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Prostate cancer treatment: strategies for managing side effects
After skin cancer, prostate cancer is the most common cancer diagnosed in men in the U.S., with one in eight men at risk of being diagnosed with this cancer during his lifetime. If you or a man you care about is undergoing prostate cancer treatment, you may be living with treatment-related side effects. These can […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - January 29, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/miles-j-varn" rel="tag" > Miles J. Varn, MD < /a > < /span > Tags: Conditions Oncology/Hematology Urology Source Type: blogs

Are early detection and treatment always best?
Throughout my medical career, I’ve heard statements like these: Early detection offers the best chance of cure. If you wait for symptoms, you’ve waited too long. Knowledge is power, and the sooner you have the information, the better. Over time, I’ve realized they are often untrue. Many health conditions go away on their own. In such cases, early testing may amount to wasted effort, time, and medical cost. Some testing is invasive and has a significant risk of complications. And minor abnormalities may lead to more testing. There’s also the anxiety of waiting for results, or learning you have an abnormality of unce...
Source: Harvard Health Blog - January 28, 2021 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Back Pain Heart Health Managing your health care Prevention Screening Tests and procedures Source Type: blogs

Hormonal therapies for advanced prostate cancer linked to a higher risk of falls and fractures
Falls rank among the top causes of death and injuries among the elderly, and the risk increases significantly in older people being treated for cancer. Now, investigators are reporting that a newer class of drugs for advanced prostate cancer is associated with a significant increase in fall risk. Called androgen receptor inhibitors, or ARIs, these drugs target testosterone, a hormone that accelerates the growth of prostate tumors. Unlike traditional hormonal treatments that interfere with the body’s ability to make testosterone (known as androgen deprivation therapy, or ADT), ARIs work by preventing testosterone from...
Source: Harvard Health Blog - January 7, 2021 Category: Consumer Health News Authors: Charlie Schmidt Tags: Health Living With Prostate Cancer Prostate Knowledge Treatments HPK Source Type: blogs

Who should give bad news?
I’m starting this post with a disclaimer, and while it’s been a hell of a lot of days since I posted, disclaimers are only an occasional thing. Generally. So my return starts with a disclaimer. Please enjoy this setup Tweet, and enjoy the foreshadowing: https://twitter.com/gruntdoc/status/1342323360580202497 then https://twitter.com/gruntdoc/status/1342325476929503233 Let’s start with the premise, and then I’ll fill in the details. Who is the best person to break bad news? Short version, it’s an ER doctor! Why??? Well, let’s get into that. When in med school one of the thousands of papers we were assigned (I th...
Source: GruntDoc - December 26, 2020 Category: Emergency Medicine Authors: GruntDoc Tags: Medical Source Type: blogs

New high-resolution imaging scans approved for use in prostate cancer
Imagine trying to find a single match from a book of matches in a large room. Not an easy task, right? But if the lights were dimmed and the match was lit, then its location would be immediately apparent. This is the basic idea behind PSMA imaging, a newly approved method for detecting prostate cancer that is spreading, or metastasizing. The method relies on a minimally radioactive tracer called gallium-68 PSMA-11. Delivered in tiny amounts by injection, the tracer travels throughout the body and gloms onto a protein called PSMA that is found at high levels on prostate cancer cell surfaces. The labeled cells will then ligh...
Source: Harvard Health Blog - December 17, 2020 Category: Consumer Health News Authors: Charlie Schmidt Tags: Diagnosis Health Prostate Knowledge HPK Source Type: blogs

Radiotherapy to Prevent Recurrence Post Brain Tumor Excision: Interview with Matthew Likens, President and CEO of GT Medical
GT Medical Technologies, a company based in Arizona, has developed the FDA-approved GammaTile system, which can provide localized radiation therapy for brain tumor excision sites. Its goal is to reduce tumor recurrence and enhance patient survival. T...
Source: Medgadget - December 15, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Materials Medicine Neurosurgery Oncology Radiation Oncology Radiology Source Type: blogs

Fight Aging! Newsletter, December 14th 2020
In conclusion, aging alters the cerebral vasculature to impair mitochondrial function and mitophagy and increase IL-6 levels. These alterations may impair BBB integrity and potentially reduce cerebrovascular health with aging. Senescent Cells Fail to Maintain Proteostasis https://www.fightaging.org/archives/2020/12/senescent-cells-fail-to-maintain-proteostasis/ Given the newfound consensus in the research community regarding the importance of senescent cells to degenerative aging, it isn't surprising to see a great deal more fundamental research into the biochemistry of cellular senescence now taking pla...
Source: Fight Aging! - December 13, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Bayer G4A Agents of Change: Watch the Panels, Meet the Co ’s that Got Deals
By JESSICA DaMASSA, WTF HEALTH Bayer G4A, the global life science company’s digital health innovation arm, held their splashy “Agents of Change” event last month to not only introduce their latest cohort of health tech partners, but to also demonstrate the pharma co’s commitment to digital transformation. The entire C-suite of Bayer’s Pharma division became a panel itself — marking the first time the full leadership team of a major pharmaceutical company appeared together to talk strategically about tech’s role in shaping the pharma business model of the future.  The rest of the program’s age...
Source: The Health Care Blog - December 10, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Health Technology Jessica DaMassa Start-Ups WTF Health Source Type: blogs

Incontinence Management Change Up Could Make Dad ’s Buddy Trip Possible
Dear Carol: My father is 72 and is in the moderate stages of dementia. Before his dementia diagnosis, he was an active hunter and fisherman. He also has incontinence issues due to prostate cancer, surgery, and treatment. This requires an external urinary attachment system to maintain an active daily life. My mother, as his primary caregiver, works diligently to keep the system and attachments clean and in working order. However, he is at the stage in his dementia journey where he is not able to maintain this attachment on his own. Yet he is defiant when we try to explain that he cannot go on trips with friends becaus...
Source: Minding Our Elders - December 10, 2020 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

How Much of Cognitive Decline is Actively Maintained via Dysfunctional Cell States or Signaling, and is thus Quickly Reversible?
Demonstrations in which researchers adjust cell state or signaling to reverse cognitive decline in old mice suggest that a meaningfully large fraction of this age-related cognitive decline is actively maintained via dysfunctions in cell signaling and cell activity. Senescent cells and their inflammatory signaling are a likely culprit, though it is challenging to join the dots between signaling and specific mechanisms inside cells in the highly complex environment of cellular biochemistry. The important point is that much of the decline in cognitive function could be quickly reversed if specific signals and mechanisms can b...
Source: Fight Aging! - December 8, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, December 7th 2020
In this study, except for the reduction in body weight, the aging characteristics related to epidermal and muscle tissue in mice were significantly ameliorated in the CR group compared with the control group. Additional studies have indicated that not stem cells themselves but the stem cell microenvironment is the key factor mediating stem cell activation, proliferation and differentiation. Mitochondrial dysfunction is an important factor leading to age-related muscular atrophy. Considering the dependence of skeletal muscle on ATP, loss of mitochondrial function, which can lead to a decrease in strength and enduranc...
Source: Fight Aging! - December 6, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Towards Control Over the Dynamic Equilibrium of Bone Tissue Maintenance
Bone loses mass and strength with age, leading to the condition called osteoporosis. The extracellular matrix of bone is dynamically remodeled throughout life, built up osteoblast cells and broken down by osteoclast cells. Osteoporosis is the result of a growing imbalance in cell activity and cell creation that favors osteoclasts. There are many contributing causes, and some uncertainty of which of these causes are more or less important. The chronic inflammation that accompanies aging does appear to be important, particularly that connected to the senescence-associated secretory phenotype (SASP) of senescent cells. ...
Source: Fight Aging! - December 2, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

The sequence of hormonal therapy and radiation affects outcomes in men treated for prostate cancer
A common treatment for men with intermediate-risk prostate cancer is to combine radiation with drugs that block testosterone — a hormone that makes the tumors grow faster. (This type of treatment is also called androgen deprivation therapy, or ADT). New research is suggesting the sequence of these treatments may be crucially important. Dr. Dan Spratt, a professor of radiation oncology at the University of Michigan, led the research. He and his colleagues pooled data from two previously published clinical trials (here and here). Taken together, the studies enrolled just over 1,000 men who had been randomly assigned to one...
Source: Harvard Health Blog - November 24, 2020 Category: Consumer Health News Authors: Charlie Schmidt Tags: Living With Prostate Cancer Prostate Knowledge Treatments HPK Source Type: blogs

Fight Aging! Newsletter, November 9th 2020
In this study, young adult mice were submitted to endurance exercise training and the function, differentiation, and metabolic characteristics of satellite cells were investigated in vivo and in vitro. We found that injured muscles from endurance-exercised mice display improved regenerative capacity, demonstrated through higher densities of newly formed myofibres compared with controls (evidenced by an increase in embryonic myosin heavy chain expression), as well as lower inflammation (evidenced by quantifying CD68-marked macrophages), and reduced fibrosis. Enhanced myogenic function was accompanied by an increased ...
Source: Fight Aging! - November 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs