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Should You Care for Aging Parents Who Neglected or Abused You in Childhood
Photo credit Berhard Grossgasteiger Years ago, a journalist (we’ll call her Nancy) requested an interview with me to discuss common caregiving issues for an article she was writing. We bonded during our chat, and Nancy shared some of her own experiences trying to cope with her aging parents’ needs. In addition to notoriously difficult decisions that come with caregiving, like whether Dad should continue driving or if Mom needs more help at home, Nancy was also struggling with years and years of toxic family history. Initially, she felt that her experience was unusual. After all, we mostly hear about family caregi...
Source: Minding Our Elders - March 31, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Balancing Elder Care with Other Relationships Is Challenging
Photo credit Alex Iby Becoming a family caregiver is often something that either happens very suddenly or slowly sneaks up on a person. When a loved one has a health setback or begins needing more assistance, we tend to go into “crisis mode” and haphazardly shift our priorities around to ensure their immediate needs are met. Most family caregivers take on these responsibilities thinking they will be short-term commitments and that life will soon return to “normal.” But the reality is that caregiving can drag on for weeks, months, and even years. Without any solid plans or reprioritizing, things that were once at th...
Source: Minding Our Elders - March 30, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Keeping Older Adults Active and and Engaged
Photo credit Bret Meliti As family caregivers, we strive to meet all our loved ones’ needs. We give medication reminders, cook meals, manage doctor’s appointments and keep schedules. Our daily tasks can be challenging, but one, in particular, gives families a lot of grief: ensuring our loved ones are stimulated and entertained. If a senior’s abilities have waned, it can be challenging to find ways to adapt or replace the pastimes they once loved. Sometimes, though, our loved ones simply lose their motivation to participate in life. They may complain, nag us, or spend all day sleeping or watching television. What is a...
Source: Minding Our Elders - March 29, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Arts Improve Quality of life for Stroke Survivors and People with Alzheimer's
Photo credit Crystal de Pasille Chabot "Patients who appreciated music, painting and theatre recovered better from their stroke than patients who did not"Patients interested in art had better general health, found it easier to walk, and had more energy. They were also happier, less anxious or depressed, and felt calmer. They had better memory and were superior communicators (speaking with other people, understanding what people said, naming people and objects correctly)." Read more on HealthCentral about how the arts can improve quality of life for stroke survivors: Minding Our Elders: Caregivers Share Their Personal Stori...
Source: Minding Our Elders - March 28, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Fight Aging! Newsletter, March 28th 2022
In conclusion, we summarized here evidence for a novel therapeutic approach to exploit the incredible ability of mitochondria to engage multifaceted neuroprotective stress response triggered by partial complex I inhibition. This approach promises relief for multiple human conditions, and to promote healthy aging to delay the onset of neurogenerative diseases, AD in particular, where age is the greatest risk factor. There is a mounting body of evidence generated in model organisms and humans in support of the safety of chronic application of complex I inhibitors. However, a better understanding of the molecular mechanisms i...
Source: Fight Aging! - March 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, March 21st 2022
This study was the first to examine how these networks interact with physical activity and fitness to impact how the brain functions. "This paper is exciting because it gives us some evidence that when people whose brain networks aren't functioning optimally engage in physical activity, we see improvement in their executive function and their independence. Maybe just take the stairs on the way to work. Stand up and walk around a little bit more. That's where you get the most bang for your buck, not crazy, high-intensity exercise." Variations in Biological Age Across Organs in Younger Individuals https://...
Source: Fight Aging! - March 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, March 14th 2022
This study tests the feasibility of chronically elevating skeletal muscle NAD+ in mice and investigates the putative effects on mitochondrial respiratory capacity, insulin sensitivity, and gene expression. The metabolic effects of NR and PT treatment were modest. We conclude that the chronic elevation of skeletal muscle NAD+ by the intravenous injection of NR is possible but does not affect muscle respiratory capacity or insulin sensitivity in either sedentary or physically active mice. Our data have implications for NAD+ precursor supplementation regimens. Muscle Strengthening Activities in Later Life Correlate ...
Source: Fight Aging! - March 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Clearance of Senescent Cells is a Promising Approach to the Treatment of Alzheimer ' s Disease
Today's open access review discusses the growing burden of cellular senescence with age in the context of brain tissue and neurodegenerative disease. Cells become senescent constantly throughout life, largely the result of ordinary somatic cells hitting the Hayflick limit on replication, but also, and increasingly with age, due to a stressful, damaging, inflammatory environment. Senescent cells serve a useful purpose when present for the short term, in the context of wound healing or cancer suppression for example, by rousing the immune system into action and changing the behavior of nearby cells. But the signaling of sene...
Source: Fight Aging! - March 10, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, March 7th 2022
This study estimates that prescreening with a 500 blood test could reduce by half both the cost and the time it takes to enroll patients in clinical trials that use PET scans. Screening with blood tests alone could be completed in less than six months and cut costs by tenfold or more, the study finds. Known as Precivity AD, the commercial version of the test is marketed by C2N Diagnostics. The current study shows that the blood test remains highly accurate, even when performed in different labs following different protocols, and in different cohorts across three continents. xCT Knockout Modestly Extends Life in M...
Source: Fight Aging! - March 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, February 28th 2022
In conclusion, as BMI and waist circumference are related to elevations of immune markers in the IL-6 pathway, chronic inflammation might be an important mediator of the relationship between BMI and frailty. Fat Tissue Becomes Dysfunctional with Age as Mitochondria Falter https://www.fightaging.org/archives/2022/02/fat-tissue-becomes-dysfunctional-with-age-as-mitochondria-falter/ Mitochondria are effectively power plants, hundreds of them working in every cell to produce chemical energy store molecules to power cellular processes. Mitochondrial function declines with age, unfortunately, for underlying re...
Source: Fight Aging! - February 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fat Tissue Becomes Dysfunctional with Age as Mitochondria Falter
Mitochondria are effectively power plants, hundreds of them working in every cell to produce chemical energy store molecules to power cellular processes. Mitochondrial function declines with age, unfortunately, for underlying reasons that appear to involve gene expression changes that reduce the effectiveness of mitochondrial quality control mechanisms. This has profound effects on tissue function throughout the body, and is an important contribution to degenerative aging. Here, researchers discuss some of the effects on fat tissue specifically. Researchers looked at the role of age and physical training in mainta...
Source: Fight Aging! - February 25, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, February 21st 2022
In conclusion, clinical trials targeting aging in humans have shown promising but limited results on biomarkers so far. Mycobacterium Vaccae Immunization as an Anti-Inflammatory Strategy https://www.fightaging.org/archives/2022/02/mycobacterium-vaccae-immunization-as-an-anti-inflammatory-strategy/ In today's open access paper, researchers discuss immunization with Mycobacterium vaccae as an approach to reduce the inflammatory overactivity of the aged immune system. Researchers have made some initial inroads into studying the way in which this bacteria can alter the function of the immune system, and here...
Source: Fight Aging! - February 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, February 14th 2022
In conclusion, this first examination of the effects of age and the ageing process on the small intestinal microbiome demonstrates that the duodenal microbiome changes with increasing age, with significant decreases in duodenal microbial diversity due to increased prevalence of phylum Proteobacteria, particularly coliforms and anaerobic taxa. Given the key roles of small intestinal microbes in nutrient absorption and host metabolism, these changes may be clinically relevant for human health during the ageing process. Naked Mole Rats Exhibit Minimal Cardiac Aging https://www.fightaging.org/archives/2022/02/naked...
Source: Fight Aging! - February 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, February 7th 2022
In this study, we used accelerometer measurements (1) to examine the association of physical activity and mortality in a population-based sample of US adults and (2) to estimate the number of deaths prevented annually with modest increases in moderate-to-vigorous physical activity (MVPA) intensity. This analysis included 4,840 participants. Increasing MVPA by 10, 20, or 30 minutes per day was associated with a 6.9%, 13.0%, and 16.9% decrease in the number of deaths per year, respectively. We estimated that approximately 110,000 deaths per year could be prevented if US adults aged 40 to 85 years or older increased th...
Source: Fight Aging! - February 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, January 31st 2022
In conclusion, the effects of MR on the gut barrier were likely related to alleviation of the oscillations of inflammation-related microbes. MR can enable nutritional intervention against age-related gut barrier dysfunction. Clearing Senescent Cells from the Neural Stem Cell Niche Rapidly Improves Neurogenesis in Old Mice https://www.fightaging.org/archives/2022/01/clearing-senescent-cells-from-the-neural-stem-cell-niche-rapidly-improves-neurogenesis-in-old-mice/ Neurogenesis is the generation of new neurons in the brain, and their integration into existing neural circuits. It is essential to learning an...
Source: Fight Aging! - January 30, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs