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Fight Aging! Newsletter, January 16th 2023
Conclusions
Implanted Hair Follicle Cells Produce Remodeling of Scar Tissue
Assessment of Somatic Mosaicism as a Biomarker of Aging
The Gut Microbiome of Centenarians
https://www.fightaging.org/archives/2023/01/the-gut-microbiome-of-centenarians/
The state of the gut microbiome is arguably as influential on health as exercise. Various microbial species present in the gut produce beneficial metabolites, such as butyrate, or harmful metabolites, such as isoamylamine, or can provoke chronic inflammation in a variety of ways. An individual can have a better or worse microbiome, assessing these and other fu...
Source: Fight Aging! - January 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Using Engineered Cancer Cells to Rouse an Immune Response Against Tumors
Researchers here report on an interesting approach to encouraging the immune system to attack cancer cells in an established tumor. They engineer cancer cells to be more visible to the immune system and then return them to the body, where they will naturally home to the site of the tumor. At present the proof of concept is established in animal models; time will tell as to whether this line of work attracts the support needed to progress further towards the clinic.
Cancer vaccines are an active area of research for many labs, but the new approach to treating the brain cancer glioblastoma that researchers have take...
Source: Fight Aging! - January 12, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Pharma – 2023 Health IT Predictions
As we head into 2023, we wanted to kick off the new year with a series of 2023 Health IT predictions. We asked the Healthcare IT Today community to submit their predictions and we received a wide ranging set of responses that we grouped into a number of themes. Check out our communities predictions below and be sure to add your own thoughts and/or places you disagree with these predictions in the comments and on social media.
Check out our community’s pharma predictions.
Jesse Cugliotta, Global Industry GTM Lead, Healthcare & Life Sciences at Snowflake
Industry investments in data platforms to enable decentra...
Source: EMR and HIPAA - January 9, 2023 Category: Information Technology Authors: John Lynn Tags: Health IT Company Healthcare IT 2023 Health IT Predictions Abrpo BrainCheck Doceree Harshit Jain Ian Chen Jesse Cugliotta Kimberly Powell Lance Hill Lauren Ohlsson Mike Montalto NVIDIA Ofer Sharon OncoHost PathAI Pharma Source Type: blogs
Fight Aging! Newsletter, January 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules.
MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity
https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/
Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, prod...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2022: Progress Towards the Treatment of Aging as a Medical Condition
At the end of 2022, we can reflect on the fact that we are steadily entering a new era of medicine, one in which mechanisms of aging are targeted rather than ignored. It is a profound change, one that will change the shape of a human life and ultimately the human condition by eliminating the greatest sources of suffering and death in the world. Year after year, we see increased funding, ongoing progress towards therapies capable of slowing aging or reversing aspects of aging, and a growing taxonomy of such potential therapies and their target mechanisms.
The view of aging in the medical community and public at large...
Source: Fight Aging! - December 30, 2022 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Notes on the 2022 Longevity Summit at the Buck Institute
The Buck Institute recently hosted the 2022 Longevity Summit, and here find some notes on the event from a participant. The number of conferences dedicated to the field of longevity science is increasing steadily, year after year. The best are those in which one finds a mix of entrepreneurs, scientists, and investors, all networking to advance the state of the art in the treatment of aging as a medical condition.
The Longevity Summit at the Buck Institute, a relatively short two-day geroscience and longevity biotech conference held on December 6-7, was nevertheless densely packed with new research - to the point w...
Source: Fight Aging! - December 28, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 26th 2022
This article on senolytic therapies to selectively remove senescent cells in old tissues is in part a matter of Unity Biotechnology talking up their position. The company suffered from first mover disadvantage in bringing senolytic drugs into clinical development. The field has made progress very rapidly over the last decade, and startups founded even just a couple of years after Unity's launch benefited from greater knowledge and a selection of better technologies to work with. Still, one can be talking up one's position and also be right. The accumulation of senescent cells is profoundly harmful, a significant contributi...
Source: Fight Aging! - December 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Somatic Mosaicism in the Aging Brain
Somatic mosaicism is the result of the random mutational damage that occurs to stem cells and progenitor cells, leading to a spread of different mutation patterns throughout the descendant cells making up a tissue. It is thought to be involved in aging, a way for random mutation, different in every cell, to lead to specific dysfunctions occurring throughout a tissue, and potentially prime a tissue for a later combination of mutations that gives rise to cancer. This commentary on recent research discusses somatic mosaicism in the brain, intending to see whether there were differences in neurological disease states, but the ...
Source: Fight Aging! - December 20, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
6 Potential Medical Use Cases for ChatGPT
The internet is buzzing with news on ChatGPT, and how everyone uses it to write love poems, homework, summaries of articles, or python codes. ChatGPT is the latest generation of a large language model, designed to generate text upon user input. There is a lot of discussion regarding its potential use in medicine, so let’s see, what you can expect from it and what you should not use it for – at least in its current form.
Unlike the text-to-image tool Midjourney, which we introduced earlier, and which is a GAN (generative adversarial network, explained here) algorithm, ChatGPT is a different kind of algorithm R...
Source: The Medical Futurist - December 19, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine AI chatbot AI text generator AI in heaalthcare ChatGPT Conversationlal_AI Source Type: blogs
Fight Aging! Newsletter, December 19th 2022
In conclusion, p16 deletion or p16 positive cell clearance could be a novel strategy preventing long term HFD-induced skin aging.
Association of LDL-Cholesterol with Mortality
https://www.fightaging.org/archives/2022/12/association-of-ldl-cholesterol-with-mortality/
Researchers here report on a study of LDL-cholesterol and mortality risk in older people. As they note, data on this topic is conflicted once one moves beyond the matter of cardiovascular disease. Over a lifetime, higher LDL-cholesterol makes it easier to reach the tipping point at which cholesterol deposited in blood vessel walls produces en...
Source: Fight Aging! - December 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Top 8 Most Controversial Stories About Medical Innovations
I spend my days monitoring progress, analysing new trends, and learning about spectacular new initiatives. Needless to say: not just me, but the whole team of The Medical Futurist is fascinated by what we learn. And then sometimes there is a story that just melts the fuses at one or more team members – and our readers.
Below I picked 8 of our favourite controversial stories from – almost exclusively – this year. It’s important to note that controversial doesn’t equal bad/useless. Sometimes it’s just not widely accepted (yet) and so exotic that they can surely provide a unique talking point at a...
Source: The Medical Futurist - December 13, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF 3d printing AI artificial intelligence bioprinting digital health CRISPR designer baby designer babies robotics in healthcare assisted dying DIY blood draw DIY blood test medical innovation deepfake Source Type: blogs
Fight Aging! Newsletter, December 12th 2022
In conclusion, selective removal of senescent dermal fibroblasts can improve the skin aging phenotype, indicating that BPTES may be an effective novel therapeutic agent for skin aging.
Non-Dividing Neurons Do In Fact Become Senescent, Impairing Brain Function
https://www.fightaging.org/archives/2022/12/non-dividing-neurons-do-in-fact-become-senescent-impairing-brain-function/
Cellular senescence is generally thought of as a characteristic of replicating cells; it is an end state reached when telomeres, reduced in length with each cell division, become too short. This is followed by programmed cell death ...
Source: Fight Aging! - December 11, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Non-Dividing Neurons Do In Fact Become Senescent, Impairing Brain Function
In this study, researchers took skin samples from people with Alzheimer's disease and converted those cells directly into neurons in the lab. They tested these neurons to see if they undergo senescence and examined the mechanisms involved in the process. They also explored senescence markers and gene expression of post-mortem brains from 20 people with Alzheimer's disease and matched healthy controls. This allowed the team to confirm that their results from the lab held true in actual human brain tissue.
The team found that senescent neurons are a source of the late-life brain inflammation observed in Alzheimer's di...
Source: Fight Aging! - December 8, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 5th 2022
In conclusion, the PAAIs examined (i.e. mTOR loss of function, Ghrhr loss of function, intermittent fasting-based version of dietary restriction) often influenced age-sensitive traits in a direct way and not by slowing age-dependent change. Previous studies often failed to include young animals subjected to PAAI to account for age-independent PAAI effects. However, any study not accounting for such age-independent intervention effects will be prone to overestimate the extent to which an intervention delays the effects of aging on the phenotypes studied. This can result in a considerable bias of our view on how modifiable a...
Source: Fight Aging! - December 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
