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Fight Aging! Newsletter, October 26th 2020
In conclusion, all NAFLD histological stages were associated with significantly increased overall mortality, and this risk increased progressively with worsening NAFLD histology. Most of this excess mortality was from extrahepatic cancer and cirrhosis, while in contrast, the contributions of cardiovascular disease and HCC were modest.
BMP6 as a Target for Pro-Angiogenic Therapies
https://www.fightaging.org/archives/2020/10/bmp6-as-a-target-for-pro-angiogenic-therapies/
Today's research materials are focused on the fine details of angiogenesis, the formation of new blood vessels, and point to BMP6 as a po...
Source: Fight Aging! - October 25, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
COVID-19 Is Only One of the Compelling Arguments for Developing the Means of Immune System Rejuvenation
Infectious disease is a far greater risk for the old than for the young. But then so is cancer. Both are conditions driven by the age-related failure of immune system competence, a growing inability to respond to vaccines and to destroy pathogens and errant cells, a state known as immunosenescence. Further, the failing immune system becomes inappropriately overactive at the same time as losing its efficacy, generating chronic inflammation that disrupts normal tissue function and spurs the development of numerous age-related diseases. Restoring a youthful immune function would be enormously beneficial and greatly reduce mor...
Source: Fight Aging! - October 22, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Hepatitis A in the United States
Few Americans are aware of a major epidemic that has taken hold of large areas of their country in recent years – by a disease that is easily diagnosed and prevented. Sadly, public – and even professional interest in these events have been overshadowed by COVID-19.
AN UPTICK IN CASES
Hepatitis A had been largely under control until three years ago and can be easily prevented through the use of a safe and effective vaccine.
From January 2017 to January 2019, at least 26 separate outbreaks were reported, to a total of 11,628 cases and 99 deaths, nationwide. Homeless individuals and users of illicit dru...
Source: GIDEON blog - October 21, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Epidemiology News Outbreaks Source Type: blogs
Fight Aging! Newsletter, October 12th 2020
We report that FMT from aged donors led to impaired spatial learning and memory in young adult recipients, whereas anxiety, explorative behaviour, and locomotor activity remained unaffected.
This was paralleled by altered expression of proteins involved in synaptic plasticity and neurotransmission in the hippocampus. Also, a strong reduction of bacteria associated with short-chain fatty acids (SCFAs) production (Lachnospiraceae, Faecalibaculum, and Ruminococcaceae) and disorders of the CNS (Prevotellaceae and Ruminococcaceae) was observed. Finally, the detrimental effect of FMT from aged donors on the CNS was confir...
Source: Fight Aging! - October 11, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, October 5th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 4, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
America needs to invest in proactive patient outreach now
The COVID-19 pandemic has introduced multiple new threats for physical and mental health. The novel coronavirus itself continues to infect more than 30,000 Americans as we enter the influenza season. The pandemic, economic devastation, and racial reckoning have led to a tripling of emotional distress. Essential preventive services such as cancer screenings, childhood vaccination, maintenance visits for […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more.
Source: Kevin, M.D. - Medical Weblog - October 3, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/jason-bae-and-alan-glaseroff" rel="tag" > Jason Bae, MD and Alan Glaseroff, MD < /a > < /span > Tags: Policy COVID-19 coronavirus Infectious Disease Public Health & Source Type: blogs
Cellular Senescence as a Mediator of Age-Related COVID-19 Severity
Wherever we find the intersection of inflammation and aging, important in many age-related conditions, it has become the case that attention is drawn to the role of senescent cells. Senescent cells cease replication, grow in size, and secrete a potent mix of inflammatory signals. Usually they self-destruct or are destroyed by the immune system shortly after entering a senescent state. Cells become senescent constantly throughout life, and for a variety of reasons, but only with advancing age do these cells linger and build up in number. Senescent cells serve a number of useful purposes when present in the short term, assis...
Source: Fight Aging! - September 30, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 28th 2020
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results.
Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - September 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Veterinary Vaccines
Laurel J. Gershwin and Amelia R. Woolums present a new book on Veterinary Vaccines: Current Innovations and Future Trends This concise book captures the essence of current and future shifts in vaccine development research that will likely transform our understanding of methods to stimulate specific and protective immune responses to infectious diseases, and to offer improved therapeutic applications for oncology patients. The book opens with a chapter on reverse vaccinology and systems vaccinology approaches that should lead to more effective vaccines with fewer side effects. This is followed by a chapter describing rece...
Source: Microbiology Blog: The weblog for microbiologists. - September 23, 2020 Category: Microbiology Source Type: blogs
Discrimination, high blood pressure, and health disparities in African Americans
Over the past few months, we have all seen the results of significant disruption to daily life due to the COVID-19 pandemic, high levels of unemployment, and civil unrest driven by chronic racial injustice. These overlapping waves of societal insult have begun to bring necessary attention to the importance of health care disparities in the United States.
Direct links between stress, discrimination, racial injustice, and health outcomes occurring over one’s lifespan have not been well studied. But a recently published article in the journal Hypertension has looked at the connection between discrimination and increased ris...
Source: Harvard Health Blog - September 21, 2020 Category: Consumer Health News Authors: Chester Hedgepeth, III, MD, PhD Tags: Health care disparities Hypertension and Stroke Source Type: blogs
Federal Aid Creates Central ‐Planning Power
This study argues that Congress should repeal all federal aid-to-state programs for many reasons, including that aid comes with costly strings attached that destroy local democracy.Richard Epstein and Mario Loyolanoted about aid programs: “When Americans vote in state and local elections, they think they are voting on state and local policies. But often they are just deciding which local officials get to implement the dictates of distant and insulated federal bureaucrats, whom even Congress can’t control.”I came across a table (p. 82) in New Jersey ’s budget that lists the $15 billion the state received in 2020 fro...
Source: Cato-at-liberty - September 4, 2020 Category: American Health Authors: Chris Edwards Source Type: blogs
Back to school Mums
There’s an amusing, “Which back-to-school Mum are you?” doing the social media rounds. It sees Sue sending her kids back fully PPE’d, Trisha seriously concerned for the teachers’ safety, Betty in floods until they get home, and Mavis foreseeing burnout by the end of the week because of her newly full diary. But, they overlooked one kind of Mum…
The one that will insist on her human right not to wear a mask, completely ignores social distancing everywhere, brings husband Mick and Auntie Helen to wave the kids off, storms into the Head’s office shouting her mouth off about the HPV va...
Source: David Bradley Sciencebase - Songs, Snaps, Science - September 3, 2020 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs
New Cato Book: Ten Global Trends Every Smart Person Should Know: And Many Others You Will Find Interesting
In conclusion, I hope that you will buy this book and share it with your family and friends. It is meant to be a conversation piece. Instead of gathering dust on a bookshelf, it is designed to lie on a living room table (like so many architecture and interior design books), for visitors to see and discuss over a martini or glass of wine. I hope that it will alleviate some depression and anxiety, spark a fact ‐filled discussion around the dining room table, and maybe even change some minds. Strangers things have happened. Cheers!
Source: Cato-at-liberty - August 31, 2020 Category: American Health Authors: Marian L. Tupy Source Type: blogs
Fight Aging! Newsletter, August 24th 2020
We report that electrical stimulation (ES) stimulation of post-stroke aged rats led to an improved functional recovery of spatial long-term memory (T-maze), but not on the rotating pole or the inclined plane, both tests requiring complex sensorimotor skills. Surprisingly, ES had a detrimental effect on the asymmetric sensorimotor deficit.
Histologically, there was a robust increase in the number of doublecortin-positive cells in the dentate gyrus and SVZ of the infarcted hemisphere and the presence of a considerable number of neurons expressing tubulin beta III in the infarcted area. Among the genes that were unique...
Source: Fight Aging! - August 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards Better Vaccines and a Lower Burden of Infectious Disease in Old People
Over a lifetime, the burden of infectious disease - and particularly persistent infections such as cytomegalovirus - influences the pace of aging via its detrimental impact on immune function in later life. The slow upward trend in life expectancy over the past two centuries is due in no small part to reductions in infectious disease that accompanied improvements in sanitation and then medicine. In addition, in old age, once the immune system declines into ineffectieness, infectious disease becomes a much more serious concern. Infections that a young person defeats with ease become life-threatening. The primary strategy to...
Source: Fight Aging! - August 17, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
