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Fight Aging! Newsletter, June 29th 2020
In conclusion, metabolomics is a promising approach for the assessment of biological age and appears complementary to established epigenetic clocks. Sedentary Behavior Raises the Risk of Cancer Mortality https://www.fightaging.org/archives/2020/06/sedentary-behavior-raises-the-risk-of-cancer-mortality/ Living a sedentary lifestyle is known to be harmful to long term health, raising the risk of age-related disease and mortality. Researchers here show that a sedentary life specifically increases cancer mortality, and does so independently of other factors. This is one of many, many reasons to maintain a re...
Source: Fight Aging! - June 28, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, June 22nd 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 21, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Blood Pressure Control Increases Life Expectancy Even in the Most Frail Elderly People
Chronically raised blood pressure, or hypertension, is highly damaging to tissues throughout the body. It is an important mechanism linking the molecular damage of aging to gross structural damage to organs, causing loss of function, age-related disease, and death. Many of the underlying causes of aging lead to stiffness of blood vessel walls, from cross-linking in the extracellular matrix to the effects of senescent cell signaling on vascular smooth muscle cells. That stiffness causes dysfunction in the regulation of blood pressure, which in turn causes pressure damage, increased pace of the development of atherosclerosis...
Source: Fight Aging! - June 17, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Quantifying Loss of Kidney Function with Age in a Human Population
Kidney function is critical to health, but, as is the case for all organs, the kidneys declines with age. The damage of aging produces harmful outcomes in many ways. For example, hypertension causes structural pressure damage in sensitive tissues in the kidneys. Further, senescent cells and other sources of chronic inflammation disrupt normal tissue maintenance processes in the kidneys, leading to the scar-like collagen deposits of fibrosis. In turn, loss of kidney function accelerates many other aspects of aging, including neurodegeneration and the onset of cognitive decline. An international study that has been ...
Source: Fight Aging! - June 16, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, June 15th 2020
In this study, we used markers to monitor the formation of SGs in Caenorhabditis elegans. We found that, in addition to acute heat stress, SG formation could also be triggered by dietary changes, such as starvation and dietary restriction (DR). We found that HSF-1 is required for the SG formation in response to acute heat shock and starvation but not DR, whereas the AMPK-eEF2K signaling is required for starvation and DR-induced SG formation but not heat shock. Moreover, our data suggest that this AMPK-eEF2K pathway-mediated SG formation is required for lifespan extension by DR, but dispensable for the longevity by reduced ...
Source: Fight Aging! - June 14, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Can forest therapy enhance health and well-being?
According to this study, green spaces are restorative and boost attention, while viewing concrete worsens attention during tasks. Finding a forest therapy guide The Association of Nature and Forest Therapy trains and certifies forest therapy guides across the world. Guides help people forge a partnership with nature through a series of invitations that allow participants to become attentive to the forest, to deepen their relationship with nature, and allow the natural world to promote healing and well-being. Ultimately, guides support what the forests have to offer us, inviting participants into practices that deepen physi...
Source: Harvard Health Blog - May 29, 2020 Category: Consumer Health News Authors: Susan Abookire, BSEE, MD, MPH, FACP Tags: Exercise and Fitness Health Mental Health Stress Source Type: blogs

What ’s a diagnosis about? COVID-19 and beyond
By MICHEL ACCAD Last month marked the 400th anniversary of the birth of John Graunt, commonly regarded as the father of epidemiology.  His major published work, Natural and Political Observations Made upon the Bills of Mortality, called attention to the death statistics published weekly in London beginning in the late 16th century.  Graunt was skeptical of how causes of death were ascribed, especially in times of plagues.  Evidently, 400 years of scientific advances have done little to lessen his doubts!  A few days ago, Fox News reported that Colorado governor Jared Polis had “pushed back against recen...
Source: The Health Care Blog - May 28, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Medical Practice Physicians Diagnosis MICHEL ACCAD Source Type: blogs

Some healthcare can safely wait (and some can ’t)
Among the many remarkable things that have happened since the COVID-19 pandemic began is that a lot of our usual medical care has simply stopped. According to a recent study, routine testing for cervical cancer, cholesterol, and blood sugar is down nearly 70% across the country. Elective surgeries, routine physical examinations, and other screening tests have been canceled or rescheduled so that people can stay at home, avoid being around others who might be sick, and avoid unknowingly spreading the virus. Many clinics, hospitals, and doctors’ offices have been closed for weeks except for emergencies. Even if these facil...
Source: Harvard Health Blog - May 20, 2020 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Health Health care Healthy Aging Men's Health Women's Health Source Type: blogs

Inside Schizophrenia: The Role Nurses Play in Schizophrenia Treatment
Some of the professionals that work most with helping people with schizophrenia are nurses. There are so many types with different skill sets. Host Rachel Star Withers and Co-host Gabe Howards learn who these often overlooked healthcare workers are. Dr. Tari Dilks, Professor and President of the American Psychiatric Nurses Association, joins with insight on what goes into being a psychiatric nurse.  Highlights in “The Role Nurses Play in Schizophrenia Treatment” Episode [01:14] Doctor sidekicks? [04:00] The types of nurses [06:40] Nurse Practitioners [11:00] Nurses specialties [13:00] Psychiatric Nursing [1...
Source: World of Psychology - May 20, 2020 Category: Psychiatry & Psychology Authors: Rachel Star Withers Tags: Inside Schizophrenia Mental Health and Wellness Psychiatry Psychology Mental Disorder Mental Illness Nurses Nursing Psychiatric Nurse Psychotherapy Treatment For Schizophrenia Source Type: blogs

Fight Aging! Newsletter, May 18th 2020
This study provides direct evidence for the contribution of gut microbiota to the cognitive decline during normal aging and suggests that restoring microbiota homeostasis in the elderly may improve cognitive function. On Nutraceutical Senolytics https://www.fightaging.org/archives/2020/05/on-nutraceutical-senolytics/ Nutraceuticals are compounds derived from foods, usually plants. In principle one can find useful therapies in the natural world, taking the approach of identifying interesting molecules and refining them to a greater potency than naturally occurs in order to produce a usefully large therape...
Source: Fight Aging! - May 17, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Physical Activity Slows the Consequences of Aging
We live in a world in which most people do not undertake anywhere near the level of physical activity that is optimal. Thus adding greater physical activity as a lifestyle choice appears very beneficial. There is a great deficiency, one that has serious consequences to health, and fixing that deficiency is touted as a successful intervention. But in reality, the situation is one in which most people harm their long term health through a form of self-neglect. This era of cheap calories and comfort is a time of vast benefits for humanity - but it has a few downsides, and this is one of them. This meta-analysis showe...
Source: Fight Aging! - May 12, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Weight loss can help head off lasting damage caused by fatty liver
Non-alcoholic fatty liver disease is the most common cause of liver disease in the United States, and is estimated to affect up to a quarter of adults in the world. It is defined by excess fat accumulating in the liver and usually occurs in people with obesity, high blood sugars (diabetes), abnormal cholesterol or triglyceride levels, or high blood pressure. These disorders often run together and as a group are called metabolic syndrome. The “non-alcoholic” part of “non-alcoholic fatty liver disease” is important to distinguish it from alcohol-related liver disease, which can also cause excess liver fat. How fat ca...
Source: Harvard Health Blog - April 30, 2020 Category: Consumer Health News Authors: Irun Bhan, MD Tags: Diet and Weight Loss Digestive Disorders Source Type: blogs

Looking past the pandemic: Could building on our willingness to change translate to healthier lives?
If the COVID-19 pandemic has taught us anything, it’s that people have the capacity to change entrenched behaviors when the stakes are high enough. Who among us declared that 2020 would be the year for us to perfect the practice of physical distancing? Although we were clueless about pandemic practices a mere three months ago, we’ve adopted this new habit to avoid getting or spreading the virus. But what about other unhealthy behaviors that have the potential to shorten life spans across the US? On January 1, 2020, some of us made New Year’s resolutions aimed at improving our health: to eat less, lose weight, exercis...
Source: Harvard Health Blog - April 28, 2020 Category: Consumer Health News Authors: Steven A. Adelman, MD Tags: Addiction Behavioral Health Healthy Aging Healthy Eating Heart Health Source Type: blogs

Hypertension induced by tyrosine kinase inhibitor
Well known adverse effect of chemotherapeutic agents are cardiomyopathy and myocarditis leading to heart failure and arrhythmias. Hypertension induced by tyrosine kinase inhibitor (TKI) is an important adverse effect and has specific mechanisms. Hypertension is noted with vascular endothelial growth factor (VEGF) and vascular signalling pathway (VSP) inhibitors [1]. The incidence ranges from 5% to 80% among VEGF inhibitors and is dose dependent. Incidence of hypertension is lower in new generation small molecule TKI [1]. Mechanism of hypertension is through vascular signally pathway inhibition which causes decrease in nit...
Source: Cardiophile MD - April 27, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardio Oncology Source Type: blogs

Weight-loss surgery may lower risk of heart disease in people with diabetes
Obesity is a serious, chronic, treatable, and global disease epidemic. Over 98 million people currently have the disease of obesity, and in a recent New England Journal of Medicine article, Harvard researchers predicted that by 2030, 50% of the population in the United States will have the disease of obesity. Type 2 diabetes (T2D) is significantly associated with obesity. While many people with obesity do not have diabetes, most people with T2D have the disease of obesity. Excess adiposity (body fat storage), which is present in obesity, contributes to many chronic diseases beyond T2D. These include high blood pressure, he...
Source: Harvard Health Blog - April 16, 2020 Category: Consumer Health News Authors: Angela Fitch, MD Tags: Diabetes Diet and Weight Loss Health Heart Health Surgery Source Type: blogs