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Targeting the Failure of Mitophagy as a Basis for Treating Age-Related Disease
Evidence strongly suggests that the global faltering of mitochondrial function throughout the body with advancing age has a lot to do with a decline in the effectiveness of mitophagy. Mitochondria are the power plants of the cell, a herd of hundreds swarming and replicating like bacteria in every cell to produce the chemical energy store molecule ATP. Mitophagy is the specialized form of autophagy that destroys worn and damaged mitochondria, recycling their component parts. Without it, cells would become overtaken by broken, malfunctioning mitochondria. Mitochondrial dysfunction leads to too little ATP, but also higher lev...
Source: Fight Aging! - June 3, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 1st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - May 31, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Chemicals and Pregnant Women: Taking Care of Your Unborn Baby
This study is not a warning of a scary new epidemic of problems arriving with next year’s babies.
Instead, it’s a peak behind the curtain at what might be the hidden story behind the marvelous kids we already see on today’s playgrounds across the country. Most are very healthy – among the healthiest kids in history. Yes, too many are overweight. Too many have asthma. Too many have allergies. Too many have learning problems. Too many start puberty early. More than half have some chronic illness. But this isn’t slowing kids down as much as the devastating infectious diseases of the past. It is a vib...
Source: Conversations with Dr Greene - May 25, 2020 Category: Child Development Authors: Alan Greene MD Tags: Uncategorized Source Type: blogs
Inside Schizophrenia: The Role Nurses Play in Schizophrenia Treatment
Some of the professionals that work most with helping people with schizophrenia are nurses. There are so many types with different skill sets. Host Rachel Star Withers and Co-host Gabe Howards learn who these often overlooked healthcare workers are.
Dr. Tari Dilks, Professor and President of the American Psychiatric Nurses Association, joins with insight on what goes into being a psychiatric nurse.
Highlights in “The Role Nurses Play in Schizophrenia Treatment” Episode
[01:14] Doctor sidekicks?
[04:00] The types of nurses
[06:40] Nurse Practitioners
[11:00] Nurses specialties
[13:00] Psychiatric Nursing
[1...
Source: World of Psychology - May 20, 2020 Category: Psychiatry & Psychology Authors: Rachel Star Withers Tags: Inside Schizophrenia Mental Health and Wellness Psychiatry Psychology Mental Disorder Mental Illness Nurses Nursing Psychiatric Nurse Psychotherapy Treatment For Schizophrenia Source Type: blogs
Fight Aging! Newsletter, May 18th 2020
This study provides direct evidence for the contribution of gut microbiota to the cognitive decline during normal aging and suggests that restoring microbiota homeostasis in the elderly may improve cognitive function.
On Nutraceutical Senolytics
https://www.fightaging.org/archives/2020/05/on-nutraceutical-senolytics/
Nutraceuticals are compounds derived from foods, usually plants. In principle one can find useful therapies in the natural world, taking the approach of identifying interesting molecules and refining them to a greater potency than naturally occurs in order to produce a usefully large therape...
Source: Fight Aging! - May 17, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
On Nutraceutical Senolytics
Nutraceuticals are compounds derived from foods, usually plants. In principle one can find useful therapies in the natural world, taking the approach of identifying interesting molecules and refining them to a greater potency than naturally occurs in order to produce a usefully large therapeutic effect. Unfortunately, in practice the nutraceutical industry is a largely a lazy one, in which entrepreneurs take advantage of a short path to market, and a lack of interest among consumers in whether or not products actually work, in order to repackage cheap ingredients into expensive brands that have minimal, unreliable, or even...
Source: Fight Aging! - May 15, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, May 11th 2020
In this study, we found that older nematodes have higher ROS levels. Interestingly, after hydrogen treatment, the ROS levels were significantly decreased, and hydrogen could significantly extend the lifespans of the N2, sod-3 and sod-5 mutant strains, by approximately 22.7%, 9.5%, and 8.7%, respectively.
In addition, aging is regulated by a variety of pathways, such as the insulin signaling pathway, the rapamycin target signaling pathway, and the caloric restriction pathway. However, our results showed that the lifespans of the daf-2 and daf-16 strains, in which these pathways are upregulated, were not affected afte...
Source: Fight Aging! - May 10, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 27th 2020
In conclusion, our study demonstrated that Nrf2 deficiency promoted the increasing trend of autophagy during aging in skeletal muscle. Nrf2 deficiency and increasing age may cause excessive autophagy in skeletal muscle, which can be a potential mechanism for the development of sarcopenia.
To What Degree is Chondrocyte Hypertrophy in Osteoarthritis Due to Cellular Senescence?
https://www.fightaging.org/archives/2020/04/to-what-degree-is-chondrocyte-hypertrophy-in-osteoarthritis-due-to-cellular-senescence/
Senescent cells are large. They do not replicate, that function is disabled, but it is as if they go ...
Source: Fight Aging! - April 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 20th 2020
In conclusion, elevated brain amyloid was associated with family history and APOE ε4 allele but not with multiple other previously reported risk factors for AD. Elevated amyloid was associated with lower test performance results and increased reports of subtle recent declines in daily cognitive function. These results support the hypothesis that elevated amyloid represents an early stage in the Alzheimer's continuum.
Blood Metabolites as a Marker of Frailty
https://www.fightaging.org/archives/2020/04/blood-metabolites-as-a-marker-of-frailty/
Frailty in older people is usually diagnosed in a symptomatic ...
Source: Fight Aging! - April 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 13th 2020
This study is par for the course, looking at Japanese Olympic participants. Interestingly, it hints at the upper end of the dose-response curve for physical activity, in that a longer career as a professional athlete may be detrimental in comparison to lesser degrees of exercise and training.
From this large, retrospective cohort study targeting 3546 Japanese Olympic athletes, we observed significant lower mortality among Olympians compared with the Japanese general population. The overall standardised mortality ratio (SMR) was 0.29. The results were consistent with previous studies conducted in other non-Asian co...
Source: Fight Aging! - April 12, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A TAT Peptide Based Approach to Upregulation of Proteasomal Activity
The proteasome is a construct in cells that shreds damaged, misfolded, or unwanted proteins, reducing them to component parts that can be reused. It is a part of the ubuiquitin-proteasome system: molecules to be destroyed are tagged with ubiquitin, and drawn into a proteasome for recycling. Greater proteasome activity is thought to be a good thing, improving cell function. This is of particular relevance to aging, as proteasomal function declines with age, contributing to faltering cell and tissue function, particularly in the long-lived cells of the nervous system.
While established drugs exist to inhibit activity ...
Source: Fight Aging! - April 10, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, April 6th 2020
This study delves into the mechanisms by which a short period of fasting can accelerate wound healing. Fasting triggers many of the same cellular stress responses, such as upregulated autophagy, as occur during the practice of calorie restriction. It isn't exactly the same, however, so it is always worth asking whether any specific biochemistry observed in either case does in fact occur in both situations. In particular, the period of refeeding following fasting appears to have beneficial effects that are distinct from those that occur while food is restricted.
Multiple forms of therapeutic fasting have been repor...
Source: Fight Aging! - April 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, March 30th 2020
This study, for the first time, shows that transplantation of non-autologous mitochondria from healthy skeletal muscle cells into normal cardiomyocytes leads to short-term improvement of bioenergetics indicating "supercharged" state. However, over time these improved effects disappear, which suggests transplantation of mitochondria may have a potential application in settings where there is an acute stress.
Outlining Some of the Science Behind Partial Reprogramming at Turn.bio
https://www.fightaging.org/archives/2020/03/outlining-some-of-the-science-behind-partial-reprogramming-at-turn-bio/
Turn.bio is a...
Source: Fight Aging! - March 29, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Natural Killer Cells May Act to Reduce Neuroinflammation
Researchers here provide evidence for natural killer cells to act to reduce inflammation in the brain. This is of interest because chronic inflammation in brain tissue, neuroinflammation, is a prominent feature of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. If a natural mechanism that suppresses inflammation can be harnessed, it might be possible to slow or reverse neurodegenerative conditions, given that inflammation appears to play such a significant role in their progression. That said, recent work on cellular senescence in the supporting cells of brain suggests that selectively elimi...
Source: Fight Aging! - March 26, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 23rd 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - March 22, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
