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Fight Aging! Newsletter, March 8th 2021
Conclusion
Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome.
The Role of Reactive Oxygen Species in Aging is Complex
https://www.fightaging.org/archives/2021/03/the-role-of-reactive-oxygen-species-in-ag...
Source: Fight Aging! - March 7, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Lamin B1 in the Age-Related Loss of Neural Stem Cell Activity
Neurogenesis is the creation and integration of new neurons into neural circuits, necessary for learning, and for the maintenance of functional brain tissue. Neural stem cells are responsible for providing a supply of new neurons, but, as is the case for stem cells throughout the body, their activity declines with age. Loss of neurogenesis is one important contributing factor in the aging of the brain. Considered at the high level, a progressive loss of stem cell activity may be an evolved response to rising levels of cell and tissue damage and dysfunction, reducing the risk of death by cancer at the cost of a slow decline...
Source: Fight Aging! - March 2, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
5 Reasons Why Artificial Intelligence Won ’t Replace Physicians
Artificial intelligence-based solutions are changing healthcare for the better. We saw it coming over the past years, and as COVID-19 has put an extra accent on the use of such tools, that initial wave grew into a tsunami. But would this mean that medical professionals are not needed anymore? Of course not. Here are five fundamental reasons why A.I. won’t replace doctors – and it never will.
The medical community should not fall for the fear-mongering around A.I. Despite the wide-scale automatisation and digitalisation, humans will always be needed for specific tasks and, according to a new study, the use of robo...
Source: The Medical Futurist - March 2, 2021 Category: Information Technology Authors: berci.mesko Tags: Covid-19 Artificial Intelligence in Medicine Digital Health Research E-Patients Future of Medicine Healthcare Design Healthcare Policy Medical Education AI algorithm brain diagnosis doctor physician Radiology technology tel Source Type: blogs
Pain model – helping to target change
In my recent post on behavioural approaches to pain management, I had a number of commentators ask why do it, why not focus on pain intensity, and aren’t I invalidating a person’s experience if I target a person’s response to their experience. Today’s post will explore some of these points.
I suppose my first point needs to distinguish between pain as an experience, and pain behaviour – or what we do when we experience pain. I like to use a pretty old “model” or diagram to help untangle these concepts. It’s drawn from Loeser’s “Onion ring” model, and he w...
Source: HealthSkills Weblog - February 28, 2021 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Clinical reasoning Coping strategies Pain Pain conditions Therapeutic approaches models pain models Source Type: blogs
Fight Aging! Newsletter, March 1st 2021
This study may have important implications for preventing cell senescence and aging-induced tendinopathy, as well as for the selection of novel therapeutic targets of chronic tendon diseases.
Our results showed that the treatment of bleomycin, a DNA damaging agent, induced rat patellar TSC (PTSC) cellular senescence. The senescence was characterized by an increase in the senescence-associated β-galactosidase activity, as well as senescence-associated changes in cell morphology. On the other hand, rapamycin could extend lifespan in multiple species, including yeast, fruit flies, and mice, by decelerating DNA damage ...
Source: Fight Aging! - February 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Lowering cholesterol protects your heart and brain, regardless of your age
High or abnormal cholesterol levels, inflammation, and endothelial dysfunction play a key role in atherosclerosis and plaque buildup, the most common cause of heart attacks and strokes. (Endothelial dysfunction refers to impaired functioning of the inner lining of blood vessels on the heart’s surface. It results in these vessels inappropriately narrowing instead of widening, which limits blood flow.) There are many different types of cholesterol, including high density lipoprotein (HDL, or good, cholesterol); triglycerides (a byproduct of excess calories consumed, which are stored as fat); and low-density lipoprotein (LD...
Source: Harvard Health Blog - February 24, 2021 Category: Consumer Health News Authors: Hanna Gaggin, MD, MPH Tags: Drugs and Supplements Healthy Eating Heart Health Source Type: blogs
Calico, As Expected, is Working on Low Yield Projects in Aging
Calico represents a sizable investment in research and development related to aging and age-related disease. Unfortunately, all the signs have pointed towards this effort going into projects that cannot possibly do more than very modestly affect aging. The publicity materials here further confirm this view of their strategy. They are not targeting the underlying damage that causes aging, but rather manipulating stress response mechanisms in order to try to tinker the aged metabolism into a state that is slightly more resilient to that damage. Upregulation of stress responses, as illustrated by the practice of calorie restr...
Source: Fight Aging! - February 24, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Clear Cranial Implant Allows Ultrasound Imaging of Brain: Interview with CEO of Longeviti Neuro Solutions
Longeviti Neuro Solutions, a medtech company based in Maryland, has announced that its ClearFit cranial implant has been cleared by the FDA for post-surgery ultrasound imaging. The clear implants are used for cranial reconstruction after brain surger...
Source: Medgadget - February 22, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Neurosurgery Orthopedic Surgery longeviti Source Type: blogs
Six Reasons Why Cancer is an Emotional Diagnosis Too
By Cynthia Hayes, Author, The Big Ordeal: Understanding and Managing the Psychological Turmoil of Cancer
No matter when you hear the words, “You’ve got cancer,” you are bound to have an emotional reaction. The news is devastating, and the physical challenges that lie ahead are very real. But, unfortunately, that is only half the story. Cancer is an emotional diagnosis too, and our psychological and physical responses to the disease and its treatment are intertwined, coloring the entire experience. Why is cancer so emotional?
We fear we will die
For millennia, cancer has been a death sentence. So even though ...
Source: PickTheBrain | Motivation and Self Improvement - February 22, 2021 Category: Consumer Health News Authors: Cynthia Hayes Tags: featured health and fitness philosophy psychology self-improvement cancer healing illness pickthebrain self improvement Source Type: blogs
Fight Aging! Newsletter, February 22nd 2021
In conclusion, long term LRIC could decrease blood pressure and ameliorate vascular remodeling via inflammation regulation.
The Damage of a Heart Attack Causes the Immune System to Overreact
https://www.fightaging.org/archives/2021/02/the-damage-of-a-heart-attack-causes-the-immune-system-to-overreact/
Researchers here note a mechanism that causes T cells of the adaptive immune system to spur chronic inflammation and tissue damage following a heart attack. As the researchers note, not all inflammation is the same. Some is maladaptive, and this is particularly the case in older individuals. The aged immune...
Source: Fight Aging! - February 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, February 15th 2021
This study assessed cancer risk associations for 3 recently developed methylation-based biomarkers of aging: PhenoAge, GrimAge, and predicted telomere length.
We observed relatively strong associations of age-adjusted PhenoAge with risk of colorectal, kidney, lung, mature B-cell, and urothelial cancers. Similar findings were obtained for age-adjusted GrimAge, but the association with lung cancer risk was much larger, after adjustment for smoking status, pack-years, starting age, time since quitting, and other cancer risk factors. Most associations appeared linear, larger than for the first-generation measures, and w...
Source: Fight Aging! - February 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, February 8th 2021
This study was divided in two phases: CALERIE-1 and CALERIE-2. CALERIE-1 study was performed to assess the possible effects induced by a reduction of 10-30% of caloric intake on body composition parameters and lipid profile after 6 and 12 months in a population of middle-aged non-obese subjects. CALERIE-1 results showed an improvement in lipid and glycemic profile and a reduction in body weight (BW) and fat mass.
CALERIE-2 was the largest multi-center study on CRD. A total of 220 subjects were enrolled randomly with a 2:1 allocation into two subgroups: 145 in the CRD group and 75 in the ad libitum group. The CRD gro...
Source: Fight Aging! - February 7, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, February 1st 2021
In this study, we characterize age-related phenotypes of human hematopoietic stem cells (HSCs). We report increased frequencies of HSC, hematopoetic progenitor cells (HPC), and lineage negative cells in the elderly but a decreased frequency of multi-lymphoid progenitors. Aged human HSCs further exhibited a delay in initiating division ex vivo though without changes in their division kinetics. The activity of the small RhoGTPase Cdc42 was elevated in aged human hematopoietic cells and we identified a positive correlation between Cdc42 activity and the frequency of HSCs upon aging.
The frequency of human HSCs polar fo...
Source: Fight Aging! - January 31, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 25th 2021
In conclusion, our studies highlight the important role of the tyrosine degradation pathway and position TAT as a link between neuromediator production, dysfunctional mitochondria, and aging.
Source: Fight Aging! - January 24, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Stomach Cancer Stage 4 Treatment
Stomach cancer stage 4 is a complex diagnosis. It is the stage of cancer that requires specific treatment options.
Is surgery an option for patients with stomach cancer stage 4?
Stage 4 stomach cancer is characterized by rapid tumor growth, metastasizing to regional lymph nodes and distant organs (liver, bones, pancreas, less often lungs). With the development of metastases in other organs, characteristic symptoms occur such as jaundice and liver failure with liver damage, ascites with metastases in the peritoneum, bowel obstruction with metastases in the small intestine, etc.
Therefore, at the advanced stages, ga...
Source: PickTheBrain | Motivation and Self Improvement - January 22, 2021 Category: Consumer Health News Authors: Booking Health Tags: health and fitness self-improvement cancer stomach cancer treatment Source Type: blogs
