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When Two Different Viruses Have Offspring
by Gertrud U. Rey Have you ever wondered what would happen if you were infected with two different viruses at the same time? A recent study aimed at addressing this question has produced some astounding new findings. The authors of the study wanted to observe the interactions between respiratory syncytial virus (RSV) and influenza A […]
Source: virology blog - January 5, 2023 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey antigenicity co-infection HA hemagglutinin hybrid virus hybrid virus particle IAV influenza A neuraminidase rsv RSV F protein sialic acid virus-virus interaction Source Type: blogs

Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules. MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/ Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, prod...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Look Back at 2022: Progress Towards the Treatment of Aging as a Medical Condition
At the end of 2022, we can reflect on the fact that we are steadily entering a new era of medicine, one in which mechanisms of aging are targeted rather than ignored. It is a profound change, one that will change the shape of a human life and ultimately the human condition by eliminating the greatest sources of suffering and death in the world. Year after year, we see increased funding, ongoing progress towards therapies capable of slowing aging or reversing aspects of aging, and a growing taxonomy of such potential therapies and their target mechanisms. The view of aging in the medical community and public at large...
Source: Fight Aging! - December 30, 2022 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs

Going Viral
Helen Bramwell of StatNews is an excellent writer about public health. Here she interviews a bunch of scientists to ask what surprised them about Covid19.  It ' s a long read, and I won ' t try to summarize it all, but a couple of points stand out.The first is that most experts originally thought, based on experience with other coronaviruses, that this one would be stable -- that it would not be able to mutate so as to avoid immunity from previous infections or vaccination. Therefore they believed that the pandemic would peak after a few months and we ' d enter an endemic phase. (You might remember those models from t...
Source: Stayin' Alive - December 30, 2022 Category: American Health Source Type: blogs

A Change Of Heart: " For The Children "
Last night, I archived everything on the blog except " Why Pediatrics " .  More and more, it ' s become a question rather than a statement of purpose.  In the wake of the COVID 19 pandemic, where the entire US system shifted on its axis to shut down community Pediatrics services and " feed " children ' s hospitals (to free up resources for sick adults), the situation for those of us practicing inpatient Pediatrics (as " Pediatric Hospitalists " ) really went to hell.  You could not find/beg a job in the community setting during the pandemic.  Actually, jumping through the ABP ' s hoops to do a...
Source: Dr.J's HouseCalls - December 24, 2022 Category: American Health Source Type: blogs

TWiV 966: 1918 influenza with Jeffery Taubenberger
Vincent travels to the NIH campus to speak with Jeffery Taubenberger about his career, the 1918 influenza pandemic, deciphering the genome sequence of the virus from tissues of disease victims and using it to rescue infectious virus.
Source: virology blog - December 23, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology 1918 influenza pandemic Spanish flu vaccine viral virus viruses zoonosis Source Type: blogs

Super busy
Hi everyone! Well, I won’t bore you with too many details, but wow, what a busy period this has been for Stefano and me. And in the middle of it, just when I was thinking of going to have my blood tests done, I caught the awful flu that is going around. High fever and whatnot. The good news is that I am well again, although still a bit tired, which is normal. The days are going by so fast…suddenly it’s almost Xmas! And that is why this morning I decided to write this quick post just to reassure everyone that I’m okay…just…BUSY, busy with, among other things, our house renovation project, and with no access t...
Source: Margaret's Corner - December 12, 2022 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll Source Type: blogs

A physician in denial after being diagnosed with COVID-19
Over the last three years, we have faced the original COVID-19, followed by Omicron, Delta, and monkeypox. It is apropos that on the third anniversary of COVID-19, we are facing the tripledemic of COVID, influenza, and RSV. After almost three years of not getting COVID-19, I started believing that my childhood fantasies about me being Read more… A physician in denial after being diagnosed with COVID-19 originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - December 11, 2022 Category: General Medicine Authors: Tags: Conditions COVID Infectious Disease Source Type: blogs

Fight Aging! Newsletter, November 21st 2022
In this study researchers added new insight, showing that high-intensity aerobic exercise, which derives its energy from sugar, can reduce the risk of metastatic cancer by as much as 72%. If so far the general message to the public has been 'be active, be healthy', now researchers can explain how aerobic activity can maximize the prevention of the most aggressive and metastatic types of cancer. The study combined an animal model in which mice were trained under a strict exercise regimen, with data from healthy human volunteers examined before and after running. The human data, obtained from an epidemiological study ...
Source: Fight Aging! - November 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Investigating PGE2, Cellular Senescence, and Macrophage Function in the Aging Lungs
Researchers here show that blocking increased PGE2 signaling in the aging lung helps to restore resistance to influenza infection. There is an interaction between PGE2, cellular senescence in cells of the alveoli in the lung, and the behavior of local macrophages of the innate immune system. It remains to be seen whether PGE2 signaling is regulating much the same issues connected to cellular senescence elsewhere in the body. Previous research by another group showed that when macrophages from an old mouse were put into a young mouse, and cells looked young again. Signs pointed to a lipid immune modulator known as ...
Source: Fight Aging! - November 17, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Preparing for fall and winter: Importance of COVID-19 vaccination during the flu season PODCAST
This article is sponsored by Novavax. In this special sponsored episode. I’m joined by Dr. Filip Dubovsky, chief medical officer at Novavax, to discuss topics like COVID-19 and influenza in the fall and winter seasons, the importance of education to understand your vaccine options while given the freedom to make that choice, navigating misinformation, and Read more… Preparing for fall and winter: Importance of COVID-19 vaccination during the flu season [PODCAST] originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - November 16, 2022 Category: General Medicine Authors: Tags: Podcast Sponsored COVID Infectious Disease Source Type: blogs

79 Unappreciated Quotes You Can Relate To But Also Be Motivated By
One of the bigger disappointments in everyday life is when we don’t get the appreciation we think we have worked for, that we have loved for or we simply and honestly deserve. It’s disheartening. It makes you feel undervalued and can bring on a funk of sadness and cut into your self-esteem. In this post I'd like to share something that I think could help out during such times. The 79 best and most powerful unappreciated quotes. I hope these timeless and relatable words of wisdom will give you some comfort if you’re feeling unappreciated and undervalued. And give you the motivation to make a change in your life if you...
Source: Practical Happiness and Awesomeness Advice That Works | The Positivity Blog - November 10, 2022 Category: Consumer Health News Authors: Henrik Edberg Tags: Inspirational Quotes Personal Development Source Type: blogs

TWiV 951: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses Influenza incidence and vaccine effectiveness during the southern hemisphere influenza season in Chile, Nirsevimab for prevention of RSV infection in healthy late-preterm and term infants, severe Monkeypox in hospitalized patients, reinfections with different SARS-CoV-2 Omicron subvariants, impact of community masking on COVID-19 in Bangladesh, unadjuvanted intranasal spike vaccine elicits protective […]
Source: virology blog - November 5, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation influenza Long Covid marburg virus monkeypox monoclonal antibody Omicron pandemic poliovirus SARS-CoV-2 vaccine vaccine booster variant of concern Source Type: blogs