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Fight Aging! Newsletter, August 10th 2020
This study aimed to characterize the role of BDNF in age-related microglial activation. Initially, we found that degrees of microglial activation were especially evident in the substantia nigra (SN) across different brain regions of aged mice. The levels of BDNF and TrkB in microglia decreased with age and negatively correlated with their activation statuses in mice during aging. Interestingly, aging-related microglial activation could be reversed by chronic, subcutaneous perfusion of BDNF. Peripheral lipopolysaccharide (LPS) injection-induced microglial activation could be reduced by local supplement of BDNF, while shTrkB...
Source: Fight Aging! - August 9, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, August 3rd 2020
In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice.
To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the treatment with the...
Source: Fight Aging! - August 2, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, July 27th 2020
In this study, we applied a well studied prediction model developed on data from five CpG sites, to increase the practicability of these tests.
We have determined the biological age of the heart, specifically of the right atrium (RA) and left atrium (LA), and of peripheral blood leucocytes, by measuring the mitotic telomere length (TL) and the non-mitotic epigenetic age (DNAmAge). We found that DNAmAge, of both atrial tissues (RA and LA), was younger in respect to the chronological age (-12 years). Furthermore, no significant difference existed between RA and LA, suggesting that, although anatomically diverse and ex...
Source: Fight Aging! - July 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mechanisms by Which Somatic Mosaicism May Contribute to Degenerative Aging
Cells are liquid bags of molecules, constantly interacting and reacting with one another. Many of those reactions are unwanted and damaging to the molecular machinery of the cell, but repair of structures and replacement of damaged molecules is also a constant and ongoing process. The most efficient repair processes are those that attend the DNA that is folded away in the cell nucleus. Despite these processes, mutational damage to nuclear DNA slips though the layered schemes of protection and repair. It has to: without that damage, evolution would not occur.
There is some debate over the degree to which nuclear DNA ...
Source: Fight Aging! - July 24, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Do Non-Replicating Cells Exhibit Senescence During the Aging Process?
Most somatic cells in the body replicate, but sizable populations do not, known as post-mitotic cells, such as varieties of neuron in the central nervous system. Cellular senescence is fundamentally a process by which cell division is halted, a reaction to DNA damage, short telomeres, or a toxic signaling environment. Cells that become senescent swell in size, as though about to divide, but instead remain large. While in that state, they secrete a potent mix of inflammatory molecules that rouse the immune system, degrade surrounding tissue structure, and alter the behavior of nearby cells. In the short term this can be use...
Source: Fight Aging! - July 23, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Does air pollution cause Alzheimer ’s disease?
Have you ever spent the day in a city with such bad air pollution that when you blew your nose the mucus had a black tinge? Have you ever coughed as you breathed in diesel fumes from a passing bus and thought to yourself, “Well, that’s a year gone from my life”? Could it actually be true — that air pollution leads to an early death? The answer, in fact, is an unqualified yes.
Air pollution causes heart disease, lung disease, and early death
It has been known for some time that air pollution causes lung cancer, chronic obstructive pulmonary disease, emphysema, asthma, heart disease, and stroke. One recent study in C...
Source: Harvard Health Blog - July 23, 2020 Category: Consumer Health News Authors: Andrew E. Budson, MD Tags: Alzheimer's Disease Environmental health Healthy Aging Memory Neurological conditions Source Type: blogs
Fight Aging! Newsletter, July 20th 2020
This study was the first to demonstrate a causal relationship between glial senescence and neurodegeneration. In this study, accumulations of senescent astrocytes and microglia were found in tau-associated neurodegenerative disease model mice. Elimination of these senescent cells via a genetic approach can reduce tau deposition and prevent the degeneration of cortical and hippocampal neurons.
Most recently, it was shown that clearance of senescent oligodendrocyte progenitor cells in AD model mice with senolytic agents could lessen the Aβ plaque load, reduce neuroinflammation, and ameliorate cognitive deficits. This...
Source: Fight Aging! - July 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, July 6th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - July 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, June 29th 2020
In conclusion, metabolomics is a promising approach for the assessment of biological age and appears complementary to established epigenetic clocks.
Sedentary Behavior Raises the Risk of Cancer Mortality
https://www.fightaging.org/archives/2020/06/sedentary-behavior-raises-the-risk-of-cancer-mortality/
Living a sedentary lifestyle is known to be harmful to long term health, raising the risk of age-related disease and mortality. Researchers here show that a sedentary life specifically increases cancer mortality, and does so independently of other factors. This is one of many, many reasons to maintain a re...
Source: Fight Aging! - June 28, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Update: Repetitive negative thinking may increase (or perhaps be caused by) Alzheimer ’s pathology
Time for a new edition of SharpBrains’ e‑newsletter, featuring this month 13 research findings, resources and brain teasers for lifelong brain and mental health.
#1. “We found that people who exhibited higher repetitive negative thinking patterns experienced more cognitive decline over a four-year period. They also had specific declines in memory (which is an early sign of Alzheimer’s disease), and had more amyloid and tau deposits in their brain … There’s increasing evidence that chronic stress is both harmful to your body – and your brain. But more research is needed to understand this link.” Repetit...
Source: SharpBrains - June 25, 2020 Category: Neuroscience Authors: SharpBrains Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness Technology Alzheimer’s Disease biofeedback brain health Brain Teasers DSM FDA mental health neurotechnology noninvasive neurotechnologies noninvasive ne Source Type: blogs
Reviewing the Role of the Immune System in Clearance of Senescent Cells
Cells in the body become senescent constantly, in response to reaching the Hayflick limit on replication, to DNA damage, to a toxic local environment, to injury. A senescent cell grows large, ceases replication, and secretes a potent mix of signals, the senescence-associated secretory phenotype (SASP). The SASP rouses the immune system into an inflammatory state, disrupts tissue maintenance and structure, and encourages other cells to also become senescent. In the short term this is a necessary part of wound healing and cancer suppression. If maintained for the long term, the SASP becomes very harmful, however.
Near...
Source: Fight Aging! - June 22, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, June 22nd 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 21, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Your Smartphone As The Swiss Knife Of Digital Health
7:39 a.m. That’s the time that your smartphone’s sonar deems as optimal for you to wake up today. With its gentle vibration from your bedside table, you pick it up to turn off the smart alarm. As you do so, your phone asks for your permission to use the built-in sensors and camera to run your routine morning scan. It analyzes your voice; evaluates your stress level based on a facial scan; checks your vital signs; and notifies you to take a picture of that mole on your forearm in order to detect any anomalies.
Thereafter, it outputs a comprehensible report with recommendations which you can send over to your ph...
Source: The Medical Futurist - June 16, 2020 Category: Information Technology Authors: Prans Tags: Artificial Intelligence E-Patients Health Sensors & Trackers Telemedicine & Smartphones stress health trackers Huntington's Alzheimer's disease covid19 camera apple health google fit WHO hemoglobin SpO2 Samsung oximetry F Source Type: blogs
Fight Aging! Newsletter, June 8th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 7, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reuse of a Small Molecule to Increase Autophagy in the Brain is Trialed for Alzheimer ' s Disease
Today I'll point out an example of drug reuse and autophagy upregulation. The processes of autophagy are responsible for recycling molecular waste and broken cellular structures. Autophagy is upregulated in response to stress placed upon cells, whether by heat, cold, lack of nutrients, a toxic local environment, and so forth. This is beneficial to tissue function, health, and longevity, and thus there is considerable interest in the research community in producing therapies that boost the operation of autophagy. This hasn't made a great deal of progress towards the clinic, but nonetheless in any of the sizable databases of...
Source: Fight Aging! - June 5, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
