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Last Christmas – a Xmas Gothic
Last Christmas by David Bradley (PDF/Kindle version here) Funnily enough, it was four years to the day since the fourth variant had emerged. So, it was Christmas Day. Four years since the death toll passed 200 million. What a gift. Four years since the last dying embers of the theory of herd immunity had burned out and even the rich and the beyond-rich were suffering. Four years. It’s hard to believe. What started as a very localised outbreak, with a mere handful of hospitalisations had quickly thrown the global community into panic and ultimately pandemic. The present that keeps on giving. Each genetic mutation unwrappi...
Source: David Bradley Sciencebase - Songs, Snaps, Science - December 29, 2020 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs

Last Christmas – a short story
Last Christmas by David Bradley (PDF/Kindle version here) Funnily enough, it was four years to the day since the fourth variant had emerged. So, it was Christmas Day. Four years since the death toll passed 200 million. What a gift. Four years since the last dying embers of the theory of herd immunity had burned out and even the rich and the beyond-rich were suffering. Four years. It’s hard to believe. What started as a very localised outbreak, with a mere handful of hospitalisations had quickly thrown the global community into panic and ultimately pandemic. The present that keeps on giving. Each genetic mutation unwrappi...
Source: David Bradley Sciencebase - Songs, Snaps, Science - December 29, 2020 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs

Behind the scenes of a hospital ’s COVID response PODCAST
“In the midst of a COVID-19 pandemic, getting a flu shot has never been more important. Many people are staying indoors, wearing a mask, and washing their hands frequently. In this environment, patients ask me, “With all this social distancing, do I really need a flu shot this year?” The answer is unequivocally, “Yes!” Even […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - December 29, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/the-podcast-by-kevinmd" rel="tag" > The Podcast by KevinMD < /a > < /span > Tags: Podcast COVID-19 coronavirus Hospital-Based Medicine Infectious Disease Source Type: blogs

Fight Aging! Newsletter, December 28th 2020
In conclusion, our study demonstrated that the molecular processes of aging are relatively subtle in their progress, and the aging process of every tissue depends on the tissue's specialized function and environment. Hence, individual gene or process alone cannot be described as the key of aging in the whole organism. Mouse Age Matters: How Age Affects the Murine Plasma Metabolome A large part of metabolomics research relies on experiments involving mouse models, which are usually 6 to 20 weeks of age. However, in this age range mice undergo dramatic developmental changes. Even small age differences may l...
Source: Fight Aging! - December 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

ECMO – Extracorporeal membrane oxygenation
ECMO – extracorporeal membrane oxygenation ECMO – Extracorporeal membrane oxygenation – has been in use for the past four decades to support persons who are unlikely to survive with mechanical ventilation. ECMO is used in both adult and pediatric practice, though in the initial years, use of ECMO was restricted to pediatric intensive care. The enthusiasm for use of ECMO in adults have been triggered by the beneficial effect noted during the last H1N1 influenza pandemic [1]. In contrast from cardiopulmonary bypass which is used for a short period during cardiac surgery, ECMO is used to support for a ...
Source: Cardiophile MD - December 26, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiac Surgery Source Type: blogs

Data for COVID-19 Mortality in Older People in the US
The general consensus on mortality due to COVID-19 is that it falls most heavily on people who are more impacted by aging: poor immune function when it comes to defense against pathogens; high levels of chronic inflammation that create a greater susceptibility to the way in which SARS-CoV-2 kills people; existing chronic disease; and a mortality rate that is already high even setting aside the pandemic. When younger people die due to the virus, in much smaller numbers, it is where they share these characteristics of inflammation, deficient immune systems, and chronic disease. This level of morbidity is unusual in younger i...
Source: Fight Aging! - December 23, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Encouraging clinical data for universal flu vaccine candidate
by Helen Stillwell The results from a phase I clinical trial to test the safety and immunogenicity of a universal flu vaccine candidate reported encouraging results – strong titers of broad and functional antibodies persisted for over a year in healthy adults following vaccination.  Influenza viruses contain segmented RNA genomes. The viral envelope contains two types glycoproteins […]
Source: virology blog - December 17, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Helen Stilwell antibody HA stem influenza phase I clinical trial universal flu vaccine viral virus viruses Source Type: blogs

The Year When Everything Changed: Covid, Self Care and High Tech Innovation In Medicine
By HANS DUVEFELT Life as we knew it and medicine as we had viewed it shapeshifted so dramatically in the past year that it is still hard to believe. Medicine has started to move from an in-person only profession to one that finally recognizes that clinical assessment and treatment have fewer boundaries than people assumed. A patient of mine with newly diagnosed mastocytosis had a productive first consultation with an immunologist hundreds of miles away right from her own living room. Efficiency increased when we could handle straightforward clinical issues electronically, even over the telephone, and still get...
Source: The Health Care Blog - December 14, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Medical Practice Hans Duvefelt Source Type: blogs

Should you take the Covid-19 Vaccine if You ’re Pregnant?
(Updated 12/27/20) The FDA took an important step on Friday by authorizing the Emergency Use for Pfizer-BioNTech’s COVID-19 vaccine. Recognizing the risks inherent in COVID-19 infection can be significant, while those identified to date for its vaccine appear to be low, they have not advised against vaccination during pregnancy. However, its important to note that have they not specifically approved the vaccine for use in pregnancy. That’s because we have only limited animal and human data on use of the COVID-19 vaccine during pregnancy or breastfeeding. This is incredibly frustrating to those of us ...
Source: The Blog That Ate Manhattan - December 13, 2020 Category: Primary Care Authors: Margaret Polaneczky, MD Tags: Uncategorized Covid-19 pfizer pregnancy pregnant Vaccine Source Type: blogs

Should you take the Covid-19 Vaccine if You ’ re Pregnant?
(Updated 12/27/20) The FDA took an important step on Friday by authorizing the Emergency Use for Pfizer-BioNTech’s COVID-19 vaccine. Recognizing the risks inherent in COVID-19 infection can be significant, while those identified to date for its vaccine appear to be low, they have not advised against vaccination during pregnancy. However, its important to note that have they not specifically approved the vaccine for use in pregnancy. That’s because we have only limited animal and human data on use of the COVID-19 vaccine during pregnancy or breastfeeding. This is incredibly frustrating to those of us ...
Source: The Blog That Ate Manhattan - December 13, 2020 Category: Primary Care Authors: Margaret Polaneczky, MD Tags: Uncategorized Covid-19 pfizer pregnancy pregnant Vaccine Source Type: blogs

Should you take the Covid-19 Vaccine if You ’re Pregnant?
The FDA took an important step on Friday by authorizing the Emergency Use for Pfizer-BioNTech’s COVID-19 vaccine. Recognizing the risks inherent in COVID-19 infection can be significant, while those identified to date for its vaccine appear to be low, they have not advised against vaccination during pregnancy. However, its important to note that have they not specifically approved the vaccine for use in pregnancy. That’s because we have neither animal or human data on use of the COVID-19 vaccine during pregnancy or breastfeeding. This is incredibly frustrating to those of us who care from women of repro...
Source: The Blog That Ate Manhattan - December 13, 2020 Category: Primary Care Authors: Margaret Polaneczky, MD Tags: Uncategorized Covid-19 pfizer pregnancy pregnant Vaccine Source Type: blogs

What this medical epidemiologist learned from prior pandemic vaccination efforts
It was the fall of 2009.   I was a medical epidemiologist at the largest local health department in the state of Colorado, in charge of coordinating the area’s H1N1 pandemic vaccination efforts.  The CDC was distributing vaccine to state and local health departments, and we were in turn responsible for getting it out to our […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - December 13, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/tista-s-ghosh" rel="tag" > Tista S. Ghosh, MD, MPH < /a > < /span > Tags: Physician COVID-19 coronavirus Infectious Disease Source Type: blogs

COVID-19 : What we have either amazingly gotten right, ridiculously predicted wrong or mind bogglingly don ’t understand, so far..
Early this year, out of necessity or this human propensity to“predict” the unknowns, I unceremoniously made some bold predictions about COVID-19 and this pandemic. Some of these unsolicited predictions seem logical, based on our previous historical experience with pandemics. I used quite a number of these“modelling” predictions, to help run a COVID-19 Management team. Many of the“other predictions” I made were now, seemingly immaterial and ridiculous. Part of the“bargaining” and grieving stage for a life that was disrupted by an underrated“flu like” disease. As a ...
Source: The Orthopedic Logbook - December 12, 2020 Category: Orthopaedics Authors: Remo Aguilar Tags: Healthcare Medicine COVID-19 predictions SARS COV-2 tweetchat Source Type: blogs