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Fight Aging! Newsletter, August 23rd 2021
In this study, we used the UK Biobank (n = 440,185) to resolve previous ambiguities in the relationship between serum IGF-1 levels and clinical disease. We examined prospective associations of serum IGF-1 with mortality, dementia, vascular disease, diabetes, osteoporosis, and cancer, finding two generalized patterns.
First, IGF-1 interacts with age to modify risk in a manner consistent with antagonistic pleiotropy; younger individuals with high IGF-1 are protected from disease, while older individuals with high IGF-1 are at increased risk for incident disease or death. Second, the association between IGF-1 and risk ...
Source: Fight Aging! - August 22, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Do Senescent Cells Have Sufficiently Distinct Surface Markers to be Targeted for Destruction?
Many of the approaches to selective cell destruction pioneered in the cancer research community distinguish target cells from bystander cells via cell surface markers. Do senescent cells have a sufficiently distinct set of surface markers to safely employ this strategy to reduce the burden of cellular senescence in old tissue, and thereby produce rejuvenation of tissue function? Almost certainly yes, as the immune system uses exactly this approach to identify and kill senescent cells. Identifying the surface markers involved is a plausible goal, presently underway. Several biotech companies work on forms of senolytic immun...
Source: Fight Aging! - August 17, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 16th 2021
In conclusion, cancer survivors, especially older individuals, demonstrate greater odds of and accelerated functional decline, suggesting that cancer and/or its treatment may alter aging trajectories.
Linking Particulate Air Pollution and Dementia in a Small Region of the US
https://www.fightaging.org/archives/2021/08/linking-particulate-air-pollution-and-dementia-in-a-small-region-of-the-us/
It is fairly settled that evident particulate air pollution, such as daily exposure to smoke from wood-fueled cooking fires, has a strongly detrimental effect on long-term health. The mechanisms involved are inflamm...
Source: Fight Aging! - August 15, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
We Live in an Age of Biotechnology, In Which We Could Choose to End the Suffering of Aging
Bringing degenerative aging under medical control, ending the tens of millions of deaths each year, ending the suffering of hundreds of millions more. This is a plausible goal for our era of biotechnology. Yet even as the first rejuvenation therapies have become a reality, in the form of first generation senolytic drugs that clear a sizable fraction of senescent cells from the body, there is little public enthusiasm for - and understanding of - the path ahead to a better world. A world in which people have the choice not to decay in body and mind as they gather wisdom and experience in later life. Change is in the air, but...
Source: Fight Aging! - August 10, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 9th 2021
In conclusion, the present study supports that some age-related diseases as well as education are causally related to longevity and highlights several new targets for achieving longevity, including management of venous thromboembolism, appropriate intake of sugar, and control of body fat. Our results warrant further studies to elucidate the underlying mechanisms of these reported causal associations.
Pol III Inhibition Extends Longevity in Short-Lived Species
https://www.fightaging.org/archives/2021/08/pol-iii-inhibition-extends-longevity-in-short-lived-species/
As this paper notes, Pol III is downstream...
Source: Fight Aging! - August 8, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, August 2nd 2021
This study aimed to determine the association between: (i) cognitive decline and bone loss; and (ii) clinically significant cognitive decline on Mini Mental State Examination (MMSE) over the first 5 years and subsequent fracture risk over the following 10 years. A total of 1741 women and 620 men aged ≥65 years from the population-based Canadian Multicentre Osteoporosis Study were followed from 1997 to 2013. Over 95% of participants had normal cognition at baseline. After multivariable adjustment, cognitive decline was associated with bone loss in women but not men. Approximately 13% of participants experienced sign...
Source: Fight Aging! - August 1, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
On the bias of science: Part three
Okay, we have established that universities, as a class, do not have any agenda or preference for that the outcome of scientific investigations will be. The exceptions, obviously, are institutions like Liberty University, Bob Jones, and Oral Roberts, that deny evolution and cosmologya priori. But at colleges and universities that are not run by religious fanatics, faculty investigators are independent and they pursue their own lines of research, conduct investigations of their design, and interpret the results as they understand them. We have also established that the government does not have any agenda or preference for w...
Source: Stayin' Alive - July 11, 2021 Category: American Health Source Type: blogs
Fight Aging! Newsletter, July 12th 2021
In conclusion, our study demonstrated that elevated cumulative SBP or DBP was independently associated with increased risk of CVD in the Chinese population. Among participants with 15-year cumulative BP levels higher than the median, that is, 1970.8/1239.9 mmHg-year for cumulative SBP/DBP, which was equivalent to maintaining SBP/DBP level higher than 131/83 mmHg in 15 years, the CVD risk would increase significantly irrespective of whether or not the BP measurements at one examination was high. Our findings emphasize the importance of cumulative BP level in identifying individuals with high risk of CVD in the future.
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Source: Fight Aging! - July 11, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Lack Of This Vitamin Linked To Brain Damage
Low levels have also been linked to Alzheimer's disease, as well as cancer and heart disease.
Source: PsyBlog | Psychology Blog - July 8, 2021 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Nutrition Source Type: blogs
Fight Aging! Newsletter, July 5th 2021
In conclusion, the findings suggest that DNAm GrimAge is a strong predictor of mortality independent of genetic influences.
Heart Failure Correlates with Increased Cancer Risk
https://www.fightaging.org/archives/2021/07/heart-failure-correlates-with-increased-cancer-risk/
Age-related disease results from the underlying cell and tissue damage that causes aging. Different people accumulate that damage at modestly different rates, the result of lifestyle choices and exposure to infectious disease. Thus the presence of a sufficient burden of damage to produce one age-related disease will be accompanied by a ...
Source: Fight Aging! - July 4, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Emerging Trends: Technology ’s Response To Alzheimer’s Disease
In our new series, Emerging Trends, we are looking at those technologies in digital health that are on a particular ‘hype cycle’ – technologies and solutions that currently stand out from the rest because of their novelty, timeliness, or greatness. These are solutions everyone’s talking about or the ones they should.
Technological solutions to cognitive decline and Alzheimer’s disease, in particular, are rising with increasing pipeline drug development, promising biomarkers, and more. Let’s jump right in.
Liza Marshall was “over the moon” when she said yes to the love of her life in a small cerem...
Source: The Medical Futurist - June 29, 2021 Category: Information Technology Authors: berci.mesko Tags: Forecast Lifestyle medicine Artificial Intelligence in Medicine E-Patients Future of Medicine Personalized Medicine Robotics Telemedicine & Smartphones alzheimer brain diagnosis digital digital health Healthcare Innovation me Source Type: blogs
Fight Aging! Newsletter, June 28th 2021
In conclusion, in our prospective community-based study, aging-related biomarkers were associated with measures of subclinical atherosclerosis cross-sectionally and with all-cause mortality prospectively, supporting the concept that these biomarkers may reflect the aging process in community-dwelling adults.
The Role of Aging Macrophages in Skin Inflammation
https://www.fightaging.org/archives/2021/06/the-role-of-aging-macrophages-in-skin-inflammation/
The immune system is complex and ages in complex ways, pressed by the lifetime burden of infection and rising levels of molecular damage that trigger many...
Source: Fight Aging! - June 27, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How To Stay Positive While Caregiving
...My dad is in the middle stages of Alzheimer’s disease. Meanwhile, my mom is recovering from cancer surgery, and the prognosis isn’t good. I’m trying my best to be a good caregiver for both of them and stay positive while doing it, but it’s hard. I recognize that we’re fortunate in that my parents are able to hire an agency that supplies a rotation of in-home caregivers. The other side of it is that I have a brother and a sister, both living hundreds of miles away from our parents and me, so they can’t help out much. They try to be sympathetic and appreciative of what I’m doing, but their suggestions usuall...
Source: Minding Our Elders - June 22, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins."
Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, June 14th 2021
In conclusion, a number of high-income countries, changes in health expectancies over time have not kept pace with the growth in life expectancy. That is, people are living longer but disability and poor health are occupying an increasing proportion of later life. Our findings suggest that countries still need to make significant progress to achieve the WHO's Decade of Healthy Ageing goal of healthier, longer lives for all.
Progress on Understanding Why Human Growth Hormone Receptor Variants are Associated with Greater Longevity
https://www.fightaging.org/archives/2021/06/progress-on-understanding-why-human-gro...
Source: Fight Aging! - June 13, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
