heinzerling Source Type: research
The Possible Mechanisms of Cu and Zn in the Treatment and Prevention of HIV and COVID-19 Viral Infection
Biol Trace Elem Res. 2023 Aug 23. doi: 10.1007/s12011-023-03788-9. Online ahead of print.ABSTRACTDue to their unique properties and their potential therapeutic and prophylactic applications, heavy metals have attracted the interest of many researchers, especially during the outbreak of COVID-19. Indeed, zinc (Zn) and copper (Cu) have been widely used during viral infections. Zn has been reported to prevent excessive inflammatory response and cytokine storm, improve the response of the virus to Type I interferon (IFN-1), and enhance the production of IFN-a to counteract the antagonistic effect of SARS-CoV-2 virus protein on...
Source: Cell Research - August 22, 2023 Category: Cytology Authors: Shatha A Albalawi Raneem A Albalawi Amaal A Albalawi Raghad F Alanazi Raghad M Almahlawi Basma S Alhwity Bashayer D Alatawi Nehal Elsherbiny Saleh F Alqifari Mohamed S Abdel-Maksoud Source Type: research
