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2018: The Near Future of Flu
The influenza virus continues to be wildly successful at growing and spreading in people around the world because it slightly changes its structure from time to time to avoid our body’s detection systems. In particular, influenza periodically changes some of the proteins in the outer envelope of the virus to mislead our immune systems. We get fooled again and again. When someone with the flu coughs or sneezes, huge amounts of virus are spewed out in droplets that travel up to about 6 feet. Inhaling these droplets is the surest way for the virus to enter our bodies. It can also enter through landing on the eye. Beyond thi...
Source: Conversations with Dr Greene - December 14, 2017 Category: Child Development Authors: Dr. Alan Greene Tags: Dr. Greene's Blog Colds & Flu Cough Source Type: blogs

65-yo patient received a standard-dose flu shot already this season. Should she get the high-dose shot too? Or get a second regular flu shot?
A 65-yo female patient received a standard-dose flu shot already this season. Should he get the high-dose shot too? Or try to get a second regular flu shot?The simple answer is no. The patients should consider herself immunized. Studies show that getting a delayed second dose doesn't necessarily increase antibody response, and there's some concern that it might actually have a negative effect on the immunity. If you've already had the regular seasonal dose, wait until next year for another dose.Image of the H1N1 Influenza Virus, CDC.From CDC's Immunize.org website:Sometimes patients age 65 years and older who have received...
Source: Clinical Cases and Images - Blog - October 15, 2014 Category: Universities & Medical Training Tags: Infectious Diseases Vaccines Source Type: blogs

Flu shots during pregnancy
Is your head already spinning from all of the confusing information about the safety of routine vaccinations? Well, news of the latest findings regarding the flu vaccine during pregnancy certainly won’t help things. A group of researchers recently reported an association between a pregnant woman getting the flu vaccine and having a miscarriage. The authors were clear that the study could not establish that flu shots cause miscarriage. It could only report the observation that, in this small group of women, miscarriage was slightly more common within 28 days of getting the flu shot. But only in women who had also gotten a...
Source: Harvard Health Blog - September 27, 2017 Category: Consumer Health News Authors: Andrea Chisholm, MD Tags: Cold and Flu Family Planning and Pregnancy Health Infectious diseases Prevention Vaccines Women's Health Source Type: blogs

Google's Big Data Flu Flop
This article in Science finds that the real-world predictive power has been pretty unimpressive. And the reasons behind this failure are not hard to understand, nor were they hard to predict. Anyone who's ever worked with clinical trial data will see this one coming: The initial version of GFT was a particularly problematic marriage of big and small data. Essentially, the methodology was to find the best matches among 50 million search terms to fit 1152 data points. The odds of finding search terms that match the propensity of the flu but are structurally unrelated, and so do not predict the future, were quite high. GFT d...
Source: In the Pipeline - March 24, 2014 Category: Chemists Tags: Clinical Trials Source Type: blogs

Flu Expected to Continue Several More Weeks
According to the latest CDC Update, flu is expected to continue for several more weeks. Influenza activity in the United States began to increase in mid-December, remained elevated through February 4, 2017, and is expected to continue. To date, influenza A (H3N2) viruses have predominated overall, but influenza A (H1N1)pdm09 and influenza B viruses have also been identified. CDC collects, compiles, and analyzes data on influenza activity year round in the United States. Timing of influenza activity and predominant circulating influenza viruses vary by season. For more details, see the article itself. Blanton L, Mustaquim ...
Source: BHIC - March 2, 2017 Category: Databases & Libraries Authors: Kay Deeney Tags: Articles General Public Health Source Type: blogs

Influenza in France, India, and England and Wales
Le Monde is reporting 600000 new cases of flu in a week, the article referring to a bulletin from the INVS, the Institut Veille Sanitaire.Another article in Le Monde describes this year's outbreak of flu as the most important in the last five years, and has graphs of the number of people hospitalised, the incidence per 100000 people, and one depicting the cases in the last five years.  The INVS is suggesting this year's outbreak, mostly due to H3N2, is nearing its peak.Thinking of flu, the HPA's weekly bulletin for England and Wales is here (for 19th February), and the New York Times has a topic page drawing together ...
Source: Browsing - February 22, 2015 Category: Databases & Libraries Tags: influenza Source Type: blogs

Reconstruction of 1918-like avian influenza virus stirs concern over gain of function experiments
The gain of function experiments in which avian influenza H5N1 virus was provided the ability to transmit by aerosol among ferrets were met with substantial outrage from both the press and even some scientists; scenarios of lethal viruses escaping from the laboratory and killing millions proliferated (see examples here and here). The recent publication of new influenza virus gain of function studies from the laboratories of Kawaoka and Perez have unleashed another barrage of criticism. What exactly was done and what does it mean? According to critics, virologists should not be entrusted to carry out gain of function studie...
Source: virology blog - June 20, 2014 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information 1918 pandemic aerosol transmission avian influenza ferret gain of function H5N1 viral virus Source Type: blogs

TWiV 296: Influenza viruses with Peter Palese
Vincent speaks with Peter Palese about his illustrious career in virology, from early work on neuraminidases to universal influenza virus vaccines, on episode #396 of the science show This Week in Virology. You can find TWiV #396 at microbe.tv/twiv, or listen below. Click arrow to play Download TWiV 396 (54 MB .mp3, 74 min) Subscribe (free): iTunes, RSS, email
Source: virology blog - July 3, 2016 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology aerosol transmission ferret Flu gain of function H5N1 influenza influenza virus neuraminidase relenza swine flu tamiflu universal vaccine viral viruses Source Type: blogs

TWiV 396: Influenza viruses with Peter Palese
Vincent speaks with Peter Palese about his illustrious career in virology, from early work on neuraminidases to universal influenza virus vaccines, on episode #396 of the science show This Week in Virology. You can find TWiV #396 at microbe.tv/twiv, or listen below. Click arrow to play Download TWiV 396 (54 MB .mp3, 74 min) Subscribe (free): iTunes, RSS, email
Source: virology blog - July 3, 2016 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology aerosol transmission ferret Flu gain of function H5N1 influenza influenza virus neuraminidase relenza swine flu tamiflu universal vaccine viral viruses Source Type: blogs

Unusual mortality pattern of 1918 influenza A virus
The 1918 influenza pandemic was particularly lethal, not only for the very young and the very old (as observed for typical influenza), but unexpectedly also for young adults, 20 to 40 years of age (pictured). It has been suggested that the increased lethality in young adults occurred because they lacked protective immunity that would be conferred by previous infection with a related virus. Reconstruction of the origins of the 1918 influenza virus provides support for this hypothesis. Analysis of influenza virus genome sequences using a host-specific molecular clock together with seroarchaeology (analysis of stored sera fo...
Source: virology blog - May 2, 2014 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information 1918 pandemic H1N1 H2N2 H3N8 HA influenza seroarchaeology vaccine viral virus Source Type: blogs

Virology question of the week: why a segmented viral genome?
This week’s virology question comes from Eric, who writes: I’m working on an MPH and in one of my classes we are currently studying the influenza virus. I’d forgotten that the genome is in 8 separate parts. Curious, I’ve been searching but can’t find any information as to why that is? What evolutionary advantage is conferred by having a segmented genome? Terrific question! Here is my reply: It’s always hard to have answers to ‘why’ questions such as yours. We answer these questions from a human-centric view of what viruses ‘need’. We might not be right. But I’d guess there ...
Source: virology blog - April 22, 2014 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information evolution gene expression influenza reassortment segmented genome viral virus Source Type: blogs

Influenza virus in breast milk
During breastfeeding, mothers provide the infant with nutrients, beneficial bacteria, and immune protection. Fluids from the infant may also enter the mammary gland through retrograde flux of the nipple. Studies in a ferret model reveal that influenza virus replicates in the mammary gland, is shed in breast milk and transmitted to the infant. Virus may also travel in the opposite direction, from infant to mother. The role of the mammary gland in influenza virus transmission was studied using a ferret model comprising lactating mothers and nursing infants. Intranasal inoculation of nursing mother ferrets with the 2009 H1N1 ...
Source: virology blog - November 12, 2015 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information aerosol breast breastfeeding H1N1 infant influenza influenza virus mammary gland milk mother pandemic transmission viral Source Type: blogs

Flu news: Now most people with egg allergies can get a flu shot
There are hundreds of viruses that can cause respiratory illnesses; influenza (the “flu”) is just one group of viruses which can cause mild to severe illness, and sometimes even death. Certain people — such as the very young or the very old, pregnant women, or those with chronic medical conditions like asthma, diabetes, or heart disease — are at greater risk for serious complications from the flu. Though the numbers fluctuate, the flu leads to hundreds of thousands of hospitalizations and anywhere from 3,000 to 49,000 deaths every year in the U.S., based on the numbers from the last few decades. How bad the flu sea...
Source: Harvard Health Blog - October 6, 2016 Category: Consumer Health News Authors: Wynne Armand, MD Tags: Cold and Flu Infectious diseases Prevention Vaccines Source Type: blogs

Does the flu vaccine cause miscarriages?
A recent study claims to have found a link between influenza vaccination and miscarriage, and antivaxers are rejoicing. The study itself suffers mightily from post hoc subgroup analyses and small numbers in the subgroup, so much so that even its authors don't really believe its results. The post Does the flu vaccine cause miscarriages? appeared first on RESPECTFUL INSOLENCE.
Source: Respectful Insolence - September 14, 2017 Category: Surgery Authors: Orac Tags: Antivaccine nonsense Clinical trials Medicine case control study Frank DeStefano H1N1 influenza J.B. Handley miscarriage Source Type: blogs

Bad flu season predicted — did you get your shot?
What can we expect from the flu season this year? Unfortunately, many experts are predicting an active, and possibly severe, flu season. This projection is based on data from Australia, where the flu season is just wrapping up. Australia was hit early and hard by flu this year: over 300,000 patients had laboratory-confirmed influenza, a record number of cases. Flu outbreaks in the Southern Hemisphere happen during our summers, and they often give us a clue as to what we should expect when the flu lands on our shores in the fall. Who should get the flu vaccine? Basically, everybody over the age of 6 months, except for those...
Source: Harvard Health Blog - November 4, 2019 Category: Consumer Health News Authors: John Ross, MD, FIDSA Tags: Cold and Flu Health Prevention Vaccines Source Type: blogs