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Consciously Exploring Your Relationship with Drugs
Humanity has a complex, long-term relationship with a wide variety of drugs. In this article let’s delve into your personal relationship with drugs, how you frame them, and how you might upgrade these relationships to be more conscious and aligned with your path of self-development. Let’s include common drug sources like coffee, tea, and chocolate too, so this will be very inclusive. My purpose here isn’t to encourage or discourage you from using any particular substances but rather to invite you to take a more conscious and honest look at your current frames, attitudes, biases, and behaviors, and dete...
Source: Steve Pavlina's Personal Development Blog - July 21, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Creating Reality Emotions Health Lifestyle Relationships Values Source Type: blogs

Reviewing What is Known of the Biochemistry of Klotho Relevant to Effects on Life Span
Increased klotho expression increases longevity in mice, while reduced klotho expression accelerates aging. The most well studied effects of klotho on organ function involve the kidney and brain, where in both cases it appears protective via a number of different mechanisms. Unfortunately, klotho expression declines with age. Whether treating humans with therapies that increase levels of klotho will produce effects that are as large as those observed in mice remains to be seen. Programs that might lead to treatments remain at a preclinical stage of development, though recently advanced to the point of testing in non-human ...
Source: Fight Aging! - July 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Further Work on Small Molecules that Can Induce Cell Reprogramming
In this study, we developed and utilized novel screening methods including a quantitative nucleocytoplasmic compartmentalization assay (NCC) that can readily distinguish between young, old, and senescent cells. We identify a variety of novel chemical cocktails capable of rejuvenating cells and reversing transcriptomic age to a similar extent as OSK overexpression. Thus, it is possible to reverse aspects of aging without erasing cell identity using chemical rather than genetic means.
Source: Fight Aging! - July 19, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Career Conversations: Q & A With Biomedical Engineer Elizabeth Wayne
Courtesy of Dr. Elizabeth Wayne. “It’s so fun to try to make meaning from a confusing experimental result and talk to other scientists who are excited by the same questions you are,” says Elizabeth Wayne, Ph.D., an assistant professor of biomedical engineering and chemical engineering at Carnegie Mellon University (CMU) in Pittsburgh, Pennsylvania. We talked to Dr. Wayne about her career trajectory, research on immune cells, and belief that scientists can change the world. Q: How did you first become interested in science? A: I was introduced to atoms during 6th grade science class. The idea that we’re ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - July 19, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cellular Imaging Profiles Source Type: blogs

Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues. Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/ With the caveat that mouse models of Alzheimer's...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, July 10th 2023
In conclusion, the examination of the GBA can aid in understanding the etiology and development of NDs, which may benefit the improvement of clinical treatments for these disorders and ND interventions. This review indicates existing knowledge about the involvement of microbiota present in the gut in NDs and potential treatment options. The Aging of the Enteric Nervous System https://www.fightaging.org/archives/2023/07/the-aging-of-the-enteric-nervous-system/ The enteric nervous system is the nervous system of the intestines, and likely an important part of the relationship between the gut microbiome a...
Source: Fight Aging! - July 9, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Major evidence review supports an “exercise prescription” for most adults to boost mental health and well-being
Conclusion and relevance: Physical activity is highly beneficial for improving symptoms of depression, anxiety and distress across a wide range of adult populations, including the general population, people with diagnosed mental health disorders and people with chronic disease. Physical activity should be a mainstay approach in the management of depression, anxiety and psychological distress. The Study in Context: Can you grow your hippocampus? Yes. Here’s how, and why it matters Three ways to protect your mental health during –and after– COVID-19 Solving the Brain Fitness Puzzle Is the Key to Self-Empowered Aging ...
Source: SharpBrains - July 6, 2023 Category: Neuroscience Authors: Greater Good Science Center Tags: Brain/ Mental Health Education & Lifelong Learning Peak Performance anxiety depression exercise exercise prescription gym improve mental health lift weights medication mental-health-treatment physical-health therapy yoga class Source Type: blogs

Fight Aging! Newsletter, July 3rd 2023
In this study, cultured adipose-derived stem cells (ASCs) were derived from subcutaneous white adipose tissue isolated from mice fed a normal diet. We performed senescence-associated-β-galactosidase (SA-β-gal) staining, real-time PCR, and Western blot to evaluate the levels related to cellular senescence markers. The mRNA expression levels of senescence markers were significantly increased in the later passages of ASCs. We show that light activation reduced the expression of senescent genes, and SA-β-Gal in all cells at passages. Moreover, the light-activated ASCs-derived exosomes decrease the expression of senes...
Source: Fight Aging! - July 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Biodegradable Ultrasound Implant Helps Chemo Reach Brain
Researchers at the University of Connecticut have developed an ultrasound implant that can assist in opening the blood brain barrier to allow chemotherapy to enter and treat brain cancer. However, unlike cumbersome ultrasound systems, this technology...
Source: Medgadget - June 28, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Neurosurgery Oncology UConn Source Type: blogs

What goes on in the brain matters
I am the first to say (quite loudly at times) that pain is a whole person experience. I say this because my experience of pain is mine and utterly unable to be shared in all its complexity. The only way other people know about my pain is through my actions – both involuntary and voluntary. And even then: the way I express myself differs depending on my social context, my mood, my goals, and what I think my pain represents. Yet when I’m asleep, I don’t have pain, when I have anaesthetic for my colonoscopy, I don’t have pain – so what goes on in my brain is kinda important. Now there have bee...
Source: HealthSkills Weblog - June 25, 2023 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Pain conditions Research Therapeutic approaches Source Type: blogs

Fight Aging! Newsletter, June 26th 2023
This study explored the association between different cooking fuel types and the risk of cancer and all-cause mortality among seniors constructing Cox regression models. Data were obtained by linking waves of 6, 7, and 8 of the Chinese Longitudinal Healthy Longevity Survey, which included a total of 7,269 participants who were 65 years old and over. Cooking fuels were categorized as either biomass, fossil, or clean fuels. And the effects of switching cooking fuels on death risk were also investigated using Cox regression models. The results indicate that, compared with the users of clean fuels, individuals using bio...
Source: Fight Aging! - June 25, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The power of liquid biopsies and the challenge of health care disparities
Laura Nuttall was diagnosed with deadly brain cancer at the age of 18 after going for a routine eye exam. She completed an incredible bucket list, which included meeting Michelle Obama, driving a monster truck, and commanding a Royal Navy warship before ultimately succumbing to her cancer this past Monday at the age of 23. Read more… The power of liquid biopsies and the challenge of health care disparities originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - June 23, 2023 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs

Dealing with Brain MRIs
Shedding light on a little-discussed aspect of having brain cancer.
Source: Depth-First - June 22, 2023 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs

Attacking Cancer by Disabling Macrophage Recognition of CD47 " Don ' t Eat Me " Marker
CD47 is a "don't eat me" decoration found on the surface of cells. This is a necessary mechanism for the prevention of autoimmunity, but it is also subverted by cancer in order to prevent the innate immune system from attacking tumor cells. The cancer research community has investigated a range of approaches to prevent CD47 from holding back the immune response to cancerous cells. One possibility, demonstrated here, is to engineer the innate immune cells known as macrophages in order to block the CD47 interaction and thus ensure an aggressive response to cancerous cells. Cancer remains one of the leading causes of...
Source: Fight Aging! - June 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs