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New drugs approved for advanced BRCA-positive prostate cancer
Defective BRCA genes are well known for their ability to cause breast and ovarian cancers in women. But these same gene defects are also strong risk factors for aggressive prostate cancer in men. About 10% of men with metastatic prostate cancer — meaning cancer that is spreading away from the prostate — test positive for genetic mutations in BRCA genes. Fortunately, these cancers can be treated with new types of personalized therapies.
In May, the FDA approved two new drugs specifically for men with BRCA-positive metastatic prostate cancer that has stopped responding to other treatments. One of the drugs, called rucapa...
Source: Harvard Health Blog - June 15, 2020 Category: Consumer Health News Authors: Charlie Schmidt Tags: Health Prostate Knowledge Treatments HPK Source Type: blogs
More Women Are Pursuing Majority-Male Specialties and Changing Patients ’ Perceptions
By AMY E. KRAMBECK, MD
With the exceptions of pediatrics and obstetrics/gynecology, women make up fewer than half of all medical specialists. Representation is lowest in orthopedics (8%), followed by my own specialty, urology (12%). I can testify that the numbers are changing in urology – women are up from just 8% in 2015, and the breakdown in our residency program here at Indiana University is now about 20% of the 5-year program.
One reason for the increase is likely the growth of women in medicine – 60% of doctors under 35 are women, as are more than half of medical school enrollees. I also credit a generat...
Source: The Health Care Blog - June 5, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Amy Krambeck female physicians majority male specialties Patients Source Type: blogs
Massachusetts Health Committee Makes History: Approves End of Life Options Bill for 1st Time since 2011 Introduction
On Friday afternoon, the Massachusetts Joint Committee on Public Health approved legislation that would authorize medical aid in dying as an end-of-life care option. This is the first time the committee approved such legislation since it was originally introduced
in 2011.
The Massachusetts End of Life Options
Act (H.1926 / S.1208), would give mentally capable, terminally ill individuals
with a prognosis of six months or less to live the option to request, obtain
and self-ingest medication to die peacefully in their sleep if their suffering
becomes unbearable.
“I can’t tell you how much this hist...
Source: blog.bioethics.net - June 1, 2020 Category: Medical Ethics Authors: Thaddeus Mason Pope, JD, PhD Tags: Health Care syndicated Source Type: blogs
Combining different biopsies limits uncertainty in prostate cancer diagnosis
Are prostate cancer biopsies reliably accurate?
Not always.
The most common method, called a systematic biopsy, sometimes misses tumors, and it can also misclassify cancer as being either more or less aggressive than it really is. During systematic biopsy, a doctor takes 12 evenly-spaced samples of the prostate, called cores, while looking at the gland with an ultrasound machine.
A new method, called MRI-targeted biopsy, guides doctors to suspicious abnormalities in the prostate, and emerging evidence suggests that it’s better at detecting high-grade, aggressive tumors that need immediate treatment. These biopsies re...
Source: Harvard Health Blog - May 26, 2020 Category: Consumer Health News Authors: Charlie Schmidt Tags: Diagnosis Health Prostate Knowledge HPK Source Type: blogs
Chemicals and Pregnant Women: Taking Care of Your Unborn Baby
This study is not a warning of a scary new epidemic of problems arriving with next year’s babies.
Instead, it’s a peak behind the curtain at what might be the hidden story behind the marvelous kids we already see on today’s playgrounds across the country. Most are very healthy – among the healthiest kids in history. Yes, too many are overweight. Too many have asthma. Too many have allergies. Too many have learning problems. Too many start puberty early. More than half have some chronic illness. But this isn’t slowing kids down as much as the devastating infectious diseases of the past. It is a vib...
Source: Conversations with Dr Greene - May 25, 2020 Category: Child Development Authors: Alan Greene MD Tags: Uncategorized Source Type: blogs
Parent's Decision Not To Be Treated for Cancer Upsets Daughter
Photo credit Aaron Andrew
Dear Carol: There’s probably no right answer to what I’m asking but I felt the need to write just for comfort. My mother died when I was in my teens, so Dad has been the only parent that I’ve had for more than 20 years. I have no siblings. Dad’s now in his 70s and has been diagnosed with prostate cancer. He’s beaten both melanoma and lung cancer in the past, but he tells me that this cancer should be slow-growing and that he’ll probably die before it’s a problem so he doesn’t want to treat it. I want him to go full-on with every treatment possible. I watched both of my parents figh...
Source: Minding Our Elders - May 14, 2020 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Fight Aging! Newsletter, May 4th 2020
The objective is to start treating chronic diseases from the root and not the symptoms of the disease. As we are starting to enroll patients in "senolytics-clinical trials," it will be imperative to assess if senolysis efficiently targets the primary cause of disease or if it works best in combination with other drugs. Additional basic science research is required to address the fundamental role of senescent cells, especially in the established contexts of disease.
Notes on Self-Experimentation with Sex Steroid Ablation for Regrowth of the Thymus
https://www.fightaging.org/archives/2020/04/notes-on-self-experim...
Source: Fight Aging! - May 3, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Notes on Self-Experimentation with Sex Steroid Ablation for Regrowth of the Thymus
I periodically publish thoughts on self-experiments that seem interesting and relevant to aging. Despite the influence of the quantified self movement, the broader self-experimentation community is largely terrible on matters of research, rigor, reporting, and safety. My motivation is to something to raise the bar on all of these items.
For every discussion I've published on a particular self-experiment, there are half a dozen others sitting at some stage of research and interest. Over the past year or so, I've been on and off looking into sex steroid ablation as a mechanism for thymus regrowth. Since my company, Re...
Source: Fight Aging! - April 30, 2020 Category: Research Authors: Reason Tags: Self-Experimentation Source Type: blogs
More sexual partners, more cancer?
Two headlines caught my eye recently:
The relationship between chronic diseases and number of sexual partners: an exploratory analysis
and
Study warns more sex might mean higher likelihood for cancer
It may be hard to believe, but both of these refer to same medical research. I’m not sure which one I like better. The first one is the actual title of the research, which provides no information about its findings. The second one is a newspaper headline. It cuts right to the chase about the study’s main findings. While it’s much more specific — and alarming — it is also misleading.
Is there a link between the number...
Source: Harvard Health Blog - April 28, 2020 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Cancer Relationships Sex Sexual Conditions Source Type: blogs
New radiation therapies keep advanced prostate cancer in check
Treatments for prostate cancer are always evolving, and now research is pointing to new ways of treating a cancer that has just begun to spread, or metastasize, after initial surgery or radiation. Doctors usually give hormonal therapies in these cases to block testosterone, which is a hormone that makes the cancer grow faster. But newer evidence shows that treating the metastatic tumors directly with radiation can produce better results.
In March, researchers published the latest study that supports this approach. Based at Johns Hopkins University School of Medicine in Baltimore, the team used a method for delivering power...
Source: Harvard Health Blog - April 28, 2020 Category: Consumer Health News Authors: Charlie Schmidt Tags: Living With Prostate Cancer Prostate Knowledge Treatments HPK Source Type: blogs
Fight Aging! Newsletter, March 9th 2020
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - March 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Targeting cancers ’ surroundings
Can targeting a tumours' surroundings, rather than the tumour itself, be a way of preventing metastasis? Related items fromOnMedica Breast cancer deaths down due to screening and new therapies UK cancer survival improved, but lags behind similar nations Genetic risk model could guide prostate cancer screening Blood test for breast cancer may be a step closer Doctors urge government to act on rising alcohol impact
Source: OnMedica Blogs - March 2, 2020 Category: General Medicine Source Type: blogs
An Update from the Methuselah Foundation on Progress at Methuselah Fund Portfolio Companies
The Methuselah Foundation is one of the oldest of the present generation of organizations focused on advancing human rejuvenation, founded more than 15 years ago. At that time there was none of the present enthusiasm for treating aging as a medical condition, and indeed the concept was mocked outside the scientific community and actively discouraged within research circles by leading scientists in the field of gerontology. The Methuselah Foundation and its network of allies are a large part of the reason why things have changed: it took a great deal of work to change this dismissive culture into one that saw and embraced t...
Source: Fight Aging! - March 2, 2020 Category: Research Authors: Reason Tags: Investment Source Type: blogs
New study compares long-term side effects from different prostate cancer treatments
Prostate cancer therapies are improving over time. But how do the long-term side effects from the various options available today compare? Results from a newly published study are providing some valuable insights.
Investigators at Vanderbilt University and the University of Texas MD Anderson Cancer Center spent five years tracking the sexual, bowel, urinary, and hormonal status of nearly 2,000 men after they had been treated for prostate cancer, or monitored with active surveillance (which entails checking the tumor periodically and treating it only if it begins to grow). Cancers in all the men were still confined to the p...
Source: Harvard Health Blog - February 27, 2020 Category: Consumer Health News Authors: Charlie Schmidt Tags: Health Prostate Knowledge Treatments HPK Source Type: blogs
