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Total 2036 results found since Jan 2013.

To Improve Vaccination in the Elderly, Target Mechanisms of Aging
That vaccinations decline in effectiveness with advancing age is only one of countless ways in which the underlying mechanisms of aging collectively harm health and resilience in later life. If the urge to improve vaccination efficacy in older individuals turns out to be a major contribution to driving greater investment in the development of means of rejuvenation, therapies that target the causes of aging, then the benefits will extend far beyond this narrow goal. Despite the availability of flu vaccines formulated to better protect older adults, older adults remain disproportionally at-risk for severe infection,...
Source: Fight Aging! - May 30, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, May 29th 2023
In this study, we used a Drosophila model to understand the role of the dec2P384R mutation on animal health and elucidate the mechanisms driving these physiological changes. We found that the expression of the mammalian dec2P384R transgene in fly sleep neurons was sufficient to mimic the short sleep phenotype observed in mammals. Remarkably, dec2P384Rmutants lived significantly longer with improved health despite sleeping less. In particular, dec2P384R mutants were more stress resistant and displayed improved mitochondrial fitness in flight muscles. Differential gene expression analyses went on to reveal several altered tr...
Source: Fight Aging! - May 28, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Sufficient Physical Activity Correlates With a Halving of the Risk of Influenza Mortality
Analysis of a large epidemiological database here shows that sufficient exercise correlates with a halving of the risk of mortality due to influenza. Like many other studies, it also shows that too much exercise may be harmful, actually increasing the risk of mortality. While correlation does not imply causation, there is plenty of evidence for physical fitness and physical activity to reduce impacts of aging related to immune function. Alternative explanations revolve around the tendency of more robust individuals to conduct more exercise, while also tending to be more resilient independently of the effects of exercise. ...
Source: Fight Aging! - May 24, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Reviewing the Complexity of Immunosenescence
The immune system becomes more inflammatory and less competent with advancing age, undergoing sweeping changes in immune cell characteristics and relative population sizes. The cells, structures, and processes that produce immune cells similarly undergo significant changes. Taken together, this is called immunosenescence, though many researchers choose to break out the inflammatory component of dysfunction into its own category, calling it inflammaging. One of the most important goals for the research community is to find ways to improve immune function in older people. Evidently, the decline of the immune system is...
Source: Fight Aging! - May 22, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Poor Healthcare Technology Experiences Erode Consumer Trust. AI Can Repair Relationships
The following is a guest article by Sanjeev Sawai, Chief Product and Technology Officer at mPulse Mobile The expansion and specialization of health networks has made it difficult for most consumers to navigate and advocate for themselves within today’s healthcare organizations. For the average health consumer, simply identifying in-network providers, requesting a cost estimate, or scheduling a medical test presents a major hassle. Add a chronic condition or difficult diagnosis in the mix and the burden of accessing required care only increases. Over time, unsatisfactory healthcare interactions leave consumers frustra...
Source: EMR and HIPAA - April 14, 2023 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System Interoperability AI Tools AI-Assisted Chat Artificial Intelligence ChatGPT Data Challenges health networks Healthcare Source Type: blogs

" The Second Request " Podcast Episode Request: Spotting Anticompetitive Conduct in Pharma Supply Chain, with 46brooklyn
The Capitol Forum is what I suppose can be called a Washington, DC-based, center-left leaning investigative news organization. In 2017, the website " Talking Biz News " (which is apparently about the news business)https://talkingbiznews.com/media-moves/whats-behind-capitol-forum-and-its-growth-plans/ operated by Chris Roush, who ' s dean of the School of Communications at Quinnipiac University (a university which happens to be a few miles away from where I grew up, so it seemed legitimate to me) described The Capitol Forum this way: " Digging deep into the connection between business and government regulation. "Anyway, The...
Source: Scott's Web Log - April 12, 2023 Category: Endocrinology Tags: 2023 46Brooklyn Research Antonio Ciaccia drug prices laissez-faire antitrust enforcement Monopoly Problems The Capitol Forum The Second Request podcast Source Type: blogs

" The Second Request " Podcast Episode Recommendation: Spotting Anticompetitive Conduct in Pharma Supply Chain, with 46brooklyn
The Capitol Forum is what I suppose can be called a Washington, DC-based, center-left leaning investigative news organization. In 2017, the website " Talking Biz News " (which is apparently about the news business)https://talkingbiznews.com/media-moves/whats-behind-capitol-forum-and-its-growth-plans/ operated by Chris Roush, who ' s dean of the School of Communications at Quinnipiac University (a university which happens to be a few miles away from where I grew up, so it seemed legitimate to me) described The Capitol Forum this way: " Digging deep into the connection between business and government regulation. "Anyway, The...
Source: Scott's Web Log - April 12, 2023 Category: Endocrinology Tags: 2023 46Brooklyn Research Antonio Ciaccia drug prices laissez-faire antitrust enforcement Monopoly Problems The Capitol Forum The Second Request podcast Source Type: blogs

A big data COVID train wreck
BY ANISH KOKA If there was any doubt the academic research enterprise is completely broken, we have an absolute train wreck of a study in one of the many specialty journals of the Journal of the American Medical Association — JAMA Health. I had no idea the journal even existed until today, but I now know to approach the words printed in this journal to the words printed in supermarket tabloids. You should too! The paper that was brought to my attention is one that purports to examine the deleterious health effects of Long COVID. A sizable group of intellectuals who are still socially distancing and wearing n95s ...
Source: The Health Care Blog - March 13, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Anish Koka Covid research COVID-19 Long Covid Source Type: blogs

H5N1 – It ’ s All About the Transmission
by Gertrud U. Rey Recent news headlines have been highlighting the global spread of H5N1, the strain of influenza virus that is typically associated with “bird flu.” This outbreak is the largest in recorded history, involving at least 50 million dead birds and countless non-human mammals, including sea lions, otters, mink, foxes, cats, dogs, and […]
Source: virology blog - March 2, 2023 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey avian influenza H5N1 bird flu human-to-human transmission lower respiratory tract pandemic sialic acid upper respiratory tract vaccine Source Type: blogs

Updates and an artificial album cover
As regular readers will know, I’ve been running the Sciencebase site since July 1999. Its precursor, Elemental Discoveries, had various homes on the web from December 1995 until that fateful summer. There are almost 4000 articles in the archives, so it’s quite a hefty site for a one-man show. Anyway, having played around with various website options in the last couple of weeks, I’ve finally done a proper spring clean, got rid of some very out-of-date articles and updated others that were worth keeping. I’ve upgraded security and performance stuff so the site should load much faster than ever before...
Source: David Bradley Sciencebase - Songs, Snaps, Science - March 1, 2023 Category: Science Authors: David Bradley Tags: Artificial Intelligence Sciencebase Source Type: blogs

Myocarditis update from Sweden
BY ANISH KOKA The COVID19/vaccine myocarditis debate continues in large part because our public health institutions are grossly mischaracterizing the risks and benefits of vaccines to young people. A snapshot of what the establishment says as it relates to the particular area of concern: college vaccine mandates: Dr. Arthur Reingold, an epidemiology professor at UC-Berkeley, notes that UC also requires immunizations for measles and chickenpox, and people still are dying from COVID at rates that exceed those for influenza. As of Feb. 1, there were more than 400 COVID deaths a day across the U.S. “The arg...
Source: The Health Care Blog - February 27, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Anish Koka covid19 myocarditis Sweden Source Type: blogs

Avian influenza, bird flu, H5N1
A bird flu pandemic has killed thousands of wild birds over the last couple of years. Scientists have now seen infection in mammals, and very recently a person died from avian influenza and several close contacts show signs of  infection. The concern is that we might be headed for another H5N1 pandemic. Previous strains of H5N1 that infected people had a mortality rate of 60 percent. Avian influenza, bird flu, H5N1 There are fifteen known variants of avian influenza. The most virulent, and usually fatal in birds, are the H5 and H7 strains. There are then nine variants of the H5 strain and the type of most concern because ...
Source: David Bradley Sciencebase - Songs, Snaps, Science - February 27, 2023 Category: Science Authors: David Bradley Tags: Bird Flu Health and Medicine Vaccines Source Type: blogs

TWiV 984: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi’s cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during […]
Source: virology blog - February 18, 2023 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation influenza Long Covid monkeypox monoclonal antibody Omicron pandemic poliovirus SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs