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Fight Aging! Newsletter, January 18th 2021
In this study, Desferal, deferoxamine mesylate for injection, which is approved for the treatment of acute iron intoxication and chronic iron overload, was used to explore the beneficial effects on preventing aging-induced bone loss and mitigating dysfunction of aged BMSCs. High-dose Desferal significantly prevented bone loss in aged rats. Compared with controls, the ex vivo experiments showed that short-term Desferal administration could promote the potential of BMSC growth and improve the rebalance of osteogenic and adipogenic differentiation, as well as rejuvenate senescent BMSCs and revise the expression of stemness/se...
Source: Fight Aging! - January 17, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

All you need to know about waterborne diseases
  Waterborne diseases are contracted through exposure to contaminated water including drinking water, water used in food preparation, and swimming water.  They can be caused by bacteria, viruses, and parasites. Below is a partial list of waterborne disease pathogens, their microbial classification, and their resulting illnesses. Classification Microorganism Disease Bacterium Campylobacter spp. Campylobacteriosis Bacterium Escherichia coli E. Coli Diarrhea Bacterium Legionella pneumophila Legionnaires’ Disease Bacterium Salmonella enterica Salmonellosis Bacterium Salmonella typhi Typhoid fever ...
Source: GIDEON blog - January 14, 2021 Category: Databases & Libraries Authors: Kristina Symes Tags: Microbiology News Tips Source Type: blogs

Fight Aging! Newsletter, January 11th 2021
This study demonstrates the potential of a natural (o-Vanillin) and a synthetic (RG-7112) senolytic compounds to remove senescent IVD cells, decrease SASP factors release, reduce the inflammatory environment and enhance the IVD matrix production. Removal of senescent cells, using senolytics drugs, could lead to improved therapeutic interventions and ultimately decrease pain and a provide a better quality of life of patients living with intervertebral disc degeneration and low back pain. From Ying Ann Chiao of Oklahoma Medical Research Foundation: Mitochondrial dysfunction plays a central role in aging and cardiovasc...
Source: Fight Aging! - January 10, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Hormonal therapies for advanced prostate cancer linked to a higher risk of falls and fractures
Falls rank among the top causes of death and injuries among the elderly, and the risk increases significantly in older people being treated for cancer. Now, investigators are reporting that a newer class of drugs for advanced prostate cancer is associated with a significant increase in fall risk. Called androgen receptor inhibitors, or ARIs, these drugs target testosterone, a hormone that accelerates the growth of prostate tumors. Unlike traditional hormonal treatments that interfere with the body’s ability to make testosterone (known as androgen deprivation therapy, or ADT), ARIs work by preventing testosterone from...
Source: Harvard Health Blog - January 7, 2021 Category: Consumer Health News Authors: Charlie Schmidt Tags: Health Living With Prostate Cancer Prostate Knowledge Treatments HPK Source Type: blogs

3 easy ways to eat a healthier diet
While many people might be taking a pass on formal New Year’s resolutions this year, others may mark a fresh start this month by resolving to make up for poor eating habits of the past. But this motivation is often focused on a diet that’s too ambitious, or too restrictive. Without a solid plan, you may fail quickly. So consider a compromise: start with these three easy ways to eat a healthier diet. Aim for real food only Look at your plate and note what’s processed and what isn’t. Maybe it’s the whole thing (like a frozen dinner), or maybe it’s just part of your meal (like the bottled dressing on your salad). ...
Source: Harvard Health Blog - January 4, 2021 Category: Consumer Health News Authors: Heidi Godman Tags: Diet and Weight Loss Health Healthy Eating Source Type: blogs

Fight Aging! Newsletter, January 4th 2021
The objective of this study is to quantify the overall and cancer type-specific risks of subsequent primary cancers (SPCs) among adult-onset cancer survivors by first primary cancer (FPC) types and sex. Among 1,537,101 survivors (mean age, 60.4 years; 48.8% women), 156,442 SPC cases and 88,818 SPC deaths occurred during 11,197,890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general po...
Source: Fight Aging! - January 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Look Back at 2020: Progress Towards the Treatment of Aging as a Medical Condition
While I suspect that COVID-19 will feature prominently in most retrospectives on 2020, I'll say only a little on it. The data on mortality by year end, if taken at face value, continues to suggest that the outcome will fall at the higher end of the early estimates of a pandemic three to six times worse than a bad influenza year, ten times worse than a normal influenza year. The people who die are near entirely the old, the co-morbid, and the immunocompromised. They die because they are suffering the damage and dysfunction of aging. Yet the societal conversation and the actions of policy makers ignore this. There is ...
Source: Fight Aging! - December 31, 2020 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs

Fight Aging! Newsletter, December 28th 2020
In conclusion, our study demonstrated that the molecular processes of aging are relatively subtle in their progress, and the aging process of every tissue depends on the tissue's specialized function and environment. Hence, individual gene or process alone cannot be described as the key of aging in the whole organism. Mouse Age Matters: How Age Affects the Murine Plasma Metabolome A large part of metabolomics research relies on experiments involving mouse models, which are usually 6 to 20 weeks of age. However, in this age range mice undergo dramatic developmental changes. Even small age differences may l...
Source: Fight Aging! - December 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

An Enlightening Protein
A fruit fly expressing GFP. Credit: Jay Hirsh, University of Virginia. During the holiday season, twinkling lights are a common sight. But no matter what time of the year, you can see colorful glows in many biology labs. Scientists have enabled many organisms to light up in the dark—from cells to fruit flies and Mexican salamanders. These glowing organisms help researchers better understand basic cell processes because their DNA has been edited to express molecules such as green fluorescent protein. Illuminating Cell Processes A zebrafish fin with GFP glowing (green dots) where gene sox9b is expressed. This...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 23, 2020 Category: Research Authors: Chrissa Chverchko Tags: Genes Tools and Techniques Cool Tools/Techniques DNA Proteins Source Type: blogs

Fight Aging! Newsletter, December 21st 2020
In this study, we have found that administration of a specific Sgk1 inhibitor significantly reduces the dysregulated form of tau protein that is a pathological hallmark of AD, restores prefrontal cortical synaptic function, and mitigates memory deficits in an AD model. These results have identified Sgk1 as a potential key target for therapeutic intervention of AD, which may have specific and precise effects." Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer's disease Epigenetic aberration is implicated in aging and neurodegeneration. Using p...
Source: Fight Aging! - December 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Radiotherapy to Prevent Recurrence Post Brain Tumor Excision: Interview with Matthew Likens, President and CEO of GT Medical
GT Medical Technologies, a company based in Arizona, has developed the FDA-approved GammaTile system, which can provide localized radiation therapy for brain tumor excision sites. Its goal is to reduce tumor recurrence and enhance patient survival. T...
Source: Medgadget - December 15, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Materials Medicine Neurosurgery Oncology Radiation Oncology Radiology Source Type: blogs

Midline Glioma – research fundraiser
UPDATE: Since posting, the fundraiser has gone from 57% to 62% target reached! Thank you! Keep those donations coming in. Diffuse Midline Glioma, H3 K27M Mutation is not a phrase you want to hear from a doctor. It’s a type of tumour that most commonly affects people under about the age of 25 years but over 3 years. It’s very rare – 100 people in the UK annually – but always lethal, sadly. The tumour grows rapidly within the Central Nervous System and has a devastating effect on the spinal cord or the brain depending on precisely where it grows. I must admit I’d heard of spinal tumours, but do...
Source: David Bradley Sciencebase - Songs, Snaps, Science - December 15, 2020 Category: Science Authors: David Bradley Tags: Cancer Source Type: blogs

Your Relationship With Unreasonable Standards
Here’s a simple rule of thumb that I learned at the start of the pandemic: If you think you’re being reasonably cautious, you’re probably taking on too much risk. If you think you’re being unreasonably cautious, you’re probably doing it right. This made sense to me, so I aimed to keep my COVID-prevention standards higher than I thought was reasonable. I sought to keep them at a level that made me wonder if I was overdoing it. Since the start of the pandemic, Rachelle and I haven’t had friends or family over, we stopped doing in-person meetups, and we stopped all travel. We have ...
Source: Steve Pavlina's Personal Development Blog - December 13, 2020 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Health Lifestyle Relationships Source Type: blogs

Fight Aging! Newsletter, December 14th 2020
In conclusion, aging alters the cerebral vasculature to impair mitochondrial function and mitophagy and increase IL-6 levels. These alterations may impair BBB integrity and potentially reduce cerebrovascular health with aging. Senescent Cells Fail to Maintain Proteostasis https://www.fightaging.org/archives/2020/12/senescent-cells-fail-to-maintain-proteostasis/ Given the newfound consensus in the research community regarding the importance of senescent cells to degenerative aging, it isn't surprising to see a great deal more fundamental research into the biochemistry of cellular senescence now taking pla...
Source: Fight Aging! - December 13, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs