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The Days of Miracles and Wonder
Here ' s a good overview by Derek Thompson in The Atlantic ofthe history of mRNA technology. This heretofore obscure field of biomedical research burst into view with the Covid-19 vaccines, but the apparent suddenness of vaccine development was misleading. As I have noted here before, the technology was decades in development. As the technology became more mature, Pfizer partnered with one of the speculative ventures, BionTech, originally to develop flu vaccines, and then of course pivoted to Covid-19. Unlike Moderna, Pfizer actually didn ' t take federal funding for that final stage of development. But for most of the dec...
Source: Stayin' Alive - April 6, 2021 Category: American Health Source Type: blogs

NIRVANA Test Rapidly Identifies and Sequences COVID-19 Viral Variants
Researchers at the Salk Institute in California, working with outside collaborators, have developed a COVID-19 test that can rapidly identify and sequence the causative virus, helping to track new variants. The test, called “nanopore sequencing...
Source: Medgadget - April 5, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Public Health Source Type: blogs

An unexpected COVID-19 vaccine side effect PODCAST
“Just a few seconds after the needle penetrated my arm, I felt a mild soreness, kind of like a flu shot. But as I sat for the required 15 minutes of observation time, a wave of something engulfed my body. It was such a strange, unfamiliar sensation that I didn ’t realize what was happening. I […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - April 3, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/the-podcast-by-kevinmd" rel="tag" > The Podcast by KevinMD < /a > < /span > Tags: Podcast COVID-19 coronavirus Infectious Disease Source Type: blogs

Fight Aging! Newsletter, March 29th 2021
Discussion of Systemic Inflammation and its Contribution to Dementia Fisetin Reduces D-Galactose Induced Cognitive Loss in Mice Reprogramming Cancer Cells into Normal Somatic Cells Considering Longevity Medicine and the Education of Physicians Researchers Generate Thyroid Organoids Capable of Restoring Function in Mice In Search of Transcriptional Signatures of Aging A Pace of Aging Biomarker Correlates with Manifestations of Aging Targeting Tissues with Extracellular Vesicles Calorie Restriction Slows Aging of the Gut Microbiome in Mice Mitochondrial DNA Heteroplasmy in the Aging Heart Evidence for Hea...
Source: Fight Aging! - March 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

COVID-19 recovery? My long-haul experience with infectious illness suggests disability.
People who say, “I’ve recovered from COVID-19, what’s the big deal?” are wrong. I have lived with long-term disability stemming from acute infectious illnesses like COVID-19 and polio. One winter when I was 17, I was struck with a relentless flu. I “recovered,” yet when spring came, a relative observed how my legs were different […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - March 25, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/melissa-j-dupont-reyes" rel="tag" > Melissa J. DuPont-Reyes, PhD, MPH < /a > < /span > Tags: Conditions COVID-19 coronavirus Infectious Disease Source Type: blogs

Fully vaccinated against COVID-19? So, what can you safely do?
Congrats on getting your COVID-19 vaccine! You qualify as fully vaccinated two weeks after your second dose of the Moderna or Pfizer/BioNTech vaccine, or two weeks after your single dose of the Johnson & Johnson vaccine, according to the US Centers for Disease Control and Prevention (CDC). Maybe you’re wondering what you can safely do now that you’re fully vaccinated. As an infectious disease specialist, I’ve provided answers to some common questions. Please keep in mind that information about COVID-19 and vaccines is evolving, and recommendations may change as we learn more. Can I gather with people outside my h...
Source: Harvard Health Blog - March 25, 2021 Category: Consumer Health News Authors: Amy C. Sherman, MD Tags: Coronavirus and COVID-19 Health Parenting Relationships Vaccines Source Type: blogs

What the Exponential Rise in Mortality with Age Tells Us About the Nature of Aging
When charting rising mortality against increasing chronological age, the result is a smooth exponential curve - the Gompertz-Makeham law of mortality. We might well ask how the exceptionally complicated process of degenerative aging, consisting of many distinct mechanisms butting heads and breaking things in a stochastic manner, can produce this outcome. This is one of the questions posed by epidemiologists in today's open access paper. It is a good example that shows how a scientist can hypothesize about the operation of mechanisms given only data on the outcomes of those mechanisms. For context, the authors of the...
Source: Fight Aging! - March 22, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

The Year of Living Dangerously
It ' s been exactly one year since our lives changed. On March 10, 2020, Governor Charlie Baker declared a state of emergency for Massachusetts, changing the way many of us travel. On March 11, 2020, the World Health Organization declared COVID-19 a global pandemic, its first such designation since declaring H1N1 influenza a pandemic in 2009. On March 15, 2020, I flew to Minnesota and prepared my Rochester apartment for a lockdown. I said my goodbyes to colleagues on March 16 and flew back to Boston. We ' ve run the Mayo Clinic Platform at a distance for the past year.During the pandemic, those old enough to have overcome ...
Source: Life as a Healthcare CIO - March 16, 2021 Category: Information Technology Source Type: blogs

Influenza: a deadly risk in schools before COVID
The Washington Post published an interesting article in its weekly health section on March 2. 2021. The article had an impactful graphic using data from the Centers for Disease Control that showed the number of pediatric deaths due to influenza over the last four years. Of course, this was a flu season and year unlike […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - March 11, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/joan-naidorf" rel="tag" > Joan Naidorf, DO < /a > < /span > Tags: Conditions COVID-19 coronavirus Infectious Disease Source Type: blogs

What is COVID-19 brain fog — and how can you clear it?
As a cognitive behavioral neurologist, I’ve been hearing from many individuals who are complaining of “brain fog” after infection with COVID-19. So I thought it was worth discussing exactly what COVID-19 brain fog is, and some things to do that might help clear it. What is brain fog? Let’s start by trying to understand brain fog. Brain fog is not a medical or scientific term; it is used by individuals to describe how they feel when their thinking is sluggish, fuzzy, and not sharp. We all experience this feeling from time to time. Perhaps you couldn’t think clearly when you were sick with the flu or another illnes...
Source: Harvard Health Blog - March 8, 2021 Category: Consumer Health News Authors: Andrew E. Budson, MD Tags: Coronavirus and COVID-19 Health Memory Neurological conditions Source Type: blogs

Fight Aging! Newsletter, March 1st 2021
This study may have important implications for preventing cell senescence and aging-induced tendinopathy, as well as for the selection of novel therapeutic targets of chronic tendon diseases. Our results showed that the treatment of bleomycin, a DNA damaging agent, induced rat patellar TSC (PTSC) cellular senescence. The senescence was characterized by an increase in the senescence-associated β-galactosidase activity, as well as senescence-associated changes in cell morphology. On the other hand, rapamycin could extend lifespan in multiple species, including yeast, fruit flies, and mice, by decelerating DNA damage ...
Source: Fight Aging! - February 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

On the Aging Adaptive Immune System
An interesting fact about the adaptive immune system: the number of T cells in the body remains much the same across the entire lifespan, even after the supply of new T cells all but ceases in middle age. T cells are created as thymocytes by hematopoietic cells in the bone marrow, and then mature in the thymus. The supply of new cells from the bone marrow is negatively affected by age, while the thymus atrophies, active tissue becoming replaced with fat. Lacking replacements, the T cell population in the body becomes increasingly exhausted, senescent, and otherwise damaged. Many T cells become inappropriately specialized t...
Source: Fight Aging! - February 26, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

This Is How We Can End COVID In 6 Steps
There is frankly one question today on everybody’s mind: when will all this end? And although deep inside we all know this won’t really be over till it’s… over, we strive for a definite answer. Say, in June. The sad news is, the pandemic will be with us until we finally take individual responsibility. Instead of trying to avoid the jab, we should get ourselves vaccinated as soon as possible. Why? I’ll tell you in six simple, self-explanatory logical steps. 1. COVID-19 will end when the coronavirus becomes endemic A virus becomes endemic when it has a constant presence within a population in a certain ar...
Source: The Medical Futurist - February 25, 2021 Category: Information Technology Authors: Judit Kuszkó Tags: Covid-19 Digital Health Research E-Patients Healthcare ethical vaccination coronavirus lockdown vaccine flu hospitals Italy Spanish flu Source Type: blogs

This Is How We Can End COVID In 6 Logical Steps
There is frankly one question today on everybody’s mind: when will all this end? And although deep inside we all know this won’t really be over till it’s… over, we strive for a definite answer. Say, in June. The sad news is, the pandemic will be with us until we finally take individual responsibility. Instead of trying to avoid the jab, we should get ourselves vaccinated as soon as possible. Why? I’ll tell you in six simple, self-explanatory logical steps. 1. COVID-19 will end when the coronavirus becomes endemic A virus becomes endemic when it has a constant presence within a population in a certain ar...
Source: The Medical Futurist - February 25, 2021 Category: Information Technology Authors: Judit Kuszkó Tags: Covid-19 Digital Health Research E-Patients Healthcare ethical vaccination coronavirus lockdown vaccine flu hospitals Italy Spanish flu Source Type: blogs

The Feds ’ Sorry Record on COVID-19
David BoazThey say journalism is the first rough draft of history. With the Covid pandemic now a year old, we are starting to seebooks on the topic. And variouslibertarianstudies andarticles, critically examining government andprivate-sector responses to the crisis, have appeared. But some of those rough drafts in the major media add up to a pretty strong critique of government failure by themselves. Just consider the disappointing, even tragic, analyses that have been appearing over the past year:The federal government hadreports andwarnings andwar games aboutpandemic danger at least as far back as 2001, butwas apparently...
Source: Cato-at-liberty - February 24, 2021 Category: American Health Authors: David Boaz Source Type: blogs