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Vaccination: Vaccines
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Total 88601 results found since Jan 2013.
Personalized Medicine's Coming of Age: One Drug, One Patient
Clin Cancer Res. 2023 Sep 21. doi: 10.1158/1078-0432.CCR-23-2194. Online ahead of print.ABSTRACTA dendritic cell/myeloma fusion vaccine, given with lenalidomide and GM-CSF, did not result in a statistically significant increase in CR rates at 1-year post-transplant but was associated with a significant increase in circulating multiple myeloma-reactive lymphocytes indicative of tumor-specific immunity.PMID:37733765 | DOI:10.1158/1078-0432.CCR-23-2194
Source: Clinical Cancer Research - September 21, 2023 Category: Cancer & Oncology Authors: Muzaffar H Qazilbash Larry W Kwak Source Type: research
Insights into enterovirus a-71 antiviral development: from natural sources to synthetic nanoparticles
Arch Microbiol. 2023 Sep 21;205(10):334. doi: 10.1007/s00203-023-03660-3.ABSTRACTEnteroviruses are pathogens responsible for several diseases, being enterovirus A71 (EVA71) the second leading cause of hand, foot, and mouth disease (HFMD), especially in Asia-Pacific countries. HFMD is mostly common in infants and children, with mild symptoms. However, the disease can result in severe nervous system disorders in children as well as in immunosuppressed adults. The virus is highly contagious, and its transmission occurs via fecal-oral, oropharyngeal secretions, and fomites. The EVA71 burdens the healthy systems and economies a...
Source: Archives of Microbiology - September 21, 2023 Category: Microbiology Authors: Shiraz Feferbaum-Leite Igor Andrade Santos Vict ória Riquena Grosche Gislaine Celestino Dutra da Silva Ana Carolina Gomes Jardim Source Type: research
Continued challenges in pediatric anesthesia during COVID-19 in 2022: An international survey from the pediatric anesthesia COVID-19 collaborative
CONCLUSION: Our study found that COVID-19 has continued to impact pediatric anesthesiology. There are major discrepancies between what anesthesiologists believe are important for job satisfaction and faculty retention compared to implemented initiatives. Data from this survey provide insight for institutions and departments for addressing these challenges.PMID:37732382 | DOI:10.1111/pan.14762
Source: Paediatric Anaesthesia - September 21, 2023 Category: Anesthesiology Authors: John Zhong Victoria Bradford Allison M Fernandez Andrew Infosino Codruta N Soneru Steven J Staffa Vidya T Raman Joseph Cravero David Zurakowski Petra M Meier Pediatric Anesthesia COVID-19 Collaborative Source Type: research
Pentavalent outer membrane vesicles immunized mice sera confers passive protection against five prevalent pathotypes of diarrhoeagenic Escherichia coli in neonatal mice
Immunol Lett. 2023 Sep 19:S0165-2478(23)00158-X. doi: 10.1016/j.imlet.2023.09.009. Online ahead of print.ABSTRACTDiarrhoeagenic Escherichia coli (DEC) pathotypes are one of the major causative agents of diarrhoea induced childhood morbidity and mortality in developing countries. Licensed vaccines providing broad spectrum protection against DEC mediated infections are not available. Outer membrane vesicles (OMVs) are microvesicles released by gram-negative bacteria during the growth phase and contain multiple immunogenic proteins. Based on prevalence of infections, we have formulated a pentavalent outer-membrane vesicles (P...
Source: Immunology Letters - September 21, 2023 Category: Allergy & Immunology Authors: Soumalya Banerjee Prolay Halder Sanjib Das Suhrid Maiti Ushasi Bhaumik Moumita Dutta Goutam Chowdhury Kei Kitahara Shin-Ichi Miyoshi Asish Kumar Mukhopadhyay Shanta Dutta Hemanta Koley Source Type: research
Identification of a novel transcriptional regulator, CorR, for copper stress response in < em > Edwardsiella piscicida < /em >
Appl Environ Microbiol. 2023 Sep 21:e0089923. doi: 10.1128/aem.00899-23. Online ahead of print.ABSTRACTCopper plays a vital role in the host-pathogen interface, potentially making components of the bacterial copper response suitable targets for the development of innovative antimicrobial strategies. The anti-copper arsenal of intracellular pathogens has expanded as an adaptation to survive copper toxicity in order to escape intracellular killing by the host immune system. Herein, we employed transposon insertion sequencing to investigate the genetic mechanisms underlying the survival of Edwardsiella piscicida under copper ...
Source: Applied and Environmental Microbiology - September 21, 2023 Category: Microbiology Authors: Feng Xia Pengfei Xu Boya Zhang Yibei Zhang Xiaohong Liu Yue Ma Yuanxing Zhang Qiyao Wang Shuai Shao Source Type: research
Review: Factors influencing parents' decisions to vaccinate children against COVID-19
CONCLUSION: This review identified critical factors affecting parents' vaccination behavior for their children. Awareness of these factors may reduce parents' COVID-19 vaccine refusal for their children and guide future planning and development of public health studies.PMID:37735055 | DOI:10.1016/j.vaccine.2023.09.020
Source: Vaccine - September 21, 2023 Category: Allergy & Immunology Authors: Haifa S Alharbi Source Type: research
Identification of γ-Fagarine as a novel antiviral agent against respiratory virus (hMPV) infection
In this study, we aim to investigate the effect of γ-Fagarine on hMPV infection and explore its underlying molecular mechanisms. Vero-E6 and 16HBE cells were used as cell models. Virus replication and microcosm character were explored in Vero-E6 cells. Then, the antiviral activities were investigated by quantitative real-time PCR (RT-qPCR), western blotting (WB), and indirect immunofluorescence assays (IFAs) in Vero-E6 and 16HBE. Potential mechanisms of γ-Fagarine related to HSPG and lysosome pH were assessed in 16HBE cells. Lastly, a virus-infected mouse model was established and antiviral assay in vivo was conducted. Î...
Source: Virus Research - September 21, 2023 Category: Virology Authors: Jinhua Li Yao Zhao Ying Dai Junning Zhao Source Type: research
Nervous system-related tropism of SARS-CoV-2 and autoimmunity in COVID-19 infection
This article is protected by copyright. All rights reserved.PMID:37733584 | DOI:10.1002/eji.202250230
Source: European Journal of Immunology - September 21, 2023 Category: Allergy & Immunology Authors: Robert Weissert Source Type: research
Identification of γ-Fagarine as a novel antiviral agent against respiratory virus (hMPV) infection
In this study, we aim to investigate the effect of γ-Fagarine on hMPV infection and explore its underlying molecular mechanisms. Vero-E6 and 16HBE cells were used as cell models. Virus replication and microcosm character were explored in Vero-E6 cells. Then, the antiviral activities were investigated by quantitative real-time PCR (RT-qPCR), western blotting (WB), and indirect immunofluorescence assays (IFAs) in Vero-E6 and 16HBE. Potential mechanisms of γ-Fagarine related to HSPG and lysosome pH were assessed in 16HBE cells. Lastly, a virus-infected mouse model was established and antiviral assay in vivo was conducted. Î...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Jinhua Li Yao Zhao Ying Dai Junning Zhao Source Type: research
Research Progress in Immunotherapy of Gliomas
J Integr Neurosci. 2023 Aug 14;22(5):118. doi: 10.31083/j.jin2205118.ABSTRACTAlthough some progress has been made in tumor treatment, gliomas remain one of the tumors that can still seriously threaten human life and health. Due to the particularity of the immune microenvironment of the central nervous system and the strong invasiveness of tumors, the treatment of gliomas remains a major challenge. Currently, researchers have explored a large number of immunotherapy programs to improve the survival and prognosis of glioma patients, including tumor vaccines, immune checkpoint inhibitors, adoptive cell transfer therapy, viral...
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Zhi-Hong Duan Zi-Long Wei Source Type: research
Personalized Medicine's Coming of Age: One Drug, One Patient
Clin Cancer Res. 2023 Sep 21. doi: 10.1158/1078-0432.CCR-23-2194. Online ahead of print.ABSTRACTA dendritic cell/myeloma fusion vaccine, given with lenalidomide and GM-CSF, did not result in a statistically significant increase in CR rates at 1-year post-transplant but was associated with a significant increase in circulating multiple myeloma-reactive lymphocytes indicative of tumor-specific immunity.PMID:37733765 | DOI:10.1158/1078-0432.CCR-23-2194
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Muzaffar H Qazilbash Larry W Kwak Source Type: research
Human CD34 < sup > + < /sup > -derived complete plasmacytoid and conventional dendritic cell vaccine effectively induces antigen-specific CD8 < sup > + < /sup > T cell and NK cell responses in vitro and in vivo
In this study, we aimed to dissect the phenotypic identity of these non-DCs and their potential immune modulatory functions on the potency of cDCs and pDCs in stimulating tumor-reactive CD8+ T and NK cell responses, in order to obtain rationale for clinical translation of our DC-complete vaccine. The non-DC compartment was heterogeneous and comprised of myeloid progenitors and (immature) granulocyte- and monocyte-like cells. Importantly, non-DCs potentiated toll-like receptor-induced DC maturation, as reflected by increased expression of co-stimulatory molecules and enhanced cDC-derived IL-12 and pDC-derived IFN-α product...
Source: Cellular and Molecular Life Sciences : CMLS - September 20, 2023 Category: Cytology Authors: Jesper van Eck van der Sluijs Diede van Ens Jolanda Brummelman Daan Heister Aastha Sareen Lisa Truijen Dorette S van Ingen Schenau Mirjam H M Heemskerk Marieke Griffioen Michel G D Kester Nicolaas P M Schaap Joop H Jansen Anniek B van der Waart Harry Dols Source Type: research
Neonatal erythema multiforme associated with a rotavirus infection: A case report
CONCLUSION: The possibility of rotavirus, a major cause of pediatric gastrointestinal infections, being a trigger for neonatal EM should be considered.PMID:37727716 | PMC:PMC10506005 | DOI:10.12998/wjcc.v11.i24.5749
Source: Herpes - September 20, 2023 Category: Infectious Diseases Authors: Jung Jae Kim Joon Kee Lee Source Type: research
Evaluation the effect of dietary vitamin E, sesamin and thymoquinone bioactive compounds on immunological response, intestinal traits and MUC-2 gene expression in broiler Japanese quails ( < em > Coturnix japonica < /em > )
Anim Biotechnol. 2023 Sep 20:1-11. doi: 10.1080/10495398.2023.2259437. Online ahead of print.ABSTRACTThe current study was performed to determine the effect of dietary vitamin E, sesamin and thymoquinone bioactive lignans derived from sesame and black seed on immunological response, intestinal traits and Mucin2 gene expression in broiler quails. Three hundred and fifty (one days-old) quails were allotted to seven dietary treatments with five replicates as an experimental randomized design study. Treatments were basal diet as a control, control +100 and +200 mg of vitamin E, sesamin and thymoquinone per each kg of diet resp...
Source: Animal Biotechnology - September 20, 2023 Category: Biotechnology Authors: Yaser Rahimian Farshid Kheiri Mostafa Faghani Source Type: research
