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Fight Aging! Newsletter, May 29th 2023
In this study, we used a Drosophila model to understand the role of the dec2P384R mutation on animal health and elucidate the mechanisms driving these physiological changes. We found that the expression of the mammalian dec2P384R transgene in fly sleep neurons was sufficient to mimic the short sleep phenotype observed in mammals. Remarkably, dec2P384Rmutants lived significantly longer with improved health despite sleeping less. In particular, dec2P384R mutants were more stress resistant and displayed improved mitochondrial fitness in flight muscles. Differential gene expression analyses went on to reveal several altered tr...
Source: Fight Aging! - May 28, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, May 15th 2023
In this study, we examined the average telomere length and telomerase activity, as well as the formation of telomere associated foci (TAFs) and the mRNA expression levels of the shelterin components in cultured primary cells of Spalax, a long-lived, hypoxia-tolerant, and cancer-resistant blind mole-rat species. We showed that with cell passages, Spalax fibroblasts demonstrated significant shortening in telomere length, similar to rat cells, and in line with the processes observed earlier in tissues. We also demonstrated that the average telomere length in Spalax fibroblasts was significantly higher than the average ...
Source: Fight Aging! - May 14, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Athletes Exhibit Half the Incidence of Hypertension in the General Population
Cardiovascular aging is greatly influenced by exercise and physical fitness, to the point at which one can point to physically active hunter-gatherer populations that exhibit very few of the common cardiovascular issues present in wealthier first world populations. Researchers here report on a study of cardiovascular aging in competitive athletic individuals, noting that they exhibit less than half of the risk of hypertension observed in the general population. This is one of many examples of the way in which athletes tend to be healthier than the average. Master athlete is a term applied to individuals typically ...
Source: Fight Aging! - May 8, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

CBG Oil ’ s Impact on Blood Pressure: Risks, Benefits, and Future Potential
Uncover the fascinating findings of a recent study on CBG oil and its effects on blood pressure, the potential dangers for those with normal levels, and the promising avenues for further research and therapeutic applications in the realm of cannabinoids. Quick Summary CBG oil, a lesser-known cannabinoid, has been found to significantly decrease blood pressure in healthy mice, according to a study conducted at the Pennsylvania State University College of Medicine. While CBG oil has potential as a treatment for high blood pressure, it could be dangerous for individuals with normal blood pressure levels due to the r...
Source: The EMT Spot - May 7, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs

Science Snippet: The Power of Proteins
Some might think that protein is only important for weightlifters. In truth, all life relies on the activity of protein molecules. A single human cell contains thousands of different proteins with diverse roles, including: Actin proteins in a cell’s cytoskeleton. Credit: Xiaowei Zhuang, HHMI, Harvard University, and Nature Publishing Group. Providing structure. Proteins such as actin make up the three-dimensional cytoskeleton that gives cells structure and determines their shapes. Aiding chemical reactions. Many proteins are biological catalysts called enzymes that speed up the rate of chemical reactions by redu...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - May 3, 2023 Category: Research Authors: Chrissa Chverchko Tags: Cells Molecular Structures Cellular Processes Medicines Proteins Science Snippet Source Type: blogs

A man in his 60s with acute chest pain and high voltage
Sent by Anonymous, written by Pendell MeyersA man in his 60s with history of CAD and 2 prior stents presented to the ED complaining of acute heavy substernal chest pain that began while eating breakfast about an hour ago, and had been persistent since then, despite EMS administering aspirin and nitroglycerin. There was associated diaphoresis, but no dyspnea, nausea, or vomiting. He reported having covid 2 weeks ago, but had seemingly fully recovered.Triage 1104:What do you think?The triage ECG was sent to me with no history (I did not have access to baseline ECGs), and I said that I thought this was just LVH causing the an...
Source: Dr. Smith's ECG Blog - April 14, 2023 Category: Cardiology Authors: Pendell Source Type: blogs

Obesity is crippling the US, but there are solutions
By STEPHANIE TILENIUS Well over a third of Americans are obese — and the percentage keeps growing at a staggering rate. Over the last twenty years, obesity prevalence grew from 30% to 42% of the US population and rates of severe obesity nearly doubled. If we don’t make serious changes to our healthcare system, it’s scary to think where we’re headed in a few short years. The fact is, obesity is far from a cosmetic condition. It can be a devastating disease and was classified as such by the American Medical Association in 2013. Obesity is the leading risk factor for deadly diseases like type 2 diabetes, heart d...
Source: The Health Care Blog - April 13, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy GLP-1 Obesity Stephanie Tilenius vida health Source Type: blogs

Fight Aging! Newsletter, April 10th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 9, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Off and on chest pain for 24 hours in a 50s year old man
Submitted by Ali Khan MD and James Mantas MD, MS, written by Pendell MeyersA man in his 50s with history of diabetes, hypertension, and tobacco use presented to the ED with 24 hours of worsening left sided chest pain radiating to the back, characterized as squeezing and pinching, associated with shortness of breath. His pain was initially mild, then became severely worse several hours prior to presentation, but then eased off again and was minimal on arrival. There was no associated diaphoresis, nausea, vomiting, arm pain, jaw pain, syncope, lightheadedness or other acute symptoms.Initial vitals: Temp 36.7 C, BP 161/79, RR...
Source: Dr. Smith's ECG Blog - April 9, 2023 Category: Cardiology Authors: Pendell Source Type: blogs

Fight Aging! Newsletter, March 27th 2023
This study has potentially significant implications in the field of OA as it provides a novel strategy for OA treatment. A Vicious Cycle of Heart Failure and Dementia https://www.fightaging.org/archives/2023/03/a-vicious-cycle-of-heart-failure-and-dementia/ The end of life is not pretty. The body is a failing machine of many complex essential parts, and the failures cascade and feed into one another as it breaks down. There is pain, loss of capacity, loss of the self as the brain runs down. There is a tendency to paper over the ugly reality in public discussion, to not talk about the facts of the matter,...
Source: Fight Aging! - March 26, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Empowering Stroke Survivors: Interview with Kirsten Carroll, General Manager at Kandu Health
Kandu Health, a digital health company based in California, has developed a platform to assist stroke survivors with aftercare. Healthcare for stroke patients is primarily focused on acute care to limit the damage caused by the stroke. However, the c...
Source: Medgadget - March 20, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Neurology Rehab kanduhealth stroke rehab Source Type: blogs

Empowering Stroke Survivors: Interview with Kirsten Carroll, CEO at Kandu Health
Kandu Health, a digital health company based in California, has developed a platform to assist stroke survivors with aftercare. Healthcare for stroke patients is primarily focused on acute care to limit the damage caused by the stroke. However, the c...
Source: Medgadget - March 20, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Neurology Rehab kanduhealth stroke rehab Source Type: blogs

Fight Aging! Newsletter, February 27th 2023
This study tested the hypothesis that ischemic vascular repair in aging by Ang-(1-7) involves attenuation of myelopoietic potential in the bone marrow and decreased mobilization of inflammatory cells. Young or Old male mice of age 3-4 and 22-24 months, respectively, received Ang-(1-7) for four weeks. Myelopoiesis was evaluated in the bone marrow (BM) cells by carrying out the colony forming unit (CFU-GM) assay followed by flow cytometry of monocyte-macrophages. Expression of pro-myelopoietic factors and alarmins in the hematopoietic progenitor-enriched BM cells was evaluated. Hindlimb ischemia (HLI) was induced by ...
Source: Fight Aging! - February 26, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

How Omnichannel Messaging Can Solve Headaches for Healthcare Communications
The following is a guest article by Sandro Stupar, Product Management Director at Mitto. Navigating the healthcare system in America can be byzantine and time-consuming. Despite the many advances in telehealth, mobile apps and walk-in health clinics, patients and caregivers frequently find themselves waiting (often impatiently) in long phone queues to make an appointment, renew a prescription or obtain lab results. There should be a better way.  There is. Increasingly, medical providers are borrowing from the classical marketing playbook and weaving omnichannel messaging into their communications. And, just as it has in o...
Source: EMR and HIPAA - February 14, 2023 Category: Information Technology Authors: Guest Author Tags: Administration Ambulatory Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System Telemedicine and Remote Monitoring Automation Group Communication HealthGrades Improve Patient Outcomes Mitto N Source Type: blogs

Tivity Health Acquires Industry Leading Digital Health and Wellness Platform Burnalong
Acquisition will accelerate digital transformation and enhance efforts to support diverse populations and address chronic disease Tivity Health®, a leading provider of healthy life-changing solutions, today announced that it has acquired Burnalong®, a digital health, wellness and fitness platform. The acquisition will accelerate Tivity Health’s efforts to provide consumers with a robust digital platform and extensive health and wellness content, in addition to in-person opportunities through its network of fitness locations. Burnalong will also further enable Tivity Health to support diverse and at-risk populations...
Source: EMR and HIPAA - February 14, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Burnalong Chronic Disease Management Chronic Diseases Chronic Illness Daniel Freedman Digital Health Fitness and Wellness Health IT Acquisitions Healthcare M&A Mike Kott Richard Ashworth SilverSnea Source Type: blogs