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Calorie Restriction as a Treatment to Slow Parkinson ' s Disease
Calorie restriction is known to suppress inflammation to some degree, alongside many other benefits to health that result from the reaction of cells and biological systems to a reduced calorie intake. Since chronic inflammation in brain tissue is implicated in the onset and development of neurodegenerative conditions, this makes calorie restriction a topic of interest in this part of the field. With a few exceptions, that interest largely manifests as research aimed at reproducing some of the metabolic alterations of calorie restriction with small molecule drugs, however, rather than more more rigorously testing calorie re...
Source: Fight Aging! - December 2, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Arguing for Well Explored Approaches to Slow Aging to Not In Fact Slow Aging
In conclusion, the PAAIs examined (i.e. mTOR loss of function, Ghrhr loss of function, intermittent fasting-based version of dietary restriction) often influenced age-sensitive traits in a direct way and not by slowing age-dependent change. Previous studies often failed to include young animals subjected to PAAI to account for age-independent PAAI effects. However, any study not accounting for such age-independent intervention effects will be prone to overestimate the extent to which an intervention delays the effects of aging on the phenotypes studied. This can result in a considerable bias of our view on how modifiable a...
Source: Fight Aging! - November 28, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 28th 2022
This study explored whether determining the gain or loss of specific taxa represent a more precise metric of healthy/unhealthy aging than summary microbiome statistics, such as diversity and uniqueness. We analyzed microbiome diversity and four measures of microbiome uniqueness in 21,000 gut microbiomes for their relationship with aging and health. We show that diversity and uniqueness measures are not synonymous; uniqueness is not a uniformly desirable feature of the aging microbiome, nor is it an accurate biomarker of healthy aging. Different measures of uniqueness show different associations with diversity and with mark...
Source: Fight Aging! - November 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, November 21st 2022
In this study researchers added new insight, showing that high-intensity aerobic exercise, which derives its energy from sugar, can reduce the risk of metastatic cancer by as much as 72%. If so far the general message to the public has been 'be active, be healthy', now researchers can explain how aerobic activity can maximize the prevention of the most aggressive and metastatic types of cancer.
The study combined an animal model in which mice were trained under a strict exercise regimen, with data from healthy human volunteers examined before and after running. The human data, obtained from an epidemiological study ...
Source: Fight Aging! - November 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Science Snippet: ATP ’s Amazing Power
ATP (yellow) powering a protein (blue) that moves material within cells and helps them divide. Credit: Charles Sindelar, Yale University.
Just as electricity powers almost every modern gadget, the tiny molecule adenosine triphosphate (ATP) is the major source of energy for organisms’ biochemical reactions. ATP stores energy in the chemical bonds that hold its three phosphate groups together—the triphosphate part of its name. In the human body, ATP powers processes such as cell signaling, muscle contraction, nerve firing, and DNA and RNA synthesis. Because our cells are constantly using and producing ATP, each of us t...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - November 16, 2022 Category: Research Authors: Chrissa Chverchko Tags: Cells Chemistry, Biochemistry and Pharmacology Molecular Structures Cellular Processes Science Snippet Source Type: blogs
Bonus Features, HLTH Edition – November 15, 2022 – News from Amwell, Epic, Google, MEDITECH, Microsoft, and more, plus the dates for HLTH Europe
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
This edition is a special dispatch from HLTH 2022. There have been a lot of new research reports, new products, and news partnerships announced at the event. We wanted to try and cover as many announcements for the Healthcare IT...
Source: EMR and HIPAA - November 15, 2022 Category: Information Technology Authors: Brian Eastwood Tags: C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Accolade AMA Amwell ApoWiser Bamboo Health Bayer BioT Medical Capital Rx Carenostics Commure Consensus Cloud Solutions COTA e-Psychiatry Ellisis Source Type: blogs
7 Signs That Say “Do Not Resuscitate”
It is a moment in time that you will certainly face at some point in your EMS career. Most of us will face this decision many times over throughout our tenure. Should I attempt resuscitation?
The question may be complicated by family, friends or bystanders who have, in good faith, started CPR prior to your arrival and fully anticipate that you will continue. Or perhaps other members of emergency services arrived before you and declared the patient not workable. They may advise you of their findings, without much further detail. “This guys dead.”
Often, responders who aren’t responsible for documentin...
Source: The EMT Spot - November 14, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs
Fight Aging! Newsletter, November 14th 2022
In this study, we show that TXNIP is vital for the cell fate choice when cells are challenged by various stress signals. Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. Combined IGF1/TXNIP-induced premature senescence can be associated with a typical secretory inflammatory phenotype that is mediated by STAT3/IL-1A signaling. Finally, these mechanistic insights might help with the understanding of basic aspects of IGF1-related pathologies in the clinical setting.
Investigating the Ability of Type 2 Diabetes...
Source: Fight Aging! - November 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, November 7th 2022
In conclusion, the national prevalence of dementia and MCI in 2016 found in this cross-sectional study was similar to that of other US-based studies.
Clearing Microglia Reverses Age-Related Disruption of Sleeping Patterns in Mice
https://www.fightaging.org/archives/2022/11/clearing-microglia-reverses-age-related-disruption-of-sleeping-patterns-in-mice/
Microglia are innate immune cells of the central nervous system. They are analogous to macrophages in the rest of the body, but undertake additional duties relating to the function of neurons and in brain tissue. Microglia become overly active and inflamma...
Source: Fight Aging! - November 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Promises Made – Promises Kept: President Biden’s Support for “Obamacare.”
BY MIKE MAGEE
As the saying goes, “History repeats!” This is especially true where politics are involved.
Consider for example the past three decades in health care. It is striking how many of the players in our nation’s health policy drama remain front and center. And that includes President Biden who recently commented on the 12th anniversary of the passage of the Affordable Care Act (Obamacare):
“The ACA delivered quality, affordable health coverage to more than 30 million Americans — giving families the freedom and confidence to pursue their dreams without the fear that one accident or il...
Source: The Health Care Blog - November 2, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Affordable Care Act Biden Obamacare Source Type: blogs
forgetting my heart
When I was in college I spent a semester living in Germany and traveling around Europe. I started taking German in 9th grade, but 7 years later when I went to Germany, I still struggled with basic conversation. Many of my classmates grew up in German speaking families and they had a distinct advantage being bilingual. By the time I came back home though, I was fluent enough that I could carry on all my daily activities, eating, shopping, traveling, finances, etc in German. I was really proud of that accomplishment.
When I returned though, i experienced something unusual that I haven’t heard other people talk about...
Source: Mr. Hassle's Long Underpants - October 30, 2022 Category: Emergency Medicine Authors: Doc Shazam Tags: Tales grief Source Type: blogs
I am stupid
Conclusion: Isaac Asimov is stupid(Sorry, no post yesterday because I was doing some heavy cerebral processing.)He ' d have been the first to admit it. All of us are susceptible to cognitive errors and biases. I ' d like to think that Asimov was less susceptible than most, but he must have had his own foibles. It ' s a constant struggle to be mindful and think straight. For my own part, I once had a romanticized view of the Chinese revolution, I was an anthropogenic climate change skeptic, and I entertained the likelihood that medical intervention, on balance, did more harm than good. (Viz Illich, Medical Nemesis.)&nb...
Source: Stayin' Alive - October 28, 2022 Category: American Health Source Type: blogs
The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
October 27, 2022 Edition-----In the UK we have a political farce running with only a day or so to run when you read this, with a new PM (Rishi Sunak) in place..In the US the mid-term elections are coming in a week or so, thus some concern as to where the US is going!In China Xi has his third 5 year term so we all wonder how that will turn out!In OZ we have has a Budget with floods, inflation, data leaks, the threat of recession, Medicare concerns and other issues just rolling on! At least the Budget does not seem to have broken anything!Overall an ‘omnishambles’ as they say!-----Major Issues.-----https://www.afr.com/wo...
Source: Australian Health Information Technology - October 27, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Fight Aging! Newsletter, October 24th 2022
This study shows the uncoupling of lifespan and healthspan parameters (aerobic fitness and spontaneous activity) and provides new insights into SIRT3 function in CR adaptation, fuel utilization, and aging.
HDL Level, Age, and Smoking are the Largest Determinants of Mortality Risk in Old People
https://www.fightaging.org/archives/2022/10/hdl-level-age-and-smoking-are-the-largest-determinants-of-mortality-risk-in-old-people/
An interesting epidemiological study here stratifies the contributions of various metrics to mortality in later life, age 70 and older. The authors find that the largest effects arise ...
Source: Fight Aging! - October 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
LXA4 Levels in the Brain Decrease With Age, Perhaps Increasing Inflammation and Accelerating Neurodegeneration
Chronic inflammation in brain tissue is connected to the onset and progression of neurodegenerative conditions, so it is reasonable to expect that researchers will, from time to time, discover evidence for regulators of inflammation to be involved in aging and neurodegeneration. Here, scientists discuss LXA4, which has a role in resolution of the inflammatory response, and declines in abundance with age. Delivery of LXA4 produces functional benefits and greater resistance to inflammation in mouse models, making it a potentially interesting target for the development of therapies. The question, as always for attempts to sup...
Source: Fight Aging! - October 20, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
