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A new Alzheimer ’ s drug: From advisory panel to FDA — what ’ s at stake here?
It’s been more than 17 years since the FDA last approved an Alzheimer’s drug. Will Biogen’s drug, called aducanumab, end this drought? The FDA will decide by March 2021, based on its own analysis of clinical trial data and an advisory panel’s review of the evidence.
How does the drug work?
Aducanumab is a monoclonal antibody engineered in a laboratory to stick to the amyloid molecule that forms plaques in the brains of people with Alzheimer’s. Most researchers believe that the plaques form first and damage brain cells, causing tau tangles to form inside them, killing the cells. Once aducanumab has stuck to the pl...
Source: Harvard Health Blog - November 12, 2020 Category: Consumer Health News Authors: Andrew E. Budson, MD Tags: Alzheimer's Disease Brain and cognitive health Healthy Aging Medical Research Memory Source Type: blogs
Fight Aging! Newsletter, November 9th 2020
In this study, young adult mice were submitted to endurance exercise training and the function, differentiation, and metabolic characteristics of satellite cells were investigated in vivo and in vitro.
We found that injured muscles from endurance-exercised mice display improved regenerative capacity, demonstrated through higher densities of newly formed myofibres compared with controls (evidenced by an increase in embryonic myosin heavy chain expression), as well as lower inflammation (evidenced by quantifying CD68-marked macrophages), and reduced fibrosis. Enhanced myogenic function was accompanied by an increased ...
Source: Fight Aging! - November 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
November Appropriate Month for Celebrating Hospice and Palliative Care
“I hope we don’t have another funeral this Christmas,” my young son said after we wrapped up Halloween. Hearing my child voice that fear nearly broke my heart, but our family had endured the deaths of two elders during the last two Christmas seasons so why wouldn't he wonder if this year would be the same? Thankfully, that particular year we didn’t have a funeral during the season, though we did have another death at that time the following year. So, when it comes to death during the holidays, I have had some experience. I’ve also learned a lot since then about how hospice can not only make the death proces...
Source: Minding Our Elders - November 7, 2020 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Fight Aging! Newsletter, November 2nd 2020
In conclusion, the circulating antibody repertoire has increased binding to thousands of peptides in older donors, which can be represented as an immune age. Increased immune age is associated with autoimmune disease, acute inflammatory disease severity, and may be a broadly relevant biomarker of immune function in health, disease, and therapeutic intervention. The immune age has the potential for wide-spread use in clinical and consumer settings.
In Vivo Reprogramming Improves Cognitive Function in Old Mice
https://www.fightaging.org/archives/2020/10/in-vivo-reprogramming-improves-cognitive-function-in-old-mic...
Source: Fight Aging! - November 1, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Research into the Mechanisms of Aging is Very Poorly Funded in Comparison to its Importance to Health
Research into aging is sparsely funded in comparison to research into the biochemistry and treatment of any specific common age-related disease, such as atherosclerosis or Alzheimer's disease. Yet these conditions are caused by aging. So we have the strange situation in which the past century of work on treating age-related conditions has produced only small gains, because the research and development communities have steadfastly refused to work on the root cause of these conditions - which is to say the mechanisms of aging, the accumulation of cell and tissue damage that causes degeneration and dysfunction.
This pr...
Source: Fight Aging! - October 26, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Targeting Aging is the Way to Treat Diseases of Aging
Near all work to date on the treatment of age-related disease has failed to consider or target underlying mechanisms of aging, the molecular damage that accumulates to cause pathology. It has instead involved one or another attempt to manipulate the complicated, disrrayed state of cellular metabolism in late stage disease, chasing proximate causes of pathology that are far downstream of the mechanisms of aging. This strategy has largely failed, and where it has succeeded has produced only modest benefits. Consider that statins, widely thought to be a major success in modern medicine, do no more than somewhat reduce and del...
Source: Fight Aging! - October 26, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 26th 2020
In conclusion, all NAFLD histological stages were associated with significantly increased overall mortality, and this risk increased progressively with worsening NAFLD histology. Most of this excess mortality was from extrahepatic cancer and cirrhosis, while in contrast, the contributions of cardiovascular disease and HCC were modest.
BMP6 as a Target for Pro-Angiogenic Therapies
https://www.fightaging.org/archives/2020/10/bmp6-as-a-target-for-pro-angiogenic-therapies/
Today's research materials are focused on the fine details of angiogenesis, the formation of new blood vessels, and point to BMP6 as a po...
Source: Fight Aging! - October 25, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Caregiving for Schizophrenia
A third of all people will be a caregiver at some point in their lives. Caregiving for people with schizophrenia presents challenges that many people are ill-prepared for.
Host Rachel Star breaks down the principles of caregiving and creative ways to navigate schizophrenia.
Dr. Sarah Kopelovich joins to share schizophrenia caregiver specific training.
About our Guest
Sarah Kopelovich, PhD is a forensically-trained licensed clinical psychologist in the Department of Psychiatry and Behavioral Sciences at the University of Washington School of Medicine. Dr. Kopelovich is an Assistant Professor in the department and holds the...
Source: World of Psychology - October 21, 2020 Category: Psychiatry & Psychology Authors: Rachel Star Withers Tags: Brain and Behavior Caregivers Family Inside Schizophrenia Mental Health and Wellness Psychology Adult Caregiver Caregiver stress Family Caregivers life with schizophrenia Living With Schizophrenia Mental Illness Psychotherapy Sel Source Type: blogs
Inside Schizophrenia: Caregiving for Schizophrenia
A third of all people will be a caregiver at some point in their lives. Caregiving for people with schizophrenia presents challenges that many people are ill-prepared for.
Host Rachel Star breaks down the principles of caregiving and creative ways to navigate schizophrenia.
Dr. Sarah Kopelovich joins to share schizophrenia caregiver specific training.
About our Guest
Sarah Kopelovich, PhD is a forensically-trained licensed clinical psychologist in the Department of Psychiatry and Behavioral Sciences at the University of Washington School of Medicine. Dr. Kopelovich is an Assistant Professor in the department and holds the...
Source: World of Psychology - October 21, 2020 Category: Psychiatry & Psychology Authors: Rachel Star Withers Tags: Brain and Behavior Caregivers Family Inside Schizophrenia Mental Health and Wellness Psychology Adult Caregiver Caregiver stress Family Caregivers life with schizophrenia Living With Schizophrenia Mental Illness Psychotherapy Sel Source Type: blogs
Myokines Mediate the Effects of Exercise on Health
Mapping mammalian biochemistry is a sizable task, and much of that biochemistry remains poorly understood and categorized. Cell signaling is a vast topic in and of itself. Here researchers discuss myokines, signal molecules generated by muscle cells as a result of exercise. These diverse signals are influential on tissue function and health, and mediate some fraction of the benefits resulting from physical activity. Further, some clearly change in abundance with age, and might therefore be useful targets for interventions intended to better maintain health and function with aging.
In recent decades, it has been di...
Source: Fight Aging! - October 20, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 19th 2020
In conclusion, we found that regardless of the presence of multimorbidity, engaging in a healthier lifestyle was associated with up to 6.3 years longer life for men and 7.6 years for women; however, not all lifestyle risk factors equally correlated with life expectancy, with smoking being significantly worse than others.
A Hydrogel Scaffold to Encourage Peripheral Nerve Regeneration
https://www.fightaging.org/archives/2020/10/a-hydrogel-scaffold-to-encourage-peripheral-nerve-regeneration/
The nervous system of mammals is poorly regenerative at best. The use of implantable scaffold materials is one of the...
Source: Fight Aging! - October 18, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, October 12th 2020
We report that FMT from aged donors led to impaired spatial learning and memory in young adult recipients, whereas anxiety, explorative behaviour, and locomotor activity remained unaffected.
This was paralleled by altered expression of proteins involved in synaptic plasticity and neurotransmission in the hippocampus. Also, a strong reduction of bacteria associated with short-chain fatty acids (SCFAs) production (Lachnospiraceae, Faecalibaculum, and Ruminococcaceae) and disorders of the CNS (Prevotellaceae and Ruminococcaceae) was observed. Finally, the detrimental effect of FMT from aged donors on the CNS was confir...
Source: Fight Aging! - October 11, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Alzheimer's Semi-Postal Stamp: It Never Goes Out Of Season
Kathy Siggins and Lynda Everman are thrilled to share the welcome news that the US Postal Service has reinstated sales of the Alzheimer’s Disease Research Semipostal Stamp effective October 5, 2020. It is now available for purchase at most post offices and online at https://store.usps.com/store/product/buy-stamps/alzheimers-S_564204, and by phone at 1-800 STAMP-24.
Before it was withdrawn in November 2019, over 8.2 million stamps were sold during its two-year run raising $1,061,777 for NIH-supported research to advance better treatments, prevention, and one day, a cure of Alzheimer’s and related dementias. The reinstat...
Source: Minding Our Elders - October 10, 2020 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Fight Aging! Newsletter, October 5th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 4, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, September 28th 2020
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results.
Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - September 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
