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Fight Aging! Newsletter, April 6th 2020
This study delves into the mechanisms by which a short period of fasting can accelerate wound healing. Fasting triggers many of the same cellular stress responses, such as upregulated autophagy, as occur during the practice of calorie restriction. It isn't exactly the same, however, so it is always worth asking whether any specific biochemistry observed in either case does in fact occur in both situations. In particular, the period of refeeding following fasting appears to have beneficial effects that are distinct from those that occur while food is restricted. Multiple forms of therapeutic fasting have been repor...
Source: Fight Aging! - April 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Ranitidine (Zantac) recall expanded, many questions remain
Update: On April 1, 2020, the FDA requested manufacturers to withdraw all prescription and over-the-counter (OTC) ranitidine drugs (Zantac, others) from the market immediately, due to the presence of a contaminant known as N-Nitrosodimethylamine (NDMA). Although the FDA did not observe unacceptable levels of NDMA in many of the samples they tested, they have determined that the impurity in some ranitidine products increases over time and when stored at higher than room temperatures. As a result of this recall, ranitidine products will no longer be available for prescription or OTC use in the US. The FDA is also advising co...
Source: Harvard Health Blog - April 2, 2020 Category: Consumer Health News Authors: Joshua Gagne, PharmD, ScD Tags: Digestive Disorders Drugs and Supplements Source Type: blogs

COVID-19: If you ’re older and have chronic health problems, read this
By now, you’ve probably heard this warning about the new coronavirus pandemic: those who are older and have a chronic medical condition are at increased risk for severe disease and death. If you fall into this category, here’s important information about the coronavirus outbreak tailored to you. If you look at the data, older adults and those with chronic health problems who get COVID-19 are more likely to require hospitalization and admission to an intensive care unit. And so far in the US, 80% of the deaths from the new coronavirus virus have occurred in people who were older. But this raises a number of questions: ...
Source: Harvard Health Blog - April 1, 2020 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Health Healthy Aging Infectious diseases Men's Health Prevention Women's Health Source Type: blogs

Fight Aging! Newsletter, March 23rd 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - March 22, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Go figure: A healthy eating approach helps people be healthy
This study was not perfect. You could argue, as these authors do, that the fact that participants chose their preferred diet is a good thing, as it could theoretically improve adherence. However, it also resulted in very different-sized groups to start with. The varying adherence and exercise option choices were adjusted for as well as possible. And the study relied heavily on self-reporting, which is always iffy. Healthy eating patterns have benefits beyond weight loss But we can still learn a great deal here. The Mediterranean approach to eating (which can be easily modified to suit any country or cultural food preferenc...
Source: Harvard Health Blog - March 16, 2020 Category: Consumer Health News Authors: Monique Tello, MD, MPH Tags: Cooking and recipes Diet and Weight Loss Healthy Eating Source Type: blogs

Insulin Resistance: the silent killer that you can completely reverse – even if your doctor doesn ’ t know how
You may have already heard the term “insulin resistance,” as it has been widely discussed by doctors and the media. But did you know that you can reduce or reverse it in the vast majority of people? Insulin resistance, i.e., the inability of the body’s cells, especially liver, muscle, and brain, to respond to insulin and allow blood sugar to enter cells, drives numerous abnormal health conditions including type 2 diabetes, hypertension, coronary heart disease, fatty liver, Alzheimer’s dementia, and cancer. It is therefore a driving force behind so many modern and common chronic health conditions. Yo...
Source: Wheat Belly Blog - March 12, 2020 Category: Cardiology Authors: Dr. Davis Tags: Open can belly fat can insulin resistance be reversed lose weight reduce belly fat reverse inflammation visceral fat wheat belly Source Type: blogs

Fight Aging! Newsletter, March 9th 2020
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - March 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Alcohol Damage to the Liver – What Happens?
Alcohol use disorder and heavy drinking present many harmful health risks. They can include everything from high blood pressure to fatal seizures. One of the most well-known health risks that come along with prolonged heavy drinking is liver damage. How does alcohol impact the liver, and what types of alcohol damage to the liver are there? In order to better understand alcohol damage to the liver, it is important to learn how the liver processes alcohol. According to MyDr, there are 2 ways that alcohol can be processed by your liver: Most alcohol is broken down, or metabolized, by an enzyme in your liver cells known as a...
Source: Cliffside Malibu - March 4, 2020 Category: Addiction Authors: Jaclyn Uloth Tags: Alcohol Alcohol Rehab Information Alcoholism Detox Resources for Alcohol and Drugs/Opiates alcohol abuse alcohol dependence alcohol detox alcohol treatment alcohol treatment center alcohol treatment facility Source Type: blogs

COVID-19 Deaths and Incredible WHO Estimates
Alan Reynolds“Death Toll Hits 9 as Outbreak Spreads, ” was the scaryWall Street Journalheadline in print before it was toned downonline. COVID-19 deaths at a nursing home and hospital in Washington state were unrelated to the virusspreading“across the U.S.” The facts tell us much more about the exceptionally high risks of fatal infection from COVID-19 (or pneumonia or flu) among elderly people living close together in nursing homes or hospitals, many of them already sick.The ongoing COPD-19 outbreak in Kirkland Washington at the Life Care nursing home and Evergreen hospital represents high ‐​risk...
Source: Cato-at-liberty - March 4, 2020 Category: American Health Authors: Alan Reynolds Source Type: blogs

Can short bouts of running lengthen lives?
Working hard and feeling like you don’t have any time to exercise? Well, the reality is we all have time. If you’re feeling bad about not exercising enough or at all, some exciting data crunching from a recent British Journal of Sports Medicine (BJSM) analysis of research on running and mortality rates could supply the motivation you need. What amount of running is better than no running? An abundance of research supports the health benefits of exercise. In a blog post last year, I wrote about a study in JAMA that took the first look at the effect of various cardiorespiratory fitness levels on longevity. That study sho...
Source: Harvard Health Blog - March 4, 2020 Category: Consumer Health News Authors: Marwa A. Ahmed, MD, MS Tags: Exercise and Fitness Health Healthy Aging Heart Health Source Type: blogs

Fight Aging! Newsletter, March 2nd 2020
In conclusion, the recently demonstrated protective effects of NMN treatment on neurovascular function can be attributed to multifaceted sirtuin-mediated anti-aging changes in the neurovascular transcriptome. Our present findings taken together with the results of recent studies using mitochondria-targeted interventions suggest that mitochondrial rejuvenation is a critical mechanism to restore neurovascular health and improve cerebral blood flow in aging. Wnt/β-Catenin Signaling as a Point of Intervention to Spur Greater Neural Regeneration https://www.fightaging.org/archives/2020/02/wnt-%ce%b2-catenin-signali...
Source: Fight Aging! - March 1, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Reasons to chill and reasons not to chill
Okay, I ' m not an epidemiologist or a virologist. But I do know something about those subjects, I ' m a public health professor, and I am an expert in clinical communication and risk communication. So I ' m going to offer some observations that I hope will help people keep this public health scare in proper perspective and maybe be of practical use.There are two important parameters we need to understand the risk caused by any communicable disease. I ' m going to broadly say transmissibility, and the probability that exposure will lead to serious disease.We often see transmissibility represented as a single number, called...
Source: Stayin' Alive - February 26, 2020 Category: American Health Source Type: blogs

Fight Aging! Newsletter, February 24th 2020
In conclusion, taller body height at the entry to adulthood, supposed to be a marker of early-life environment, is associated with lower risk of dementia diagnosis later in life. The association persisted when adjusted for educational level and intelligence test scores in young adulthood, suggesting that height is not just acting as an indicator of cognitive reserve. A Comparison of Biological Age Measurement Approaches https://www.fightaging.org/archives/2020/02/a-comparison-of-biological-age-measurement-approaches/ Researchers here assess the performance of a range of approaches to measuring biological...
Source: Fight Aging! - February 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Request for Startups in the Rejuvenation Biotechnology Space, 2020 Edition
This is the latest in a series of yearly posts in which I suggest areas of development for biotech startups I'd like to see actively developed as a part of the longevity industry in the near future. Today, this year, is a good time to be starting a company focused on the production of a novel therapeutic approach to intervening in the aging process. There is a great deal of funding for seed stage investment, and many compelling projects lacking champions, yet to be carried forward from academia into preclinical development. Numerous scientific and industry crossover conferences are now held every year, at which it is possi...
Source: Fight Aging! - February 17, 2020 Category: Research Authors: Reason Tags: Investment Source Type: blogs

Fight Aging! Newsletter, February 17th 2020
Discussion of the Evolutionary Genetics of Aging Thymic Involution Contributes to Immunosenescence and Inflammaging The Potential for Exosome Therapies to Treat Sarcopenia Correlations of Mitochondrial DNA Copy Number and Epigenetic Age Measures Evidence for PASK Deficiency to Reduce the Impact of Aging in Mice The Aging Retina, a Mirror of the Aging Brain Evidence for Loss of Capillary Density to be Important in Heart Disease Aspects of Immune System Aging Proceed More Rapidly in Men Deacetylation of the NLRP3 Inflammasome as a Way to Control Chronic Inflammation Transplantation of Senescent Cells is an ...
Source: Fight Aging! - February 16, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs